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1. 发明授权

US5336613A Cephalosporin C acylase 失效
标题翻译：头孢菌素C酰基转移酶
公开(公告)号：US5336613A
公开(公告)日：1994-08-09
申请号：US19870
申请日：1993-02-19
申请人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Yoshinori Ishii
发明人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Yoshinori Ishii
IPC分类号： C12N1/21 , C12N9/80 , C12N15/09 , C12N15/55 , C12P35/02 , C12P35/06 , C12R1/19 , C12N15/52
CPC分类号： C12P35/02 , C12N9/80
摘要： The present invention concerns a mutant cephalosporin C acylase derived from a precursor of the formula:A.sup.1-268 --X.sup.1 --Tyr--X.sup.2 --A.sup.272-304 --X.sup.3 --A.sup.306-773(SEQ ID NO:1), wherein:A.sup.1-268 is the same amino acid sequence as that from Thr.sup.1 to Gly.sup.268 of native CC acylase,A.sup.272-304 is the same amino acid sequence as that from Gln.sup.272 to Tyr.sup.304 of native CC acylase,A.sup.306-773 is the same amino acid sequence as that from Val.sup.306 to Ala.sup.773 of native CC acylase,X.sup.1 is Met or other amino acid,X.sup.2 is Ala or Tyr, andX.sup.3 is Cys or Ser,provided that when X.sup.1 is Met and X.sup.2 is Ala, X.sup.3 is Ser; and that the mutant cephalosporin C acylase has a property selected from the group consisting of higher enzymatic potency and higher processing efficiency, as compared to native CC acylase. The present invention also concerns DNA encoding the mutant cephalosporin C acylase, an expression vector containing the DNA, a host cell transformed with the expression vector, a process for producing the mutant cephalosporin C acylase by culturing the transformed host cell, and a process for preparing a cephalosporin C using the mutant cephalosporin C acylase.
摘要翻译：本发明涉及衍生自下式的前体的突变型头孢菌素C酰基转移酶：A1-268-X1-Tyr-X2-A272-304-X3-A306-773（SEQ ID NO：1），其中：A1-268是与天然CC酰基转移酶A272-304的Thr1至Gly268相同的氨基酸序列与天然CC酰基转移酶从Gln272至Tyr304的氨基酸序列相同，氨基酸序列与Val306至天然CC酰基转移酶的Ala773，X1是Met或其他氨基酸，X2是Ala或Tyr，X3是Cys或Ser，条件是当X1是Met，X2是Ala时，X3是Ser; 并且与天然CC酰基转移酶相比，突变型头孢菌素C酰基转移酶具有选自较高酶效力和较高加工效率的性质。本发明还涉及编码突变型头孢菌素C酰基转移酶的DNA，含有DNA的表达载体，用表达载体转化的宿主细胞，通过培养转化的宿主细胞产生突变型头孢菌素C酰基转移酶的方法，以及制备使用突变型头孢菌素C酰基转移酶的头孢菌素C。

2. 发明授权

US5840533A Tissue plasminogen activator 失效
标题翻译：组织纤溶酶原激活剂
公开(公告)号：US5840533A
公开(公告)日：1998-11-24
申请号：US811949
申请日：1997-03-05
申请人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Masako Hayashi , Jouji Notani , Masakazu Kobayashi
发明人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Masako Hayashi , Jouji Notani , Masakazu Kobayashi
IPC分类号： C12N15/09 , A61K38/46 , A61K38/48 , A61P7/02 , C07H21/04 , C07K14/745 , C12N1/20 , C12N1/21 , C12N5/10 , C12N9/64 , C12N9/72 , C12N15/58 , C12R1/19 , C12R1/91 , C12P21/02 , C12N15/70
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： The invention relates to a new tissue plasminogen activator which has strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clots to form soluble products and therefore is useful as a thrombolytic agent. The invention also relates to a DNA sequence encoding the amino acid sequence for the tissue plasminogen activator, to a process for producing the plasminogen activator, and to a pharmaceutical composition comprising the new tissue plasminogen activator.
摘要翻译：本发明涉及一种新的组织纤溶酶原激活剂，其具有将纤溶酶原转化成纤溶酶的强烈活性，其使血凝块的纤维蛋白网络降解形成可溶性产物，因此可用作血栓溶解剂。本发明还涉及编码组织纤溶酶原激活剂的氨基酸序列的DNA序列，以及制备纤溶酶原激活物的方法，以及包含新组织纤溶酶原激活剂的药物组合物。

3. 发明授权

US5648250A Tissue plasminogen activator 失效
标题翻译：组织纤溶酶原激活剂
公开(公告)号：US5648250A
公开(公告)日：1997-07-15
申请号：US412859
申请日：1995-03-29
申请人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Masako Hayashi , Jouji Notani , Masakazu Kobayashi
发明人： Mineo Niwa , Yoshimasa Saito , Hitoshi Sasaki , Masako Hayashi , Jouji Notani , Masakazu Kobayashi
IPC分类号： C12N15/09 , A61K38/46 , A61K38/48 , A61P7/02 , C07H21/04 , C07K14/745 , C12N1/20 , C12N1/21 , C12N5/10 , C12N9/64 , C12N9/72 , C12N15/58 , C12R1/19 , C12R1/91 , C12N15/70 , A61K38/49
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： The invention relates to a new tissue plasminogen activator which has strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clots to form soluble products and therefore is useful as a thrombolytic agent. The invention also relates to a DNA sequence encoding the amino acid sequence for the tissue plasminogen activator, to a process for producing the plasminogen activator, and to a pharmaceutical composition comprising the new tissue plasminogen activator.
摘要翻译：本发明涉及一种新的组织纤溶酶原激活剂，其具有将纤溶酶原转化成纤溶酶的强烈活性，其使血凝块的纤维蛋白网络降解形成可溶性产物，因此可用作血栓溶解剂。本发明还涉及编码组织纤溶酶原激活剂的氨基酸序列的DNA序列，以及制备纤溶酶原激活物的方法，以及包含新组织纤溶酶原激活剂的药物组合物。

4. 发明申请

US20160082753A1 IMAGE FORMING APPARATUS AND IMAGE FORMING METHOD 有权
标题翻译：图像形成装置和图像形成方法
公开(公告)号：US20160082753A1
公开(公告)日：2016-03-24
申请号：US14848210
申请日：2015-09-08
申请人： Hitoshi Sasaki , Yuuichiroh Tsujiguchi , Takuji Kawaguchi , Shigeru Yoshigai , Keizoh Shigaki
发明人： Hitoshi Sasaki , Yuuichiroh Tsujiguchi , Takuji Kawaguchi , Shigeru Yoshigai , Keizoh Shigaki
IPC分类号： B41J13/00
CPC分类号： B41J13/0009 , B41J3/60 , B41J13/0045
摘要： An image forming apparatus includes a conveyance unit configured to convey a recording medium; a reversing unit configured to reverse front and back sides of the recording medium; a recording head configured to reciprocatingly scan to form a first image on a first side of the recording medium, which is reciprocatingly conveyed by the conveyance unit at a first conveyance speed V1, and a second image on a second side of the recording medium, which is conveyed at a second conveyance speed V2 and ejected, in a case of performing a double-sided printing; and a control unit configured to control the first conveyance speed V1 and the second conveyance speed V2 to satisfy a relation V2≦W/t
摘要翻译：一种图像形成装置，包括：传送单元，被配置为传送记录介质; 反转单元，其构造成反转记录介质的前侧和后侧; 记录头，被配置为在记录介质的第一侧上以第一传送速度V1和第二图像在记录介质的第二面上往复扫描以形成由传送单元往复传送的第一图像，在执行双面打印的情况下以第二传送速度V2传送并被弹出; 以及控制单元，被配置为控制第一输送速度V1和第二输送速度V2以满足关系V2＆lt; nlE; W / t

5. 发明授权

US09028797B2 Composite body for antigen or drug delivery 有权
标题翻译：用于抗原或药物递送的复合体
公开(公告)号：US09028797B2
公开(公告)日：2015-05-12
申请号：US13581194
申请日：2011-02-24
申请人： Hitoshi Sasaki , Tomoaki Kurosaki , Takashi Kitahara , Hideto To , Katsuyuki Yui , Kenji Hirayama , Kouichi Morita , Takahiro Mukai , Yasuhiro Magata , Mikako Ogawa , Kohei Sano
发明人： Hitoshi Sasaki , Tomoaki Kurosaki , Takashi Kitahara , Hideto To , Katsuyuki Yui , Kenji Hirayama , Kouichi Morita , Takahiro Mukai , Yasuhiro Magata , Mikako Ogawa , Kohei Sano
IPC分类号： A61K49/00 , A61K51/06 , A61K31/711 , A61K31/713 , A61K39/00 , A61K39/015 , A61K39/145 , A61K39/39 , A61K47/48
CPC分类号： A61K49/0002 , A61K31/711 , A61K31/713 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K47/6455 , A61K51/065 , A61K2039/5252 , A61K2039/55555 , C12N2760/16034
摘要： The invention provides an antigen or drug delivery complex containing a complex of an antigen or drug and a cationic molecule, and an anionic molecule encapsulating the same. The antigen or drug delivery complex can be used as a main component of a drug delivery system that delivers various antigens and drugs to a particular cell or organ.
摘要翻译：本发明提供了包含抗原或药物和阳离子分子的复合物的抗原或药物递送复合物，以及包封其的阴离子分子。抗原或药物递送复合物可用作药物递送系统的主要成分，其将各种抗原和药物递送至特定的细胞或器官。

6. 发明申请

US20120016669A1 APPARATUS AND METHOD FOR VOICE PROCESSING AND TELEPHONE APPARATUS 有权
标题翻译：用于语音处理和电话设备的装置和方法
公开(公告)号：US20120016669A1
公开(公告)日：2012-01-19
申请号：US13072992
申请日：2011-03-28
申请人： Kaori Endo , Takeshi Otani , Hitoshi Sasaki , Mitsuyoshi Matsubara , Rika Nishiike , Kaoru Chujo
发明人： Kaori Endo , Takeshi Otani , Hitoshi Sasaki , Mitsuyoshi Matsubara , Rika Nishiike , Kaoru Chujo
IPC分类号： G10L19/14
CPC分类号： G10L21/038 , G10L21/02 , G10L21/0208 , G10L21/0232
摘要： A voice processing apparatus includes a voice signal acquiring unit that acquires a voice signal converted to plural frequency bands from an input signal having a narrowed band; an expanding unit that generates based on a narrowband component of the voice signal acquired by the voice signal acquiring unit, an expansion band component expanding the band of the voice signal; a correcting unit that corrects the power of the expansion band component by a correction amount determined based on a noise component included in the voice signal acquired by the voice signal acquiring unit; and an output unit that outputs the voice signal of which the band has been expanded based on the expansion band component corrected by the correcting unit and based on the narrowband component of the voice signal acquired by the voice signal acquiring unit.
摘要翻译：语音处理装置包括语音信号获取单元，其从具有变窄频带的输入信号中获取被转换成多个频带的语音信号; 扩展单元，其基于由语音信号获取单元获取的语音信号的窄带分量生成扩展频带分量，扩展语音信号的频带; 校正单元，其通过基于由语音信号获取单元获取的语音信号中包括的噪声分量确定的校正量校正扩展频带分量的功率; 以及输出单元，其基于由所述校正单元校正的所述扩展频带分量，并且基于由所述语音信号获取单元获取的所述语音信号的窄带分量来输出已经扩展了所述频带的语音信号。

7. 发明授权

US07679104B2 Vertical type semiconductor device and manufacturing method of the device 有权
标题翻译：垂直型半导体器件及其制造方法
公开(公告)号：US07679104B2
公开(公告)日：2010-03-16
申请号：US11937090
申请日：2007-11-08
申请人： Yoshihiro Sato , Sadahiro Kato , Masayuki Iwami , Hitoshi Sasaki , Shinya Ootomo , Yuki Niiyama
发明人： Yoshihiro Sato , Sadahiro Kato , Masayuki Iwami , Hitoshi Sasaki , Shinya Ootomo , Yuki Niiyama
IPC分类号： H01L29/267
CPC分类号： H01L29/267 , H01L21/02381 , H01L21/02433 , H01L21/02458 , H01L21/0254 , H01L21/02576 , H01L21/0262 , H01L21/02639 , H01L21/76895 , H01L29/0657 , H01L29/2003 , H01L29/41 , H01L29/417 , H01L29/41766 , H01L29/66143 , H01L29/66727 , H01L29/66734 , H01L29/7813 , H01L29/872
摘要： A vertical semiconductor element comprises: an electro-conductive substrate; a GaN layer, as a nitride compound semiconductor layer, which is selectively grown as a convex shape on one surface of the electro-conductive substrate through a buffer layer; a source electrode as a first electrode formed on the GaN layer; and a drain electrode as a second electrode formed on another surface of the electro-conductive substrate.
摘要翻译：垂直半导体元件包括：导电基板; 作为氮化物半导体层的GaN层，其通过缓冲层在导电性基板的一个表面上选择性地生长为凸形; 源极，形成在GaN层上的第一电极; 以及作为形成在导电基板的另一表面上的第二电极的漏电极。

8. 发明授权

US07672840B2 Voice speed control apparatus 有权
标题翻译：语音速度控制装置
公开(公告)号：US07672840B2
公开(公告)日：2010-03-02
申请号：US11653952
申请日：2007-01-17
申请人： Hitoshi Sasaki , Hiroshi Katayama , Rika Nishiike
发明人： Hitoshi Sasaki , Hiroshi Katayama , Rika Nishiike
IPC分类号： G10L21/04 , G10L11/02
CPC分类号： G11B27/005 , G10L21/04 , G10L25/93
摘要： A voice speed control apparatus comprising: an utterance/non-utterance judging unit judging whether a processing target segment in inputted a voice signal is an utterance segment or a non-utterance segment; a non-utterance continuation length acquiring unit acquiring a non-utterance continuation length representing a length of the voice signal judged continuously to be the non-utterance; a determining unit determining a reproducing speed of the processing target segment in the voice signal in accordance with the non-utterance continuation length so that the reproducing speed gets higher as the non-utterance continuation length gets larger and so that an increase in reproducing speed is restrained to a greater degree as the non-utterance continuation length becomes smaller; and a changing unit changing the reproducing speed of the voice signal, corresponding to the reproducing speed.
摘要翻译：一种话音速度控制装置，包括：发声/非发声判断单元，判断输入的语音信号中的处理目标片段是话音段还是非话音段; 非话语连续长度获取单元获取表示连续判断为非话语的语音信号的长度的非话语连续长度; 确定单元，根据非话语连续长度来确定语音信号中的处理目标段的再现速度，使得再现速度随着非话语连续长度变大而变高，并且再现速度的增加是随着非话语连续长度变小，限制在更大程度上; 以及改变单元，改变对应于再现速度的语音信号的再现速度。

9. 发明授权

US07454345B2 Word or collocation emphasizing voice synthesizer 有权
标题翻译：词或搭配强调语音合成器
公开(公告)号：US07454345B2
公开(公告)日：2008-11-18
申请号：US11063758
申请日：2005-02-23
申请人： Hitoshi Sasaki , Yasushi Yamazaki , Yasuji Ota , Kaori Endo , Nobuyuki Katae , Kazuhiro Watanabe
发明人： Hitoshi Sasaki , Yasushi Yamazaki , Yasuji Ota , Kaori Endo , Nobuyuki Katae , Kazuhiro Watanabe
IPC分类号： G10L13/00
CPC分类号： G10L13/08 , G10L13/04 , G10L13/10
摘要： A voice synthesizer, which obtains a voice by emphasizing a specific part of a sentence, includes an emphasis degree deciding unit that extracts a word or a collocation to be emphasized from among respective words or respective collocations on the basis of an extracting reference with respect to the each word or the each collocation included in a sentence and deciding an emphasis degree of the extracted word or the extracted collocation, an acoustic processing unit that synthesizes a voice having an emphasis degree which is decided by the emphasis degree deciding unit applied to the word to be emphasized or the collocation to be emphasized, whereby the emphasized part of the word or the collocation can be obtained automatically on the basis of the extracting reference, such as a frequency of appearance and a level of importance of the word or the collocation.
摘要翻译：通过强调句子的特定部分来获取语音的语音合成器包括：强调度决定单元，其基于相对于所述语句的提取参考，从各个单词或各个搭配中提取要强调的单词或搭配包括在句子中的每个单词或每个搭配，并且决定所提取的单词或所提取的搭配的强调程度;声学处理单元，其将由强调度决定单元决定的强调度的声音合成到该单词中要强调的搭配，或者要强调的搭配，从而可以基于提取参考（例如出现的频率和单词的重要性或搭配的水平）自动获得单词或搭配的强调部分。

10. 发明授权

US07067768B2 Motor driven resistance spot welding gun 失效
标题翻译：电机驱动电阻点焊枪
公开(公告)号：US07067768B2
公开(公告)日：2006-06-27
申请号：US10478015
申请日：2002-05-17
申请人： Hiroshi Miwa , Shigemitsu Nakabayashi , Hitoshi Sasaki , Masaaki Shoji , Hiroki Hashimoto , Osamu Kurihara , Takuro Kugimiya , Akiyoshi Shimizu , Shigenori Yoshimi
发明人： Hiroshi Miwa , Shigemitsu Nakabayashi , Hitoshi Sasaki , Masaaki Shoji , Hiroki Hashimoto , Osamu Kurihara , Takuro Kugimiya , Akiyoshi Shimizu , Shigenori Yoshimi
IPC分类号： B23K9/12 , B23K9/10 , H02K7/14 , H02K9/00
CPC分类号： H02K7/06 , B23K11/315 , B23K11/317
摘要： A motor-driven welding gun has a servomotor for displacing a movable electrode tip toward and away from a fixed electrode tip. The servomotor has a motor housing with a copper pipe which is inserted therein when the motor housing is cast. The copper pipe provides a coolant passage in the motor housing for supplying a coolant therethrough. When the coolant passage is supplied with the coolant, the motor housing is forcibly cooled, reducing the amount of heat generated by the servomotor.
摘要翻译：电动焊枪具有伺服电动机，用于使可动电极尖端朝向和远离固定电极尖端移动。伺服电动机具有带有铜管的电动机壳体，当电动机壳体被铸造时，其被插入其中。铜管在电动机壳体中提供冷却剂通道，用于通过其供应冷却剂。当冷却剂通道被供应冷却剂时，电动机壳体被强制冷却，减少了由伺服电动机产生的热量。

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