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1. 发明专利

JP2006312086A System and method for forming aerosol of medical agent 有权
标题翻译：用于形成医药用神经药物的系统和方法
公开(公告)号：JP2006312086A
公开(公告)日：2006-11-16
申请号：JP2006227120
申请日：2006-08-23
申请人： Nektar Therapeutics , ネクターセラピューティクス
发明人： SCHULER CARLOS , PABOOJIAN STEVE , TUTTLE DERRICK J , SMITH ADRIAN E , RASMUSSEN DENNIS R , BAKSHI ANEESH , CLARK ANDREW , WARD BRIAN R S , ALSTON WILLIAM W JR , NASON KEVIN S
IPC分类号： A61M15/00 , A61M16/20
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： PROBLEM TO BE SOLVED: To provide a system and method for forming aerosol of medical agent. SOLUTION: In this method, breathing air is prevented from flowing into lungs when it is inhaled. Next, breathing air is suddenly let to flow into the lungs. Then, the flow of the breathing air is usable for extracting medical agent from a receiver, and putting the medical agent into the flow of the breathing air so as to form aerosol. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于形成药剂气溶胶的系统和方法。
解决方案：在这种方法中，吸入时防止呼吸空气流入肺部。接下来，呼吸空气突然流入肺部。然后，呼吸空气的流动可用于从接收器中提取药剂，并将医药置于呼吸空气流中，形成气溶胶。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2008068114A Dry powder dispersing apparatus and method for use thereof 有权
标题翻译：干粉分散装置及其使用方法
公开(公告)号：JP2008068114A
公开(公告)日：2008-03-27
申请号：JP2007273213
申请日：2007-10-19
申请人： Nektar Therapeutics , ネクターセラピューティックス
发明人： BURR JOHN D , SMITH ADRIAN E , HALL RANDY K , SNYDER HERM , SCHULER CARLOS , AXFORD GEORGE S , RAY CHARLES
IPC分类号： A61M13/00 , A61K31/505 , A61M15/00 , B05B11/06 , C07D239/70 , C07D487/12
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and method for aerosolizing a powdered medicament. SOLUTION: The apparatus 10 is for aerosolizing a powered medicament and includes: a housing; a pressurization cylinder; a piston which is slidable within the cylinder to pressurize a gas, the piston being pivotally mounted on the housing; a handle 40 operably mounted on the housing and the cylinder to move the cylinder with respect to the piston to pressurize the gas within the cylinder; and an aerosolizing mechanism 16 configured to accept the gas from the cylinder and aerosolize a powdered medicament. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于使粉末状药物雾化的装置和方法。解决方案：装置10用于使动力药物雾化，并且包括：壳体; 加压缸活塞，其可在所述气缸内滑动以对气体加压，所述活塞枢转地安装在所述壳体上; 手柄40，其可操作地安装在壳体和气缸上，以使气缸相对于活塞移动以对气缸内的气体加压; 以及雾化机构16，被配置为接受来自气缸的气体并使粉末状药物雾化。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2009136688A Flow resistance modulated aerosolized active agent delivery 审中-公开
标题翻译：流动电阻调节的活性剂递送
公开(公告)号：JP2009136688A
公开(公告)日：2009-06-25
申请号：JP2009002017
申请日：2009-01-07
申请人： Nektar Therapeutics , ネクターセラピューティックス
发明人： ANDREW CLARKE , SCHULER CARLOS , PABOOJIAN STEVE
IPC分类号： A61K9/12 , A61M15/00 , A61M11/00 , A61M16/00
CPC分类号： A61M15/00 , A61M2016/0021 , A61M2202/064
摘要： PROBLEM TO BE SOLVED: To provide methods and devices for delivering an active agent formulation to the lung of a human patient, in which the active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant, and the active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.
SOLUTION: The device 104 for delivering an active agent formulation to the lung of a human patient comprises a flow resistance modulator that modulates resistance to the flow of the aerosolized active agent formulation to produce an initial target flow rate of the aerosolized active agent formulation in a manner that is independent of patient instruction and flow rate monitoring 106.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供将活性剂制剂递送到人类患者的肺中的方法和装置，其中活性剂制剂可以是干粉形式，其可以是雾化的，或者可以是与推进剂混合，并且活性剂制剂以低吸入流速在初始时期递送给患者以提高活性剂的生物利用度。解决方案：用于将活性剂制剂输送到人类患者的肺的装置104包括流阻阻抗调节剂，其调节对雾化活性剂制剂的流动的阻力以产生雾化活性剂的初始目标流速以不同于患者指导和流量监测106的方式进行制定。版权所有（C）2009年，JPO＆INPIT

4. 发明申请

WO2004041340A3 INCREASED DOSAGE METERED DOSE INHALER 审中-公开
标题翻译：增加剂量计量剂吸入剂
公开(公告)号：WO2004041340A3
公开(公告)日：2005-02-24
申请号：PCT/US0334473
申请日：2003-10-30
申请人： NEKTAR THERAPEUTICS , SCHULER CARLOS , CLARK ANDREW R , WALSH KEVIN R , ALSTON WILLIAM
发明人： SCHULER CARLOS , CLARK ANDREW R , WALSH KEVIN R , ALSTON WILLIAM
IPC分类号： A61M15/00 , B65D83/14 , B65D83/52
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus (100) comprises a container (105) containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus (100) further comprises a metering chamber (130) in communication with the container (105), the metering chambe (130) adapted to hold a metered amount of the pharmaceutical formulation, a valve (140) to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber (130) when the valve (140) is actuated, and a pressurizer (165) that applies pressure to the pharmaceutical formulation in the metering chamber (130) while the pharmaceutical formulation is being released from the metering chamber (130). In one version, the metering chamber (130) is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译：雾化装置（100）包括容纳药物制剂的容器（105），所述药物制剂包含活性剂和推进剂。雾化装置（100）还包括与容器（105）连通的计量腔室（130），计量腔体（130）适于容纳计量的药物制剂，阀（140）允许计量量所述药物制剂在所述阀（140）被致动时从所述计量室（130）释放;以及加压器（165），其在所述药物制剂被释放时向所述计量室（130）中的药物制剂施加压力从计量室（130）。在一个版本中，计量室（130）的尺寸使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。

5. 发明专利

DE60035289T2 未知
公开(公告)号：DE60035289T2
公开(公告)日：2008-02-21
申请号：DE60035289
申请日：2000-12-15
申请人： NEKTAR THERAPEUTICS
发明人： SCHULER CARLOS , PABOOJIAN STEVE , CLARK ANDREW , ROURKE ANDREA M , CURLEY JOANNE , MINAMI DON S , TUTTLE DERRICK J
IPC分类号： A61M13/00 , A61M15/00 , A61M11/00 , B05B17/06 , B65D69/00 , B65D83/06
摘要： Systems and methods are provided for conditioning packaged powders. According to one method, a receptacle is provided having an enclosed chamber that contains a powder. At least one pulse of energy is applied to the receptacle to increase the efficiency at which the powder may be extracted from the chamber when flowing a gas through the chamber.

6. 发明专利

SG135936A1 SYSTEMS AND METHODS FOR AEROSOLIZING PHARMACEUTICAL FORMULATIONS 未知
公开(公告)号：SG135936A1
公开(公告)日：2007-10-29
申请号：SG2003078904
申请日：2000-06-29
申请人： NEKTAR THERAPEUTICS
发明人： SCHULER CARLOS , PABOOJIAN STEVE , TUTTLE DERRICK J , SMITH ADRIAN , RASMUSSEN DENNIS R , BAKSHI ANEESH , CLARK ANDREW , WARD BRIAN R S , WILLIAM W ALSTON JR , NASON KEVIN S
IPC分类号： A61M15/00 , A61M16/20
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.

7. 发明专利

ES2273490T3 APARATOS DE DISPERSION DE POLVO SECO Y METODOS PARA SU USO. 未知
公开(公告)号：ES2273490T3
公开(公告)日：2007-05-01
申请号：ES99924396
申请日：1999-05-19
申请人： NEKTAR THERAPEUTICS
发明人： BURR JOHN D , SMITH ADRIAN E , HALL RANDY K , SNYDER HERM , SCHULER CARLOS , AXFORD GEORGE S
IPC分类号： A61M15/00 , A61K31/505 , B05B11/06 , C07D239/70 , C07D487/12
摘要： Un aparato (10) para la aerosolización de un medicamento en polvo, el aparato consta de: un cilindro de presurización (186); un pistón (188) deslizable dentro del cilindro (186) para la presurización de un gas dentro del cilindro (186); un mango (40) conectado al cilindro (186), el mango (40) que es móvil entre una posición extendida y una posición en el alojamiento para la presurización del gas dentro del cilindro (186); y un ensamblaje del carro (38) adaptado para recibir un receptáculo (22) que contiene un medicamento en polvo, el ensamblaje del carro (38) también está adaptado para conectar el receptáculo a un mecanismo de aerosolización (16); caracterizado por: un enclavamiento (130, 102) que se puede conectar de modo operable con el ensamblaje del carro (38) para evitar la conexión del receptáculo (22) al mecanismo de aerosolización (16) donde el enclavamiento (130, 102) se puede soltar para permitir la conexión del receptáculo (22) al mecanismo de aerosolización (16) con (i) el movimiento del mango (40) una cantidad predeterminada; y/o con (ii) la inserción adecuada del receptáculo (22) en el ensamblaje del carro (38).

8. 发明专利

PL193881B1 FLOW RESISTANCE MODULATED AEROSOLIZED ACTIVE AGENT DELIVERY 未知
公开(公告)号：PL193881B1
公开(公告)日：2007-03-30
申请号：PL34790699
申请日：1999-10-07
申请人： NEKTAR THERAPEUTICS
发明人： CLARK ANDREW , SCHULER CARLOS , PABOOJIAN STEVE
IPC分类号： A61K9/12 , A61M15/00 , A61M11/00 , A61M16/00
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

9. 发明专利

MY129112A FLOW RESISTANCE MODULATED AEROSOLIZED ACTIVE AGENT DELIVERY 未知
公开(公告)号：MY129112A
公开(公告)日：2007-03-30
申请号：MYPI9904331
申请日：1999-10-07
申请人： NEKTAR THERAPEUTICS
发明人： CLARK ANDREW , PABOOJIAN STEVE , SCHULER CARLOS
IPC分类号： A61K9/12 , A61M5/00 , A61M11/00 , A61M15/00 , A61M16/00
摘要： THE PRESENT INVENTION IS DIRECTED TO METHODS AND DEVICES FOR DELIVERING AN ACTIVE AGENT FORMULATION TO THE LUNG OF HUMAN PATIENT.THE ACTIVE AGENT FORMULATION MAY BE IN DRY POWDER FORM, IT MAY BE NEBULIZED, OR IT MAY BE IN ADMIXTURE WITH A PROPELLANT.THE ACTIVE AGENT FORMULATION IS DELIVERED TO A PATIENT AT A LOW INSPIRATORY FLOW RATE FOR AN INITIAL PERIOD OF TIME TO INCREASE BIOAVAILABILITY OF THE ACTIVE AGENT.(FIG.1)

10. 发明专利

ES2265944T3 APARATO Y PROCEDIMIENTO PARA AEROSOLIZAR UNA COMPOSICION FARMACEUTICA EN POLVO. 未知
公开(公告)号：ES2265944T3
公开(公告)日：2007-03-01
申请号：ES00936239
申请日：2000-05-24
申请人： NEKTAR THERAPEUTICS
发明人： SCHULER CARLOS , PABOOJIAN STEVE , BAKSHI ANEESH K , TUTTLE DERRICK
IPC分类号： A61M11/02 , A61M15/00 , A61M11/04 , A61M11/06 , B05B7/00
摘要： Un procedimiento para aerosolizar una formulación farmacéutica en polvo contenida dentro de un receptáculo (12), que comprende: proporcionar una cantidad medida de un gas a presión que estaba previamente en equilibrio con un líquido; liberar el gas medido para crear una corriente gaseosa a alta presión; y hacer circular la corriente gaseosa a alta presión a través de un mecanismo de aerosolización (32) que, en funcionamiento, está aplicado al receptáculo (12) y está adaptado para recibir la corriente gaseosa a alta presión, de manera que la corriente gaseosa a alta presión circula por parte del receptáculo, extrayendo así la formulación farmacéutica en polvo al sacarla del receptáculo (12) y dispersarla dentro de la corriente gaseosa para formar un aerosol, en el que la formulación farmacéutica en polvo no se administra a un cuerpo humano o animal.

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