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1. 发明申请

US20090042894A1 NOVEL SPECIES OF ACROCARPOSPORA, A METHOD OF PREPARING IODININ, AND THE USES OF IODININ 审中-公开
标题翻译： ACROCARPOSPORA的新品种，制备IODININ的方法，以及IODININ的用途
公开(公告)号：US20090042894A1
公开(公告)日：2009-02-12
申请号：US12165782
申请日：2008-07-01
申请人： Min Tseng , Ming-Jen Cheng , Shu-Feng Yang , Gwo-Fang Yuan , Li-Wen Yu , Wen-Jung Wu
发明人： Min Tseng , Ming-Jen Cheng , Shu-Feng Yang , Gwo-Fang Yuan , Li-Wen Yu , Wen-Jung Wu
IPC分类号： A61K31/498 , C12N1/14 , A61P35/00 , C12P17/12
CPC分类号： C12R1/01 , C12P17/12
摘要： The present invention provides a novel species of Acrocarpospora gen. that is capable of producing iodinin. The invention also provides a method of preparing iodinin, and uses of iodinin in inducing cytotoxicity and treating cancers.
摘要翻译：本发明提供了一种新型Acrocarpospora gen。它能够产生碘素。本发明还提供了一种制备碘蛋白的方法，以及碘喹啉在诱导细胞毒性和治疗癌症中的用途。

2. 发明授权

US08957057B2 Use of azaphilone compounds for the modulation of the activity of a nuclear hormone receptor 有权
标题翻译：使用azaphilone化合物调节核激素受体的活性
公开(公告)号：US08957057B2
公开(公告)日：2015-02-17
申请号：US12753918
申请日：2010-04-05
申请人： Ta-Wei D. Liu , Yen-Lin Chen , Ming-Der Wu , Ming-Jen Cheng , Hui-Ping Chen , Wen-Jung Wu , Kai-Ping Chen , Yu-Shan Lin , Gwo-Fang Yuan
发明人： Ta-Wei D. Liu , Yen-Lin Chen , Ming-Der Wu , Ming-Jen Cheng , Hui-Ping Chen , Wen-Jung Wu , Kai-Ping Chen , Yu-Shan Lin , Gwo-Fang Yuan
IPC分类号： A01N43/00 , A61K31/33 , A61K31/365
CPC分类号： A61K31/365
摘要： The present invention concerns the uses of an azaphilone compound of formula (I):formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.
摘要翻译：本发明涉及式（I）的阿扎伐隆化合物：式（I）：或其药学上可接受的衍生物在本说明书中所述的用于调节核激素受体的活性和用于预防和/或治疗与核激素受体活性有关的疾病或病症。

3. 发明申请

US20100256227A1 USE OF AZAPHILONE COMPOUNDS FOR THE MODULATION OF THE ACTIVITY OF A NUCLEAR HORMONE RECEPTOR 有权
标题翻译：用于调节核细胞受体活性的AZAPILONE化合物的使用
公开(公告)号：US20100256227A1
公开(公告)日：2010-10-07
申请号：US12753918
申请日：2010-04-05
申请人： Ta-Wei D. LIU , Yen-Lin Chen , Ming-Der Wu , Ming-Jen Cheng , Hui-Ping Chen , Wen-Jung Wu , Kai-Ping Chen , Yu-Shan Lin , Gwo-Fang Yuan
发明人： Ta-Wei D. LIU , Yen-Lin Chen , Ming-Der Wu , Ming-Jen Cheng , Hui-Ping Chen , Wen-Jung Wu , Kai-Ping Chen , Yu-Shan Lin , Gwo-Fang Yuan
IPC分类号： A61K31/365 , A61P35/00 , A61P5/00 , A61P17/10
CPC分类号： A61K31/365
摘要： The present invention concerns the uses of an azaphilone compound of formula (I):formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.
摘要翻译：本发明涉及式（I）的阿扎伐隆化合物：式（I）：或其药学上可接受的衍生物在本说明书中所述的用于调节核激素受体的活性和用于预防和/或治疗与核激素受体活性有关的疾病或病症。

4. 发明授权

US09474774B2 Pyridine alkaloids, preparation process thereof, and the uses of the pyridine alkaloids 有权
标题翻译：吡啶生物碱，其制备方法以及吡啶生物碱的用途
公开(公告)号：US09474774B2
公开(公告)日：2016-10-25
申请号：US12981915
申请日：2010-12-30
申请人： Ming-Der Wu , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
发明人： Ming-Der Wu , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
IPC分类号： A61K45/06 , A61K36/062 , A61K31/44 , C07D213/80 , C12P17/12 , C12R1/645
CPC分类号： A61K36/062 , A61K31/44 , A61K45/06 , C07D213/80 , C12P17/12 , C12R1/645 , A61K2300/00
摘要： The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.

5. 发明申请

US20120164120A1 NOVEL MONASCUSPURPURONES, PREPARATION PROCESS THEREOF, AND USES OF THE MONASCUSPURPURONES 审中-公开
标题翻译：新世纪麻醉药品，其制备方法及其使用方法
公开(公告)号：US20120164120A1
公开(公告)日：2012-06-28
申请号：US13336234
申请日：2011-12-23
申请人： Ming-Jen Cheng , Ping-Hsun Yang , Ming-Der Wu , Shie-Jea Lin , Gwo-Fang Yuan , Yen-Lin Chen , Hsuen-Chun Liao , Kai-Ping Chen
发明人： Ming-Jen Cheng , Ping-Hsun Yang , Ming-Der Wu , Shie-Jea Lin , Gwo-Fang Yuan , Yen-Lin Chen , Hsuen-Chun Liao , Kai-Ping Chen
IPC分类号： A61K31/365 , A61K36/899 , A61K31/455 , A61K38/28 , A61K31/426 , C12P17/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/12 , A61P9/00 , C07D307/86 , A61P3/10
CPC分类号： C07D307/86 , A61K31/365 , A61K31/426 , A61K31/455 , A61K36/899 , A61K45/06 , A61K2236/19 , B01D15/18 , B01D15/424 , C12P17/04 , C12R1/645 , A61K2300/00
摘要： The present invention relates to a novel monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPARγ and/or C/EBPα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.
摘要翻译：本发明涉及如说明书中所述的式（I）的新型monascrourururur化合物或其药学上可接受的衍生物，其制备方法及其组合物。用于促进脂肪细胞分化，增加PPARγ和/或C /EBPα的活性以降低血糖，用于预防和/或治疗与胰岛素抵抗相关的疾病或障碍的用途，以及用于预防和/或还提供治疗代谢综合征或其并发症。

6. 发明申请

US20110165186A1 NOVEL PYRIDINE ALKALOIDS, PREPARATION PROCESS THEREOF, AND THE USES OF THE PYRIDINE ALKALOIDS 有权
标题翻译：新型吡啶类碱性物质，其制备方法以及吡啶类碱性物质的用途
公开(公告)号：US20110165186A1
公开(公告)日：2011-07-07
申请号：US12981915
申请日：2010-12-30
申请人： Ming-Der WU , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
发明人： Ming-Der WU , Ming-Jen Cheng , Shie-Jea Lin , Chi-Hua Chen , Yen-Lin Chen , Hui-Ping Chen , Kai-Ping Chen , Ping-Shin Yang , Shiow-Wen Chen , Gwo-Fang Yuan
IPC分类号： A61K36/062 , C07D213/80 , A61K31/44 , A61P3/04 , A61P3/10 , A61P9/00 , C12P17/12
CPC分类号： A61K36/062 , A61K31/44 , A61K45/06 , C07D213/80 , C12P17/12 , C12R1/645 , A61K2300/00
摘要： The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPARγ, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.
摘要翻译：本发明涉及式（I）的新型吡啶类生物碱化合物或其说明书所述的药学上可接受的衍生物，其制备方法及其组合物。还提供了吡啶化合物用于增加PPARγ的活性，用于预防和/或治疗与胰岛素抵抗有关的疾病或病症以及预防和/或治疗代谢综合征或其并发症的用途。本发明还提供红酵母发酵产物的提取物及其用于预防和/或治疗与胰岛素抵抗相关的疾病或病症如代谢综合征的用途。

7. 发明申请

US20060219696A1 Method for detecting the inclined status of hot plate 审中-公开
标题翻译：检测热板倾斜状态的方法
公开(公告)号：US20060219696A1
公开(公告)日：2006-10-05
申请号：US11098493
申请日：2005-04-05
申请人： Ming-Jen Cheng
发明人： Ming-Jen Cheng
IPC分类号： H05B3/68
CPC分类号： H05B3/68 , G03F7/168
摘要： A method for detecting the inclined status of a hot plate comprising selecting a sensitive photoresist coated on a wafer. A first wafer is positioned on a standard hot plate to perform a bake treatment. A stepping exposure with gradually changing light intensity is performed to obtain the minimum exposure energy of the thickness of the first photoresist layer. A second photoresist layer the same as the first wafer is coated on the surface of the second wafer, and positioned on a hot plate under test to perform a bake treatment. The second photoresist layer is exposed by a minimum exposure energy, thereby having the first photoresist layer being uniformly exposed or not to determine whether the hot plate under test is inclined or not.
摘要翻译：一种用于检测热板的倾斜状态的方法，包括选择涂覆在晶片上的敏感光刻胶。将第一晶片定位在标准热板上以进行烘烤处理。执行逐渐变化的光强度的步进曝光以获得第一光致抗蚀剂层的厚度的最小曝光能量。将与第一晶片相同的第二光致抗蚀剂层涂覆在第二晶片的表面上，并定位在被测试的热板上进行烘烤处理。第二光致抗蚀剂层以最小曝光能量曝光，从而使第一光致抗蚀剂层均匀地曝光或不能确定被测热板是否倾斜。

8. 发明申请

US20080123879A1 Digital wireless stereophonic music transmission device 审中-公开
标题翻译：数字无线立体声音乐传输装置
公开(公告)号：US20080123879A1
公开(公告)日：2008-05-29
申请号：US11606318
申请日：2006-11-28
申请人： Ming-Jen Cheng
发明人： Ming-Jen Cheng
IPC分类号： H04R5/02
CPC分类号： H04S3/004 , H04R2420/07 , H04S1/005 , H04S1/007 , H04S3/008 , H04S2400/01
摘要： A digital wireless stereophonic music transmission device includes a transmission module and a headphone. The transmission module includes a digital signal input device for receiving digital audio signals from an external digital music player, a stereophonic input device for receiving stereophonic signals from an external stereophonic music player, an analog/digital converter for converting the stereophonic signals into digital audio signals, and a signal transmitting module that receives digital audio signals from one of the digital signal input device and the analog/digital converter and then codes and transmits the signals received. The headphone includes a signal receiving module, an analog/digital converter, an amplifier, and at least one loudspeaker unit. The signal receiving module receives the signals from the signal transmitting module. The analog/digital converter of the headphone converts the signals received by the signal receiving module into analog audio signals that are output via the amplifier and the loudspeaker unit.
摘要翻译：数字无线立体声音乐传输装置包括传输模块和耳机。传输模块包括用于从外部数字音乐播放器接收数字音频信号的数字信号输入装置，用于从外部立体声音乐播放器接收立体声信号的立体声输入装置，用于将立体声信号转换成数字音频信号的模拟/数字转换器以及信号发送模块，其从数字信号输入装置和模拟/数字转换器之一接收数字音频信号，然后对所接收的信号进行编码和发送。耳机包括信号接收模块，模拟/数字转换器，放大器和至少一个扬声器单元。信号接收模块从信号发送模块接收信号。耳机的模拟/数字转换器将由信号接收模块接收的信号转换为通过放大器和扬声器单元输出的模拟音频信号。

9. 发明申请

US20080024994A1 COMBINATION HEAT SINK 审中-公开
标题翻译：组合式散热器
公开(公告)号：US20080024994A1
公开(公告)日：2008-01-31
申请号：US11491988
申请日：2006-07-25
申请人： Ming-Jen Cheng
发明人： Ming-Jen Cheng
IPC分类号： H05K7/20
CPC分类号： H01L23/3672 , H01L23/467 , H01L2924/0002 , H01L2924/00
摘要： A combination heat sink formed of a plurality of radiation fins radially fastened together to show a circular configuration having a top rounded recess that is defined by a notch on each radiation fin for gathering currents of air for enabling gathered currents of air to be guided by a curved surface portion of each radiation fin to the outside of the heat sink to carry heat away from the heat sink rapidly and efficiently. Each radiation fin has a coupling portion so arranged that the radiation fins are fastened together by securing the coupling portion of one radiation fin to the coupling portion of another without the use of any external fastening means of tools.
摘要翻译：由多个径向固定在一起的辐射翅片形成的组合散热片，以示出圆形结构，其具有顶部圆形凹槽，该顶部圆形凹槽由每个辐射翅片上的凹口限定，用于收集空气流，以使得能够通过每个辐射翅片的弯曲表面部分到散热器的外部，从而将热量快速有效地从散热器携带。每个辐射翅片具有一个联接部分，其布置成使得通过将一个辐射翅片的联接部分固定到另一个辐射翅片的联接部分而将散热片固定在一起，而不需要使用任何外部紧固装置。

10. 发明申请

US20070029068A1 Heat sink 审中-公开
标题翻译：散热器
公开(公告)号：US20070029068A1
公开(公告)日：2007-02-08
申请号：US11195632
申请日：2005-08-03
申请人： Ming-Jen Cheng , Yuh-Chieh Chu
发明人： Ming-Jen Cheng , Yuh-Chieh Chu
IPC分类号： H05K7/20
CPC分类号： H01L23/3672 , H01L2924/0002 , H01L2924/00
摘要： A heat sink has a base and multiple fins. The fins are attached to the base, and each fin has a radiating surface and a conducting surface. The conducting surface is formed on the radiating surface and has at least one side abutting the base. The base is attached to an integrated circuit to dissipate heat from the integrated circuit. Because at least one of the two sides of the conducting surfaces is in full contact with the base, more heat is conducted from the base to the fins. Therefore the heat sink can cool the integrated circuit effectively.
摘要翻译：散热器有一个底座和多个散热片。翅片附接到基座，并且每个翅片具有辐射表面和导电表面。导电表面形成在辐射表面上，并且至少一个侧面邻接底座。该基座连接到集成电路以从集成电路散热。因为导电表面的两侧中的至少一个与基底完全接触，所以从基底向鳍片传导更多的热量。因此，散热器可以有效地冷却集成电路。

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