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1. 发明申请

WO2002076248A3 CUSTOMIZED THERAPEUTICS AND IN SITU DIAGNOSTICS 审中-公开
公开(公告)号：WO2002076248A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008809
申请日：2002-03-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： A61K49/04
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.

2. 发明申请

WO2002076248A2 CUSTOMIZED THERAPEUTICS AND IN SITU DIAGNOSTICS 审中-公开
标题翻译：定制的治疗方法和原位诊断
公开(公告)号：WO2002076248A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008809
申请日：2002-03-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： A41B
CPC分类号： G01N33/585 , A61K47/6923 , B82Y5/00 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N2610/00
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.
摘要翻译：用于患者治疗和诊断的定制治疗和原位诊断利用工具，包括用自组装单层衍生胶体的技术。这提供了各种测定的能力，包括化学或生物化学试剂/药物相互作用研究。具有或不具有信号传导实体的生物衍生胶体用于探测与非胶体结构物质的相互作用。本发明提供了将胶体颗粒固定在各种非胶体结构上的技术。包括装饰各种非胶体结构（包括珠粒）的能力，胶体作为可检测的测定法。这在许多情况下允许通过无辅助人眼可检测的测定，以及通过自动测定电磁辐射与胶体的相互作用变化（例如吸收，光散射等）可检测的测定。

3. 发明申请

WO2003020280A3 COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2003020280A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/028578
申请日：2002-09-05
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia, C.
IPC分类号： A61K31/517
摘要： The present invention relates to compositions useful in the treatment or prevention of cancer, by limiting or preventing angiogenesis. Other compositions useful for the treatment or prevention of cancer or angiogenesis include homologs, analogs, derivatives, enantiomers or functionally equivalent compositions of the present invention. The present compositions can be packaged in kits. The present invention also relates to the use of compositions useful for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer, for example, patients with solid tumors.

4. 发明申请

WO2003020279A2 COMPOSITIONS AND METHODS OF TREATMENT OF CANCER 审中-公开
标题翻译：癌症治疗的组成和方法
公开(公告)号：WO2003020279A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/028576
申请日：2002-09-05
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia, C.
IPC分类号： A61K31/517
CPC分类号： A61K31/517 , A61K31/17 , A61K31/401 , A61K31/403 , A61K31/475 , A61K31/55
摘要： This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact (e.g.,bind to) with MUC1 growth factor receptor or its ligands, and methods for treating the same. The invention also relates to assays or use of such compositions for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer or tumorigenesis. Other compositions of the present invention useful for the treatment or prevention of cancer or tumorigenesis include homologs, analogs, derivatives, enantiomers or functional equivalents. The present compositions can also be packaged in kits in some cases.
摘要翻译：本发明一般涉及用于癌症治疗的组合物和方法，特别是涉及能够与MUC1生长因子受体或其配体相互作用（例如结合）的组合物及其治疗方法。本发明还涉及这种组合物的测定或用途，用于治疗易患或表现出癌症或肿瘤发生特征的症状的患者。可用于治疗或预防癌症或肿瘤发生的本发明的其它组合物包括同系物，类似物，衍生物，对映异构体或功能等同物。在一些情况下，本发明的组合物也可以包装在试剂盒中。

5. 发明申请

WO2007053135A1 METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：癌症诊断和治疗方法
公开(公告)号：WO2007053135A1
公开(公告)日：2007-05-10
申请号：PCT/US2005/032821
申请日：2005-09-14
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： A01N43/54 , A61K31/517 , C07D419/00 , C07D239/72 , A61K31/495 , C07D209/00 , C07D209/48
CPC分类号： A61K31/495 , A61K31/517 , B82Y30/00
摘要： The present application discloses methods of detecting and treating cancer which express MUC1 aberrantly.
摘要翻译：本申请公开了一种异常表达MUC1的癌症检测方法。

6. 发明申请

WO2005007282A2 STORAGE AND USE OF COLLOIDS 审中-公开
标题翻译：存储和使用胶体
公开(公告)号：WO2005007282A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/015088
申请日：2004-05-13
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： B01J
CPC分类号： G01N33/54346 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N2610/00
摘要： The present invention discloses compositions and methods for enabling the longterm storage and/or use of colloid particles without substantial degradation of their performance, for example, by chemical or physical degradation, by particle aggregation, changes in pH and/or relative humidity, changes in salt concentration, and/or by a decrease in the binding activity or other detrimental change in biological, chemical, or physical properties of the colloid particles. In one aspect of the invention, the colloid particles are treated with an aggregation-preventing entity, for example, by immobilizing the entity relative to the colloid particle. In one embodiment, the aggregation-preventing entity forms at least a part of, and/or is immobilized relative to, a self-assembled monolayer ("SAM") immobilized to the colloid particle. The aggregation-preventing entity may be added to non-aggregated or aggregated particles, for example to prevent aggregation and/or to reduce the degree of aggregation. In some embodiments of the invention, the colloid particles are essentially free of surfactants and/or other non immobilized aggregation-preventing entities. The colloid particles and/or solutions thereof may be stored before use without substantial degradation or aggregation over long periods of time in a dried state and/or at low temperatures. After storage, certain colloid particles provided by the invention can remain substantially non-aggregated. Various colloid particles of the invention may be used in many techniques, for example, in gels or other assay systems. In some cases, the colloid particles have a high degree of specificity and/or activity, which is due, at least in part, to their ability to remain in a substantially non-aggregated and detergent-free state during storage and/or use.
摘要翻译：本发明公开了能够长期储存和/或使用胶体颗粒的组合物和方法，而不会通过化学或物理降解，通过颗粒聚集，pH和/或相对湿度的变化，盐浓度，和/或通过胶体颗粒的生物学，化学或物理性质的结合活性或其它有害变化的降低。在本发明的一个方面，胶体颗粒用聚集防止实体进行处理，例如通过相对于胶体颗粒固定该实体。在一个实施方案中，聚集防止实体相对于固定在胶体颗粒上的自组装单层（“SAM”）形成至少一部分和/或固定。可以将聚集防止实体添加到非聚集或聚集的颗粒，例如以防止聚集和/或降低聚集度。在本发明的一些实施方案中，胶体颗粒基本上不含表面活性剂和/或其它非固定的聚集防止物质。胶体颗粒和/或其溶液可以在使用前储存，在干燥状态和/或低温下长时间不会显着降解或聚集。储存后，本发明提供的某些胶体颗粒可以保持基本上不聚集。本发明的各种胶体颗粒可用于许多技术中，例如在凝胶或其它测定系统中。在一些情况下，胶体颗粒具有高度的特异性和/或活性，其至少部分是由于其在储存和/或使用期间保持基本上非聚集和无去污剂状态的能力。

7. 发明申请

WO2004059347A3 OPTICAL DEVICES AND METHODS INVOLVING NANOPARTICLES 审中-公开
公开(公告)号：WO2004059347A3
公开(公告)日：2004-07-15
申请号：PCT/US2003/041258
申请日：2003-12-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： G01N21/00
摘要： The present invention relates generally to optical materials and applications of optical materials and, more particularly, to optical materials incorporating particles , such as nanoparticles, methods of forming such materials, and applications of such materials in various devices, for example, for filters, displays, coatings for glare reduction, and the like. The present invention can provide control over fabrication dimensions at very small scale, for example, at the molecular scale rather than at a macroscopic scale. The invention also involves, in some cases, controlling the interaction of many wavelengths of electromagnetic radiation with these materials. The optical materials and devices of the invention may be constructed and arranged for a response to, control of, and/or interaction with essentially any electromagnetic radiation, electric field, and/or magnetic field.

8. 发明申请

WO2005019269A2 TECHNIQUES AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER (MUC1) 审中-公开
标题翻译：用于诊断和治疗癌症的技术和组合物（MUC1）
公开(公告)号：WO2005019269A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/027954
申请日：2004-08-26
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： C07K16/30
CPC分类号： C07K14/71 , A61K2039/505 , B82Y30/00 , C07K14/4727 , C07K16/2863 , C07K2319/21
摘要： The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1cell proliferation are discussed.
摘要翻译：本发明提供了主要与细胞增殖，特别是癌症的诊断和/或治疗相关的一系列组合物，方法，试剂盒，物品和物种。与MUC1异常表达相关的细胞增殖特别集中于。讨论了与MUC1细胞增殖有关的机制。

9. 发明申请

WO2003020279A3 COMPOSITIONS AND METHODS OF TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2003020279A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/028576
申请日：2002-09-05
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia, C.
IPC分类号： A61K31/517
摘要： This invention generally relates to compositions and methods for cancer treatment and, in particular, to compositions able to interact (e.g.,bind to) with MUC1 growth factor receptor or its ligands, and methods for treating the same. The invention also relates to assays or use of such compositions for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer or tumorigenesis. Other compositions of the present invention useful for the treatment or prevention of cancer or tumorigenesis include homologs, analogs, derivatives, enantiomers or functional equivalents. The present compositions can also be packaged in kits in some cases.

10. 发明申请

WO2003018846A1 AFFINITY TAG MODIFIED PARTICLES 审中-公开
标题翻译： AFFINITY TAG修饰颗粒
公开(公告)号：WO2003018846A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/027952
申请日：2002-08-30
申请人： MINERVA BIOTECHNOLOGIES CORPORATION
发明人： BAMDAD, Cynthia, C.
IPC分类号： C12Q1/68
CPC分类号： B82Y15/00 , C40B40/00 , G01N33/542 , G01N33/58 , G01N33/588
摘要： The present invention provides methods, assays, kits, and components for the detection and analysis of binding between various biological or chemical species, as well as techniques for facilitating the attachment of various biological or chemical species to a particle. In some cases, particles having the ability to emit electromagnetic radiation within a narrow wavelength band, for example, semiconductor nanocrystals, are attached to a substrate or a structure, such as a molecule, a particle, a fluid sample, a cell, or a tissue. The attachment may be a direct attachment or an indirect attachment, for example, an attachment comprising an affinity tag/recognition entity interaction. The particles may then be further used to assay biological or chemical entities, or combined with other detection techniques.
摘要翻译：本发明提供用于检测和分析各种生物或化学物质之间的结合的方法，测定，试剂盒和组分，以及有助于将各种生物或化学物质附着到颗粒的技术。在一些情况下，具有在窄波长带内发射电磁辐射的能力的颗粒例如半导体纳米晶体附着到基底或结构，例如分子，颗粒，流体样品，细胞或细胞组织。附件可以是直接附件或间接附件，例如包括亲和标签/识别实体交互的附件。然后可以将颗粒进一步用于测定生物或化学实体，或与其他检测技术组合。

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