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1. 发明申请

WO2002039999A3 USE OF SURAMINE, L-HISTIDINE, QUISQUALIC ACID OR D-CYCLOSERINE FOR ANGIOGENESIS INHIBITION 审中-公开
公开(公告)号：WO2002039999A3
公开(公告)日：2002-05-23
申请号：PCT/US2001/046221
申请日：2001-11-15
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, R., Shoshana , BAMDAD, Cynthia, Carol
IPC分类号： A61K31/185
摘要： A treatment for cancer is provided. The treatment may include administering a therapeutic amount of L-histidine, D-cycloserine, quisqualic acid or suramin or analogs thereof.

2. 发明申请

WO2002076248A3 CUSTOMIZED THERAPEUTICS AND IN SITU DIAGNOSTICS 审中-公开
公开(公告)号：WO2002076248A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008809
申请日：2002-03-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： A61K49/04
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.

3. 发明申请

WO2002076248A2 CUSTOMIZED THERAPEUTICS AND IN SITU DIAGNOSTICS 审中-公开
标题翻译：定制的治疗方法和原位诊断
公开(公告)号：WO2002076248A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008809
申请日：2002-03-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： A41B
CPC分类号： G01N33/585 , A61K47/6923 , B82Y5/00 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N2610/00
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.
摘要翻译：用于患者治疗和诊断的定制治疗和原位诊断利用工具，包括用自组装单层衍生胶体的技术。这提供了各种测定的能力，包括化学或生物化学试剂/药物相互作用研究。具有或不具有信号传导实体的生物衍生胶体用于探测与非胶体结构物质的相互作用。本发明提供了将胶体颗粒固定在各种非胶体结构上的技术。包括装饰各种非胶体结构（包括珠粒）的能力，胶体作为可检测的测定法。这在许多情况下允许通过无辅助人眼可检测的测定，以及通过自动测定电磁辐射与胶体的相互作用变化（例如吸收，光散射等）可检测的测定。

4. 发明公开

EP1147416A2 ASSAYS INVOLVING COLLOIDS AND NON-COLLOIDAL STRUCTURES 有权
标题翻译： ASSAYS使用胶体和非胶体结构
公开(公告)号：EP1147416A2
公开(公告)日：2001-10-24
申请号：EP00911609.6
申请日：2000-01-21
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, Carol , BAMDAD, R., Shoshana
IPC分类号： G01N33/543
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/5438 , G01N2610/00 , G01N2800/52
摘要： The invention provides novel techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.

5. 发明授权

EP1336104B1 PROTEOMICS BASED DRUG COMPARISON METHODS 有权
标题翻译：蛋白质组学方法比较药物
公开(公告)号：EP1336104B1
公开(公告)日：2009-03-25
申请号：EP01992891.0
申请日：2001-11-01
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/68 , G01N30/02
CPC分类号： B82Y30/00 , G01N33/54313 , G01N33/585 , G01N33/586
摘要： The invention provides novel techniques for determining the interaction between binding partners. The first binding partner is immobilized to a surface or a colloid and a second binding partner immobilized to a surface or a colloid. Non-specific binding techniques, including a SAM, provide for the immobilization of a wide variety of species. A mixture may be separated into various componens and these components may then be fastened to either the colloids or the surfaces. Binding interaction between the binding partners may be determined through a variety of assays.

6. 发明公开

EP1336104A2 DETECTION OF BINDING SPECIES WITH COLLOIDAL AND NON-COLLOIDAL STRUCTURES 有权
标题翻译：蛋白质组学方法比较药物
公开(公告)号：EP1336104A2
公开(公告)日：2003-08-20
申请号：EP01992891.0
申请日：2001-11-01
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/68 , G01N30/02
CPC分类号： B82Y30/00 , G01N33/54313 , G01N33/585 , G01N33/586
摘要： The invention provides novel techniques for determining the interaction between binding partners. The first binding partner is immobilized to a surface or a colloid and a second binding partner immobilized to a surface or a colloid. Non-specific binding techniques, including a SAM, provide for the immobilization of a wide variety of species. A mixture may be separated into various componens and these components may then be fastened to either the colloids or the surfaces. Binding interaction between the binding partners may be determined through a variety of assays.

7. 发明授权

EP1354196B1 DIAGNOSTICS, DRUG SCREENING AND TREATMENT FOR CANCER 有权
标题翻译：诊断方法，药物的筛查和治疗癌症
公开(公告)号：EP1354196B1
公开(公告)日：2010-09-15
申请号：EP01989135.7
申请日：2001-11-27
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： G01N33/543 , G01N33/68 , G01N33/566 , A61P35/00 , C07K14/00 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/54313 , B82Y30/00 , C07K16/3092 , C07K2317/74 , G01N33/543 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2333/4725 , G01N2500/02
摘要： The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUCI is particularly focused upon. Mechanisms associated with MUCI cell proliferation are discussed.

8. 发明公开

EP1356296A2 RAPID AND SENSITIVE DETECTION OF PROTEIN AGGREGATION 有权
标题翻译：蛋白质积累快速，灵敏的检测
公开(公告)号：EP1356296A2
公开(公告)日：2003-10-29
申请号：EP01948711.5
申请日：2001-06-25
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： G01N33/68
CPC分类号： B82Y30/00 , G01N33/54393 , G01N33/6896 , G01N2500/00
摘要： Methods, assays, and components are described in which biological samples can be rapidly and sensitively analyzed for the presence of species associated with neurodegenerative disease. Techniques and components are provided for diagnosis of disease, as well as for screening of candidate drugs for treatment of neurodegenerative disease. The techniques are simple, extremely sensitive, and utilize readily-available components. Binding species, capable of binding a neurodegenerative disease aggregate-forming or aggregate-forming species, are fastened to surfaces of electrodes and surfaces of particles, or provided free in solution, to bind aggregate-forming species and/or be involved in aggregation.

9. 发明授权

EP1356296B1 RAPID AND SENSITIVE DETECTION OF PROTEIN AGGREGATION 有权
标题翻译：蛋白质积累快速，灵敏的检测
公开(公告)号：EP1356296B1
公开(公告)日：2016-04-20
申请号：EP01948711.5
申请日：2001-06-25
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： B82Y30/00 , G01N33/543 , G01N33/68
CPC分类号： B82Y30/00 , G01N33/54393 , G01N33/6896 , G01N2500/00

10. 发明公开

EP1354196A2 DIAGNOSTICS, DRUG SCREENING AND TREATMENT FOR CANCER 有权
标题翻译：诊断方法，药物的筛查和治疗癌症
公开(公告)号：EP1354196A2
公开(公告)日：2003-10-22
申请号：EP01989135.7
申请日：2001-11-27
申请人： Minerva Biotechnologies Corporation
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： G01N33/543 , G01N33/68 , G01N33/566 , A61P35/00 , C07K14/00 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/54313 , B82Y30/00 , C07K16/3092 , C07K2317/74 , G01N33/543 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449 , G01N33/57484 , G01N33/57488 , G01N33/57492 , G01N2333/4725 , G01N2500/02
摘要： The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUCI is particularly focused upon. Mechanisms associated with MUCI cell proliferation are discussed.

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