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    • 2. 发明申请
    • APPARATUS AND METHOD FOR MAKING SOLID BEADS
    • 制造实心珠的装置和方法
    • US20130259961A1
    • 2013-10-03
    • US13876773
    • 2011-09-30
    • Daniel PalmerOwen Shadick
    • Daniel PalmerOwen Shadick
    • B01J2/06
    • B01J2/06B01J2/08B01J2/18
    • An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
    • 提供了一种用于制造实心珠的装置,该装置包括至少一个液滴发生器,其可操作以产生包含溶解在溶剂中的溶质的液滴,以及用于承载第二液体的至少一个流动通道,至少一个液滴发生器 至少一个流动通道相对于彼此间隔开,使得在使用中,液滴通过气体进入设置在所述流动通道中的第二液体中,溶剂可溶于第二液体中,以使溶剂离开液滴 ,从而形成固体珠粒。 还提供了制备固体珠粒的方法。
    • 5. 发明授权
    • Apparatus and method for making solid beads
    • 固体珠的制备方法
    • US09156016B2
    • 2015-10-13
    • US13876773
    • 2011-09-30
    • Daniel PalmerOwen Shadick
    • Daniel PalmerOwen Shadick
    • B29B9/00B01J2/06B01J2/08B01J2/18
    • B01J2/06B01J2/08B01J2/18
    • An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
    • 提供了一种用于制造实心珠的装置,该装置包括至少一个液滴发生器,其可操作以产生包含溶解在溶剂中的溶质的液滴,以及用于承载第二液体的至少一个流动通道,至少一个液滴发生器 至少一个流动通道相对于彼此间隔开,使得在使用中,液滴通过气体进入设置在所述流动通道中的第二液体中,溶剂可溶于第二液体中,以使溶剂离开液滴 ,从而形成固体珠粒。 还提供了制备固体珠粒的方法。
    • 10. 发明申请
    • Device and Method for Making Solid Beads
    • 制作实心珠的装置和方法
    • US20110160134A1
    • 2011-06-30
    • US12999578
    • 2009-06-16
    • Daniel PalmerRichard CalderOwen Shadick
    • Daniel PalmerRichard CalderOwen Shadick
    • A61K38/22C08G63/08B01L3/00A61P5/00
    • B01J2/08A61K9/1647A61K9/1694
    • A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
    • 公开了一种制备固体珠粒的方法,所述方法包括:(i)提供微流体装置,其包括在连接区域相遇的载体流体导管和功能流体导管; (ii)提供功能流体的层流,其包括沿着功能流体导管的溶剂和溶质,并且沿载体流体导管提供载体流体的层流,以便在载体流体流中形成功能流体液滴 ; (iii)冷却所述微流体装置的管道中的功能流体段以形成冷却(优选冷冻的)液滴; 和(iv)将液体与冷却的液滴紧密混合,以使所述溶剂离开所述冷却的液滴,从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。