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1. 发明公开

EP1210607A4 MICROELECTRONIC MOLECULAR DESCRIPTOR ARRAY DEVICES, METHODS, PROCEDURES, AND FORMATS FOR COMBINATORIAL SELECTION OF INTERMOLECULAR LIGAND BINDING STRUCTURES AND FOR DRUG SCREENING 审中-公开
标题翻译：微电子，MOLECULAR描述符字段的装置，政策，组合选择INTER分子配体结合结构，并且对药物的审查程序和格式
公开(公告)号：EP1210607A4
公开(公告)日：2004-12-22
申请号：EP00955293
申请日：2000-07-28
申请人： NANOGEN INC , AVENTIS RES & TECH GMBH & CO
发明人： HELLER MICHAEL J , WINDHAB NORBERT , ANDERSON RICHARD R , ACKLEY DONALD E , NOVA TINA S , HOPPE HANS-ULLRICH , HAMON CHRISTIAN J
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12Q1/68 , C40B30/04 , C40B40/06 , C40B40/10 , G01N21/17 , G01N21/59 , G01N33/15 , G01N33/50 , G01N33/68 , G01N37/00 , G01N35/00 , G01N33/543
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C12Q1/6825 , C40B40/06 , C40B40/10 , G01N21/171 , G01N21/59 , G01N33/6845 , G01N2800/52
摘要： These inventions relate to microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening. More particularly, those devices and methods rapidly carry out higher order selectivity of combinatorially produced intermolecular ligand binding components, supramolecular structures and supramolecular complexes by application of unique stringency parameters. Preferably, the invention includes the formation of exponential libraries by aggregation of sublibraries through the influence of electronic stringency to influence formation or detection of supramolecular structures or complexes. In addition, this invention relates to microelectronic array devices, procedures, methods and formats for molecular recognition processes, new drug discovery, generation of new affinity reagents, generation of synthetic antibodies, and for immunoassays.

2. 发明申请

WO0032744A9 APPARATUS AND METHODS FOR TRANSPORT OF CHARGED BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于运输带电生物材料的装置和方法
公开(公告)号：WO0032744A9
公开(公告)日：2000-11-23
申请号：PCT/US9927668
申请日：1999-11-22
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , SHELDON EDWARD L , KRIHAK MICHAEL K
IPC分类号： C12M1/40
CPC分类号： C12M1/40
摘要： Methods, apparatus, and applications for use of a stacked, reconfigurable system for electrophoretic transport are provided. In one embodiment, a system having a first chamber including at least a bottom support and an intermediate support, and a second chamber, said second chamber including a bottom support and a top member, the first and second chambers being coupled through a via. Electrophoretic, and optional electroosmotic and thermal, transport is effected. In another aspect of this invention, three or more chambers are coupled by an electrophoretic buss. The electrophoretic buss includes driving electrodes and is adapted to receive fluid containing materials for transport. The chambers are coupled to the electrophoretic buss and serve as a tap from the buss for delivery of charged materials. In one embodiment, certain functions are performed in different chambers. For example, the first chamber may receive the sample and perform sample processing functions, the second chamber may perform amplification procedures, yet a third chamber may perform hybridization or other assays, and yet another chamber may perform immunoassays. By separating various functions to different chambers, speed and sensitivity may be improved. In yet another aspect of this invention, analysis from a earlier stage may be utilized in a subsequent stage to reconfigure the system for optimum use. In one application, analysis at a first level is utilized to determine an action at a second level, such as the synthesis of a compound. The synthesized compound in response to a biohazard may comprise vaccine or antidote.
摘要翻译：提供了用于电泳传输的堆叠可重构系统的方法，设备和应用。在一个实施例中，一种具有第一腔室和第二腔室的系统，所述第一腔室包括至少底部支撑件和中间支撑件以及第二腔室，所述第二腔室包括底部支撑件和顶部构件，所述第一和第二腔室通过通孔耦合。电泳和任选的电渗透和热传输是有效的。在本发明的另一方面，三个或更多个腔室通过电泳总线耦合。电泳总线包括驱动电极并且适于接收包含运输材料的流体。这些腔室连接到电泳总线上，并用作来自总线的抽头以输送带电材料。在一个实施例中，某些功能在不同的室中执行。例如，第一室可以接收样品并执行样品处理功能，第二室可以执行扩增程序，但第三室可以执行杂交或其他测定，而另一室可以执行免疫测定。通过将不同的功能分离到不同的室中，可以提高速度和灵敏度。在本发明的另一个方面，可以在后续阶段利用来自较早阶段的分析来重新配置系统以获得最佳使用。在一个应用中，利用第一级的分析来确定第二级的作用，例如化合物的合成。响应生物危害的合成化合物可以包含疫苗或解毒剂。

3. 发明专利

AU5367198A Laminated assembly for active bioelectronic devices 未知
公开(公告)号：AU5367198A
公开(公告)日：1998-06-29
申请号：AU5367198
申请日：1997-11-26
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , JACKSON THOMAS R , SHELDON EDWARD L
IPC分类号： G01N27/447 , B01J19/00 , B01L3/00 , B01L7/00 , C07B61/00 , C07H21/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/00 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , G01N33/543 , F04B43/04
摘要： A multilayer, laminated device for performing fluidic operations includes a first exterior support layer, an adjacent layer disposed in laminated relationship with a portion of the exterior support layer, a second exterior support layer disposed in laminated relationship with a portion of the adjacent layer, and a fluidic pump that is disposed in the adjacent layer. The fluidic pump includes a first gear rotationally mounted to the adjacent layer, the first gear having a magnet contained therein. A second gear is rotationally mounted to the adjacent layer, the second gear having a magnet contained therein, the second gear being engaged with the first gear in a meshed relationship.

4. 发明专利

BR9909207A 未知
公开(公告)号：BR9909207A
公开(公告)日：2001-11-06
申请号：BR9909207
申请日：1999-02-11
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , SWANSON PAUL D , GRAHAM SCOTT O , MATHER ELIZABETH L , LECLAIR TIMOTHY L , BUTLER WILLIAM F
IPC分类号： G01N27/447 , B01L3/00 , C12M1/42 , G01N37/00 , G11C13/02 , G11C19/00 , C12M1/40

5. 发明专利

CA2381750A1 MICROELECTRONIC MOLECULAR DESCRIPTOR ARRAY DEVICES, METHODS, PROCEDURES, AND FORMATS FOR COMBINATORIAL SELECTION OF INTERMOLECULAR LIGAND BINDING STRUCTURES AND FOR DRUG SCREENING 未知
公开(公告)号：CA2381750A1
公开(公告)日：2001-02-22
申请号：CA2381750
申请日：2000-07-28
申请人： NANOGEN INC , AVENTIS RES AND TECHNOLOGIES G
发明人： HOPPE HANS-ULLRICH , HAMON CHRISTIAN J , WINDHAB NORBERT , HELLER MICHAEL J , ANDERSON RICHARD R , ACKLEY DONALD E , NOVA TINA S
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12Q1/68 , C40B30/04 , C40B40/06 , C40B40/10 , G01N21/17 , G01N21/59 , G01N33/15 , G01N33/50 , G01N33/68 , G01N37/00 , G01N35/00 , G01N15/06 , G01N21/29 , G01N25/08 , G01N25/18 , G01N27/00 , G01N27/02
摘要： These inventions relate to microelectronic molecular descriptor array device s, methods, procedures, and formats for combinatorial selection of intermolecul ar ligand binding structures and for drug screening. More particularly, those devices and methods rapidly carry out higher order selectivity of combinatorially produced intermolecular ligand binding components, supramolecular structures and supramolecular complexes by application of unique stringency parameters. Preferably, the invention includes the formati on of exponential libraries by aggregation of sublibraries through the influenc e of electronic stringency to influence formation or detection of supramolecul ar structures or complexes. In addition, this invention relates to microelectronic array devices, procedures, methods and formats for molecular recognition processes, new drug discovery, generation of new affinity reagents, generation of synthetic antibodies, and for immunoassays.

6. 发明公开

EP1054949A4 ADVANCED ACTIVE DEVICES AND METHODS FOR MOLECULAR BIOLOGICAL ANALYSIS AND DIAGNOSTICS 审中-公开
标题翻译：高级有源器件和法分子，生化分析及诊断
公开(公告)号：EP1054949A4
公开(公告)日：2006-09-27
申请号：EP99908135
申请日：1999-02-11
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , SWANSON PAUL D , GRAHAM SCOTT O , MATHER ELIZABETH L , LECLAIR TIMOTHY L , BUTLER WILLIAM F
IPC分类号： G01N27/447 , B01L3/00 , C12M1/42 , G01N37/00 , G11C13/02 , G11C19/00 , C12M1/40 , B01J19/00
CPC分类号： G11C13/0019 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2400/0403 , B82Y10/00 , G11C13/0014 , G11C19/00 , H01L29/6656 , H01L2924/0002 , H01L2924/00
摘要： Methods of manufacture and devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In one embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. In yet another embodiment, a concentric ring design is provided. Various flip-chip embodiments are disclosed.

7. 发明专利

NZ506204A Advanced active devices and methods for molecular biological analysis and diagnostics 未知
公开(公告)号：NZ506204A
公开(公告)日：2003-06-30
申请号：NZ50620499
申请日：1999-02-11
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , SWANSON PAUL D , GRAHAM SCOTT O , MATHER ELIZABETH L , LECLAIR TIMOTHY L , BUTLER WILLIAM F
IPC分类号： G01N27/447 , B01L3/00 , C12M1/42 , G01N37/00 , G11C13/02 , G11C19/00 , C12M1/40
摘要： An electronic device for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. The device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. In yet another embodiment, a concentric ring design is provided.

8. 发明专利

AU733523B2 Laminated assembly for active bioelectronic devices 未知
公开(公告)号：AU733523B2
公开(公告)日：2001-05-17
申请号：AU5367198
申请日：1997-11-26
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , JACKSON THOMAS R , SHELDON EDWARD L III
IPC分类号： G01N27/447 , B01J19/00 , B01L3/00 , B01L7/00 , C07B61/00 , C07H21/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/00 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , G01N33/543 , F04B43/04
摘要： A multilayer, laminated device for performing fluidic operations includes a first exterior support layer, an adjacent layer disposed in laminated relationship with a portion of the exterior support layer, a second exterior support layer disposed in laminated relationship with a portion of the adjacent layer, and a fluidic pump that is disposed in the adjacent layer. The fluidic pump includes a first gear rotationally mounted to the adjacent layer, the first gear having a magnet contained therein. A second gear is rotationally mounted to the adjacent layer, the second gear having a magnet contained therein, the second gear being engaged with the first gear in a meshed relationship.

9. 发明专利

AU1742300A Apparatus and methods for transport of charged biological materials 未知
公开(公告)号：AU1742300A
公开(公告)日：2000-06-19
申请号：AU1742300
申请日：1999-11-22
申请人： NANOGEN INC
发明人： ACKLEY DONALD E , SHELDON EDWARD L , KRIHAK MICHAEL K
IPC分类号： C12M1/40

10. 发明专利

CA2274047A1 LAMINATED ASSEMBLY FOR ACTIVE BIOELECTRONIC DEVICES 未知
公开(公告)号：CA2274047A1
公开(公告)日：1998-06-11
申请号：CA2274047
申请日：1997-11-26
申请人： NANOGEN INC
发明人： SHELDON EDWARD L III , ACKLEY DONALD E , JACKSON THOMAS R
IPC分类号： G01N27/447 , B01J19/00 , B01L3/00 , B01L7/00 , C07B61/00 , C07H21/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/00 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , F04B43/04 , G01N33/543
摘要： Methods of manufacture and devices for performing active biological operations utilize laminated structures (30, 110). In the preferred embodiment, a first planar sample support (50, 72, 104, 122) includes at least one sample through hole (56, 74, 90) a planar electrode (32, 70, 94, 112, 114) is disposed adjacent the first planar sample support (50, 72, 104, 122), and includes an electrode through region (38, 76), a second planar support (40, 78, 96, 102, 124) includes a vent through hole (48, 80, 92, 98), the planar electrode (32, 70, 94, 112, 114) being in a laminated relationship between the first planar sample support (50, 72, 104, 122) and the second planar support (40, 78, 96, 102, 124), further characterized in that the sample through hole (56, 74, 90), electrode through hole (38, 76) and vent through hole (48, 80, 92, 98) are in overlapping arrangement. Preferably, some or all of the through holes, through regions and vent through holes are aligned. In one embodiment, the lateral dimension of the vent through hole is larger than the lateral dimension of the electrode through hole. In an alternative embodiment, the lateral dimension of the sample through hole is larger than the lateral dimension of the vent through hole. In the preferred embodiment, the sample support and planar support are formed of sheet material, most preferably polyimide, having a thickness from substantially 1 to substantially 5 mils. Electrodes are preferably chosen from noble metals, especially gold. Holes or through regions are preferably formed through laser drilling, optionally followed by chemical etching. Interconnect vias provide conductive paths through multiple supports, and are advantageously utilized with hybridized circuitry, especially chip-on flex circuitry.

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