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1. 发明授权

US07943027B2 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US07943027B2
公开(公告)日：2011-05-17
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间其照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析作为最初获取的真实值。

2. 发明授权

US08012327B2 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US08012327B2
公开(公告)日：2011-09-06
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： G01N27/447
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

3. 发明申请

US20090255814A1 ELECTROPHORESIS DEVICE 审中-公开
标题翻译：电泳装置
公开(公告)号：US20090255814A1
公开(公告)日：2009-10-15
申请号：US12420289
申请日：2009-04-08
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi
IPC分类号： C25B9/00
CPC分类号： G01N27/44721
摘要： The invention aims to improve the spatial resolution in a multi-focus type electrophoresis apparatus that irradiates a capillary array from both ends thereof with laser beams. The invention relates to an electrophoresis apparatus in which capillaries at both ends of a capillary array are irradiated respectively with laser beams, and each of the two laser beams traverses multiple capillaries. In the electrophoresis apparatus, the laser beams are coaxially introduced into the capillary array from the both ends thereof to travel in a direction vertical to axis of each capillary and horizontal to the aligrnent plane of the capillary array; and a λ/4 plate and a polarizer are arranged on the laser beam optical axes. According to the invention, the total width of the incident laser beams is made narrow, generation of pseudo signals is prevented, and an analysis performance is improved.
摘要翻译：本发明旨在提高从其两端用激光束照射毛细管阵列的多焦点型电泳装置中的空间分辨率。本发明涉及一种电泳装置，其中毛细管阵列的两端的毛细管分别照射激光束，并且两个激光束中的每一个穿过多个毛细管。在电泳装置中，激光束从其两端同轴地引入到毛细管阵列中，以沿垂直于每个毛细管的轴线的方向行进，并且横向于毛细管阵列的致密平面; 并且在激光束光轴上设置λ/ 4板和偏振片。根据本发明，使入射激光束的总宽度变窄，防止伪信号的产生，提高分析性能。

4. 发明申请

US20070170063A1 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US20070170063A1
公开(公告)日：2007-07-26
申请号：US11654683
申请日：2007-01-18
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
IPC分类号： G01N27/00
CPC分类号： G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus characterized in that a multi-bandpass filter is provided in an optical detection system. In one aspect of the invention, a signal detection area of a two-dimensional detector is divided into plural regions corresponding to wavelength transmission regions of the multi-bandpass filter. An integrated value of the fluorescence spectrum signal is determined in the region including a fluorescence spectrum peak of an analysis sample in the plural regions. The analysis is performed with the integrated value.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其特征在于在光学检测系统中提供多带通滤波器。在本发明的一个方面，二维检测器的信号检测区域被分成与多带通滤波器的波长透射区域对应的多个区域。在包括多个区域中的分析样品的荧光光谱峰的区域中确定荧光光谱信号的积分值。分析用积分值进行。

5. 发明授权

US08246803B2 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US08246803B2
公开(公告)日：2012-08-21
申请号：US11654683
申请日：2007-01-18
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Shigeru Matsui
IPC分类号： G01N27/453
CPC分类号： G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus characterized in that a multi-bandpass filter is provided in an optical detection system. In one aspect of the invention, a signal detection area of a two-dimensional detector is divided into plural regions corresponding to wavelength transmission regions of the multi-bandpass filter. An integrated value of the fluorescence spectrum signal is determined in the region including a fluorescence spectrum peak of an analysis sample in the plural regions. The analysis is performed with the integrated value.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中可以在灵敏度和数据采集之间确保同时性，以减少上拉信号，同时在每个毛细管交换中消除光谱数据采集。本发明涉及一种毛细管电泳装置，其特征在于在光学检测系统中提供多带通滤波器。在本发明的一个方面，二维检测器的信号检测区域被分成与多带通滤波器的波长透射区域对应的多个区域。在包括多个区域中的分析样品的荧光光谱峰的区域中确定荧光光谱信号的积分值。分析用积分值进行。

6. 发明申请

US20080110756A1 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US20080110756A1
公开(公告)日：2008-05-15
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析，作为最初获取的真实值。

7. 发明申请

US20070163882A1 Capillary electrophoresis apparatus and electrophoresis method 有权
标题翻译：毛细管电泳仪和电泳法
公开(公告)号：US20070163882A1
公开(公告)日：2007-07-19
申请号：US11653332
申请日：2007-01-16
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Isao Haraura , Tomoyuki Sakai
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/44704 , G01N27/44721
摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.
摘要翻译：本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。在本发明的毛细管电泳装置中设置毛细管位置测定光源。用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

8. 发明授权

US07787120B2 Spectrophotometer and liquid chromatography system 失效
标题翻译：分光光度计和液相色谱系统
公开(公告)号：US07787120B2
公开(公告)日：2010-08-31
申请号：US12146920
申请日：2008-06-26
申请人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
发明人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
IPC分类号： G01J3/10 , G01J3/36 , G01N21/33
CPC分类号： G01J3/10 , G02B5/283 , G02B27/1006 , G02B27/1086 , G02B27/145 , G02B27/148
摘要： Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.
摘要翻译：通过增加照射样品池的光束的光量而不会使紫外线束或可见光束的检测器饱和而提高检测灵敏度。该分光光度计包括存储待测样品，可见光源和紫外光源的样品池，每个用于提供进入样品的入射光束，分散已经通过样品的光束的分光器，检测从这种光束（光谱）分散的光束的光检测器，以及从紫外光源反射或透射紫外光束并从可见光源透射或反射可见光束的二向色元件。光学构造使得已经通过或已被二色性元件反射的紫外光束和可见光束进入样品池。

9. 发明授权

US07459068B2 Multi-capillary electrophoresis apparatus 有权
标题翻译：多毛细管电泳仪
公开(公告)号：US07459068B2
公开(公告)日：2008-12-02
申请号：US10309729
申请日：2002-12-04
申请人： Eric S. Nordman , Miho Ozawa , Masaya Kojima , Ryoji Inaba , Yoshitaka Kodama , Motohiro Yamazaki
发明人： Eric S. Nordman , Miho Ozawa , Masaya Kojima , Ryoji Inaba , Yoshitaka Kodama , Motohiro Yamazaki
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44704 , G01N27/44708 , G01N27/44782
摘要： A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The multi-capillary electrophoresis apparatus can contain a multi-capillary array that has a separation medium filled therein for isolating a sample. A detector component can be provided at a position remote from a sample injecting end of the array for acquiring information from the sample. A buffer container can be provided for holding a buffer solution into which the sample injecting end can be immersed. One or more temperature controlling component devices can be arranged for controlling a temperature of the buffer solution, of the detector component, or of both the buffer solution and the detector component.
摘要翻译：提供了一种多毛细管电泳装置，用于减少由于装置的多个毛细管之间的电泳时间波动引起的分析过程中的误差。多毛细管电泳装置可以包含多个毛细管阵列，其具有填充在其中的分离介质，用于分离样品。可以在远离阵列的样品注入端的位置处提供检测器部件，以从样品获取信息。可以提供缓冲容器用于保持可以浸入样品注入端的缓冲溶液。可以布置一个或多个温度控制部件装置，用于控制缓冲溶液，检测器部件或缓冲溶液和检测器部件两者的温度。

10. 发明授权

US07005053B2 Multi-capillary electrophoresis apparatus 有权
公开(公告)号：US07005053B2
公开(公告)日：2006-02-28
申请号：US10252557
申请日：2002-09-24
申请人： Motohiro Yamazaki , Masaya Kojima , Ryoji Inaba
发明人： Motohiro Yamazaki , Masaya Kojima , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44708
摘要： Scattering on analysis in a multi-capillary electrophoresis apparatus is suppressed. The multi-capillary electrophoresis apparatus has a multi-capillary array that has a sample and a separation medium for separating a sample charged therein, and has a sampling section formed at ends of the capillaries and a detector part for acquiring information depending on the sample thus separated, a means for applying a voltage between the sampling section and the detector part, a chamber part having an air blowing mechanism and a temperature controlling mechanism, a capillary housing base provided on a leeward side of the air blowing mechanism and housing the multi-capillary array, and a first straightening plate provided between the chamber part and the capillary housing base.

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