专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06583267B2 Chemically modified polypeptides 失效
公开(公告)号：US06583267B2
公开(公告)日：2003-06-24
申请号：US09230733
申请日：1999-02-03
申请人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
发明人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
IPC分类号： A61K3816
CPC分类号： C07K1/1077 , A61K38/00 , C07K14/535
摘要： The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.

2. 发明授权

US07547675B2 Chemically modified polypeptides 失效
标题翻译：化学修饰的多肽
公开(公告)号：US07547675B2
公开(公告)日：2009-06-16
申请号：US10365418
申请日：2003-02-13
申请人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
发明人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
IPC分类号： A68K38/16 , C07K1/107
CPC分类号： C07K1/1077 , A61K38/00 , C07K14/535
摘要： The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.
摘要翻译：本发明涉及化学修饰的多肽，其中所述多肽分子中的至少一个羟基用聚亚烷基二醇衍生物修饰; 生产修饰多肽的方法; 使用经修饰的多肽的治疗方法; 使用经修饰的多肽; 包含所述经修饰的多肽的药物制剂; 以及包含所述经修饰的多肽的治疗用组合物。

3. 发明授权

US06884419B1 hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same 失效
标题翻译：具有c-mpl活性的hG-CSF融合多肽，编码相同的DNA和使用其治疗贫血的方法
公开(公告)号：US06884419B1
公开(公告)日：2005-04-26
申请号：US09680514
申请日：2000-10-06
申请人： Haruhiko Yokoi , Yukimasa Shiotsu , Noboru Konishi , Hideharu Anazawa , Tatsuya Tamaoki , Motoo Yamasaki , Yoko Kato , Kazuhisa Uchida , Kinya Yamashita
发明人： Haruhiko Yokoi , Yukimasa Shiotsu , Noboru Konishi , Hideharu Anazawa , Tatsuya Tamaoki , Motoo Yamasaki , Yoko Kato , Kazuhisa Uchida , Kinya Yamashita
IPC分类号： A61K38/00 , C07K14/52 , C07K14/535 , A61K38/19
CPC分类号： C07K14/535 , A61K38/00 , C07K14/524 , C07K2319/00
摘要： The present invention relates to a fusion polypeptide which comprises a polypeptide having G-CSF activity and a polypeptide having TPO activity and DNA which codes for the fusion polypeptide, to a fusion polypeptide in which a polypeptide having G-CSF activity and a polypeptide having TPO activity are fused via a spacer peptide and DNA which codes for the fusion polypeptide and to a polypeptide in which the fusion polypeptide comprising a polypeptide having G-CSF activity and a polypeptide having TPO activity is chemically modified with a polyalkylene glycol derivative. It also relates to an anemia-treating composition containing the fusion polypeptide as an active ingredient.
摘要翻译：本发明涉及包含具有G-CSF活性的多肽和具有TPO活性的多肽和编码融合多肽的DNA的融合多肽与其中具有G-CSF活性的多肽和具有TPO的多肽的融合多肽活性通过间隔子肽和编码融合多肽的DNA和其中包含具有G-CSF活性的多肽的融合多肽和具有TPO活性的多肽的多肽用聚亚烷基二醇衍生物进行化学修饰而融合。它还涉及含有融合多肽作为活性成分的贫血治疗组合物。

4. 发明申请

US20090130662A1 Method for Diagnosis of Prostate Cancer 审中-公开
标题翻译：前列腺癌诊断方法
公开(公告)号：US20090130662A1
公开(公告)日：2009-05-21
申请号：US11886263
申请日：2006-03-14
申请人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
发明人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
IPC分类号： C12Q1/68 , G01N33/574 , C07K16/30
CPC分类号： C07K16/3069 , G01N33/564 , G01N33/57434
摘要： The present invention provides a method for detecting and/or quantifying PCA-1 in a body fluid sample from a subject as a prostate cancer marker. The present invention also provides a method for detecting and/or quantifying an anti-PCA-1 autoantibody in a body fluid sample from a subject as a prostate cancer marker. The present invention allows diagnosis of prostate cancer to be performed more simply, more rapidly and at lower cost.
摘要翻译：本发明提供一种用于检测和/或定量来自受试者的体液样品中的PCA-1作为前列腺癌标志物的方法。本发明还提供了用于检测和/或定量来自作为前列腺癌标志物的受试者的体液样品中的抗PCA-1自身抗体的方法。本发明允许更简单，更快速且更低成本地进行前列腺癌的诊断。

5. 发明申请

US20050026232A1 Antibodies specific for phosphatase subunit of LAR 审中-公开
标题翻译：特异于LAR磷酸酶亚基的抗体
公开(公告)号：US20050026232A1
公开(公告)日：2005-02-03
申请号：US10945647
申请日：2004-09-21
申请人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
发明人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
IPC分类号： A61K38/00 , A61K39/395 , C07K14/72 , C07K16/40 , C12N1/20 , C12N5/20 , C12N9/12 , C12N15/12 , C12P21/08 , G01N33/573 , G01N33/574
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/72 , C07K16/40 , G01N33/573
摘要： Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
摘要翻译：针对LAR磷酸酶亚单位的抗体，特别是对磷酸酶亚基的细胞内结构域具有特异性的抗体，其产生方法和产生这些抗体的细胞，以及使用这些抗体的LAR / LAR衍生分子的测定和检查方法，以及这些抗体在甲状腺癌的诊断和治疗中被公开。

6. 发明授权

US06846912B1 Antibody against LAR phosphatase subunit 失效
标题翻译：特异于磷酸酶亚基的抗体
公开(公告)号：US06846912B1
公开(公告)日：2005-01-25
申请号：US09719272
申请日：1999-06-07
申请人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
发明人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
IPC分类号： A61K38/00 , A61K39/395 , C07K14/72 , C07K16/40 , C12N1/20 , C12N5/20 , C12N9/12 , C12N15/12 , C12P21/08 , G01N33/573 , G01N33/574 , C07K16/00 , C12N5/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/72 , C07K16/40 , G01N33/573
摘要： Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
摘要翻译：针对LAR磷酸酶亚单位的抗体，特别是对磷酸酶亚基的细胞内结构域具有特异性的抗体，其产生方法和产生这些抗体的细胞，以及使用这些抗体的LAR / LAR衍生分子的测定和检查方法，以及这些抗体在甲状腺癌的诊断和治疗中被公开。

7. 发明授权

US07358061B2 Methods of diagnosing thyroid carcinoma 失效
标题翻译：诊断甲状腺癌的方法
公开(公告)号：US07358061B2
公开(公告)日：2008-04-15
申请号：US10945772
申请日：2004-09-21
申请人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
发明人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
IPC分类号： G01N33/574
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/72 , C07K16/40 , G01N33/573
摘要： Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
摘要翻译：针对LAR磷酸酶亚单位的抗体，特别是对磷酸酶亚基的细胞内结构域具有特异性的抗体，其产生方法和产生这些抗体的细胞，以及使用这些抗体的LAR / LAR衍生分子的测定和检查方法，以及这些抗体在甲状腺癌的诊断和治疗中被公开。

8. 发明申请

US20100297145A1 Apoptosis promoter, cell proliferation inhibitor, prophylactic/therapeutic agent for cancer, screening method for the promoter, inhibitor or agent 审中-公开
标题翻译：细胞凋亡启动子，细胞增殖抑制剂，癌症预防/治疗剂，启动子，抑制剂或药剂的筛选方法
公开(公告)号：US20100297145A1
公开(公告)日：2010-11-25
申请号：US11989959
申请日：2006-08-04
申请人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
发明人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
IPC分类号： A61K39/395 , C12N5/07 , A61K31/7088 , C12Q1/02 , A61P35/00 , G01N33/53
CPC分类号： A61K48/00 , A61K38/00 , G01N33/5023 , G01N2333/916 , G01N2510/00
摘要： Disclosed is an apoptosis promoter, cell proliferation inhibitor, prophylactic/therapeutic agent for cancer or the like which comprises a compound capable of inhibit the expression or function of PCA-1 as an active ingredient. Also disclosed is a method for screening of a compound for use in the promotion of apoptosis, the inhibition of cell proliferation or the prevention/treatment of cancer, which comprises selecting a compound capable of inhibit the expression or function of PCA-1, or the like.
摘要翻译：公开了一种凋亡启动子，细胞增殖抑制剂，癌症等的预防/治疗剂，其包含能够抑制PCA-1作为活性成分的表达或功能的化合物。还公开了用于筛选用于促进凋亡，抑制细胞增殖或预防/治疗癌症的化合物的方法，其包括选择能够抑制PCA-1的表达或功能的化合物，或喜欢。

9. 发明申请

US20080020375A1 Method Of Adjudicating On Prostate Cancer 审中-公开
标题翻译：判处前列腺癌的方法
公开(公告)号：US20080020375A1
公开(公告)日：2008-01-24
申请号：US10590146
申请日：2004-08-24
申请人： Hiroshi Yamamoto , Noboru Konishi , Kazutake Tsujikawa
发明人： Hiroshi Yamamoto , Noboru Konishi , Kazutake Tsujikawa
IPC分类号： C12Q1/68 , C07H21/04 , C07K1/00 , C07K16/18
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156
摘要： The present invention relates to a method for determining a subject having a risk of having developed or developing prostate cancer, which comprises the following steps: a) a step of analyzing the presence/absence or level of mutation in the PCA-1 gene derived from the subject; and b) a step of evaluating the presence/absence or level of the subject's risk of having developed or developing prostate cancer, based on the presence/absence or level of mutation in the PCA-1 gene. According to the determination method of prostate cancer of the present invention, a subject having a risk of having developed or developing prostate cancer can be determined conveniently and highly sensitively. Therefore, the method is effective for the diagnosis of prostate cancer, progress monitoring, prognostic prediction, diagnosis before the onset, carrier diagnosis and the like.
摘要翻译：本发明涉及一种确定具有发展中或发展中的前列腺癌风险的受试者的方法，其包括以下步骤：a）分析来源于PCA-1基因的PCA-1基因的突变的存在/不存在或水平的步骤主题; 和b）基于PCA-1基因的突变的存在/不存在或水平，评估受试者患有发展中或发展中的前列腺癌的风险的存在/不存在或水平的步骤。根据本发明的前列腺癌的测定方法，可以方便，高度敏感地测定具有发育型或发展型前列腺癌风险的受试者。因此，该方法对前列腺癌的诊断，进展监测，预后预测，发病前诊断，载体诊断等有效。

10. 发明申请

US20140068854A1 Nursing Care Support Device 审中-公开
标题翻译：护理支持设备
公开(公告)号：US20140068854A1
公开(公告)日：2014-03-13
申请号：US13606093
申请日：2012-09-07
申请人： Noboru Konishi
发明人： Noboru Konishi
IPC分类号： A61G7/10
CPC分类号： A61G7/1046 , A61G7/053 , A61G7/1019 , A61G7/1057 , A61G7/1059 , A61G7/1088 , A61G2200/34 , A61G2200/52 , A61H3/04 , A61H2003/002 , A61H2201/1633
摘要： The nursing care support device according to the present invention can help to lift and transfer a person who requires nursing care and cannot rise up and walk on their own. The nursing care support device of the present invention can ease the burden of a caregiver and a person who requires nursing care at the time of the use. The nursing care support device of the present invention can also be used as a walking auxiliary device such as a walker for a person who recovers enough to walk using a walk assistance device.
摘要翻译：根据本发明的护理支援装置可以帮助提升和转移需要护理的人，并且不能自己上升和行走。本发明的护理支援装置能够减轻在使用时护理者和需要护理的人的负担。本发明的护理支援装置也可以作为步行辅助装置，例如步行辅助装置，用于使用步行辅助装置恢复足够的步行者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式