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1. 发明授权

US08012327B2 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US08012327B2
公开(公告)日：2011-09-06
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： G01N27/447
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

2. 发明申请

US20070163882A1 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US20070163882A1
公开(公告)日：2007-07-19
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

3. 发明申请

US20090255814A1 ELECTROPHORESIS DEVICE 审中-公开
标题翻译：电泳装置
公开(公告)号：US20090255814A1
公开(公告)日：2009-10-15
申请号：US12420289
申请日：2009-04-08
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi
IPC分类号： C25B9/00
CPC分类号： G01N27/44721
摘要： The invention aims to improve the spatial resolution in a multi-focus type electrophoresis apparatus that irradiates a capillary array from both ends thereof with laser beams. The invention relates to an electrophoresis apparatus in which capillaries at both ends of a capillary array are irradiated respectively with laser beams, and each of the two laser beams traverses multiple capillaries. In the electrophoresis apparatus, the laser beams are coaxially introduced into the capillary array from the both ends thereof to travel in a direction vertical to axis of each capillary and horizontal to the aligrnent plane of the capillary array; and a λ/4 plate and a polarizer are arranged on the laser beam optical axes. According to the invention, the total width of the incident laser beams is made narrow, generation of pseudo signals is prevented, and an analysis performance is improved.
摘要翻译：本发明旨在提高从其两端用激光束照射毛细管阵列的多焦点型电泳装置中的空间分辨率。本发明涉及一种电泳装置，其中毛细管阵列的两端的毛细管分别照射激光束，并且两个激光束中的每一个穿过多个毛细管。在电泳装置中，激光束从其两端同轴地引入到毛细管阵列中，以沿垂直于每个毛细管的轴线的方向行进，并且横向于毛细管阵列的致密平面; 并且在激光束光轴上设置λ/ 4板和偏振片。根据本发明，使入射激光束的总宽度变窄，防止伪信号的产生，提高分析性能。

4. 发明申请

US20070170063A1 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US20070170063A1
公开(公告)日：2007-07-26
申请号：US11654683
申请日：2007-01-18
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
IPC分类号： G01N27/00
CPC分类号： G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus characterized in that a multi-bandpass filter is provided in an optical detection system. In one aspect of the invention, a signal detection area of a two-dimensional detector is divided into plural regions corresponding to wavelength transmission regions of the multi-bandpass filter. An integrated value of the fluorescence spectrum signal is determined in the region including a fluorescence spectrum peak of an analysis sample in the plural regions. The analysis is performed with the integrated value.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其特征在于在光学检测系统中提供多带通滤波器。在本发明的一个方面，二维检测器的信号检测区域被分成与多带通滤波器的波长透射区域对应的多个区域。在包括多个区域中的分析样品的荧光光谱峰的区域中确定荧光光谱信号的积分值。分析用积分值进行。

5. 发明授权

US08246803B2 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US08246803B2
公开(公告)日：2012-08-21
申请号：US11654683
申请日：2007-01-18
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
IPC分类号： G01N27/453
CPC分类号： G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus characterized in that a multi-bandpass filter is provided in an optical detection system. In one aspect of the invention, a signal detection area of a two-dimensional detector is divided into plural regions corresponding to wavelength transmission regions of the multi-bandpass filter. An integrated value of the fluorescence spectrum signal is determined in the region including a fluorescence spectrum peak of an analysis sample in the plural regions. The analysis is performed with the integrated value.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中可以在灵敏度和数据采集之间确保同时性，以减少上拉信号，同时在每个毛细管交换中消除光谱数据采集。本发明涉及一种毛细管电泳装置，其特征在于在光学检测系统中提供多带通滤波器。在本发明的一个方面，二维检测器的信号检测区域被分成与多带通滤波器的波长透射区域对应的多个区域。在包括多个区域中的分析样品的荧光光谱峰的区域中确定荧光光谱信号的积分值。分析用积分值进行。

6. 发明申请

US20080110756A1 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US20080110756A1
公开(公告)日：2008-05-15
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析，作为最初获取的真实值。

7. 发明授权

US07943027B2 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US07943027B2
公开(公告)日：2011-05-17
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间其照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析作为最初获取的真实值。

8. 发明申请

US20120248334A1 Refractive Index Matching In Capillary Illumination 审中-公开
$Refractive Index Matching In Capillary Illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20120248334A1
公开(公告)日：2012-10-04
申请号：US13339169
申请日：2011-12-28
申请人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/64 , F21V33/00 , F21V13/04
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

9. 发明申请

US20090128813A1 Refractive Index Matching in Capillary Illumination 审中-公开
$Refractive Index Matching in Capillary Illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US20090128813A1
公开(公告)日：2009-05-21
申请号：US12360566
申请日：2009-01-27
申请人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/00 , G01N21/41
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

10. 发明授权

US07483136B2 Refractive index matching in capillary illumination 有权
$Refractive index matching in capillary illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US07483136B2
公开(公告)日：2009-01-27
申请号：US11356875
申请日：2006-02-16
申请人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard T. Reel , Eric S. Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01N21/00
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

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