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    • 5. 发明授权
    • Measuring device with electrodes fabricated on porous membrane substrate in whole
    • 整体用多孔膜基片制作电极的测量装置
    • US06210907B1
    • 2001-04-03
    • US09381788
    • 1999-09-22
    • Geun-Sig Cha
    • Geun-Sig Cha
    • G01N3353
    • C12Q1/60C12Q1/005G01N27/3274G01N30/64G01N2030/285G01N2030/8822Y10S435/962Y10S436/806
    • The present invention relates to a measuring device which comprises electrodes fabricated on porous membrane substrate in which the sample migrates chromatographically; and the method of quantifying material in the sample by using the device. The sample material for measuring can be quantified by the measuring device of this invention, which is consists pretreatment bands in the lower part of porous membrane substrate and electrodes in the upper prt of pretreatment bands, by the procedure as foolows: The sample material for measuring is chromatographically migrated in the porous membrane substrate by applying the sample on the lower part of the porous membrane substrate; and then the changes of electric signal by the material at the electrode are measured to quantify the material. The analyzing method using the measuring device of this invention has merits that no additional preparation of the sample is needed, simple analyzing process, quantitative analysis of the material in a short time, and the economical efficiency because of the dispensability of skilled personnel due to easy manipulation.
    • 本发明涉及一种测量装置,其包括在多孔膜基底上制造的电极,其中样品在色谱上迁移; 以及通过使用该装置来量化样品中的材料的方法。 用于测量的样品材料可以通过本发明的测量装置来定量,其包括在多孔膜基材的下部中的预处理带和预处理带的上部电极中的电极,其方法如下:用于测量的样品材料 通过将样品涂布在多孔膜基材的下部上,在多孔膜基材中进行色谱迁移。 然后测量电极处的材料的电信号变化量化材料。 使用本发明的测量装置的分析方法的优点在于,不需要额外的样品制备,简单的分析过程,在短时间内对材料进行定量分析,并且由于易于使用的技术人员的可分配性而具有经济效率 操纵。
    • 6. 发明授权
    • Solid state ion sensor with polyimide membrane
    • 带聚酰亚胺膜的固体离子传感器
    • US5417835A
    • 1995-05-23
    • US137373
    • 1993-10-14
    • Richard B. BrownGeun-Sig Cha
    • Richard B. BrownGeun-Sig Cha
    • G01N27/333G01N27/26
    • G01N27/3335Y10S435/817
    • A polyimide matrix is employed to form a substance-sensitive membrane which is particularly suited for installation on a solid state sensor. Polyimide, dissolved in a solvent, such as N,N-dimethylformamide, or N-methyl-2-pyrrolidone (polyimide encapsulant), is combined with an ionophore, plasticizer, and a lipophilic additive. The ionophore may be a calcium ionophore, an ammonium ionophore, or any other ionophore. The membrane may also incorporate, or may be covered by, a bioactive agent, such as an enzyme, an immunochemical, bacteria, antibody, virus, or antigen. The plasticizer is one or both of dimethyl phthalate and diethylene glycol dibenzoate. The lipophilic additive may be potassium tetrakis(p-chlorophenyl)borate. The resulting substance-sensitive membrane has electrochemical properties which compare favorably to those of conventional PVC membranes, and exhibit significantly greater adhesion to glasses and semiconductor substrate materials. The improved adhesion may prolong the life of the sensors and prevent the formation of electrolyte shunts which have been known to render solid state sensors inoperative.
    • 采用聚酰亚胺基体形成特别适用于固态传感器的物质敏感膜。 将溶解在溶剂如N,N-二甲基甲酰胺或N-甲基-2-吡咯烷酮(聚酰亚胺密封剂)中的聚酰亚胺与离子载体,增塑剂和亲脂性添加剂组合。 离子载体可以是钙离子载体,铵离子载体或任何其它离子载体。 膜还可以包含生物活性剂,例如酶,免疫化学,细菌,抗体,病毒或抗原,或可被其覆盖。 增塑剂是邻苯二甲酸二甲酯和二甘醇二苯甲酸酯中的一种或两种。 亲脂性添加剂可以是四(对氯苯基)硼酸钾。 所得到的物质敏感膜具有与常规PVC膜相当的电化学性能,并且对玻璃和半导体衬底材料表现出显着更大的粘合性。 改进的附着力可延长传感器的使用寿命,并防止已知使固态传感器不起作用的电解液分流器的形成。
    • 7. 发明授权
    • Solid state ion sensor with silicon membrane
    • 具有硅膜的固态离子传感器
    • US5102526A
    • 1992-04-07
    • US517636
    • 1990-05-02
    • Richard B. BrownGeun-Sig Cha
    • Richard B. BrownGeun-Sig Cha
    • G01N27/327G01N27/333G01N27/414
    • G01N27/333
    • A silicone matrix is employed to form a substance-sensitive membrane which is particularly suited for installation on a solid state sensor. The ionophore may be a potassium ionophore, an ammonium ionophore or any other ionophore. The membrane may be coupled to the molecule of interest through a bioactive agent, such as an enzyme, an immunochemical, bacteria, antibody, virus, or antigen. The resulting substance-sensitive membrane has electrochemical properties which compare favorably to those of conventional PVC membranes, and exhibit significantly greater adhesion to glasses and semiconductor substrate materials. The improved adhesion will prolong the life of the sensors and prevent the formation of electrolyte shunts which have been known to render solid state sensors inoperative.
    • 使用有机硅基体形成特别适合于安装在固态传感器上的物质敏感膜。 离子载体可以是钾离子载体,铵离子载体或任何其它离子载体。 膜可以通过生物活性剂(例如酶,免疫化学,细菌,抗体,病毒或抗原)与感兴趣的分子偶联。 所得到的物质敏感膜具有与常规PVC膜相当的电化学性能,并且对玻璃和半导体衬底材料表现出显着更大的粘合性。 改善的粘合力将延长传感器的使用寿命,并防止已知使固态传感器不起作用的电解液分流器的形成。