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1. 发明授权

US6132377A Medical diagnostic ultrasonic imaging system and method using differential sub-band detection techniques 有权
标题翻译：医学诊断超声成像系统和使用差分子带检测技术的方法
公开(公告)号：US6132377A
公开(公告)日：2000-10-17
申请号：US282402
申请日：1999-03-31
申请人： Mirsaid S. Bolorforosh , Edward A. Gardner , Gregory L. Holley , Ting Lan Ji , Sriram Krishnan , Bhaskar S. Ramamurthy
发明人： Mirsaid S. Bolorforosh , Edward A. Gardner , Gregory L. Holley , Ting Lan Ji , Sriram Krishnan , Bhaskar S. Ramamurthy
IPC分类号： A61B8/00 , G01S7/52
CPC分类号： A61B8/481 , G01S15/8988 , G01S7/52038 , G01N2291/02491
摘要： A medical diagnostic ultrasound imaging system and method modulate the image signal as a function of the ratio of the harmonic receive signal to the fundamental receive signal. Tissue harmonic backscatter differs substantially in spectral shape as compared to contrast agent backscatter, and this method allows improved discrimination between contrast agent and tissue backscatter.
摘要翻译：医学诊断超声成像系统和方法根据谐波接收信号与基本接收信号的比率调制图像信号。与造影剂反向散射相比，组织谐波反向散射在光谱形状上显着不同，并且该方法允许改善对比剂和组织反向散射之间的区别。

2. 发明授权

US06340348B1 Contrast agent imaging with destruction pulses in diagnostic medical ultrasound 有权
标题翻译：在诊断医学超声中具有破坏脉冲的造影剂成像
公开(公告)号：US06340348B1
公开(公告)日：2002-01-22
申请号：US09348246
申请日：1999-07-02
申请人： Sriram Krishnan , Gregory L. Holley , Edward A. Gardner , Samuel H. Maslak
发明人： Sriram Krishnan , Gregory L. Holley , Edward A. Gardner , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B8/543 , A61B17/22004 , A61B2017/22008
摘要： The invention is directed to improvements in diagnostic medical ultrasound contrast agent imaging. In a preferred embodiment, high pulse repetition frequency (HPRF) destruction pulses are fired at a rate higher than necessary for receiving returning echoes. Pulse parameters can also be changed between the plurality of contrast agent-destroying pulses. Other preferred embodiments of the invention are directed to simultaneous transmission of multiple beams of destruction pulses. Destruction frames that consist of a plurality of destruction pulses can be triggered and swept over the entire region of tissue being imaged and at a variety of focal depths from the transmitter. The destruction frames are fired at some time triggered from a timer or some fixed part of a physiological signal, such as an ECG signal. Other preferred embodiments of the invention are directed to continuous low power imaging pulses alternating with destruction pulses triggered at a fixed point of a physiological signal, and a comparison of the received signals from imaging pulses fired before and after the destruction pulses. Alternatively, destruction pulses are triggered at a fixed point on a physiological signal different from the fixed point of a physiological signal used to trigger imaging pulses. In another embodiment, triggered destruction frames are used to enable a comparison of imaging frames in order to determine physiological functions, such as perfusion of blood in cardiac tissue. Finally, in another embodiment, destruction pulses are combined with subharmonic imaging.
摘要翻译：本发明涉及诊断医学超声造影剂成像的改进。在优选实施例中，高脉冲重复频率（HPRF）破坏脉冲以高于接收返回回波所需的速率被发射。也可以在多个造影剂破坏脉冲之间改变脉冲参数。本发明的其它优选实施例涉及同时传输多束破坏脉冲。由多个破坏脉冲组成的破坏帧可以被触发并扫过被成像的组织的整个区域并且在来自发射器的各种焦深处扫过。在由定时器或生理信号的某些固定部分（例如ECG信号）触发的某个时间触发破坏帧。本发明的其它优选实施例涉及与生理信号的固定点触发的破坏脉冲交替的连续低功率成像脉冲，以及在破坏脉冲之前和之后激发的成像脉冲的接收信号的比较。或者，在与用于触发成像脉冲的生理信号的固定点不同的生理信号上的固定点触发销毁脉冲。在另一个实施例中，触发的破坏帧用于使成像帧的比较能够确定生理功能，例如心脏组织中血液的灌注。最后，在另一个实施例中，销毁脉冲与次谐波成像组合。

3. 发明授权

US06213951B1 Medical diagnostic ultrasound method and system for contrast specific frequency imaging 有权
标题翻译：医学诊断超声方法和系统对比特定频率成像
公开(公告)号：US06213951B1
公开(公告)日：2001-04-10
申请号：US09253089
申请日：1999-02-19
申请人： Sriram Krishnan , Edward A. Gardner , Gregory L Holley
发明人： Sriram Krishnan , Edward A. Gardner , Gregory L Holley
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B8/06 , A61B8/13 , A61B8/488 , G01S7/52026 , G01S7/52038 , G01S7/52041
摘要： A medical diagnostic ultrasound imaging method and system insonify a tissue containing a contrast agent with ultrasonic transmit signals at a fundamental frequency f. Backscattered ultrasonic receive signals are acquired and filtered to emphasize frequency components between the fundamental frequency f and the second harmonic frequency 2f, and the filtered receive signals are processed for display. This filtering enhances the ability of the method and system to discriminate between contrast agent and adjacent tissue.
摘要翻译：医学诊断超声成像方法和系统以含有基本频率f的超声波发射信号对含有造影剂的组织进行增强。后向散射超声波接收信号被采集和滤波，以强调基频f和第二谐波频率2f之间的频率分量，并且滤波的接收信号被处理以进行显示。该过滤增强了方法和系统区分造影剂和相邻组织的能力。

4. 发明授权

US06306095B1 Gated ultrasound imaging apparatus and method 有权
公开(公告)号：US06306095B1
公开(公告)日：2001-10-23
申请号：US09378236
申请日：1999-08-19
申请人： Gregory L. Holley , Richard M. Bennett , Edward A. Gardner , Samuel H. Maslak
发明人： Gregory L. Holley , Richard M. Bennett , Edward A. Gardner , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B5/0456 , A61B8/543 , G01S7/52025 , G01S7/52038 , G01S7/52074 , G01S7/52085 , G01S7/52087 , G01S15/895
摘要： An ultrasound imaging system is programmed to acquire first ultrasonic image frames intermittently. These first frames, typically triggered frames synchronized with a selected portion of an ECG cycle, are optimized for high image quality of a contrast agent included in the tissue. The imaging system automatically acquires second ultrasonic image frames between at least some of the first frames. The second image frames are typically locator frames which are optimized for reduced degradation of the contrast agent. More of the second frames are acquired per unit time than first frames, and both the first and second frames are displayed, either superimposed over one another or in side-by-side relationship. In this way the user is provided with substantially continuous transducer locating information, yet contrast agent destruction between acquisitions of the first, triggered frames is reduced or eliminated.

5. 发明授权

US5957845A Gated ultrasound imaging apparatus and method 有权
公开(公告)号：US5957845A
公开(公告)日：1999-09-28
申请号：US159527
申请日：1998-09-23
申请人： Gregory L. Holley , Richard M. Bennett , Edward A. Gardner , Samuel H. Maslak
发明人： Gregory L. Holley , Richard M. Bennett , Edward A. Gardner , Samuel H. Maslak
IPC分类号： A61B5/0456 , A61B8/00 , G01S7/52 , G01S15/89
CPC分类号： A61B8/481 , A61B8/543 , G01S7/52025 , G01S7/52038 , G01S7/52085 , G01S7/52087 , A61B5/0456 , G01S15/895 , G01S7/52074
摘要： An ultrasound imaging system is programmed to acquire first ultrasonic image frames intermittently. These first frames, typically triggered frames synchronized with a selected portion of an ECG cycle, are optimized for high image quality of a contrast agent included in the tissue. The imaging system automatically acquires second ultrasonic image frames between at least some of the first frames. The second image frames are typically locator frames which are optimized for reduced degradation of the contrast agent. More of the second frames are acquired per unit time than first frames, and both the first and second frames are displayed, either superimposed over one another or in side-by-side relationship. In this way the user is provided with substantially continuous transducer locating information, yet contrast agent destruction between acquisitions of the first, triggered frames is reduced or eliminated.

6. 发明授权

US06626831B2 Gated ultrasound imaging apparatus and method 有权
标题翻译：门式超声成像设备及方法
公开(公告)号：US06626831B2
公开(公告)日：2003-09-30
申请号：US09767189
申请日：2001-01-22
申请人： Gregory L. Holley , Richard M. Bennett , Edward A. Gardner , Samuel H. Maslak
发明人： Gregory L. Holley , Richard M. Bennett , Edward A. Gardner , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B5/0456 , A61B8/543 , G01S7/52025 , G01S7/52038 , G01S7/52074 , G01S7/52085 , G01S7/52087 , G01S15/895
摘要： An ultrasound imaging system is programmed to acquire first ultrasonic image frames intermittently. These first frames, typically triggered frames synchronized with a selected portion of an ECG cycle, are optimized for high image quality of a contrast agent included in the tissue. The imaging system automatically acquires second ultrasonic image frames between at least some of the first frames. The second image frames are typically locator frames which are optimized for reduced degradation of the contrast agent. More of the second frames are acquired per unit time than first frames, and both the first and second frames are displayed, either superimposed over one another or in side-by-side relationship. In this way the user is provided with substantially continuous transducer locating information, yet contrast agent destruction between acquisitions of the first, triggered frames is reduced or eliminated.
摘要翻译：超声成像系统被编程为间歇地获取第一超声图像帧。这些第一帧，通常是与ECG周期的选定部分同步的触发帧，被优化用于组织中包括的造影剂的高图像质量。成像系统在至少一些第一帧之间自动获取第二超声图像帧。第二图像帧通常是定位器帧，其被优化用于造影剂的降低降低。与第一帧相比，每单位时间获取更多的第二帧，并且显示第一和第二帧，或者彼此叠加或并排关系。以这种方式，向用户提供基本上连续的换能器定位信息，但是减少或消除了第一触发帧的获取之间的造影剂破坏。

7. 发明授权

US06222948B1 Multiple ultrasound image registration system, method and transducer 有权
公开(公告)号：US06222948B1
公开(公告)日：2001-04-24
申请号：US09502607
申请日：2000-02-11
申请人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
发明人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
IPC分类号： G06K900
CPC分类号： A61B8/145 , A61B8/483 , G01S7/52034 , G01S7/52065 , G01S7/52071 , G01S7/52085 , G01S15/66 , G01S15/87 , G01S15/8934 , G01S15/8979 , G01S15/8993 , G06T7/246
摘要： An ultrasonic imaging system includes an ultrasonic transducer having an image data array and a tracking array at each end of the image data array. The tracking arrays are oriented transversely to the image data array. Images from the image data array are used to reconstruct a three-dimensional representation of the target. The relative movement between respective frames of the image data is automatically estimated by a motion estimator, based on frames of data from the tracking arrays. As the transducer is rotated about the azimuthal axis of the image data array, features of the target remain within the image planes of the tracking arrays. Movements of these features in the image planes of the tracking arrays are used to estimate motion as required for the three-dimensional reconstruction. Similar techniques estimate motion within the plane of an image to create an extended field of view.

8. 发明授权

US06201900B1 Multiple ultrasound image registration system, method and transducer 有权
标题翻译：多重超声图像配准系统，方法和传感器
公开(公告)号：US06201900B1
公开(公告)日：2001-03-13
申请号：US09340542
申请日：1999-06-28
申请人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
发明人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
IPC分类号： G06K900
CPC分类号： A61B8/145 , A61B8/483 , G01S7/52034 , G01S7/52065 , G01S7/52071 , G01S7/52085 , G01S15/66 , G01S15/87 , G01S15/8934 , G01S15/8979 , G01S15/8993 , G06T7/246
摘要： An ultrasonic imaging system includes an ultrasonic transducer having an image data array and a tracking array at each end of the image data array. The tracking arrays are oriented transversely to the image data array. Images from the image data array are used to reconstruct a three-dimensional representation of the target. The relative movement between respective frames of the image data is automatically estimated by a motion estimator, based on frames of data from the tracking arrays. As the transducer is rotated about the azimuthal axis of the image data array, features of the target remain within the image planes of the tracking arrays. Movements of these features in the image planes of the tracking arrays are used to estimate motion as required for the three-dimensional reconstruction. Similar techniques estimate motion within the plane of an image to create an extended field of view.
摘要翻译：超声波成像系统包括在图像数据阵列的每一端具有图像数据阵列和跟踪阵列的超声波换能器。跟踪阵列横向于图像数据阵列。来自图像数据阵列的图像用于重建目标的三维表示。基于来自跟踪阵列的数据的帧，运动估计器自动地估计图像数据的各个帧之间的相对移动。当传感器围绕图像数据阵列的方位角旋转时，目标的特征保持在跟踪阵列的图像平面内。使用跟踪阵列的图像平面中的这些特征的运动来估计针对三维重建所需的运动。类似的技术估计图像平面内的运动以产生扩展的视场。

9. 发明授权

US6102865A Multiple ultrasound image registration system, method and transducer 有权
公开(公告)号：US6102865A
公开(公告)日：2000-08-15
申请号：US346090
申请日：1999-07-01
申请人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
发明人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
IPC分类号： A61B8/00 , G01S7/52 , G01S15/66 , G01S15/87 , G01S15/89 , G06T7/20 , A61B8/14
CPC分类号： A61B8/145 , A61B8/483 , G01S15/8934 , G01S15/8979 , G01S15/8993 , G01S7/52085 , G06T7/2033 , G01S15/66 , G01S15/87 , G01S7/52034 , G01S7/52065 , G01S7/52071
摘要： An ultrasonic imaging system includes an ultrasonic transducer having an image data array and a tracking array at each end of the image data array. The tracking arrays are oriented transversely to the image data array. Images from the image data array are used to reconstruct a three-dimensional representation of the target. The relative movement between respective frames of the image data is automatically estimated by a motion estimator, based on frames of data from the tracking arrays. As the transducer is rotated about the azimuthal axis of the image data array, features of the target remain within the image planes of the tracking arrays. Movements of these features in the image planes of the tracking arrays are used to estimate motion as required for the three-dimensional reconstruction. Similar techniques estimate motion within the plane of an image to create an extended field of view.

10. 发明授权

US06360027B1 Multiple ultrasound image registration system, method and transducer 失效
标题翻译：多重超声图像配准系统，方法和传感器
公开(公告)号：US06360027B1
公开(公告)日：2002-03-19
申请号：US09669818
申请日：2000-09-26
申请人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
发明人： John A. Hossack , John W. Sliwa, Jr. , Samuel H. Maslak , Edward A. Gardner , Gregory L. Holley , David J. Napolitano
IPC分类号： G06K900
CPC分类号： A61B8/145 , A61B8/483 , G01S7/52034 , G01S7/52065 , G01S7/52071 , G01S7/52085 , G01S15/66 , G01S15/87 , G01S15/8934 , G01S15/8979 , G01S15/8993 , G06T7/246
摘要： An ultrasonic imaging system includes an ultrasonic transducer having an image data array and a tracking array at each end of the image data array. The tracking arrays are oriented transversely to the image data array. Images from the image data array are used to reconstruct a three-dimensional representation of the target. The relative movement between respective frames of the image data is automatically estimated by a motion estimator, based on frames of data from the tracking arrays. As the transducer is rotated about the azimuthal axis of the image data array, features of the target remain within the image planes of the tracking arrays. Movements of these features in the image planes of the tracking arrays are used to estimate motion as required for the three-dimensional reconstruction. Similar techniques estimate motion within the plane of an image to create an extended field of view.
摘要翻译：超声波成像系统包括在图像数据阵列的每一端具有图像数据阵列和跟踪阵列的超声波换能器。跟踪阵列横向于图像数据阵列。来自图像数据阵列的图像用于重构目标的三维表示。基于来自跟踪阵列的数据的帧，运动估计器自动地估计图像数据的各个帧之间的相对移动。当传感器围绕图像数据阵列的方位角旋转时，目标的特征保持在跟踪阵列的图像平面内。使用跟踪阵列的图像平面中的这些特征的运动来估计针对三维重建所需的运动。类似的技术估计图像平面内的运动以产生扩展的视场。

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