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1. 发明授权

US08343455B2 Flaky titanic acid having polymerizable functional groups, suspension of the same, and coating films made therefrom 有权
公开(公告)号：US08343455B2
公开(公告)日：2013-01-01
申请号：US11990735
申请日：2006-08-10
申请人： Minoru Yamamoto , Takuya Nomoto
发明人： Minoru Yamamoto , Takuya Nomoto
IPC分类号： C01G23/00
CPC分类号： C09C1/0018 , C01G23/003 , C01G23/005 , C01P2004/24 , C09C1/36 , C09C1/3669 , C09D1/00 , C23C26/00 , C23C30/00
摘要： The invention provides flaky titanic acid having polymerizable functional groups, a suspension of the same, titanic acid coating films excellent in tight adhesion, and resin bases with titanic acid coating films, namely, flaky titanic acid obtained by treating a layered titanate with an acid and then making an organic basic compound act on the obtained product to conduct interlaminar swelling or delamination, characterized in that at least part of the organic basic compound is one having a polymerizable functional group such as acryl or methacryl and, preferably, in that the layered titanate is one represented by the general formula: AxMy□zTi2-(y+z)O4 [wherein A and M are different from each other and are each a mono- to tri-valent metal; □ represents a Ti-defective site; x is a positive real number satisfying the relationship: 0

2. 发明申请

US20090061257A1 Flaky titanic acid having polymerizable functional groups, suspension of the same, and coating films made therefrom 有权
标题翻译：具有可聚合官能团的片状钛酸，其悬浮液和由其制成的涂膜
公开(公告)号：US20090061257A1
公开(公告)日：2009-03-05
申请号：US11990735
申请日：2006-08-10
申请人： Minoru Yamamoto , Takuya Nomoto
发明人： Minoru Yamamoto , Takuya Nomoto
IPC分类号： C01G27/02 , C09D1/00 , B32B27/06
CPC分类号： C09C1/0018 , C01G23/003 , C01G23/005 , C01P2004/24 , C09C1/36 , C09C1/3669 , C09D1/00 , C23C26/00 , C23C30/00
摘要： The invention provides flaky titanic acid having polymerizable functional groups, a suspension of the same, titanic acid coating films excellent in tight adhesion, and resin bases with titanic acid coating films, namely, flaky titanic acid obtained by treating a layered titanate with an acid and then making an organic basic compound act on the obtained product to conduct interlaminar swelling or delamination, characterized in that at least part of the organic basic compound is one having a polymerizable functional group such as acryl or methacryl and, preferably, in that the layered titanate is one represented by the general formula: AxMy□zTi2−(y+z)O4 [wherein A and M are different from each other and are each a mono- to tri-valent metal; □ represents a Ti-defective site; x is a positive real number satisfying the relationship: 0
摘要翻译：本发明提供了具有可聚合官能团的片状钛酸，其悬浮液，紧密粘合性优异的钛酸涂膜，以及具有钛酸涂膜的树脂碱，即通过用酸处理层状钛酸得到的片状钛酸，以及然后使有机碱性化合物作用于所得产物以进行层间膨胀或分层，其特征在于至少部分有机碱性化合物是具有可聚合官能团的化合物，例如丙烯酸或甲基丙烯酸，并且优选地，层状钛酸盐是由以下通式表示的物质：AxMy□zTi2-（y + z）O4 [其中A和M彼此不同，各自为一价至三价金属; □表示Ti缺陷部位; x是满足关系的正实数：0

3. 发明申请

US20090035605A1 Composite titanic acid coating film and composite titanic acid-coated resin substrate 审中-公开
标题翻译：复合钛酸涂膜和复合钛酸涂层树脂基板
公开(公告)号：US20090035605A1
公开(公告)日：2009-02-05
申请号：US11990749
申请日：2006-08-10
申请人： Minoru Yamamoto , Takuya Nomoto
发明人： Minoru Yamamoto , Takuya Nomoto
IPC分类号： B32B9/04 , C09D1/00
CPC分类号： C01G23/002 , B05D3/144 , B82Y30/00 , C01G23/003 , C01G23/005 , C01G23/006 , C01P2002/52 , C01P2002/88 , C01P2004/20 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C09C1/36 , C09C1/3684 , C09D1/00
摘要： Disclosed are a composite titanic acid coating film excellent in coating film hardness and adhesion, and a composite titanic acid-coated resin substrate. Specifically disclosed is a composite titanic acid coating film which is obtained as follows: an aqueous medium suspension, which contains a metal alkoxide and a flaky titanic acid obtained by treating a layered titanate with an acid and then having an organic basic compound act thereon for causing interlayer swelling or separation, is applied onto a base, and then the resulting is subjected to a heat treatment for crosslinking and curing the metal alkoxide. Preferably, the layered titanate is represented by the following formula: AxMy□zTi2−(y+z)O4 [wherein A and M represent different monovalent to trivalent metals, □ represents a defective portion of Ti, x represents a positive real number satisfying 0
摘要翻译：公开了涂膜硬度和粘合性优异的复合钛酸涂膜和复合钛酸树脂基材。具体公开了如下获得的复合钛酸涂膜：含有金属醇盐和通过用酸处理层状钛酸盐然后具有有机碱性化合物而获得的片状钛酸的水性介质悬浮液，层间膨胀或分离，施加到基底上，然后将所得物进行热处理以交联和固化金属醇盐。优选地，层状钛酸酯由下式表示：AxMy□zTi2-（y + z）O4 [其中A和M表示不同的一价至三价金属，□表示Ti的缺陷部分，x表示满足0的正实数

4. 发明授权

US08507485B2 Cyclic compound having pyrimidinylalkylthio group 有权
标题翻译：具有嘧啶基烷硫基的环状化合物
公开(公告)号：US08507485B2
公开(公告)日：2013-08-13
申请号：US12931072
申请日：2011-01-24
申请人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
发明人： Hisashi Tajima , Takahiro Honda , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto
IPC分类号： A61K31/5377 , A61K31/506
CPC分类号： C07D401/14 , C07D239/42 , C07D401/12 , C07D409/12
摘要： A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.
摘要翻译：通过施用治疗有效量的由式（1）表示的化合物或其盐来治疗与血管生成相关的疾病的方法，其中环X表示R 1和R 2独立地表示氢原子，烷基，芳基或芳香杂环; R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基芳硫基，烷基亚磺酰基或非芳族杂环; A1表示硫原子，亚磺酰基或磺酰基; A2表示亚烷基。

5. 发明申请

US20120323350A1 SUPPORT SYSTEM FOR SETTING EQUIPMENT PARAMETERS 审中-公开
标题翻译：用于设置设备参数的支持系统
公开(公告)号：US20120323350A1
公开(公告)日：2012-12-20
申请号：US13055334
申请日：2010-06-16
申请人： Minoru Yamamoto , Tatsushi Imori , Shinobu Hirano
发明人： Minoru Yamamoto , Tatsushi Imori , Shinobu Hirano
IPC分类号： G05B19/18
CPC分类号： G05B11/42 , G05B13/042 , G05B17/02
摘要： An object is to provide an equipment parameter setting support system for supporting the setting of parameters in various processing equipment. The equipment parameter setting support system has an execution results acquisition unit for acquiring, from an equipment controller or EES of the equipment design and manufacturing support system, execution results of a real equipment at any two points in time; a parameter calculation unit for calculating PID parameters at each time point on the basis of the acquired execution results; a difference calculation unit for calculating the difference between the calculated PID parameters; and a variation value calculation unit for calculating a variation value for a unit interval in relation to the calculated difference, wherein, in the equipment design and manufacturing support system, the calculated variation value and a PID parameters stored in the equipment simulator are computed to calculate a new PID parameter, and PID control is executed in the equipment simulator using the new PID parameter.
摘要翻译：目的是提供一种用于支持各种处理设备中参数设置的设备参数设置支持系统。设备参数设置支持系统具有执行结果获取单元，用于从设备控制器或设备设计制造支持系统的EES获取任意两点的实际设备的执行结果; 参数计算单元，用于基于所获取的执行结果来计算每个时间点的PID参数; 差分计算单元，用于计算所计算的PID参数之间的差; 以及变化值计算单元，用于计算与计算出的差异相关的单位间隔的变化值，其中，在设备设计和制造支持系统中，计算计算的变化值和存储在设备模拟器中的PID参数，以计算使用新的PID参数在设备模拟器中执行新的PID参数和PID控制。

6. 发明授权

US08288380B2 Thiophenediamine derivative having urea structure 有权
标题翻译：具有尿素结构的噻吩并二胺衍生物
公开(公告)号：US08288380B2
公开(公告)日：2012-10-16
申请号：US13448674
申请日：2012-04-17
申请人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
发明人： Hiroyuki Mogi , Hisashi Tajima , Noriko Mishina , Yusuke Yamazaki , Shinji Yoneda , Katsuhiko Watanabe , Junko Fujikawa , Minoru Yamamoto
IPC分类号： A61K31/5377 , A61K31/4436 , A61K31/381 , A61K31/496 , A61K31/4439 , A61K31/444 , C07D409/14 , C07D409/12 , C07D413/12 , C07D333/36 , C07D417/14 , A61P27/02 , A61P27/06
CPC分类号： C07D333/36 , C07D409/12
摘要： A compound of formula (1): wherein R1 and R2 represent hydrogen, lower alkyl, lower alkenyl, lower alkynyl or R3 represents hydroxyl, lower alkoxy, lower cycloalkyloxy, aryloxy, carboxy, lower alkoxycarbonyl, or NRaRb of the formula R4 and R5 represent halogen, lower alkyl, hydroxyl, or lower alkoxy; R6 represents halogen, lower alkyl, aryl, heterocyclic, hydroxy, lower alkoxy, mercapto, lower alkylthio, lower alkylcarbonyl, amino, nitro or cyano; R7 represents lower alkyl, hydroxyl or lower alkoxy; Ra and Rb represent hydrogen or lower alkyl; ring A represents a cyclic hydrocarbon or a heterocyclic ring; ring B represents a heterocyclic ring; X represents lower alkylene; Z represents a single bond or lower alkylene; Y represents lower alkylene and W1—W2 represents CH—CH, or Y represents a single bond and W1—W2 represents N—CH, CH—N or CH—CH; and 1, m, n and o represent 0, 1, 2, or 3.
摘要翻译：式（1）的化合物：其中R 1和R 2表示氢，低级烷基，低级烯基，低级炔基或R 3表示羟基，低级烷氧基，低级环烷氧基，芳氧基，羧基，低级烷氧基羰基或NR 4 R b R 5表示卤素，低级烷基，羟基或低级烷氧基; R6表示卤素，低级烷基，芳基，杂环，羟基，低级烷氧基，巯基，低级烷硫基，低级烷基羰基，氨基，硝基或氰基; R7表示低级烷基，羟基或低级烷氧基; Ra和Rb代表氢或低级烷基; 环A表示环状烃或杂环; 环B表示杂环; X表示低级亚烷基; Z表示单键或低级亚烷基; Y表示低级亚烷基，W1-W2表示CH-CH，或Y表示单键，W1-W2表示N-CH，CH-N或CH-CH; 和1，m，n和o表示0,1,2或3。

7. 发明授权

US08258242B2 Compatibilizing agent for polymer alloy, polymer alloy, and master batch for preparation of polymer alloy 失效
标题翻译：用于聚合物合金，聚合物合金和母料的增容剂用于制备聚合物合金
公开(公告)号：US08258242B2
公开(公告)日：2012-09-04
申请号：US12310314
申请日：2007-08-16
申请人： Ryoichi Hiroi , Minoru Yamamoto
发明人： Ryoichi Hiroi , Minoru Yamamoto
IPC分类号： C08G65/321
CPC分类号： C08L77/00 , C08J3/226 , C08K3/22 , C08K7/00 , C08L23/06 , C08L23/083 , C08L23/30 , C08L67/07 , C08L69/00 , C08L71/12 , C08L81/02 , C08L101/00 , C08L81/00 , C08L2666/02
摘要： Disclosed are: a compatibilizing agent for a polymer alloy, which can increase the compatibility with a variety of polymers; a polymer alloy using the compatibilizing agent; and master batch for a polymer alloy. Specifically disclosed is a compatibilizing agent which is used for the preparation of a polymer alloy by blending at least one polymer (A) selected from the group consisting of a polyphenylene sulfide, a polyphenylene ether and a polyamide with a polymer (B) of a different type from the polymer (A) at such a ratio that the amount of the polymer (A) blended is the same as or more than that of the polymer (B). The compatibilizing agent comprises a nanosheet-shaped layered titanic acid which is produced by intercalate an organic basic compound between the layers of a layered titanic acid.
摘要翻译：公开了一种用于聚合物合金的相容剂，其可以增加与各种聚合物的相容性; 使用相容剂的聚合物合金; 和聚合物合金的母料。具体公开了一种相容剂，其通过将选自聚苯硫醚，聚苯醚和聚酰胺的至少一种聚合物（A）与不同的聚合物（B）共混而用于制备聚合物合金以聚合物（A）的配合量与聚合物（B）相同或更多的比例从聚合物（A）中加入。相容剂包括通过在层状钛酸的层之间插入有机碱性化合物而制备的纳米片状层状钛酸。

8. 发明授权

US08017775B2 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity 有权
标题翻译：具有糖皮质激素受体结合活性的1-2-二氢喹啉衍生物
公开(公告)号：US08017775B2
公开(公告)日：2011-09-13
申请号：US11992088
申请日：2006-09-14
申请人： Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Masato Nagatsuka , Sachiko Kobayashi , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Tomoko Oda
发明人： Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Masato Nagatsuka , Sachiko Kobayashi , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Tomoko Oda
IPC分类号： C07D215/38
CPC分类号： C07D215/14 , C07D215/20 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S(O)R8 or S(O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.
摘要翻译：本发明的目的是研究新型1,2-二氢喹啉衍生物的合成，并找到衍生物的药理作用。由通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面是有效的。在该式中，环X表示苯环或吡啶环; R1表示卤素原子，烷基，羟基，烷氧基，氨基等; p表示0〜5的整数， R2表示卤素原子，烷基，羟基等; q表示0〜2的整数， R3表示氢原子，烷基，烯基等; R4和R5表示氢原子等; R6表示氢原子等; A表示亚烷基等; 并且R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8或S（O）2 R 8，其中R 8表示芳基，杂环基等，R 9表示氢原子等。

9. 发明申请

US20110124668A1 NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP 失效
标题翻译：新加坡衍生产品有限公司，卡巴集团，乌代组和替代氧化集团
公开(公告)号：US20110124668A1
公开(公告)日：2011-05-26
申请号：US13054041
申请日：2009-07-14
申请人： Kenji Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
发明人： Kenji Kawashima , Hiroshi Enomoto , Minoru Yamamoto , Masaaki Murai
IPC分类号： A61K31/404 , C07D209/42 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/4439 , C07D405/10 , A61P29/00 , A61P27/06 , A61P17/00 , A61P27/02 , A61P35/00 , A61P3/00 , A61P25/00 , A61P37/06 , A61P31/00 , A61P37/08
CPC分类号： C07D209/42 , A61K31/404 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D403/12 , C07D405/04
摘要： The present invention relates to synthetic studies on novel indole derivatives having a carbamoyl group, a ureido group and a substituted oxy group or a salt thereof, and pharmaceutical actions of the derivatives. The compound and a salt thereof represented by the general formula (1) has an IKKβ inhibitory activity and is useful as a preventive and/or therapeutic agent for diseases considered to be associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group which may have a substituent, a hydroxy group, or a lower alkoxy group which may have a substituent, or the like; R2 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, or a heterocyclic group which may have a substituent, or the like; R3 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or the like; m represents 0, 1, 2, or the like.
摘要翻译：本发明涉及具有氨基甲酰基，脲基和取代的氧基或其盐的新型吲哚衍生物的合成研究以及衍生物的药物作用。由通式（1）表示的化合物及其盐具有IKK＆bgr; 抑制活性，并且可用作被认为与IKK＆bgr相关的疾病的预防和/或治疗剂。式中，R 1表示氢原子，可以具有取代基的低级烷基，羟基或可具有取代基的低级烷氧基等。 R2表示氢原子，可以具有取代基的低级烷基，可以具有取代基的低级环烷基，可以具有取代基的芳基或可以具有取代基的杂环基等。 R3表示卤原子，可以具有取代基的低级烷基，可以具有取代基的低级烯基，可以具有取代基的低级炔基，可以具有取代基的低级环烷基，可以具有取代基的低级环烷基，可以具有取代基，可以具有取代基的杂环基等; m表示0,1,2等。

10. 发明申请

US20100300965A1 DIFFUSER APPARATUS, AND DIFFUSER APPARATUS RUNNING METHOD 有权
标题翻译：扩压器装置和扩口装置运行方法
公开(公告)号：US20100300965A1
公开(公告)日：2010-12-02
申请号：US12734866
申请日：2008-12-25
申请人： Itaru Sakai , Takeshi Tsuji , Masanori Nagafuji , Kazutoshi Ohashi , Minoru Yamamoto
发明人： Itaru Sakai , Takeshi Tsuji , Masanori Nagafuji , Kazutoshi Ohashi , Minoru Yamamoto
IPC分类号： C02F3/20
CPC分类号： C02F3/20 , B01F3/04262 , B01F3/04269 , B01F2003/04177 , B01F2003/04297 , B01F2003/04361 , Y02W10/15
摘要： The present invention provides a diffuser apparatus which has fine pores capable of achieving a high oxygen transfer efficiency and rarely becoming clogged so that the apparatus can be operated stably over a prolonged period. The diffuser apparatus according to the present invention includes: an aeration plate 4 that is disposed in an aeration tank 12 in order to release pressurized air, fed from a diffusing air feed pipe 3, as air bubbles from fine pores formed in an aeration plate surface 4a; blow water feeding means 5 for feeding blow water into the diffusing air feed pipe 3; and an inserted pipe 7 for discharging the blow water, fed into the diffusing air feed pipe 3, from the aeration plate 4.
摘要翻译：本发明提供一种具有能够实现高氧转移效率并且很少变得堵塞的细孔的扩散器装置，从而可以在长时间内稳定地操作该装置。根据本发明的扩散装置包括：曝气板4，其设置在曝气池12中，以从扩散空气供给管3释放加压空气，作为形成在曝气板表面中的细孔的气泡 4a; 用于将吹入水供给到扩散空气供给管3中的吹出水供给单元5; 以及从充气板4排出供给到扩散空气供给管3的吹入水的插入管7。

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