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1. 发明授权

US06348333B1 VEGF-binding KDR polypeptide 失效
标题翻译： VEGF结合KDR多肽
公开(公告)号：US06348333B1
公开(公告)日：2002-02-19
申请号：US09142956
申请日：1999-03-04
申请人： Mikio Niwa , Masaji Okamoto , Tomoe Matsumoto , Toshiaki Segawa
发明人： Mikio Niwa , Masaji Okamoto , Tomoe Matsumoto , Toshiaki Segawa
IPC分类号： C07K1471
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.
摘要翻译：提供了新的多肽，其可用于治疗伴随新生血管形成的疾病，例如实体瘤，并且可用作低分子量VEGF抑制剂。该多肽包含VEGF受体KDR的细胞外结构域的免疫球蛋白样结构域1和免疫球蛋白样结构域2。由于其具有比具有保留VEGF抑制活性的常规多肽更小的分子量，因此预期其可以使用重组DNA技术容易地表达并更快地渗透到患病部位。

2. 发明授权

US06270993B1 VEGF-binding polypeptide 失效
标题翻译： VEGF结合多肽
公开(公告)号：US06270993B1
公开(公告)日：2001-08-07
申请号：US09051363
申请日：1998-07-15
申请人： Masabumi Shibuya , Masaji Okamoto , Mikio Niwa , Tomoe Matsumoto , Makoto Asano , Tosiaki Segawa
发明人： Masabumi Shibuya , Masaji Okamoto , Mikio Niwa , Tomoe Matsumoto , Makoto Asano , Tosiaki Segawa
IPC分类号： C07H2104
CPC分类号： C07K14/71
摘要： An object of the present invention is to provide a low molecular weight VEGF inhibitor that can be utilized to treat diseases accompanying neovascularization, such as solid tumors. It was found that a polypeptide containing immunoglobulin-like domain 1 and immunoglobulin-like domain 2 but neither immunoglobulin-like main 6 nor immunoglobulin-like domain 7 of the extracellular domain of the VEGF receptor FLT possess VEGF inhibitory activity.
摘要翻译：本发明的目的是提供可用于治疗伴随新生血管形成的疾病的低分子量VEGF抑制剂，例如实体瘤。已经发现，含有免疫球蛋白样结构域1和免疫球蛋白样结构域2但是VEGF受体FLT的细胞外结构域的免疫球蛋白样结构域6和免疫球蛋白样结构域7的多肽均具有VEGF抑制活性。

3. 发明申请

US20130345408A1 ANTIBODY AGAINST AMYLOID PRECURSOR PROTEIN SIGNAL PEPTIDE 有权
标题翻译：抗体蛋白前体蛋白信号肽抗体
公开(公告)号：US20130345408A1
公开(公告)日：2013-12-26
申请号：US13978584
申请日：2012-01-06
申请人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
发明人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C12N5/12
摘要： An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.
摘要翻译：本发明的一些方面的优点是提供抗淀粉样蛋白前体蛋白信号肽的抗体。本发明提供淀粉样蛋白前体蛋白信号肽。

4. 发明授权

US09309307B2 Antibody against amyloid precursor protein signal peptide 有权
标题翻译：抗淀粉样前体蛋白信号肽抗体
公开(公告)号：US09309307B2
公开(公告)日：2016-04-12
申请号：US13978584
申请日：2012-01-06
申请人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
发明人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
IPC分类号： C12N5/12 , C07K16/18
CPC分类号： C07K16/18 , C12N5/12
摘要： An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.
摘要翻译：本发明的一些方面的优点是提供抗淀粉样蛋白前体蛋白信号肽的抗体。本发明提供淀粉样蛋白前体蛋白信号肽。

5. 发明授权

US08673845B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08673845B2
公开(公告)日：2014-03-18
申请号：US13386582
申请日：2010-07-28
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
IPC分类号： A61K38/02 , A61K38/18 , C12N5/02
CPC分类号： A61K31/366 , A61K31/22 , A61K31/397 , A61K31/40 , A61K45/06 , A61K47/64 , C07K7/06 , A61K2300/00
摘要： The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：由本发明提供的转移异物的方法包括以下步骤：制备含有包含氨基酸序列WRRQARFK（SEQ ID NO.1）或任何氨基酸序列的载体肽片段的异物转移构建体通过氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成，以及与N末端和/或C末端键合的目的异物的载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

6. 发明申请

US20120122210A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 有权
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120122210A1
公开(公告)日：2012-05-17
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： C12N5/071 , C07K14/00 , C12N5/02
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

7. 发明授权

US07985831B2 Crohn's disease antibody epitope peptide and reagent for testing Crohn's disease 有权
标题翻译：克罗恩病抗体表位肽和用于测试克罗恩病的试剂
公开(公告)号：US07985831B2
公开(公告)日：2011-07-26
申请号：US11659345
申请日：2005-04-26
申请人： Mikio Niwa , Katsuhiko Matsuo , Keiichi Mitsuyama , Michio Sata
发明人： Mikio Niwa , Katsuhiko Matsuo , Keiichi Mitsuyama , Michio Sata
IPC分类号： A61K38/00 , A61K39/00 , A61K38/04
CPC分类号： G01N33/6893 , C07K14/4713 , G01N2800/065
摘要： An epitope peptide is provided, which is capable of binding specifically to an antibody characteristic of Crohn's disease that is specifically observed in patients with Crohn's disease, together with a test method for conveniently and rapidly determining whether a subject is affected by Crohn's disease by use of the above peptide. The epitope peptide to the Crohn's disease antibody comprises a peptide having an amino acid sequences represented by any one of SEQ ID NOS: 1 to 3 or a salt thereof. A test reagent and a test method for Crohn's disease are provided, which comprise the peptide as an active ingredient.
摘要翻译：提供表位肽，其能够特异性结合克隆氏病特异性克隆氏病特征性抗体，以及用于方便和快速地确定受试者是否受到克罗恩病影响的测试方法，所述测试方法通过使用上述肽。克罗恩病抗体的表位肽包含具有由SEQ ID NO：1至3中任一个表示的氨基酸序列的肽或其盐。提供了一种测试试剂和克罗恩病的试验方法，其包含肽作为活性成分。

8. 发明授权

US08603967B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08603967B2
公开(公告)日：2013-12-10
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： A61K38/04 , C07K7/00
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

9. 发明申请

US20090170115A1 Crohn's disease anitbody epitope peptide and reagent for testing crohn's disease 有权
标题翻译：克罗恩病anitbody表位肽和用于测试克罗恩病的试剂
公开(公告)号：US20090170115A1
公开(公告)日：2009-07-02
申请号：US11659345
申请日：2005-04-26
申请人： Mikio Niwa , Katsuhiko Matsuo , Keiichi Mitsuyama , Michio Sata
发明人： Mikio Niwa , Katsuhiko Matsuo , Keiichi Mitsuyama , Michio Sata
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： G01N33/6893 , C07K14/4713 , G01N2800/065
摘要： An epitope peptide is provided, which is capable of binding specifically to an antibody characteristic of Crohn's disease that is specifically observed in patients with Crohn's disease, together with a test method for conveniently and rapidly determining whether a subject is affected by Crohn's disease by use of the above peptide. The epitope peptide to the Crohn's disease antibody comprises a peptide having an amino acid sequences represented by any one of SEQ ID NOS: 1 to 3 or a salt thereof. A test reagent and a test method for Crohn's disease are provided, which comprise the peptide as an active ingredient.
摘要翻译：提供表位肽，其能够特异性结合克隆氏病特异性克隆氏病特征性抗体，以及用于方便和快速地确定受试者是否受到克罗恩病影响的测试方法，所述测试方法通过使用上述肽。克罗恩病抗体的表位肽包含具有由SEQ ID NO：1至3中任一个表示的氨基酸序列的肽或其盐。提供了一种测试试剂和克罗恩病的试验方法，其包含肽作为活性成分。

10. 发明申请

US20070283538A1 Clamp Device for Connection 失效
标题翻译：用于连接的夹具
公开(公告)号：US20070283538A1
公开(公告)日：2007-12-13
申请号：US11547672
申请日：2004-04-12
申请人： Norio Ito , Mikio Niwa
发明人： Norio Ito , Mikio Niwa
IPC分类号： F16L33/08
CPC分类号： F16L33/08 , Y10T24/1416 , Y10T24/1427 , Y10T24/1441 , Y10T24/1457
摘要： A clamping device (1) for connection in which a housing (4) rotatably accommodates a worm screw (5) to mesh with an array of teeth portion (6) of a strap band (3). The strap band (3) is diametrically contracted upon operating the worm screw (5) to wind the strap band (3) around a connecting portion (2). One end portion of the strap band (3) in which the array of teeth portion (6) resides, is formed into a wavy and concavo-convex configuration in its width direction, thus increasing a meshing area of the array of teeth portion (6) against the worm screw (5). This makes it possible for the strap band (3) to cope with a situation in which the strap band (3) is required to tightly wind the connecting portion (2) with a high tightening force.
摘要翻译：一种用于连接的夹紧装置（1），其中壳体（4）可旋转地容纳蜗杆（5）以与带带（3）的齿部分（6）的阵列啮合。在操作蜗杆（5）时，带束带（3）径向收缩，以使带条（3）围绕连接部分（2）缠绕。齿带部分（6）所在的带带（3）的一个端部在其宽度方向上形成波浪形和凹凸形状，从而增加齿部（6）阵列的啮合面积）抵靠蜗杆（5）。这使得带带（3）可以应对需要带带（3）以高的紧固力紧紧地卷绕连接部分（2）的情况。

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