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1. 发明专利

JP2013031635A Device for moving person who requires nursing care, and nursing care-assisting device suitable for using walking assisting device 有权
标题翻译：移动护理人员的设备和护理辅助设备，适合使用维护辅助设备
公开(公告)号：JP2013031635A
公开(公告)日：2013-02-14
申请号：JP2012092763
申请日：2012-04-16
申请人： Noboru Konishi , 登小西
发明人： KONISHI NOBORU
IPC分类号： A61G1/017 , A61G7/10 , A61H1/02
摘要： PROBLEM TO BE SOLVED: To provide a nursing care-assisting device which can be used as a device for moving a person who requires nursing care and a walking assisting device and can lower the load of a care giver and the person when using the former device.SOLUTION: Columnar supports 11 extends from above a carriage part 10 in an oblique direction. An upper body supporting part 13 has two arm parts 13a for supporting an upper body of the person who requires nursing care and two connecting parts 13b for connecting the arm parts 13a and the columnar support 11, and a protruding length of the connecting parts 13b from the upper part the columnar supports 11 in the oblique direction can be adjusted. A seat part 20 has: interposing members 21 which can move in a vertical direction by a lifter 30 and which are provided with two plate-like bodies 23 having distal end parts 23e the thickness of which is reduced as going to the distal ends TE; and supporting members 22 for supporting such that the interposing members 21 can move between a first position for moving the person and a second position for assisting walking. The height Hof the lower ends in end faces EP of the carriage part 12a from a floor face is 15 cm or more.
摘要翻译：要解决的问题：提供一种护理辅助装置，其可以用作移动需要护理的人和行走辅助装置的装置，并且可以在使用时降低护理人员和该人的负担前者的设备。解决方案：柱状支撑件11沿倾斜方向从托架部件10的上方延伸。上身支撑部13具有用于支撑需要护理的人的上身的两个臂部13a和用于连接臂部13a和柱状支撑件11的两个连接部13b以及连接部13b的突出长度可以调节柱状支撑件11在倾斜方向上的上部。座部20具有：可通过升降器30在垂直方向上移动的中间部件21，其具有两个具有远端部23e的板状体23，板状体23的厚度减小到远端TE; 以及用于支撑的支撑构件22，使得插入构件21可以在用于移动人的第一位置和用于辅助行走的第二位置之间移动。托架部12a的从底板面的端面EP的下端的高度H EP 为15cm以上。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2005279293A Footwear sole to reduce load on knee and footwear using the same 审中-公开
标题翻译：鞋子可以减少使用相同的尼龙和足球的负担
公开(公告)号：JP2005279293A
公开(公告)日：2005-10-13
申请号：JP2005156451
申请日：2005-05-27
申请人： Noboru Konishi , 登小西
发明人： KONISHI NOBORU
IPC分类号： A43B13/14 , A43B3/10 , A43B3/12
摘要： PROBLEM TO BE SOLVED: To provide a footwear sole which has a structure to reduce a load on the knee during walking and enables a user to walk while reducing a load on the knee, and to provide footwear using the footwear sole.
SOLUTION: This footwear sole is equipped with a foot sole support body 12 with flexibility, and grounding body 11 to support the center part 12b except the front part 12a and the rear part 12c of the foot sole support body 12. The footwear sole is made so that a first plane 21 including the rear end 12s and the rear end 12r of the center part is at an angle α of ≥20° with respect to the floor face 20 and a second plane 22 including the rear end 12r of the center part and the front end 12q of the center part is at an angle smaller than the angle α with respect to the floor face 20 in a condition the grounding body 11 is contacted on a flat floor face 20 and the rear end 12s of the foot sole support body 12 is most lowered by pressing the center part 12b and the rear part 12c of the foot sole support body 12 from the upper side.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种鞋底，其具有在步行期间减轻膝盖上的负荷的结构，并且使得使用者能够在减轻膝盖的负荷的同时行走，并且使用鞋底来提供鞋类。解决方案：该鞋底配备有具有柔性的脚底支撑体12，以及接地体11，以支撑脚底支撑体12的前部12a和后部12c之外的中心部12b。鞋底的形状使得包括中心部分的后端12s和后端12r的第一平面21相对于地板面20处于角度α≥20°，第二平面22包括后端12r的第二平面22 中心部分的中心部分和前端部12q在接地体11在平坦的地板面20和后端部12s接触的状态下，相对于地板面20的角度α成小角度通过从上侧按压脚底支撑体12的中心部分12b和后部12c，脚部底部支撑体12最大程度地降低。版权所有（C）2006，JPO＆NCIPI

3. 发明申请

US20100297145A1 Apoptosis promoter, cell proliferation inhibitor, prophylactic/therapeutic agent for cancer, screening method for the promoter, inhibitor or agent 审中-公开
标题翻译：细胞凋亡启动子，细胞增殖抑制剂，癌症预防/治疗剂，启动子，抑制剂或药剂的筛选方法
公开(公告)号：US20100297145A1
公开(公告)日：2010-11-25
申请号：US11989959
申请日：2006-08-04
申请人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
发明人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
IPC分类号： A61K39/395 , C12N5/07 , A61K31/7088 , C12Q1/02 , A61P35/00 , G01N33/53
CPC分类号： A61K48/00 , A61K38/00 , G01N33/5023 , G01N2333/916 , G01N2510/00
摘要： Disclosed is an apoptosis promoter, cell proliferation inhibitor, prophylactic/therapeutic agent for cancer or the like which comprises a compound capable of inhibit the expression or function of PCA-1 as an active ingredient. Also disclosed is a method for screening of a compound for use in the promotion of apoptosis, the inhibition of cell proliferation or the prevention/treatment of cancer, which comprises selecting a compound capable of inhibit the expression or function of PCA-1, or the like.
摘要翻译：公开了一种凋亡启动子，细胞增殖抑制剂，癌症等的预防/治疗剂，其包含能够抑制PCA-1作为活性成分的表达或功能的化合物。还公开了用于筛选用于促进凋亡，抑制细胞增殖或预防/治疗癌症的化合物的方法，其包括选择能够抑制PCA-1的表达或功能的化合物，或喜欢。

4. 发明授权

US07547675B2 Chemically modified polypeptides 失效
标题翻译：化学修饰的多肽
公开(公告)号：US07547675B2
公开(公告)日：2009-06-16
申请号：US10365418
申请日：2003-02-13
申请人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
发明人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
IPC分类号： A68K38/16 , C07K1/107
CPC分类号： C07K1/1077 , A61K38/00 , C07K14/535
摘要： The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.
摘要翻译：本发明涉及化学修饰的多肽，其中所述多肽分子中的至少一个羟基用聚亚烷基二醇衍生物修饰; 生产修饰多肽的方法; 使用经修饰的多肽的治疗方法; 使用经修饰的多肽; 包含所述经修饰的多肽的药物制剂; 以及包含所述经修饰的多肽的治疗用组合物。

5. 发明申请

US20080020375A1 Method Of Adjudicating On Prostate Cancer 审中-公开
标题翻译：判处前列腺癌的方法
公开(公告)号：US20080020375A1
公开(公告)日：2008-01-24
申请号：US10590146
申请日：2004-08-24
申请人： Hiroshi Yamamoto , Noboru Konishi , Kazutake Tsujikawa
发明人： Hiroshi Yamamoto , Noboru Konishi , Kazutake Tsujikawa
IPC分类号： C12Q1/68 , C07H21/04 , C07K1/00 , C07K16/18
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/156
摘要： The present invention relates to a method for determining a subject having a risk of having developed or developing prostate cancer, which comprises the following steps: a) a step of analyzing the presence/absence or level of mutation in the PCA-1 gene derived from the subject; and b) a step of evaluating the presence/absence or level of the subject's risk of having developed or developing prostate cancer, based on the presence/absence or level of mutation in the PCA-1 gene. According to the determination method of prostate cancer of the present invention, a subject having a risk of having developed or developing prostate cancer can be determined conveniently and highly sensitively. Therefore, the method is effective for the diagnosis of prostate cancer, progress monitoring, prognostic prediction, diagnosis before the onset, carrier diagnosis and the like.
摘要翻译：本发明涉及一种确定具有发展中或发展中的前列腺癌风险的受试者的方法，其包括以下步骤：a）分析来源于PCA-1基因的PCA-1基因的突变的存在/不存在或水平的步骤主题; 和b）基于PCA-1基因的突变的存在/不存在或水平，评估受试者患有发展中或发展中的前列腺癌的风险的存在/不存在或水平的步骤。根据本发明的前列腺癌的测定方法，可以方便，高度敏感地测定具有发育型或发展型前列腺癌风险的受试者。因此，该方法对前列腺癌的诊断，进展监测，预后预测，发病前诊断，载体诊断等有效。

6. 发明申请

US20090130662A1 Method for Diagnosis of Prostate Cancer 审中-公开
标题翻译：前列腺癌诊断方法
公开(公告)号：US20090130662A1
公开(公告)日：2009-05-21
申请号：US11886263
申请日：2006-03-14
申请人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
发明人： Kazutake Tsujikawa , Hiroshi Yamamoto , Noboru Konishi
IPC分类号： C12Q1/68 , G01N33/574 , C07K16/30
CPC分类号： C07K16/3069 , G01N33/564 , G01N33/57434
摘要： The present invention provides a method for detecting and/or quantifying PCA-1 in a body fluid sample from a subject as a prostate cancer marker. The present invention also provides a method for detecting and/or quantifying an anti-PCA-1 autoantibody in a body fluid sample from a subject as a prostate cancer marker. The present invention allows diagnosis of prostate cancer to be performed more simply, more rapidly and at lower cost.
摘要翻译：本发明提供一种用于检测和/或定量来自受试者的体液样品中的PCA-1作为前列腺癌标志物的方法。本发明还提供了用于检测和/或定量来自作为前列腺癌标志物的受试者的体液样品中的抗PCA-1自身抗体的方法。本发明允许更简单，更快速且更低成本地进行前列腺癌的诊断。

7. 发明授权

US07358061B2 Methods of diagnosing thyroid carcinoma 失效
标题翻译：诊断甲状腺癌的方法
公开(公告)号：US07358061B2
公开(公告)日：2008-04-15
申请号：US10945772
申请日：2004-09-21
申请人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
发明人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
IPC分类号： G01N33/574
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/72 , C07K16/40 , G01N33/573
摘要： Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
摘要翻译：针对LAR磷酸酶亚单位的抗体，特别是对磷酸酶亚基的细胞内结构域具有特异性的抗体，其产生方法和产生这些抗体的细胞，以及使用这些抗体的LAR / LAR衍生分子的测定和检查方法，以及这些抗体在甲状腺癌的诊断和治疗中被公开。

8. 发明授权

US06583267B2 Chemically modified polypeptides 失效
公开(公告)号：US06583267B2
公开(公告)日：2003-06-24
申请号：US09230733
申请日：1999-02-03
申请人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
发明人： Motoo Yamasaki , Toshiyuki Suzawa , Ken Kobayashi , Noboru Konishi , Shiro Akinaga , Kumiko Maruyama
IPC分类号： A61K3816
CPC分类号： C07K1/1077 , A61K38/00 , C07K14/535
摘要： The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.

9. 发明申请

US20050026232A1 Antibodies specific for phosphatase subunit of LAR 审中-公开
标题翻译：特异于LAR磷酸酶亚基的抗体
公开(公告)号：US20050026232A1
公开(公告)日：2005-02-03
申请号：US10945647
申请日：2004-09-21
申请人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
发明人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
IPC分类号： A61K38/00 , A61K39/395 , C07K14/72 , C07K16/40 , C12N1/20 , C12N5/20 , C12N9/12 , C12N15/12 , C12P21/08 , G01N33/573 , G01N33/574
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/72 , C07K16/40 , G01N33/573
摘要： Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
摘要翻译：针对LAR磷酸酶亚单位的抗体，特别是对磷酸酶亚基的细胞内结构域具有特异性的抗体，其产生方法和产生这些抗体的细胞，以及使用这些抗体的LAR / LAR衍生分子的测定和检查方法，以及这些抗体在甲状腺癌的诊断和治疗中被公开。

10. 发明授权

US06846912B1 Antibody against LAR phosphatase subunit 失效
标题翻译：特异于磷酸酶亚基的抗体
公开(公告)号：US06846912B1
公开(公告)日：2005-01-25
申请号：US09719272
申请日：1999-06-07
申请人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
发明人： Hiroshi Yamamoto , Kazutake Tsujikawa , Yukiko Uchino , Noboru Konishi
IPC分类号： A61K38/00 , A61K39/395 , C07K14/72 , C07K16/40 , C12N1/20 , C12N5/20 , C12N9/12 , C12N15/12 , C12P21/08 , G01N33/573 , G01N33/574 , C07K16/00 , C12N5/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/72 , C07K16/40 , G01N33/573
摘要： Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.
摘要翻译：针对LAR磷酸酶亚单位的抗体，特别是对磷酸酶亚基的细胞内结构域具有特异性的抗体，其产生方法和产生这些抗体的细胞，以及使用这些抗体的LAR / LAR衍生分子的测定和检查方法，以及这些抗体在甲状腺癌的诊断和治疗中被公开。

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