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1. 发明授权

US4873373A Process for preparation of 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl ethers 失效
标题翻译： 2-（4-烷氧基苯基）-2-甲基丙基醚3-苯氧基苄酯的制备方法
公开(公告)号：US4873373A
公开(公告)日：1989-10-10
申请号：US890143
申请日：1986-07-16
申请人： Mitsumasa Umemoto , Tamotsu Asano , Hironobu Horie , Akinobu Takagi , Nobuyasu Tamura , Takeshi Nishida
发明人： Mitsumasa Umemoto , Tamotsu Asano , Hironobu Horie , Akinobu Takagi , Nobuyasu Tamura , Takeshi Nishida
IPC分类号： B01J23/00 , B01J23/44 , C07B61/00 , C07C41/00 , C07C41/24 , C07C43/263 , C07C43/267 , C07C43/29 , C07C67/00
CPC分类号： C07C41/24
摘要： Disclosed is a process for preparing 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl ethers represented by the following formula (I): ##STR1## wherein R stands for a lower alkyl group, and X.sub.1 and X.sub.2 stand for a hydrogen atom or fluorine atom,which comprises subjecting a 3-phenoxybenzyl 2-(4-alkoxy-3-halogenophenyl)-2-methylpropyl ether or 3-phenoxybenzyl-2-(4-alkoxy-3,5-dihalogenophenyl)-2-methylpropyl ether represented by the following formula (II): ##STR2## wherein R stands for a lower alkyl group, X.sub.1 and X.sub.2 stand for a hydrogen atom or fluorine atom, and Y.sub.1 and Y.sub.2 stand for a hydrogen atom, chlorine atom, bromine atom or iodine atom, with the proviso that at least one of Y.sub.1 and Y.sub.2 is a chlorine atom, bromine atom or iodine atom,to dechlorination, debromination or deiodination by hydrogenation, wherein the dechlorination, debromination or deiodination is carried out in the presence of a hydrogenation catalyst by using as a hydrogenative reducing agent a lower aliphatic alcohol and an alkali compound selected from the group comprising alkali metal hydroxides and alkaline earth metal hydroxides.According to this process, compounds of the formula (I) can be obtained in high yields with safety without using hydrogen.
摘要翻译： PCT No.PCT / JP86 / 00198 Sec。 371日期：1986年7月16日 102（e）日期1986年7月16日PCT提交1986年4月18日PCT公布。公开号WO86 / 06367 日期：1986年11月6日。公开是制备由下式（I）表示的2-（4-烷氧基苯基）-2-甲基丙基醚的3-苯氧基苄基的方法：其中R代表低级烷基基团，X 1和X 2表示氢原子或氟原子，其包括使2-（4-烷氧基-3-卤代苯基）-2-甲基丙基醚或3-苯氧基苄基-2-（4-烷氧基-3-卤代苯基）由下式（II）表示的3,5-二卤代苯基）-2-甲基丙基：其中R表示低级烷基，X 1和X 2表示氢原子或氟原子，Y 1和 Y2代表氢原子，氯原子，溴原子或碘原子，条件是Y1和Y2中的至少一个是氯原子，溴原子或碘原子，通过氢化脱氯，脱溴或脱碘，其中脱氯通过使用氢还原剂，在氢化催化剂的存在下进行脱溴或脱碘脂族醇和选自碱金属氢氧化物和碱土金属氢氧化物的碱的化合物。根据该方法，可以在不使用氢气的情况下安全地以高产率获得式（I）化合物。

2. 发明授权

US08764682B2 Measurement device and puncture device 有权
标题翻译：测量装置和穿刺装置
公开(公告)号：US08764682B2
公开(公告)日：2014-07-01
申请号：US13147255
申请日：2010-02-03
申请人： Kiyohiro Horikawa , Takeshi Nishida , Yoshinori Amano , Tetsuya Takashima , Keisuke Matsumura , Masahiro Kitagawa
发明人： Kiyohiro Horikawa , Takeshi Nishida , Yoshinori Amano , Tetsuya Takashima , Keisuke Matsumura , Masahiro Kitagawa
IPC分类号： A61B5/00
CPC分类号： A61B5/15186 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/15113 , A61B5/15134 , A61B5/15136 , A61B5/157
摘要： Disclosed are a measurement device and a puncture device that prevent thermal loss and enable decreased cost in laser units. A laser unit (200) of a measurement device (100) is equipped with a lens barrel (210), a laser rod (220) disposed inside the lens barrel (210), a flash lamp (230) which is disposed opposite the laser rod (220) inside the lens barrel (210) and in which an inert gas is sealed inside a hard glass tube (231), and supports (241, 242, 243, 244), which are made from a material with thermal conductivity of 100 W/(mK) or more, at least parts of which are disposed outside of the lens barrel (210), and which support the circumferential surface of the hard glass tube (231) in a housing.
摘要翻译：公开了一种能够防止热损失并且能够降低激光单元成本的测量装置和穿刺装置。测量装置（100）的激光单元（200）配备有透镜镜筒（210），设置在镜筒（210）内部的激光棒（220），与激光器相对设置的闪光灯（230）在玻璃管（210）内的惰性气体被密封在玻璃管（231）内部的支撑件（220），以及由导热性好的材料制成的支撑件（241,242,243,244） 100W /（mK）以上，其至少一部分设置在镜筒210的外侧，并将硬玻璃管231的周面支撑在壳体内。

3. 发明授权

US08556828B2 Blood test device 有权
标题翻译：血液检测装置
公开(公告)号：US08556828B2
公开(公告)日：2013-10-15
申请号：US12278825
申请日：2007-02-09
申请人： Yoshinori Amano , Masaki Fujiwara , Takeshi Nishida
发明人： Yoshinori Amano , Masaki Fujiwara , Takeshi Nishida
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/15019 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150916 , A61B5/150954 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/1513 , A61B5/1519 , A61B5/15194
摘要： A blood test device by which the amount of plumped skin at a puncture site for conducting a blood test or collecting blood can be controlled so that a blood component can be accurately measured. The blood test device includes: a housing; an inner tube provided in one side of the housing; a reciprocating unit which reciprocates within the inner tube; a blood collection needle connected to the reciprocating unit; a blood sensor facing to the blood collection needle and being located at the tip of the inner tube; a measurement circuit to which a signal is fed from the blood sensor; and a negative pressure unit driven by the measurement circuit. An outer tube, that is a tube covering the inner tube, has an opening in the tip side of the inner tube, is capable of moving relative to the inner tube, and is provided so as to return to a definite relative position. The negative pressure provider can apply a negative pressure to the inside of the outer tube.
摘要翻译：可以控制用于进行血液检查或血液收集的穿刺部位的皮肤的皮肤的量的血液检查装置，从而能够精确地测量血液成分。血液检查装置包括：壳体; 设置在所述壳体的一侧中的内管; 在内管内往复运动的往复运动单元; 与往复运动单元连接的采血针; 位于采血针的血液传感器，位于内管的前端; 从血液传感器馈送信号的测量电路; 以及由测量电路驱动的负压单元。外管是覆盖内管的管，在内管的前端具有开口，能够相对于内管移动，并且设置成返回到确定的相对位置。负压供应器可以向外管的内部施加负压。

4. 发明授权

US08414504B2 Blood test device 失效
标题翻译：血液检测装置
公开(公告)号：US08414504B2
公开(公告)日：2013-04-09
申请号：US12293513
申请日：2007-03-22
申请人： Masaki Fujiwara , Yoshinori Amano , Takeshi Nishida , Toshihiro Akiyama , Masataka Nadaoka , Toshiki Matsumoto , Kenichi Hamanaka , Kiyohiro Horikawa , Koji Miyoshi
发明人： Masaki Fujiwara , Yoshinori Amano , Takeshi Nishida , Toshihiro Akiyama , Masataka Nadaoka , Toshiki Matsumoto , Kenichi Hamanaka , Kiyohiro Horikawa , Koji Miyoshi
IPC分类号： A61B5/00 , A61B18/18 , B65D81/00
CPC分类号： A61B5/157 , A61B5/1486 , A61B5/150022 , A61B5/150076 , A61B5/150099 , A61B5/150145 , A61B5/150213 , A61B5/150259 , A61B5/150358 , A61B5/150954 , A61B5/15138
摘要： A blood test device using a laser as a puncture member. More specifically, in a blood test device using a laser as a puncture member, the skin can be fixed at a definite position by raising the punctured skin under negative pressure, and thus the skin is brought into close contact with a blood sensor and the laser is focused on the vicinity of the blood sensor face. Thus, it is possible to provide a blood test device of the laser puncture type in which the skin can be surely punctured while giving little pain to a patient.
摘要翻译：使用激光作为穿刺部件的血液检查装置。更具体地，在使用激光作为穿刺构件的血液检查装置中，通过在负压下升高穿刺皮肤，可以将皮肤固定在确定的位置，从而使皮肤与血液传感器和激光器紧密接触聚焦在血液传感器面附近。因此，可以提供一种激光穿刺型的血液检查装置，其中可以可靠地刺穿皮肤，同时对患者几乎没有疼痛。

5. 发明申请

US20100168615A1 BLOOD TEST DEVICE 有权
标题翻译：血液测试装置
公开(公告)号：US20100168615A1
公开(公告)日：2010-07-01
申请号：US12278825
申请日：2007-02-09
申请人： Yoshinori Amano , Masaki Fujiwara , Takeshi Nishida
发明人： Yoshinori Amano , Masaki Fujiwara , Takeshi Nishida
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/15019 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150916 , A61B5/150954 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/1513 , A61B5/1519 , A61B5/15194
摘要： A blood test device by which the amount of plumped skin at a puncture site for conducting a blood test or collecting the blood can be controlled at a constant amount so that a blood component can be accurately measured. Namely, a blood test device comprising: a housing; an inner tube provided in one side of the housing; a reciprocating unit which reciprocates within the inner tube; a blood collection needle connected to the reciprocating unit; a blood sensor facing to the blood collection needle and being located at the tip of the inner tube; a measurement circuit to which a signal is fed from the blood sensor; and a negative pressure unit driven by the measurement circuit; which further has an outer tube that is a tube covering the inner tube, having an opening in the tip side of the inner tube, being capable of relatively moving to the inner tube, and being provided so as to return to a definite relative position. The negative pressure unit as described above can apply a negative pressure to the inside of the outer tube.
摘要翻译：用于血液检查装置，通过该测试装置可以将用于进行血液检查或血液收集的穿刺部位的皮肤的皮肤量控制在一定的量，从而可以精确地测量血液成分。即，一种血液检查装置，包括：壳体; 设置在所述壳体的一侧中的内管; 在内管内往复运动的往复运动单元; 与往复运动单元连接的采血针; 位于采血针的血液传感器，位于内管的前端; 从血液传感器馈送信号的测量电路; 以及由测量电路驱动的负压单元; 其还具有外管，该外管是覆盖内管的，具有在内管的前端侧的开口，能够相对移动到内管，并且设置成返回到确定的相对位置。如上所述的负压单元可以向外管的内部施加负压。

6. 发明申请

US20070148759A1 Biological sample discrimination device, biological sample discriminating method, and biological sample discriminating plate 审中-公开
标题翻译：生物样本识别装置，生物样本识别方法和生物样本鉴别板
公开(公告)号：US20070148759A1
公开(公告)日：2007-06-28
申请号：US10584300
申请日：2004-12-27
申请人： Yoshinori Amano , Hideaki Hashimoto , Takeshi Nishida , Kazuyoshi Mori , Ryuuji Shimizu , Hiroshi Andou , Kenji Nakanishi , Naoki Yanagihara , Miho Hayashi
发明人： Yoshinori Amano , Hideaki Hashimoto , Takeshi Nishida , Kazuyoshi Mori , Ryuuji Shimizu , Hiroshi Andou , Kenji Nakanishi , Naoki Yanagihara , Miho Hayashi
IPC分类号： C12M3/00
CPC分类号： B01L3/502715 , B01L3/5025 , B01L2200/027 , B01L2300/0803 , B01L2300/0864 , B01L2300/1844 , B01L2400/0409 , G01N27/447
摘要： There is provided a plate (10) on which a channel pattern (110) is formed, which channel pattern includes a first channel (116) into which a buffer agent is injected, and a second channel (117) having, in a portion thereof, a quantification part (117a) that has a portion common to the first channel and holds a predetermined amount of a biological sample, the biological sample being injected into the channel including the quantification part, and the plate (10) is rotated at a high speed by a filling unit (20) to fill the buffer agent in the first channel, and thereafter, the second channel is pressurized by a discrimination unit (30) to fill the biological sample in the second channel, and simultaneously, a predetermined amount of the biological sample is added into the buffer agent. Therefore, when performing discrimination of the biological sample, a discrimination result can be obtained accurately in a short time without the necessity of complicated preparation works.
摘要翻译：提供了一个板（10），其上形成有通道图案（110），该通道图案包括其中注入有缓冲剂的第一通道（116）和第二通道（117），第二通道，具有与第一通道相同的部分并保持预定量的生物样品的定量部分（117a），将生物样品注入包括量化部分的通道中，并且板（10）以通过填充单元（20）高速填充第一通道中的缓冲剂，此后，第二通道被鉴别单元（30）加压以填充第二通道中的生物样品，同时施加预定量的生物样品加入到缓冲剂中。因此，当进行生物样品的鉴别时，可以在短时间内准确地获得鉴别结果，而不需要复杂的准备工作。

7. 发明申请

US20060226029A1 Measuring apparatus for ulcerative colitis diagnosis/prognostic test and method of measuring 审中-公开
标题翻译：溃疡性结肠炎诊断/预后测定用测定装置及测定方法
公开(公告)号：US20060226029A1
公开(公告)日：2006-10-12
申请号：US10566155
申请日：2004-07-30
申请人： Takeshi Nishida , Hideaki Hashimoto , Fumiyo Kusu , Hideki Hakamata , Akira Kotani , Kouji Takahashi
发明人： Takeshi Nishida , Hideaki Hashimoto , Fumiyo Kusu , Hideki Hakamata , Akira Kotani , Kouji Takahashi
IPC分类号： G01N27/26
CPC分类号： G01N30/84 , G01N2030/645 , G01N2030/8429 , G01N2800/065
摘要： A measurement apparatus for ulcerative colitis diagnosis and prognostic test according to the present invention comprises a solution mixing unit (15) for mixing an eluent and a quinone solution, the eluent being supplied from a system including a tank (9) in which the eluent used for acid separation is stored, a pump (12) for sending the eluent, a sample injection unit (13) for injecting a sample into the eluent, and an acid separation column (14) for separating short-chain fatty acids included in the sample that is injected from the sample injection unit (13), and the quinone solution being supplied from a system including a tank (8) in which the quinone solution containing quinone and supporting electrolyte is stored, and a pump (11) for sending the quinone solution; and an acid degree measurement unit (16) for measuring the acid degrees of the short-chain fatty acids separated from the sample. In the measurement apparatus for ulcerative colitis diagnosis and prognostic test which is constructed as described above, it is possible to perform ulcerative colitis diagnosis speedily, easily, and accurately, without performing blood test.
摘要翻译：根据本发明的用于溃疡性结肠炎诊断和预后测试的测量装置包括用于混合洗脱液和醌溶液的溶液混合单元（15），洗脱液由包括其中使用洗脱液的罐（9）的系统供应，储存酸分离液，用于送出洗脱液的泵（12），用于将样品注入洗脱液的样品注入单元（13）和用于分离样品中所含的短链脂肪酸的酸分离塔（14）从所述样品注入单元（13）注入的醌溶液和从包含其中存储有醌和支持电解质的醌溶液的罐（8）的系统供给的醌溶液和用于发送醌的泵（11）解; 以及用于测量从样品分离出的短链脂肪酸的酸度的酸度测定单元（16）。在如上构造的溃疡性结肠炎诊断和预后测定用测定装置中，能够不进行血液试验而快速，容易，准确地进行溃疡性结肠炎诊断。

8. 发明申请

US20050156469A1 Switching device 审中-公开
标题翻译：开关装置
公开(公告)号：US20050156469A1
公开(公告)日：2005-07-21
申请号：US11014681
申请日：2004-12-16
申请人： Takeshi Nishida , Yasuyuki Masui , Takeshi Miyasaka
发明人： Takeshi Nishida , Yasuyuki Masui , Takeshi Miyasaka
IPC分类号： H01H9/44 , H01H50/00 , H01H50/54 , H02K11/00
CPC分类号： H01H9/443 , H01H2050/025
摘要： It is to provide a switching device that can be downsized and improved in reliability of the switching characteristic by making it difficult to damage and deteriorate a permanent magnet that is a component and by improving the shutoff performance. It is a switching device which makes a movable contact into/out of contact with a fixed contact, with a permanent magnet arranged in the vicinity of the fixed contact in a fixed contact terminal provided with the fixed contact on its free end. A narrow portion is formed between the fixed contact and the permanent magnet, hence to form an angle.
摘要翻译：提供一种开关装置，其可以通过使得难以破坏和劣化作为部件的永磁体并且通过提高截止性能而使开关特性的可靠性小型化和提高。这是一种开关装置，其使可动触头与固定触点接触/脱离接触，永久磁铁在固定触点的附近设置在固定触点端子上，该固定触点端子在其自由端上设有固定触头。在固定触点和永磁体之间形成狭窄部分，从而形成一个角度。

9. 发明授权

US6146514A Apparatus and method for measuring acidity 失效
标题翻译：测量酸度的仪器和方法
公开(公告)号：US6146514A
公开(公告)日：2000-11-14
申请号：US20139
申请日：1998-02-06
申请人： Kiyoko Takamura , Fumiyo Kusu , Takeshi Nishida , Hideaki Hashimoto , Hidefumi Yabu , Kazuyoshi Mori , Yuji Hiraishi , Yasuyuki Hanada , Tetsuji Soeda , Tsuyoshi Kusakabe , Tetsuya Nishio
发明人： Kiyoko Takamura , Fumiyo Kusu , Takeshi Nishida , Hideaki Hashimoto , Hidefumi Yabu , Kazuyoshi Mori , Yuji Hiraishi , Yasuyuki Hanada , Tetsuji Soeda , Tsuyoshi Kusakabe , Tetsuya Nishio
IPC分类号： G01N33/03 , G01N27/48 , G01N27/49 , G01N33/14 , G01F1/64 , G01N27/26
CPC分类号： G01N27/3277
摘要： An acidity measuring apparatus includes a measuring container for accommodating an electrolyte solution including one of a 1,2-benzoquinone derivative and a 1,4-benzoquinone derivative, an organic solvent, an electrolyte and an acid-containing subject for measurement; a working electrode, a counter electrode and a reference electrode section provided in the measuring container and immersed in the electrolyte solution; and a control section for sweeping a potential of the working electrode within a prescribed range and for detecting a value of a pre-peak current generated by the acid and flowing between the working electrode and the counter electrode.
摘要翻译：酸度测量装置包括用于容纳包含1,2-苯醌衍生物和1,4-苯醌衍生物之一的电解质溶液的测量容器，有机溶剂，电解质和含酸的受试者; 设置在测量容器中并浸入电解液中的工作电极，对电极和参比电极部分; 以及用于将工作电极的电位扫描在规定范围内并用于检测由酸产生的预峰值电流的值并在工作电极和对电极之间流动的控制部分。

10. 发明授权

US08439848B2 Blood testing device 失效
标题翻译：血液检测装置
公开(公告)号：US08439848B2
公开(公告)日：2013-05-14
申请号：US12676029
申请日：2008-09-04
申请人： Takeshi Nishida , Tetsuya Takashima
发明人： Takeshi Nishida , Tetsuya Takashima
IPC分类号： A61B5/00 , B65D81/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150793 , A61B5/150824 , A61B5/150954 , A61B5/151 , A61B5/15113 , A61B5/15134 , A61B5/15138
摘要： A blood testing device that can perform blood testing having lighting intensity independent of the number of times of piercing. The blood testing device (21) has a cover unit (20) removably installed on negative pressure chambers (25a, 25b). The cover unit (20) has a circular tube section (20b) surrounding the optical axis of a laser unit (26) and having a predetermined length in the direction of the optical axis, a cover glass (20d) placed on the optical axis of the laser unit (26) so as to be located at that end of the circular tube section (20b) which is on the laser unit (26) side, and a slit (20e) for interconnecting the inside of the circular tube section (20b) and the negative pressure chamber (25a) outside the circular tube section (20b).
摘要翻译：一种血液检查装置，其能够执行具有独立于穿刺次数的照明强度的血液测试。血液检查装置（21）具有可拆卸地安装在负压室（25a，25b）上的盖单元（20）。盖单元（20）具有围绕激光单元（26）的光轴并在光轴方向上具有预定长度的圆形管部（20b），盖玻璃（20d）所述激光单元（26）位于所述激光单元（26）侧的所述圆形管部（20b）的所述端部，以及用于将所述圆形管部（20b）的内部互连的狭缝（20e））和负压室（25a）之间。

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