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1. 发明授权

US09656228B2 Device and method for making solid beads 有权
公开(公告)号：US09656228B2
公开(公告)日：2017-05-23
申请号：US12999578
申请日：2009-06-16
申请人： Daniel Palmer , Richard Calder , Owen Shadick
发明人： Daniel Palmer , Richard Calder , Owen Shadick
IPC分类号： A61K9/50 , B01J2/08 , A61K9/16
CPC分类号： B01J2/08 , A61K9/1647 , A61K9/1694
摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.

2. 发明申请

US20110160134A1 Device and Method for Making Solid Beads 有权
标题翻译：制作实心珠的装置和方法
公开(公告)号：US20110160134A1
公开(公告)日：2011-06-30
申请号：US12999578
申请日：2009-06-16
申请人： Daniel Palmer , Richard Calder , Owen Shadick
发明人： Daniel Palmer , Richard Calder , Owen Shadick
IPC分类号： A61K38/22 , C08G63/08 , B01L3/00 , A61P5/00
CPC分类号： B01J2/08 , A61K9/1647 , A61K9/1694
摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
摘要翻译：公开了一种制备固体珠粒的方法，所述方法包括：（i）提供微流体装置，其包括在连接区域相遇的载体流体导管和功能流体导管; （ii）提供功能流体的层流，其包括沿着功能流体导管的溶剂和溶质，并且沿载体流体导管提供载体流体的层流，以便在载体流体流中形成功能流体液滴 ; （iii）冷却所述微流体装置的管道中的功能流体段以形成冷却（优选冷冻的）液滴; 和（iv）将液体与冷却的液滴紧密混合，以使所述溶剂离开所述冷却的液滴，从而形成固体珠粒。还公开了一种用于这种方法的微流体装置。

3. 发明申请

US20130259961A1 APPARATUS AND METHOD FOR MAKING SOLID BEADS 有权
标题翻译：制造实心珠的装置和方法
公开(公告)号：US20130259961A1
公开(公告)日：2013-10-03
申请号：US13876773
申请日：2011-09-30
申请人： Daniel Palmer , Owen Shadick
发明人： Daniel Palmer , Owen Shadick
IPC分类号： B01J2/06
CPC分类号： B01J2/06 , B01J2/08 , B01J2/18
摘要： An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
摘要翻译：提供了一种用于制造实心珠的装置，该装置包括至少一个液滴发生器，其可操作以产生包含溶解在溶剂中的溶质的液滴，以及用于承载第二液体的至少一个流动通道，至少一个液滴发生器至少一个流动通道相对于彼此间隔开，使得在使用中，液滴通过气体进入设置在所述流动通道中的第二液体中，溶剂可溶于第二液体中，以使溶剂离开液滴，从而形成固体珠粒。还提供了制备固体珠粒的方法。

4. 发明申请

US20130256931A1 METHOD FOR MAKING SOLID BEADS 有权
标题翻译：制造固体珠的方法
公开(公告)号：US20130256931A1
公开(公告)日：2013-10-03
申请号：US13876780
申请日：2011-09-30
申请人： Daniel Palmer , Owen Shadick
发明人： Daniel Palmer , Owen Shadick
IPC分类号： B01J2/06
CPC分类号： B01J2/06 , B01J2/08 , B01J2/18
摘要： A method of forming solid beads, the method comprising:Providing a first liquid comprising a solute and a solventForming liquid droplets of the first liquidContacting the liquid droplets with a second liquid so as to cause the solvent to exit the droplets, thus forming solid beads,the solute comprising a polymer, the concentration of polymer in the first liquid being at least 7% w/v.,the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid.
摘要翻译：一种形成固体珠的方法，所述方法包括：提供包含溶质和溶剂的第一液体形成第一液体的液滴将液滴与第二液体接触，以使溶剂离开液滴，从而形成固体小珠，包含聚合物的溶质，第一液体中聚合物的浓度为至少7％w / v，溶剂在第二液体中的溶解度为每100ml第二液体至少5g溶剂。

5. 发明授权

US09259701B2 Method for making solid beads 有权
标题翻译：固体珠的制备方法
公开(公告)号：US09259701B2
公开(公告)日：2016-02-16
申请号：US13876780
申请日：2011-09-30
申请人： Daniel Palmer , Owen Shadick
发明人： Daniel Palmer , Owen Shadick
IPC分类号： B01J2/06 , B01J2/18 , B01J2/08
CPC分类号： B01J2/06 , B01J2/08 , B01J2/18
摘要： A method of forming solid beads, the method comprising:Providing a first liquid comprising a solute and a solventForming liquid droplets of the first liquidContacting the liquid droplets with a second liquid so as to cause the solvent to exit the droplets, thus forming solid beads,the solute comprising a polymer, the concentration of polymer in the first liquid being at least 7% w/v.,the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid.
摘要翻译：一种形成固体珠的方法，所述方法包括：提供包含溶质和溶剂的第一液体形成第一液体的液滴将液滴与第二液体接触，以使溶剂离开液滴，从而形成固体小珠，包含聚合物的溶质，第一液体中聚合物的浓度为至少7％w / v，溶剂在第二液体中的溶解度为每100ml第二液体至少5g溶剂。

6. 发明授权

US09156016B2 Apparatus and method for making solid beads 有权
标题翻译：固体珠的制备方法
公开(公告)号：US09156016B2
公开(公告)日：2015-10-13
申请号：US13876773
申请日：2011-09-30
申请人： Daniel Palmer , Owen Shadick
发明人： Daniel Palmer , Owen Shadick
IPC分类号： B29B9/00 , B01J2/06 , B01J2/08 , B01J2/18
CPC分类号： B01J2/06 , B01J2/08 , B01J2/18
摘要： An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
摘要翻译：提供了一种用于制造实心珠的装置，该装置包括至少一个液滴发生器，其可操作以产生包含溶解在溶剂中的溶质的液滴，以及用于承载第二液体的至少一个流动通道，至少一个液滴发生器至少一个流动通道相对于彼此间隔开，使得在使用中，液滴通过气体进入设置在所述流动通道中的第二液体中，溶剂可溶于第二液体中，以使溶剂离开液滴，从而形成固体珠粒。还提供了制备固体珠粒的方法。

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