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1. 发明授权

US06177479B1 Continuous manufacturing method for microspheres and apparatus 失效
标题翻译：微球的连续制造方法及其设备
公开(公告)号：US06177479B1
公开(公告)日：2001-01-23
申请号：US09260412
申请日：1999-03-01
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Yoh Sano , Hiroshi Nabetani , Takahiro Kawakatsu , Isao Kobayashi , Hironoshin Takao
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Yoh Sano , Hiroshi Nabetani , Takahiro Kawakatsu , Isao Kobayashi , Hironoshin Takao
IPC分类号： B01F308
CPC分类号： B01F3/0811 , B01F5/0475 , B01F13/0059 , B01J13/04 , Y10S514/937 , Y10S514/941 , Y10S516/924
摘要： In an apparatus for continuously manufacturing microspheres, a dispersed phase (O) is supplied to a chamber 27 for the dispersed phase inside of a bulkhead member 26 via a supply port 23. Thereafter, the dispersed phase enters into a gap 31 between a plate 22 via a supply port 29 in a base 25. The dispersed phase which enters into the gap 31 grows microspheres (particles) having a certain diameter while passing through a microchannel 33 by pressure applied by, for example, a pump, and is mixed with a continuous phase (W), so that microspheres are produced. The thus-produced microspheres float or are suspended in the continuous phase without needing any particular external force in response to their specific gravity, allowing the microspheres to be generated and withdrawn from a withdrawal port 32 at a significantly reduced pressure in comparison to conventional methods and apparatus.
摘要翻译：在用于连续制造微球体的装置中，分散相（O）经由供给口23供应到隔板部件26内的分散相的室27.此后，分散相进入板22之间的间隙31 通过基底25中的供给口29.通过例如由泵施加的压力通过微通道33，进入间隙31的分散相生长具有一定直径的微球（颗粒），并与连续相（W），使得产生微球体。如此生产的微球体在连续相中漂浮或悬浮，而不需要任何特定的外力作为响应其比重，从而与常规方法相比，以显着降低的压力从取出口32产生和取出微球，并且仪器。

2. 发明授权

US06258858B1 Cross-flow microchannel apparatus and method of producing or separating emulsions making use thereof 失效
标题翻译：交叉流动微通道装置及其制造或分离乳液的方法
公开(公告)号：US06258858B1
公开(公告)日：2001-07-10
申请号：US09260416
申请日：1999-03-01
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu , Hideaki Komori , Toshikuni Yonemoto
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu , Hideaki Komori , Toshikuni Yonemoto
IPC分类号： B01D1704
CPC分类号： B01F5/0401 , B01D17/041 , B01D17/044 , B01D17/10 , B01D61/18 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0475 , B01F13/0059 , B01F2003/0834 , B01F2005/0011 , Y10S366/03 , Y10S516/924 , Y10T137/0329 , Y10T137/87652
摘要： Cross-flow microchannel apparatus for producing emulsions includes a pump 9 and a pump 11 which are driven to respectively supply a continuous phase to a concave portion 4 via a supply pipe 10, a supply hole 6 and a supply port 18 and a dispersed phase to a space between the outside of a base 3 and the inside of a concave portion 2 formed in a case 1 via a supply pipe 12 and a supply hole 7. Then, by applying a predetermined pressure to the dispersed phase, the dispersed phase is formed into fine particles via a microchannels 21 and mixed with the continuous phase, thereby forming emulsions. The emulsions are withdrawn to a tank and so on via a withdrawal port 19, a withdrawal hole 8, and a withdrawal pipe 13 for emulsions. The apparatus can alternatively be used to separate an emulsion by pumping the emulsion within the concave portion 4 via pipe 10, hole 6 and port 18, such that the emulsion is separated via the microchannels 21 into a continuous phase that is withdrawn from the hole 7, and a dispersed phase that is withdrawn from the hole 8.
摘要翻译：用于制造乳液的横流微通道装置包括泵9和泵11，其被驱动以经由供给管10，供应孔6和供给口18以及分散相分别向凹部4提供连续相，经由供给管12和供给孔7形成在基体3的外部和形成在壳体1中的凹部2的内部之间的空间。然后，通过对分散相施加规定的压力，形成分散相通过微通道21成为细颗粒并与连续相混合，从而形成乳液。乳液经由抽出口19，抽出孔8和用于乳液的抽出管13而被抽出到罐等中。该装置可以替代地用于通过管道10，孔6和端口18在凹部4内泵送乳液来分离乳液，使得乳液通过微通道21分离成从孔7中取出的连续相，以及从孔8中取出的分散相。

3. 发明授权

US6155710A Method and device for producing emulsions 失效
标题翻译：生产乳液的方法和装置
公开(公告)号：US6155710A
公开(公告)日：2000-12-05
申请号：US125403
申请日：1998-08-18
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu
IPC分类号： B01F3/08 , B01F5/00 , B01F5/02 , B01F5/04 , B01F5/06 , B01F13/00 , B01J13/00 , B01F15/02
CPC分类号： B01J13/00 , B01F13/0059 , B01F3/08 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0401 , B01F5/0475 , B01F2003/0834 , B01F2005/0011
摘要： A dispersed phase (O) supplied inside a bulkhead member (17) through a supply port (14) enters a gap (20) between a plate (16) and a base (18) through a supply port (19) of the base (18) and the dispersed phase (O) having entered the gap (20) then enters a continuous phase (W) through a boundary section (21) by virtue of pressure applied by a pressurizing means such as a pump. Then, the dispersed phase is made into a particle having a predetermined diameter by a microchannel (24) in passing through this boundary section (21), thereby forming an emulsion (E) in which the dispersed phase (O) of the predetermined diameter is dispersed in the continuous phase (W).
摘要翻译： PCT No.PCT / JP96 / 03492 Sec。 371日期1998年8月18日 102（e）1998年8月18日PCT PCT 1996年11月28日PCT公布。公开号WO97 / 30783 日期1997年8月28日通过供给口（14）在隔板部件（17）内供给的分散相（O）通过供给口（19）进入板（16）和基部（18）之间的间隙（20））和已经进入间隙（20）的分散相（O）之后，通过借助诸如泵等加压装置施加的压力，通过边界部分（21）进入连续相（W）。然后，分散相通过微通道（24）通过该边界部分（21）制成具有预定直径的颗粒，从而形成乳液（E），其中预定直径的分散相（O）为分散在连续相（W）中。

4. 发明授权

US06387301B1 Method of producing solid fatty microspheres 失效
标题翻译：固体脂肪微球的制备方法
公开(公告)号：US06387301B1
公开(公告)日：2002-05-14
申请号：US09460905
申请日：1999-12-14
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Hiroshi Nabetani , Jihong Tong , Minoru Seki , Shinji Sugiura
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Hiroshi Nabetani , Jihong Tong , Minoru Seki , Shinji Sugiura
IPC分类号： B01J1302
CPC分类号： B01F13/0059 , B01F3/0807 , B01F17/0021 , B01F17/0028 , B01F17/0057 , B01F17/0064 , B01F2003/0834 , B01F2215/0427 , B01F2215/0431 , B01F2215/0468 , B01F2215/0472
摘要： A method to efficiently and continuously produce microspheres of natural oils and fats having a high melting point, the average particle diameter of which is in dozens of &mgr;m and is uniform, comprising the steps of heating oils and fats having a high melting point to a temperature greater than the melting point thereof to liquify same holding the oils and fats in a liquid state, forming a dispersed phase of the liquid oils and fats, pressurizing the dispersed phase and forming emulsions by dispersing the dispersed phase into a continuous phase via a plurality of microchannels, and isolating microspheres of the oils and fats having a high melting point by removing the continuous phase from the emulsions.
摘要翻译：一种有效且连续地生产具有高熔点的天然油脂的微球的方法，其平均粒径为数十个，均匀，包括以下步骤：将具有高熔点的油和脂肪加热至温度大于其熔点以使液体状态下的油和脂肪液化，形成液体油和脂肪的分散相，对分散相加压并通过将分散相分散到连续相中形成乳液，经由多个微通道，并通过从乳液中除去连续相来分离具有高熔点的油和脂肪的微球。

5. 发明授权

US06281254B1 Microchannel apparatus and method of producing emulsions making use thereof 失效
标题翻译：微通道装置及其制造方法
公开(公告)号：US06281254B1
公开(公告)日：2001-08-28
申请号：US09260417
申请日：1999-03-01
申请人： Mitsutoshi Nakajima , Hiroshi Nabetani , Yuji Kikuchi , Christophe Largueze
发明人： Mitsutoshi Nakajima , Hiroshi Nabetani , Yuji Kikuchi , Christophe Largueze
IPC分类号： B01F308
CPC分类号： B01F13/0059 , B01F3/0807 , B01F5/0475 , B01F2215/0014 , B01F2215/0031 , B01F2215/0032 , Y10S366/03 , Y10S516/924 , Y10T137/0329 , Y10T137/87652
摘要： A microchannel apparatus includes a plural partition walls 4 formed as extensions of plural microchannels 1 toward a continuous phase, and a flow path 5 is formed between adjacent ones of the partition walls 4. A dispersed phase pumped into a continuous phase via each microchannel 1 generates nearly perfect spheres in the course of passing through the microchannel and the flow path 5 in between the partition walls 4, thereby producing emulsions comprising fine and homogenous microspheres.
摘要翻译：微通道装置包括形成为连续相的多个微通道1的延伸部的多个分隔壁4，并且在相邻的间隔壁4之间形成流路5.经由每个微通道1泵入连续相的分散相产生在通过微通道和分隔壁4之间的流路5的过程中几乎完美的球体，从而产生包含精细和均匀的微球体的乳液。

6. 发明授权

US06576023B2 Method and apparatus for manufacturing microspheres 有权
标题翻译：微球制造方法及装置
公开(公告)号：US06576023B2
公开(公告)日：2003-06-10
申请号：US09791085
申请日：2001-02-22
申请人： Mitsutoshi Nakajima , Hiroyuki Fujita , Yuji Kikuchi , Isao Kobayashi
发明人： Mitsutoshi Nakajima , Hiroyuki Fujita , Yuji Kikuchi , Isao Kobayashi
IPC分类号： B01J1302
CPC分类号： B01F13/0059 , B01F3/0807 , B01F5/0475 , B01F5/0485 , B01J13/04
摘要： A method and an apparatus are provided for efficiently manufacturing microspheres having a uniform particle diameter. The apparatus comprises: case 1 having a lower body 1a and an upper body 1b. A seal ring 3, a first plate 4 which is comprised of a transparent plate such as a glass plate or a plastic plate, an annular spacer 5, an intermediate plate 6 which is comprised of a silicon substrate or the like, an annular spacer 7, a second plate 8 and a seal ring 9 are inserted in this order into a concave portion 2 formed in the lower body 1a. The upper body 1b is superposed thereon. Further, the upper body 1b is attached to the lower body 1a with bolts or the like.
摘要翻译：提供了一种有效制造具有均匀粒径的微球的方法和装置。该装置包括：具有下主体1a和上主体1b的壳体1。密封环3，由透明板如玻璃板或塑料板构成的第一板4，环形间隔件5，由硅衬底等构成的中间板6，环形间隔件7 ，第二板8和密封环9依次插入形成在下体1a中的凹部2中。上身1b叠置在其上。此外，上身1b通过螺栓等附接到下身1a。

7. 发明授权

US06538019B1 Functional emulsions 失效
标题翻译：功能乳液
公开(公告)号：US06538019B1
公开(公告)日：2003-03-25
申请号：US09639541
申请日：2000-08-16
申请人： Mitsutoshi Nakajima , Hiroshi Nabetani , Sosaku Ichikawa , Qing Yi Xu
发明人： Mitsutoshi Nakajima , Hiroshi Nabetani , Sosaku Ichikawa , Qing Yi Xu
IPC分类号： A01N4302
CPC分类号： A61K8/39 , A61K8/06 , A61K8/066 , A61K9/107 , A61K47/14 , A61K2800/522 , A61Q19/00
摘要： According to the present invention, it is possible to produce emulsions containing a material that are insoluble or that have low solubility with respect to water and oil in a high concentration, so as to obtain emulsions which can be preserved for a long period of time. More specifically, ethanol, to which polyglycerol oleic acid ester (PG) is added, and vegetable oil, are stirred with a homogenizer or an emulsification method such as a membrane emulsification or a microchannel emulsification, thereby obtaining E/O type emulsions or E/O/W type emulsions wherein ethanol drops in which polyphenol is dissolved in a high concentration are dispersed into vegetable oil.
摘要翻译：根据本发明，可以制备含有高浓度的不溶于水或溶解性低的物质的乳液，从而得到长时间保存的乳液。更具体地说，加入聚甘油油酸酯（PG）的乙醇和植物油用均化器或乳化法如膜乳化或微通道乳化进行搅拌，得到E / O型乳剂或E / 将其中以高浓度溶解多酚的乙醇滴的O / W型乳液分散在植物油中。

8. 发明授权

US06528293B1 Method of producing activated lipase 失效
标题翻译：生产活性脂肪酶的方法
公开(公告)号：US06528293B1
公开(公告)日：2003-03-04
申请号：US09415924
申请日：1999-10-12
申请人： Mitsutoshi Nakajima , Hiroshi Nabetani , Sosaku Ichikawa , Minoru Seki , Tatsuo Maruyama
发明人： Mitsutoshi Nakajima , Hiroshi Nabetani , Sosaku Ichikawa , Minoru Seki , Tatsuo Maruyama
IPC分类号： C12N900
CPC分类号： C12N9/20
摘要： A method is disclosed for activating a lipase by adding a solution of lipase in an aqueous buffer at a pH near neutrality to an organic phase, e.g., tetradecane. Under these conditions lipase is activated as a function of an organic-and-water boundary surface between the organic and water phases. The lipase that is activated in this manner remains active even after lyophilization to remove the water and the organic phase. This activated lipase efficiently catalyzes a fat reforming reaction in non-aqueous and nano-aqueous conditions.
摘要翻译：公开了一种通过在与有机相（例如十四烷）接近中性的pH下将脂肪酶溶液加入水性缓冲液来活化脂肪酶的方法。在这些条件下，脂肪酶作为有机和水相之间的有机和水界面的函数被激活。以这种方式活化的脂肪酶即使在冻干以后也保持活性以除去水和有机相。该活化的脂肪酶在非水和纳米水条件下有效催化脂肪重整反应。

9. 发明授权

US4990257A Concentration of solution by reverse osmosis 失效
标题翻译：通过反向麻醉的浓度浓度
公开(公告)号：US4990257A
公开(公告)日：1991-02-05
申请号：US538540
申请日：1990-06-14
申请人： Atsuo Watanabe , Mitsutoshi Nakajima , Hiroshi Nabetani , Yasunori Yamada , Tsutomu Ohmori
发明人： Atsuo Watanabe , Mitsutoshi Nakajima , Hiroshi Nabetani , Yasunori Yamada , Tsutomu Ohmori
IPC分类号： B01D61/08 , A23L2/08 , B01D61/02 , B01D61/58
CPC分类号： A23L2/085 , B01D61/022
摘要： Provided is a multistage method and apparatus for concentrating a solution by reverse osmosis, comprising the steps and means for: maximizing the concentration of absolute in a solution in a multistage apparatus having only standard capacity pumps, including steps of providing first concentrating means for concentrating a solution to a first concentration, said first concentrating means comprising a least one concentrating unit which positioned upstream with respect to a direction in which a solution to be concentrated flows, and providing second concentrating means for concentrating the solution that has been concentrated by first concentrating means to a second concentration which is higher than said first concentrating means comprising at least one concentrating unit which is positioned downstream with respect to said direction; said concentrating units comprising consisting essentially of respective membrane modules and respective standard capacity pumps, the membrane module of the concentrating unit of said first concentrating means comprising a tight reverse osmosis membrane with a high rejection percentage sufficient to achieve a high concentration of said solution with a high flux density of solvent flowing through the membrane, and the membrane module of the concentrating unit of said second concentrating means comprising a loose reverse osmosis membrane with a lower rejection percentage sufficient to easily achieve a further concentration of said first concentrating means with a high flux density of solution flowing through the membrane.

10. 发明授权

US5096590A Concentration of solution by the reverse osmosis process 失效
标题翻译：通过逆向过程的浓度浓度
公开(公告)号：US5096590A
公开(公告)日：1992-03-17
申请号：US762159
申请日：1991-09-18
申请人： Atsuo Watanabe , Mitsutoshi Nakajima , Hiroshi Nabetani , Yasunori Yamada , Tsutomu Ohmori
发明人： Atsuo Watanabe , Mitsutoshi Nakajima , Hiroshi Nabetani , Yasunori Yamada , Tsutomu Ohmori
IPC分类号： B01D61/08 , A23L2/08 , B01D61/02 , B01D61/58
CPC分类号： A23L2/085 , B01D61/022
摘要： Provided is a multistage method and apparatus for concentrating a solution by reverse osmosis, comprising the steps and means for: maximizing the concentration of absolute in a solution in a multistage apparatus having only standard capacity pumps, including steps of providing first concentrating means for concentrating a solution to a first concentration, said first concentrating means comprising at least one concentrating unit which positioned upstream with respect to a direction in which a solution to be concentrated flows, and providing second concentrating means for concentrating the solution that has been concentrated by first concentrating means to a second concentration which is higher than said first concentrating means comprising at least one concentrating unit which is positioned downstream with respect to said direction; said concentrating units comprising consisting essentially of respective membrane modules and respective standard capacity pumps, the membrane module of the concentrating unit of said first concentrating means comprising a tight reverse osmosis membrane with a high rejection percentage sufficient to achieve a high concentration of said solution with a high flux density of solvent flowing through the membrane, and the membrane module of the concentrating unit of said second concentrating means comprising a loose reverse osmosis membrane with a lower rejection percentage sufficient to easily achieve a further concentration of said first concentrating means with a high flux density of solution flowing through the membrane.

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