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    • 2. 发明申请
    • ELECTROCHEMICAL DETERMINATION SYSTEM OF GLYCATED PROTEINS
    • 糖化蛋白质电化学测定系统
    • US20090308744A1
    • 2009-12-17
    • US12375635
    • 2006-07-29
    • Hakhyun NamFenghua ZhangSoon Hye YangBo Kyeong KangGang CuiMoon Hee ChoiJoung Su LeeGeun Sig Cha
    • Hakhyun NamFenghua ZhangSoon Hye YangBo Kyeong KangGang CuiMoon Hee ChoiJoung Su LeeGeun Sig Cha
    • G01N33/68G01N33/50G01N1/14
    • G01N33/723G01N33/5308G01N33/5438
    • Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.
    • 本发明涉及一种糖化蛋白质的电化学测定系统,该系统包括:过滤装置,用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物,其中 糖化/非糖化蛋白共存,与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。 本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量,而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质,从而简化可以以低成本提供精确测定的系统的配置 。 此外,本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化,而不是使用昂贵的且具有有限寿命的免疫抗体,此外,不改变 电极传感器的电极与抗体或酶,从而促进产品的大量生产,质量控制和循环。
    • 3. 发明授权
    • Electrochemical determination system of glycated proteins
    • 糖化蛋白质的电化学测定系统
    • US08338183B2
    • 2012-12-25
    • US12375635
    • 2006-07-29
    • Hakhyun NamFenghua ZhangSoon Hye YangBo Kyeong KangGang CuiMoon Hee ChoiJoung Su LeeGeun Sig Cha
    • Hakhyun NamFenghua ZhangSoon Hye YangBo Kyeong KangGang CuiMoon Hee ChoiJoung Su LeeGeun Sig Cha
    • G01N33/50G01N33/48
    • G01N33/723G01N33/5308G01N33/5438
    • Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.
    • 本发明涉及一种糖化蛋白质的电化学测定系统,该系统包括:过滤装置,用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物,其中 糖化/非糖化蛋白共存,与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。 本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量,而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质,从而简化可以以低成本提供精确测定的系统的配置 。 此外,本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化,而不是使用昂贵的且具有有限寿命的免疫抗体,此外,不改变 电极传感器的电极与抗体或酶,从而促进产品的大量生产,质量控制和循环。