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1. 发明申请

US20080076753A1 SUBSTITUTED SPIROHETEROCYCLES 有权
标题翻译：取代的螺旋体
公开(公告)号：US20080076753A1
公开(公告)日：2008-03-27
申请号：US11857891
申请日：2007-09-19
申请人： Min Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith Demarest , Richard Look , Bruce Maryanoff , Michael Costanzo , Stephen Yabut
发明人： Min Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith Demarest , Richard Look , Bruce Maryanoff , Michael Costanzo , Stephen Yabut
IPC分类号： A61K31/55 , A61P25/00 , A61P9/00 , C07D471/10 , C07D487/10
CPC分类号： C07D487/10
摘要： The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal insufficiency, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译：本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾功能不全，肾衰竭，糖尿病性肾病，脑水肿，还公开了脑缺血，中风，血栓形成或保水。

2. 发明申请

US20080076754A1 SUBSTITUTED SPIROHETEROCYCLES 有权
标题翻译：取代的螺旋体
公开(公告)号：US20080076754A1
公开(公告)日：2008-03-27
申请号：US11857954
申请日：2007-09-19
申请人： Min Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith Demarest , Richard Look , Bruce Maryanoff , Michael Costanzo , Stephen Yabut
发明人： Min Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith Demarest , Richard Look , Bruce Maryanoff , Michael Costanzo , Stephen Yabut
IPC分类号： A61K31/55 , A61P25/00 , A61P9/00 , C07D471/10 , C07D487/10
CPC分类号： C07D487/10
摘要： The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译：本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾衰竭，糖尿病性肾病，脑水肿，脑缺血，中风，血栓形成或保水性也被公开。

3. 发明授权

US07825111B2 Substituted spiroheterocycles 有权
标题翻译：取代螺旋环
公开(公告)号：US07825111B2
公开(公告)日：2010-11-02
申请号：US11857954
申请日：2007-09-19
申请人： Min A. Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith T. Demarest , Richard Look , Bruce Maryanoff , Michael J. Costanzo , Stephen C. Yabut
发明人： Min A. Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith T. Demarest , Richard Look , Bruce Maryanoff , Michael J. Costanzo , Stephen C. Yabut
IPC分类号： A61P9/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/10
摘要： The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译：本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾衰竭，糖尿病性肾病，脑水肿，脑缺血，中风，血栓形成或保水性也被公开。

4. 发明授权

US07825110B2 Substituted spiroheterocycles 有权
标题翻译：取代螺旋环
公开(公告)号：US07825110B2
公开(公告)日：2010-11-02
申请号：US11857891
申请日：2007-09-19
申请人： Min A. Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith T. Demarest , Richard Look , Bruce Maryanoff , Michael J. Costanzo , Stephen C. Yabut
发明人： Min A. Xiang , Mona Patel , Philip Rybczynski , Joseph Gunnet , Keith T. Demarest , Richard Look , Bruce Maryanoff , Michael J. Costanzo , Stephen C. Yabut
IPC分类号： A61P9/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/10
摘要： The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal insufficiency, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译：本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾功能不全，肾衰竭，糖尿病性肾病，脑水肿，还公开了脑缺血，中风，血栓形成或保水。

5. 发明申请

US20070179128A1 SUBSTITUTED SPIROBENZAZEPINES 有权
标题翻译：取代的SPIROBENZAZEPINES
公开(公告)号：US20070179128A1
公开(公告)日：2007-08-02
申请号：US11735149
申请日：2007-04-13
申请人： Mona Patel , Philip Rybczynski , Min Xiang
发明人： Mona Patel , Philip Rybczynski , Min Xiang
IPC分类号： A61K31/55 , C07D223/14
CPC分类号： C07C205/57 , C07D223/32
摘要： The invention is directed to nonpeptide substituted benzazepines of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension, among others disclosed. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译：本发明涉及式I的非肽取代的苯并氮杂，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心功能不全的那些，包括充血性心力衰竭，低钠血症和高血压等披露包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾衰竭，糖尿病性肾病，脑水肿，脑缺血，中风，血栓形成或保水性也被公开。

6. 发明授权

US07531671B2 Dihydroisoindolones as allosteric modulators of glucokinase 有权
标题翻译：二氢异吲哚酮作为葡萄糖激酶的变构调节剂
公开(公告)号：US07531671B2
公开(公告)日：2009-05-12
申请号：US11554523
申请日：2006-10-30
申请人： Hiayan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang
发明人： Hiayan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang
IPC分类号： C07D209/44
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.
摘要翻译：本发明涉及式（I）的化合物，这些化合物的制备方法，组合物，中间体及其衍生物以及用于治疗葡糖激酶介导的病症。更具体地，本发明的化合物是可用于治疗疾病的葡糖激酶调节剂，包括但不限于II型糖尿病。

7. 发明授权

US07511022B2 Substituted indole-O-glucosides 有权
标题翻译：取代的吲哚-O-葡萄糖苷
公开(公告)号：US07511022B2
公开(公告)日：2009-03-31
申请号：US11453726
申请日：2006-06-15
申请人： Mary Pat Beavers , Mona Patel , Philip Rybczynski , Maud Urbanski , Xiaoyan Zhang
发明人： Mary Pat Beavers , Mona Patel , Philip Rybczynski , Maud Urbanski , Xiaoyan Zhang
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H15/26 , C07H17/02
摘要： Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
摘要翻译：公开了取代的吲哚-O-葡萄糖苷，含有它们的组合物及其使用方法，例如治疗糖尿病和综合症。

8. 发明申请

US20090202525A1 DIHYDROISOINDOLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE 有权
标题翻译：作为GLUCOKINASE的无菌调节剂的二氢吲哚酮
公开(公告)号：US20090202525A1
公开(公告)日：2009-08-13
申请号：US12423948
申请日：2009-04-15
申请人： Haiyan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
发明人： Haiyan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
IPC分类号： A61K39/395 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/427
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of Formula (1), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.
摘要翻译：本发明涉及式（1）的化合物，这些化合物的制备方法，组合物，中间体及其衍生物以及用于治疗葡糖激酶介导的病症。更具体地，本发明的化合物是可用于治疗疾病的葡糖激酶调节剂，包括但不限于II型糖尿病。

9. 发明申请

US20090105164A1 SUBSTITUTED INDOLE-O-GLUCOSIDES 审中-公开
标题翻译：取代的吲哚乙酰胆碱酯酶
公开(公告)号：US20090105164A1
公开(公告)日：2009-04-23
申请号：US12337903
申请日：2008-12-18
申请人： Mary Pat Beavers , Mona Patel , Philip Rybczynski , Maud Urbanski , Xiaoyan Zhang
发明人： Mary Pat Beavers , Mona Patel , Philip Rybczynski , Maud Urbanski , Xiaoyan Zhang
IPC分类号： A61K31/7056 , A61P3/10
CPC分类号： C07H15/26 , C07H17/02
摘要： Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.
摘要翻译：公开了取代的吲哚-O-葡萄糖苷，含有它们的组合物及其使用方法，例如治疗糖尿病和综合症。

10. 发明授权

US07928246B2 Dihydroisoindolones as allosteric modulators of glucokinase 有权
标题翻译：二氢异吲哚酮作为葡萄糖激酶的变构调节剂
公开(公告)号：US07928246B2
公开(公告)日：2011-04-19
申请号：US12423948
申请日：2009-04-15
申请人： Hiayan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
发明人： Hiayan Bian , Joseph Dudash , Mona Patel , Philip Rybczynski , Yongzheng Zhang , Mary Pat Beavers , Maud Urbanski , Min (Amy) Xiang , Roxanne Zeck
IPC分类号： C07D209/44
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated disorders. More particularly, the compounds of the present invention are glucokinase modulators useful for treating disorders including, but not limited to, type II diabetes.
摘要翻译：本发明涉及式（I）的化合物，这些化合物的制备方法，组合物，中间体及其衍生物以及用于治疗葡糖激酶介导的病症。更具体地，本发明的化合物是可用于治疗疾病的葡糖激酶调节剂，包括但不限于II型糖尿病。

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