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1. 发明授权

US08337683B2 Microfluidic sensor complex structure 有权
标题翻译：微流体传感器复杂结构
公开(公告)号：US08337683B2
公开(公告)日：2012-12-25
申请号：US12670817
申请日：2008-07-24
申请人： Moon Hee Choi , Seung Hyeun Jung , Young Hoon Kim , Joo-Heon Park , Hakhyun Nam , Geun Sig Cha
发明人： Moon Hee Choi , Seung Hyeun Jung , Young Hoon Kim , Joo-Heon Park , Hakhyun Nam , Geun Sig Cha
IPC分类号： B67D1/00
CPC分类号： B01L3/502707 , B01L3/5027 , B01L2200/0621 , B01L2200/143 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406
摘要： Disclosed is a microfluidic sensor complex structure comprising a lower plate, a middle plate and an upper plate. A reference electrode, a working electrode and an electrode connection are formed on the lower plate. The middle plate comprises a microfluidic channel passage therein. The upper plate is overlaid on the middle plate so as to induce a capillary phenomenon on the microfluidic channel passage formed on in the middle plate. The microfluidic sensor complex structure allows the motion of a sample to be driven only by a capillary phenomenon, without additional operation, and allows an immune response, washing, and electrochemical analysis in one round once a sample is introduced thereinto. Hence, it requires only a short time period for measurement, is convenient to handle, and shows sensitivity and selectivity. Also, it can be produced on a mass scale because it can be formed of typical organic polymers using a simple method. Based on analytical electrochemistry, the microfluidic sensor complex structure can be used as a small-size sensor that can be applied to practice sites.
摘要翻译：公开了一种微流体传感器复合结构，其包括下板，中板和上板。在下板上形成参考电极，工作电极和电极连接。中间板包括其中的微流体通道通道。上板覆盖在中间板上，以便在形成在中间板上的微流体通道通道上引起毛细管现象。微流体传感器复合结构允许样品的运动仅由毛细管现象驱动，而无需额外的操作，并且一旦将样品引入其中就可以在一轮中进行免疫应答，洗涤和电化学分析。因此，只需要很短的时间进行测量，便于处理，显示灵敏度和选择性。此外，它可以以大规模生产，因为它可以使用简单的方法由典型的有机聚合物形成。基于分析电化学，微流体传感器复合结构可用作可应用于实践场所的小尺寸传感器。

2. 发明申请

US20100200428A1 MICROFLUIDIC SENSOR COMPLEX STRUCTURE 有权
标题翻译：微流体传感器复合结构
公开(公告)号：US20100200428A1
公开(公告)日：2010-08-12
申请号：US12670817
申请日：2008-07-24
申请人： Moon Hee Choi , Seung Hyeun Jung , Young Hoon Kim , Joo-Heon Park , Hakhyun Nam , Geun Sig Cha
发明人： Moon Hee Choi , Seung Hyeun Jung , Young Hoon Kim , Joo-Heon Park , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/26
CPC分类号： B01L3/502707 , B01L3/5027 , B01L2200/0621 , B01L2200/143 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406
摘要： Disclosed is a microfluidic sensor complex structure comprising a lower plate, a middle plate and an upper plate. A reference electrode, a working electrode and an electrode connection are formed on the lower plate. The middle plate comprises a microfluidic channel passage therein. The upper plate is overlaid on the middle plate so as to induce a capillary phenomenon on the microfluidic channel passage formed on in the middle plate. The microfluidic sensor complex structure allows the motion of a sample to be driven only by a capillary phenomenon, without additional operation, and allows an immune response, washing, and electrochemical analysis in one round once a sample is introduced thereinto. Hence, it requires only a short time period for measurement, is convenient to handle, and shows sensitivity and selectivity. Also, it can be produced on a mass scale because it can be formed of typical organic polymers using a simple method. Based on analytical electrochemistry, the microfluidic sensor complex structure can be used as a small-size sensor that can be applied to practice sites.
摘要翻译：公开了一种微流体传感器复合结构，其包括下板，中板和上板。在下板上形成参考电极，工作电极和电极连接。中间板包括其中的微流体通道通道。上板覆盖在中间板上，以便在形成在中间板上的微流体通道通道上引起毛细管现象。微流体传感器复合结构允许样品的运动仅由毛细管现象驱动，而无需额外的操作，并且一旦将样品引入其中就可以在一轮中进行免疫应答，洗涤和电化学分析。因此，只需要很短的时间进行测量，便于处理，显示灵敏度和选择性。此外，它可以以大规模生产，因为它可以使用简单的方法由典型的有机聚合物形成。基于分析电化学，微流体传感器复合结构可用作可应用于实践场所的小尺寸传感器。

3. 发明授权

US08338183B2 Electrochemical determination system of glycated proteins 有权
标题翻译：糖化蛋白质的电化学测定系统
公开(公告)号：US08338183B2
公开(公告)日：2012-12-25
申请号：US12375635
申请日：2006-07-29
申请人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
发明人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
IPC分类号： G01N33/50 , G01N33/48
CPC分类号： G01N33/723 , G01N33/5308 , G01N33/5438
摘要： Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.
摘要翻译：本发明涉及一种糖化蛋白质的电化学测定系统，该系统包括：过滤装置，用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物，其中糖化/非糖化蛋白共存，与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量，而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质，从而简化可以以低成本提供精确测定的系统的配置。此外，本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化，而不是使用昂贵的且具有有限寿命的免疫抗体，此外，不改变电极传感器的电极与抗体或酶，从而促进产品的大量生产，质量控制和循环。

4. 发明申请

US20090308744A1 ELECTROCHEMICAL DETERMINATION SYSTEM OF GLYCATED PROTEINS 有权
标题翻译：糖化蛋白质电化学测定系统
公开(公告)号：US20090308744A1
公开(公告)日：2009-12-17
申请号：US12375635
申请日：2006-07-29
申请人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
发明人： Hakhyun Nam , Fenghua Zhang , Soon Hye Yang , Bo Kyeong Kang , Gang Cui , Moon Hee Choi , Joung Su Lee , Geun Sig Cha
IPC分类号： G01N33/68 , G01N33/50 , G01N1/14
CPC分类号： G01N33/723 , G01N33/5308 , G01N33/5438
摘要： Disclosed relates to an electrochemical determination system of glycated proteins, the system comprising: a filtering means for filtering labeled compounds bound to glycated proteins and non-glycated proteins after adding labeling compounds, capable of selectively binding to the glycated proteins to a solution, in which glycated/non-glycated proteins coexist, to be bound all to the glycated proteins; and a quantifying means for quantifying the filtered labeling compounds, not bound to the glycated proteins. The system of the present invention filters the residual labeled compounds left after binding to glycated proteins to quantify, instead of directly quantifying glycated proteins via the known glycated protein determination methods, thus simplifying the configuration of the system that can provide exact determinations with a low cost. Moreover, the electrochemical determination system of glycated proteins of the present invention minimizes the interference that the proteins are absorbed to an analysis device and a sensor in the system, not using immune antibodies that are expensive and have limited lives and, furthermore, not modifying the electrodes of the electrode sensor with antibodies or enzymes, thus facilitating mass production, quality control and circulation of the products.
摘要翻译：本发明涉及一种糖化蛋白质的电化学测定系统，该系统包括：过滤装置，用于在加入能够选择性结合糖基化蛋白质至溶液的标记化合物之后过滤与糖化蛋白质和非糖基化蛋白质结合的标记化合物，其中糖化/非糖化蛋白共存，与糖基化蛋白结合; 以及用于定量未与糖基化蛋白结合的经过滤的标记化合物的定量方法。本发明的系统对结合糖化蛋白质后残留的残留标记化合物进行过滤以定量，而不是通过已知的糖化蛋白质测定方法直接定量糖化蛋白质，从而简化可以以低成本提供精确测定的系统的配置。此外，本发明的糖化蛋白质的电化学测定系统使得蛋白质被吸收到系统中的分析装置和传感器的干扰最小化，而不是使用昂贵的且具有有限寿命的免疫抗体，此外，不改变电极传感器的电极与抗体或酶，从而促进产品的大量生产，质量控制和循环。

5. 发明授权

US09512458B2 Electrochemical biosensor with sample introduction channel capable of uniform introduction of small amount of sample 有权
标题翻译：电化学生物传感器，样品引入通道能均匀引入少量样品
公开(公告)号：US09512458B2
公开(公告)日：2016-12-06
申请号：US12740016
申请日：2008-10-24
申请人： Gang Cui , Jae Hyun Yoo , Ju Yong Kim , Keun Ki Kim , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Gang Cui , Jae Hyun Yoo , Ju Yong Kim , Keun Ki Kim , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： C12Q1/00 , G01N27/327 , B01L3/00
CPC分类号： C12Q1/006 , B01L3/5027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N27/3272
摘要： Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.
摘要翻译：公开了一种具有样品导入通道的电化学生物传感器，其中采用绝缘体均匀且准确地引入少量样品并调节工作电极的面积，从而保证了样品的准确定量分析。在样品入口处提供样品收集屏障，生物传感器允许以更高的精度引入样品并以更高的再现性和可靠性进行分析。

6. 发明授权

US09192331B2 Releasing structure for lancing device 有权
标题翻译：采血装置释放结构
公开(公告)号：US09192331B2
公开(公告)日：2015-11-24
申请号：US13993059
申请日：2011-09-20
申请人： Geun Sig Cha , Hakhyun Nam , Eun-Jong Cha , Kyung-Ah Kim
发明人： Geun Sig Cha , Hakhyun Nam , Eun-Jong Cha , Kyung-Ah Kim
IPC分类号： A61B5/151 , A61B5/15
CPC分类号： A61B5/15126 , A61B5/1411 , A61B5/150022 , A61B5/150068 , A61B5/150114 , A61B5/150183 , A61B5/150412 , A61B5/150519 , A61B5/150664 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1513 , A61B5/1519 , A61B5/15194
摘要： A releasing structure for a lancing device according to an exemplary embodiment of the present invention may include: a lancet body with a lancet at the front; a lancet holder mounted with the lancet body with the lancet at the front; a stem disposed behind the lancet holder and moving the lancet holder forward/backward; a rotary housing pushing/pulling the stem while turning forward at a predetermined angle about a rotational axis defined in the movement direction of the lancet; a torsion spring storing torque for turning the rotary housing forward at a predetermined angle; and a loading handle transmitting torque to the torsion spring while turning forward at a predetermined angle.
摘要翻译：根据本发明的示例性实施例的用于采血装置的释放结构可以包括：在前部具有刺血针的柳叶刀体; 一个刺血针架，带有柳叶刀身体，前面有刺血针; 设置在刺血针保持器后方的杆，向前/向后移动刺血针保持器; 旋转壳体，其以围绕在柳叶刀的移动方向上限定的旋转轴线以预定角度向前转动的方式推动/拉动所述杆; 扭转弹簧存储用于以预定角度向前转动旋转壳体的扭矩; 以及在以预定角度向前转动的同时向扭转弹簧传递扭矩的加载手柄。

7. 发明申请

US20140014512A1 AMPEROMETRIC SENSORS AND DEVICES FOR MEASURING CONCENTRATION OF S-NITROSOTHIOLS BASED ON PHOTO-INDUCED DECOMPOSITION OF S-NITROSOTHIOLS 有权
标题翻译：用于测量S-NITROSOTOLOLS的光诱导分解的S-硝基酚的浓度的电位传感器和装置
公开(公告)号：US20140014512A1
公开(公告)日：2014-01-16
申请号：US13264382
申请日：2011-04-14
申请人： Sung A Hong , Da Yeon Sung , Jun Hee Han , Jea Hun Song , Hakhyun Nam , Geun Sig Cha , Jae Ho Shin
发明人： Sung A Hong , Da Yeon Sung , Jun Hee Han , Jea Hun Song , Hakhyun Nam , Geun Sig Cha , Jae Ho Shin
IPC分类号： G01N27/30
CPC分类号： G01N27/30 , G01N27/3271
摘要： Provided are an amperometric sensor and device for electrochemically quantifying nitrosothiol (RSNO), which is associated with storage and delivery of nitric oxide (NO) in the human body. The amperometric sensor for measuring a concentration of RSNO includes an electrode configured to measure an electric current generated by an oxidation reaction of NO, and a means configured to start and stop photo-induced decomposition of RSNO. Here, the electric current is measured by the oxidation reaction of NO before and after the photo-induced decomposition of RSNO. The amperometric sensor may measure separate signals of RSNO and NO, which are present in the sample at the same time, using one electrode, thereby preventing an inhibition action caused by NO during the measurement of RSNO. Also, the amperometric sensor is simple in structure and easy to manufacture and may be applied to manufacture of a small electrode, and thus may be developed as a sensor for in vivo measurements.
摘要翻译：提供了用于电化学量化亚硝基硫醇（RSNO）的电流传感器和装置，其与人体中一氧化氮（NO）的储存和递送相关。用于测量RSNO浓度的电流传感器包括配置为测量由NO的氧化反应产生的电流的电极和被配置为启动和停止光诱导的RSNO分解的装置。这里，通过在RSNO的光诱导分解之前和之后的NO的氧化反应来测量电流。电流传感器可以使用一个电极同时测量样品中存在的RSNO和NO的单独信号，从而防止在RSNO测量期间由NO引起的抑制作用。此外，电流传感器的结构简单，易于制造，并且可以应用于小电极的制造，因此可以被开发为用于体内测量的传感器。

8. 发明申请

US20130267977A1 LANCET HOLDER AND LANCET DEVICE INCLUDING THE SAME 有权
标题翻译： LANCET HOLDER和LANCET设备，包括它们
公开(公告)号：US20130267977A1
公开(公告)日：2013-10-10
申请号：US13995153
申请日：2011-09-20
申请人： Geun Sig Cha , Hakhyun Nam , Eun-Jong Cha , Kyung-Ah Kim
发明人： Geun Sig Cha , Hakhyun Nam , Eun-Jong Cha , Kyung-Ah Kim
IPC分类号： A61B5/151
CPC分类号： A61B5/15101 , A61B5/1411 , A61B5/150022 , A61B5/150412 , A61B5/150519 , A61B5/150664 , A61B5/150732 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/15194
摘要： The present invention provides a lancet holder that can smoothly and accurately hold all of lancets with different cross-sections and diameters and can keep them vertical, and a lancet device including the lancet holder.To this end, a lancet holder according to an exemplary embodiment of the present invention includes a holder body having a lancet seat at one end to mount a lancet and receiving the lancet and elastic fixing portions arranged in pairs to face each other on the inner side of the holder body so that the lancet received in the holder body is vertically held, and elastically fixing the lancet.According to this configuration, the lancet holder can accurately keep all of lancets vertical, even if the lancets are different in cross-section and diameter, such that the lancet can be mounted on the lancet holder and protrude at a predetermined length in releasing and the lancet needle can vertically protrude through the through-hole of the cover and damage only a predetermined target portion of a subject.
摘要翻译：本发明提供一种柳叶刀套，其能够平滑且准确地保持具有不同截面和直径的所有刺血针，并且可以使其保持垂直，并且包括刺血针保持器的刺血针装置。为此，根据本发明的一个示例性实施方式的柳叶刀套件包括：保持器主体，其在一端具有刺血针座，用于安装柳叶刀并且接收柳叶刀和成对地布置成在内侧彼此面对的弹性固定部使得容纳在保持器主体中的刺血针被竖直地保持，并且弹性地固定刺血针。根据该结构，即使柳叶刀的横截面积和直径不同，柳叶刀套也能够将所有的刺血针保持在垂直方向，使得可以将柳叶刀安装在柳叶刀套上并以预定的长度突出而释放，柳叶刀针可以垂直突出穿过盖的通孔，并且仅损坏被检体的预定目标部分。

9. 发明申请

US20110195490A1 CARTRIDGE FOR APPARATUS FOR CHEMICALLY ANALYZING BLOOD AND APPARATUS USING THE SAME 有权
标题翻译：用于化学分析血液的装置的盒子及其使用的装置
公开(公告)号：US20110195490A1
公开(公告)日：2011-08-11
申请号：US12739686
申请日：2008-10-30
申请人： Tae Young Kang , Heejun Lee , Jeonghan Ha , Jungwon Shin , Hakhyun Nam , Geun Sig Cha
发明人： Tae Young Kang , Heejun Lee , Jeonghan Ha , Jungwon Shin , Hakhyun Nam , Geun Sig Cha
IPC分类号： C12M1/34 , G01N33/48
CPC分类号： G01N33/492 , G01N2035/00089 , G01N2035/00148
摘要： The present invention provides a cartridge for an apparatus for analyzing blood chemistry that is used for medical treatment, and automatically analyzes and records data needed for medical service, such as the concentrations of electrolytes, the partial pressures of gases, and the concentrations of metabolites, or the volume ratio of red blood cells contained in blood. The apparatus for analyzing blood chemistry of present invention includes: an apparatus frame having a compartment; a cartridge that is inserted into the compartment of the apparatus frame and includes a sensor card, a solution valve unit, and a blood introducing unit; a controller that receives a signal generated from the sensor card and processes the signal; a lever for the blood introducing unit is connected to the apparatus frame; a power transmitting unit that is provide to the apparatus frame and transmits power of the lever for the blood introducing unit to open/close the blood introducing unit of the cartridge; a solution transporting unit that is provided to the apparatus frame and transports the solutions in the cartridge; and driving units that actuates the solution valve unit of the cartridge by the controller and opens or close the tubing flowing of the solutions.
摘要翻译：本发明提供一种用于分析用于医疗的血液化学物质的装置的盒，并且自动分析和记录医疗服务所需的数据，例如电解质的浓度，气体的分压和代谢物的浓度，或血液中含有的红细胞的体积比。本发明的血液化学分析装置包括：具有隔室的装置框架; 插入到装置框架的隔室中的盒，包括传感器卡，溶液阀单元和血液引入单元; 控制器，其接收从所述传感器卡生成的信号并处理所述信号; 用于血液引入单元的杆连接到装置框架; 动力传递单元，其向所述装置框架提供并且传送所述用于所述血液导入单元的所述杆的动力以打开/关闭所述盒的血液引入单元; 溶液输送单元，其被提供到所述装置框架并将所述溶液输送到所述盒中; 以及通过控制器致动药筒的溶液阀单元并打开或关闭溶液流动的管道的驱动单元。

10. 发明授权

US06554982B1 Miniaturized solid-state reference electrode with self-diagnostic function 失效
标题翻译：具有自诊断功能的小型化固态参比电极
公开(公告)号：US06554982B1
公开(公告)日：2003-04-29
申请号：US09889032
申请日：2001-07-12
申请人： Jae Ho Shin , Sung Dong Lee , Hakhyun Nam , Geun Sig Cha , Byeong Woo Bae
发明人： Jae Ho Shin , Sung Dong Lee , Hakhyun Nam , Geun Sig Cha , Byeong Woo Bae
IPC分类号： G01N27401
CPC分类号： G01N27/301
摘要： The present invention relates to a reference electrode for a potentiometric electrode system, characterized in that the junction in contact with a sample solution is enlarged and an ion-sensitive membrane containing an ion selective material as a protective membrane for the inner reference solution is employed, which comprises a substrate; a metal layer; an insoluble metal salt layer; an insulating film for insulating the metal layer from an aqueous solution; a hydrogel serving as an inner reference solution; the junction on the hydrogel contacting with a sample solution; the ion-sensitive, protective membrane formed over all surface areas of the hydrogel, except for the junction, to separate the sample solution from the inner reference solution or act as an ion-sensing membrane upon the contamination of the junction, whereby the operational abnormality caused by junction contamination may be easily checked and fast activation may be achieved.
摘要翻译：本发明涉及一种用于电位电极系统的参考电极，其特征在于，与样品溶液接触的接合点被扩大，并且使用含有作为内部参比溶液的保护膜的离子选择性材料的离子敏感膜，其包括基底; 金属层; 不溶性金属盐层; 用于将金属层与水溶液绝缘的绝缘膜; 作为内参照溶液的水凝胶; 水凝胶上的接头与样品溶液接触; 在水凝胶的所有表面区域之外形成的离子敏感的保护膜除了接合部分之外，以将样品溶液与内部参考溶液分离，或者当接合部被污染时用作离子感测膜，由此操作异常可以容易地检查结点污染引起的并且可以实现快速激活。

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