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1. 发明申请

US20090023143A1 Predicting agent for metastasis 审中-公开
标题翻译：转移预测剂
公开(公告)号：US20090023143A1
公开(公告)日：2009-01-22
申请号：US11905296
申请日：2007-09-28
申请人： Mitsuomi Hirashima , Akira Yamauchi , Toshiro Kageshita , Takanori Nakamura , Nozomu Nishi
发明人： Mitsuomi Hirashima , Akira Yamauchi , Toshiro Kageshita , Takanori Nakamura , Nozomu Nishi
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C07K16/18 , C07K16/26 , C12Q2600/158 , G01N33/5011 , G01N33/574 , G01N33/57484 , G01N2333/4724
摘要： By disclosing part of metastasis mechanisms in cancer cells, the metastatic potential of cancer cells will be determinable. Anti-galectin-9 Ab against galectin-9 is contained as an effective component with or without others, thereby enabling the evaluation or detection of galectin-9 expression levels in cancer cells wherein the metastatic potential of the cancer cells can be assessed or detected.
摘要翻译：通过揭示癌细胞中转移机制的一部分，癌细胞的转移潜力是可以确定的。含有半乳凝素-9抗体的抗半乳凝素-9抗体作为有或无其他成分的有效成分被含有，从而能够评价或检测癌细胞中的半乳凝素-9表达水平，其中可以评估或检测癌细胞的转移潜力。

2. 发明授权

US08889732B2 Fused heterocyclic compounds and thrombopoietin receptor activators 有权
标题翻译：稠合杂环化合物和血小板生成素受体激活剂
公开(公告)号：US08889732B2
公开(公告)日：2014-11-18
申请号：US13503560
申请日：2010-10-22
申请人： Yukihiro Shigeta , Shingo Umezawa , Shunsuke Iwamoto , Takanori Nakamura
发明人： Yukihiro Shigeta , Shingo Umezawa , Shunsuke Iwamoto , Takanori Nakamura
IPC分类号： A61K31/38 , C07D333/32 , C07D231/18 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D409/04 , C07D333/40
CPC分类号： C07D409/14 , C07D231/18 , C07D333/32 , C07D333/38 , C07D333/40 , C07D401/12 , C07D409/04 , C07D409/12
摘要： Fused heterocyclic compounds useful for prevention, treatment or improvement of diseases against which activation of the thrombopoietin receptor is effective are provided.A compound represented by the formula (I) (wherein R1 is an aryl group fused to a saturated ring or the like, A, B, L1, R2, L2, L3, Y, L4, R3 and X are defined in the description), a tautomer, prodrug or a pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译：提供了可用于预防，治疗或改善血小板生成素受体活化有效的疾病的融合杂环化合物。式（I）表示的化合物（其中R 1是与饱和环等稠合的芳基A，B，L1，R2，L2，L3，Y，L4，R3和X在说明书中定义），该化合物或其溶剂化物的互变异构体，前药或药学上可接受的盐。

3. 发明申请

US20140057895A1 INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：吲哚和吡咯并吡啶衍生物及其药物用途
公开(公告)号：US20140057895A1
公开(公告)日：2014-02-27
申请号：US14005659
申请日：2012-06-06
申请人： Kazuhiro Mizuno , Junya Ikeda , Takanori Nakamura , Masato Iwata , Hiromichi Otaka , Nana Goto
发明人： Kazuhiro Mizuno , Junya Ikeda , Takanori Nakamura , Masato Iwata , Hiromichi Otaka , Nana Goto
IPC分类号： C07D471/04 , C07D413/04 , C07D417/14 , C07D413/14
CPC分类号： C07D471/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/08
摘要： The present invention relates to a novel indazole- or pyrrolopyridine-derivative comprising a 5 membered heterocyclic substituent at 1 position thereof which has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及一种新颖的吲唑或吡咯并吡啶衍生物及其1位的5元杂环取代基，其具有针对5-羟色胺-4受体的激动作用或部分激动作用，以及包含其的药物组合物。

4. 发明申请

US20100310537A1 METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND 有权
公开(公告)号：US20100310537A1
公开(公告)日：2010-12-09
申请号：US12746507
申请日：2008-12-05
申请人： Takanori Nakamura , Atsushi Miyamura , Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji
发明人： Takanori Nakamura , Atsushi Miyamura , Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji
IPC分类号： A61K35/12 , C12N5/078 , A61P37/00 , A61P35/00 , A61P7/00 , A61P9/10 , A61P35/02
CPC分类号： C12N5/0647 , A61K35/12 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34+ cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34+ cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells.A method for expanding CD34+ cells, which comprises culturing CD34+ cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L1, L2, L3, L4, R1, R2, R3, X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

5. 发明授权

US07618562B2 Thermoelectric material 有权
标题翻译：热电材料
公开(公告)号：US07618562B2
公开(公告)日：2009-11-17
申请号：US12331686
申请日：2008-12-10
申请人： Masahiro Sasaki , Takanori Nakamura
发明人： Masahiro Sasaki , Takanori Nakamura
IPC分类号： H01B1/08 , H01L35/22 , C04B35/00
CPC分类号： H01L35/22 , C04B35/016 , C04B2235/3279 , C04B2235/3281 , C04B2235/9607
摘要： A p-type oxide thermoelectric material which has a high output factor and a low environmental load. The thermoelectric material is composed of an oxide represented by the compositional formula (Ni1-xCux) (Mn2-yCuy)O4 and having a structure in which Ni elements occupying the Ni sites and/or Mn elements occupying the Mn sites are partially replaced by Cu elements, wherein 0≦x≦0.7, 0≦y≦0.7, and 0.4≦x+y. In such a thermoelectric material, preferably, 0.2≦x≦0.5 and 0.2≦y≦0.5, and preferably, the output factor at 50° C. to 800° C. is 10×10−6 W/mK2 or more.
摘要翻译：具有高输出因数和低环境负荷的p型氧化物热电材料。热电材料由组成式（Ni1-xCux）（Mn2-yCuy）O4表示的氧化物构成，并且具有占据Mn位置的Ni元素和/或Mn元素的Mn元素部分被Cu取代的结构元素，其中0 <= x <= 0.7,0 <= y <= 0.7和0.4 <= x + y。在这种热电材料中，优选为0.2≤x≤0.5且0.2≤y≤0.5，优选50℃〜800℃的输出系数为10×10 -6 W / m·K以上。

6. 发明授权

US06295196B1 Monolithic ceramic electronic component 有权
标题翻译：单片陶瓷电子元件
公开(公告)号：US06295196B1
公开(公告)日：2001-09-25
申请号：US09611101
申请日：2000-07-06
申请人： Yukio Hamaji , Nobuyuki Wada , Tsuyoshi Yamana , Takanori Nakamura
发明人： Yukio Hamaji , Nobuyuki Wada , Tsuyoshi Yamana , Takanori Nakamura
IPC分类号： H01G406
CPC分类号： H01G4/0085 , H01G4/1227 , H01G4/30
摘要： A monolithic ceramic electronic component includes a laminate including a plurality of ceramic layers obtained by sintering a ceramic raw material powder, and a plurality of internal electrodes located between the ceramic layers and obtained by sintering a metallic powder. The ceramic layers have a thickness of about 3 &mgr;m or less and are composed of ceramic grains having an average particle diameter of more than about 0.5 &mgr;m, the particle diameter of the ceramic grains in the thickness direction of the ceramic layers is smaller than the thickness of the ceramic layers, and the internal electrodes have a thickness of about 0.2 to 0.7 &mgr;m. Preferably, the monolithic ceramic electronic component further includes an external electrode formed on each of the opposing ends of the laminate, the ceramic layers are composed of a ceramic dielectric material, and each of the plurality of internal electrodes is formed with an edge being exposed to either one of the opposing ends of the laminate so as to be electrically connected to either one of the external electrodes to form a monolithic ceramic capacitor.
摘要翻译：单片陶瓷电子部件包括通过烧结陶瓷原料粉末而获得的多个陶瓷层和位于陶瓷层之间并通过烧结金属粉末获得的多个内部电极的层叠体。陶瓷层的厚度为3μm以下，由平均粒径大于0.5μm的陶瓷颗粒构成，陶瓷层的厚度方向的陶瓷粒子的粒径小于陶瓷层的厚度的陶瓷层，内部电极的厚度为0.2〜0.7μm左右。优选地，所述整体式陶瓷电子部件还包括形成在所述层叠体的各相对端的外部电极，所述陶瓷层由陶瓷电介质材料构成，所述多个内部电极中的每一个形成有暴露于层压体的相对端中的任一个，以便电连接到任一个外部电极以形成单片陶瓷电容器。

7. 发明授权

US5416194A Polypeptide having affinity for lipopolysaccharide and method for preparing the same 失效
标题翻译：对脂多糖具有亲和力的多肽及其制备方法
公开(公告)号：US5416194A
公开(公告)日：1995-05-16
申请号：US926965
申请日：1992-08-07
申请人： Takanori Nakamura , Sadaaki Iwanaga
发明人： Takanori Nakamura , Sadaaki Iwanaga
IPC分类号： A61K38/00 , A61P1/04 , A61P1/12 , A61P1/16 , A61P17/00 , A61P29/00 , A61P31/04 , A61P37/00 , A61P43/00 , C07K20060101 , C07K1/02 , C07K1/04 , C07K1/06 , C07K1/113 , C07K1/14 , C07K7/08 , C07K7/64 , C07K14/435 , C07K14/81 , A61K31/715 , C07K5/12
CPC分类号： C07K7/08 , A61K38/00
摘要： This invention relates to a novel polypeptide represented by the formula: ##STR1## wherein Lys represents lysine, Trp tryptophan, Cys cystine, Phe phenylalanine, Arg arginine, Val valine, Tyr tyrosine, Gly glycine, Ile isoleucine and X a hydroxyl group or an amino group), its analogue and a method for preparing the same.The polypeptide exhibits strong affinity for lipopolysaccharide, and is useful for removing endotoxin and as a therapeutic agent of bacterial infections, and a method for preparing the same.
摘要翻译：本发明涉及由下式表示的新型多肽：其中Lys表示赖氨酸，Trp色氨酸，Cys胱氨酸，Phe苯丙氨酸，Arg精氨酸，Val缬氨酸，Tyr酪氨酸，Gly甘氨酸，异亮氨酸和X a羟基基团或氨基），其类似物及其制备方法。该多肽对脂多糖表现出很强的亲和性，并且可用于除去内毒素和作为细菌感染的治疗剂及其制备方法。

8. 发明授权

US4280982A Apparatus for treating waste material while preventing smelt-water explosions 失效
标题翻译：用于处理废料同时防止熔融水爆炸的装置
公开(公告)号：US4280982A
公开(公告)日：1981-07-28
申请号：US21538
申请日：1979-03-19
申请人： Mamoru Shindome , Takanori Yanagita , Takanori Nakamura , Hiroyuki Otsuji
发明人： Mamoru Shindome , Takanori Yanagita , Takanori Nakamura , Hiroyuki Otsuji
IPC分类号： F23G7/00 , B01J19/26 , D21C11/12
CPC分类号： F23G7/008
摘要： An apparatus for treating a water solution of a waste material containing a salt with smelt-water explosion characteristics comprises an open-bottomed incinerator and a gas-liquid separator disposed beneath the incinerator in fluid-flow communication therewith. The waste solution is sprayed into the incinerator and heated therein so that the salt in the solution is fused, water vaporized and organic components of the solution burned. The combustion gases and water vapor flow downwardly into the separator, while the fused salt forms a deposit on the inner surface of the incinerator and flows downwardly into the separator. At the junction between the incinerator and separator, cooling water is fed to the fused salt so that the deposit of salt is solidified and cracked into separate masses which fall together with the cooling water onto an inclined baffle member disposed in the separator and roll downwardly on the baffle member. A flow of water is formed on the baffle member to such a depth that the salt masses are only partially dipped in the water and are substantially cooled during its travel on the baffle member. The gaseous mixture flowing from the incinerator into the separator flows therethrough substantially horizontally to a gas outlet formed in the separator above a liquid outlet formed in the bottom of the separator.
摘要翻译：一种用于处理含有熔融水爆炸特性的废物的废水的水溶液的设备包括一个开放式焚化炉和一个设置在焚化炉下面的与其流体相通的气液分离器。将废液喷入焚化炉中并加热，使溶液中的盐熔化，水汽化，溶液的有机成分燃烧。燃烧气体和水蒸汽向下流入分离器，而熔融盐在焚化炉的内表面上形成沉积物并向下流入分离器。在焚化炉和分离器之间的接合处，将冷却水送入熔融盐，使得盐的沉积物固化并裂开成与冷却水一起落到设置在分离器中的倾斜挡板构件上的单独的质量，并向下滚动挡板构件。在挡板构件上形成水流，使得盐块仅部分地浸入水中，并且在挡板构件行进期间基本上被冷却。从焚化炉流入分离器的气态混合物基本上水平地流过形成在分离器底部形成的液体出口上方的隔板中形成的气体出口。

9. 发明授权

US09181957B2 Hydraulic machine 有权
标题翻译：液压机
公开(公告)号：US09181957B2
公开(公告)日：2015-11-10
申请号：US12573739
申请日：2009-10-05
申请人： Yasuyuki Enomoto , Kazuyuki Nakamura , Takanori Nakamura , Akira Shinohara , Kotaro Tezuka
发明人： Yasuyuki Enomoto , Kazuyuki Nakamura , Takanori Nakamura , Akira Shinohara , Kotaro Tezuka
IPC分类号： F03B3/02 , F03B3/12 , F04D29/18 , F03B11/04
CPC分类号： F04D29/181 , F03B3/02 , F03B3/121 , F03B11/04 , Y02E10/223 , Y02E10/226
摘要： A hydraulic machine having a hydro turbine runner which has a crown at a center and a band along an outer periphery, and is formed around the axis of rotation, long blades which are arranged along the circumferential direction of the axis of rotation, and whose center-side ends are supported by the crown, and periphery-side ends are supported by the band, and short blades which are arranged between the long blades, and whose center-side ends are supported by the crown, periphery-side ends are supported by the band, and rear edges are curved in a rotation direction of the hydro turbine runner in turbine operation, on a plane of projection perpendicular to the axis of rotation.
摘要翻译：一种具有水轮机转轮的液压机，所述水轮机转轮具有中心的中心和沿着外周的带，并且围绕所述旋转轴线形成，所述长叶片沿着所述旋转轴线的圆周方向布置，并且其中心端部由冠支撑，并且周边端部被带支撑，并且布置在长叶片之间并且其中心侧端部被冠部的周边侧端部支撑的短叶片由带轮和后缘在涡轮机操作中的水轮机转轮的旋转方向上在垂直于旋转轴线的突起平面上弯曲。

10. 发明授权

US09115341B2 Method for expanding hematopoietic stem cells using heterocyclic compound 有权
标题翻译：使用杂环化合物扩增造血干细胞的方法
公开(公告)号：US09115341B2
公开(公告)日：2015-08-25
申请号：US12746507
申请日：2008-12-05
申请人： Takanori Nakamura , Atsushi Miyamura , Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji
发明人： Takanori Nakamura , Atsushi Miyamura , Taito Nishino , Norihisa Ishiwata , Katsuaki Miyaji
IPC分类号： C12N5/00 , C12N5/0789 , C07D333/02 , C07D207/00 , A61K35/12
CPC分类号： C12N5/0647 , A61K35/12 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34+ cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34+ cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells.A method for expanding CD34+ cells, which comprises culturing CD34+ cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L1, L2, L3, L4, R1, R2, R3, X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译：本发明的目的是使用生物安全且廉价的低分子量化合物在短期内有效地扩增CD34 +细胞。本发明的另一个目的是提供用于治疗由功能异常的造血干细胞和/或造血祖细胞引起的各种造血障碍的CD34 +细胞的扩张剂。一种用于扩增CD34 +细胞的方法，其包括在式（I）表示的化合物（其中A，B，L1，L2，L3，L4，R1，R2，R3，X和Y）存在下离体培养CD34 +细胞在描述中定义），化合物的互变异构体或药学上可接受的盐或其溶剂合物。

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