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1. 发明申请

US20130345408A1 ANTIBODY AGAINST AMYLOID PRECURSOR PROTEIN SIGNAL PEPTIDE 有权
标题翻译：抗体蛋白前体蛋白信号肽抗体
公开(公告)号：US20130345408A1
公开(公告)日：2013-12-26
申请号：US13978584
申请日：2012-01-06
申请人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
发明人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C12N5/12
摘要： An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.
摘要翻译：本发明的一些方面的优点是提供抗淀粉样蛋白前体蛋白信号肽的抗体。本发明提供淀粉样蛋白前体蛋白信号肽。

2. 发明授权

US09309307B2 Antibody against amyloid precursor protein signal peptide 有权
标题翻译：抗淀粉样前体蛋白信号肽抗体
公开(公告)号：US09309307B2
公开(公告)日：2016-04-12
申请号：US13978584
申请日：2012-01-06
申请人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
发明人： Hitoshi Fukushima , Masato Hanamura , Mikio Niwa , Masaji Okamoto , Tomoko Naoe , Tetsuhiko Yoshida
IPC分类号： C12N5/12 , C07K16/18
CPC分类号： C07K16/18 , C12N5/12
摘要： An advantage of some aspects of the invention is to provide an antibody against an amyloid precursor protein signal peptide. The invention provides an amyloid precursor protein signal peptide.
摘要翻译：本发明的一些方面的优点是提供抗淀粉样蛋白前体蛋白信号肽的抗体。本发明提供淀粉样蛋白前体蛋白信号肽。

3. 发明授权

US06348333B1 VEGF-binding KDR polypeptide 失效
标题翻译： VEGF结合KDR多肽
公开(公告)号：US06348333B1
公开(公告)日：2002-02-19
申请号：US09142956
申请日：1999-03-04
申请人： Mikio Niwa , Masaji Okamoto , Tomoe Matsumoto , Toshiaki Segawa
发明人： Mikio Niwa , Masaji Okamoto , Tomoe Matsumoto , Toshiaki Segawa
IPC分类号： C07K1471
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.
摘要翻译：提供了新的多肽，其可用于治疗伴随新生血管形成的疾病，例如实体瘤，并且可用作低分子量VEGF抑制剂。该多肽包含VEGF受体KDR的细胞外结构域的免疫球蛋白样结构域1和免疫球蛋白样结构域2。由于其具有比具有保留VEGF抑制活性的常规多肽更小的分子量，因此预期其可以使用重组DNA技术容易地表达并更快地渗透到患病部位。

4. 发明授权

US08673845B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08673845B2
公开(公告)日：2014-03-18
申请号：US13386582
申请日：2010-07-28
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
IPC分类号： A61K38/02 , A61K38/18 , C12N5/02
CPC分类号： A61K31/366 , A61K31/22 , A61K31/397 , A61K31/40 , A61K45/06 , A61K47/64 , C07K7/06 , A61K2300/00
摘要： The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：由本发明提供的转移异物的方法包括以下步骤：制备含有包含氨基酸序列WRRQARFK（SEQ ID NO.1）或任何氨基酸序列的载体肽片段的异物转移构建体通过氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成，以及与N末端和/或C末端键合的目的异物的载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

5. 发明申请

US20120122210A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 有权
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120122210A1
公开(公告)日：2012-05-17
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： C12N5/071 , C07K14/00 , C12N5/02
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

6. 发明授权

US08603967B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08603967B2
公开(公告)日：2013-12-10
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： A61K38/04 , C07K7/00
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

7. 发明授权

US06270993B1 VEGF-binding polypeptide 失效
标题翻译： VEGF结合多肽
公开(公告)号：US06270993B1
公开(公告)日：2001-08-07
申请号：US09051363
申请日：1998-07-15
申请人： Masabumi Shibuya , Masaji Okamoto , Mikio Niwa , Tomoe Matsumoto , Makoto Asano , Tosiaki Segawa
发明人： Masabumi Shibuya , Masaji Okamoto , Mikio Niwa , Tomoe Matsumoto , Makoto Asano , Tosiaki Segawa
IPC分类号： C07H2104
CPC分类号： C07K14/71
摘要： An object of the present invention is to provide a low molecular weight VEGF inhibitor that can be utilized to treat diseases accompanying neovascularization, such as solid tumors. It was found that a polypeptide containing immunoglobulin-like domain 1 and immunoglobulin-like domain 2 but neither immunoglobulin-like main 6 nor immunoglobulin-like domain 7 of the extracellular domain of the VEGF receptor FLT possess VEGF inhibitory activity.
摘要翻译：本发明的目的是提供可用于治疗伴随新生血管形成的疾病的低分子量VEGF抑制剂，例如实体瘤。已经发现，含有免疫球蛋白样结构域1和免疫球蛋白样结构域2但是VEGF受体FLT的细胞外结构域的免疫球蛋白样结构域6和免疫球蛋白样结构域7的多肽均具有VEGF抑制活性。

8. 发明授权

US09365618B2 Synthetic peptide that induces expression of TNF receptor 2 and use thereof 有权
标题翻译：诱导TNF受体2表达的合成肽及其用途
公开(公告)号：US09365618B2
公开(公告)日：2016-06-14
申请号：US14114010
申请日：2012-04-17
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
IPC分类号： C07K7/08 , C07K7/06 , C07K14/715 , C07K14/47 , A61K35/12 , A61K38/10 , A61K35/28 , A61K35/26
CPC分类号： C07K7/08 , A61K35/26 , A61K35/28 , A61K38/10 , A61K2035/126 , C07K7/06 , C07K14/4705 , C07K14/7151 , C07K2319/09
摘要： This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a method for producing cells that express TNFR2 selectively by use of the composition. The cell production method provided by this invention includes: culturing at least one species of cells capable of expressing TNF receptor 2, and supplying the cells with a synthetic peptide consisting of a nuclear localization signal sequence (NLS) or a nucleolar localization signal sequence (NoLS) to enhance TNFR2 expression in the cells.
摘要翻译：本发明提供一种TNFR2表达诱导组合物，其包含作为活性成分的具有TNFR2表达诱导活性的肽，以及通过使用该组合物选择性地生成表达TNFR2的细胞的方法。本发明提供的细胞制备方法包括：培养能够表达TNF受体2的至少一种细胞，向细胞提供由核定位信号序列（NLS）或核仁定位信号序列（NoLS）组成的合成肽）以增强细胞中TNFR2的表达。

9. 发明授权

US08673846B2 Cell proliferation-promoting peptide and use thereof 有权
标题翻译：细胞增殖促进肽及其用途
公开(公告)号：US08673846B2
公开(公告)日：2014-03-18
申请号：US13503220
申请日：2010-10-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
IPC分类号： A61K38/02 , A61K38/18 , C12N5/02
CPC分类号： C12N5/0662 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/475 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C12N5/0018 , C12N2501/998
摘要： A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence.
摘要翻译：细胞增殖促进剂包括作为活性成分的人造合成肽，其包含（A）构成膜可渗透肽的氨基酸序列和（B）选自SEQ ID NO：19至103的氨基酸序列或氨基酸通过在所选择的氨基酸序列中取代，缺失和/或添加一个或几个氨基酸残基形成的酸序列。

10. 发明申请

US20140051647A1 SYNTHETIC PEPTIDE THAT INDUCES EXPRESSION OF TNF RECEPTOR 2 AND USE THEREOF 有权
标题翻译：诱导TNF受体2表达的合成肽及其用途
公开(公告)号：US20140051647A1
公开(公告)日：2014-02-20
申请号：US14114010
申请日：2012-04-17
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , A61K35/26 , A61K35/28 , A61K38/10 , A61K2035/126 , C07K7/06 , C07K14/4705 , C07K14/7151 , C07K2319/09
摘要： This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a method for producing cells that express TNFR2 selectively by use of the composition. The cell production method provided by this invention includes: culturing at least one species of cells capable of expressing TNF receptor 2, and supplying the cells with a synthetic peptide consisting of a nuclear localization signal sequence (NLS) or a nucleolar localization signal sequence (NoLS) to enhance TNFR2 expression in the cells.
摘要翻译：本发明提供一种TNFR2表达诱导组合物，其包含作为活性成分的具有TNFR2表达诱导活性的肽，以及通过使用该组合物选择性地生成表达TNFR2的细胞的方法。本发明提供的细胞制备方法包括：培养能够表达TNF受体2的至少一种细胞，向细胞提供由核定位信号序列（NLS）或核仁定位信号序列（NoLS）组成的合成肽）以增强细胞中TNFR2的表达。

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