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1. 发明授权

US06197299B1 Antibody conjugates 失效
标题翻译：抗体缀合物
公开(公告)号：US06197299B1
公开(公告)日：2001-03-06
申请号：US09154310
申请日：1998-09-16
申请人： Mikael Dohlsten , Eva Åkerblom , Peter A. Lando , Terje Kalland , Gunnar Hedlund
发明人： Mikael Dohlsten , Eva Åkerblom , Peter A. Lando , Terje Kalland , Gunnar Hedlund
IPC分类号： A61K39395
CPC分类号： A61K39/385 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K16/28
摘要： A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections. The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.
摘要翻译：一种可溶性抗体缀合物，其包含与由T细胞识别并具有引导T细胞裂解靶细胞的能力的抗体连接的抗体，其被抗体识别。缀合物的特征在于结构是超抗原。一种重要的模式是用于裂解靶细胞的方法，其中靶细胞与靶细胞裂解有效量的缀合物接触。溶解的方法是癌症，自身免疫，寄生虫感染和真菌，病毒和细菌感染的有效治疗方案的一部分。说明书还描述了诸如缀合物的合成和药物组合物及其制造的模式。

2. 发明授权

US6042837A Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC) 失效
标题翻译：葡萄球菌肠毒素定向细胞介导的细胞毒性（SDCC）
公开(公告)号：US6042837A
公开(公告)日：2000-03-28
申请号：US596555
申请日：1996-02-05
申请人： Terje Kalland , Gunnar Hedlund , Mikael Dohlsten , Peter Lando
发明人： Terje Kalland , Gunnar Hedlund , Mikael Dohlsten , Peter Lando
IPC分类号： A61K38/16 , A61P31/04 , A61K39/085
CPC分类号： A61K38/164
摘要： Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC), including methods of lysing malignant cells expressing MHC Class II antigens using SDCC, by the administration of staphylococcal enterotoxin to a living body.
摘要翻译：葡萄球菌肠毒素定向细胞介导的细胞毒性（SDCC）的方法，包括通过将葡萄球菌肠毒素施用于活体来裂解使用SDCC表达MHC II类抗原的恶性细胞的方法。

3. 发明授权

US5858363A Target specific antibody-superantigen conjugates and their preparation 失效
标题翻译：靶向特异性抗体 - 超抗原共轭物及其制备
公开(公告)号：US5858363A
公开(公告)日：1999-01-12
申请号：US485706
申请日：1995-06-07
申请人： Mikael Dohlsten , Eva Akerblom , Gunnar Hedlund , Peter A. Lando
发明人： Mikael Dohlsten , Eva Akerblom , Gunnar Hedlund , Peter A. Lando
IPC分类号： A61K39/385 , C07K16/28 , A61K39/395 , C07K16/00
CPC分类号： A61K39/385 , C07K16/28 , A61K2039/505 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
摘要： A soluble antibody conjugate comprising an antibody linked to a structure which is recognizable by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure being a superantigen. One important mode is a method for the lysis of target cells, wherein the target cells are contacted with a target cell lysis effective amount of the conjugate. The method of lysis is part of a potent treatment regime for cancer, autoimmunity, parasitic infestations and fungal, viral and bacterial infections The specification also describes modes such as the synthesis of the conjugate and pharmaceutical compositions and their manufacture.
摘要翻译：一种可溶性抗体缀合物，其包含与T细胞可识别的结构连接的抗体，并具有引导T细胞裂解靶细胞的能力，其被抗体识别。缀合物的特征在于结构是超抗原。一种重要的模式是用于裂解靶细胞的方法，其中靶细胞与靶细胞裂解有效量的缀合物接触。裂解的方法是癌症，自身免疫，寄生虫感染和真菌，病毒和细菌感染的有效治疗方案的一部分。本说明书还描述了诸如缀合物的合成和药物组合物及其制备的模式。

4. 发明授权

US06395750B1 Drugs for the treatment of malignant tumors 有权
公开(公告)号：US06395750B1
公开(公告)日：2002-05-28
申请号：US09694757
申请日：2000-10-24
申请人： Gunnar Hedlund , Karl Jansson , Stig Jönsson , Anders Björk
发明人： Gunnar Hedlund , Karl Jansson , Stig Jönsson , Anders Björk
IPC分类号： A61K3147
CPC分类号： A61K31/47 , C07D215/54 , C07D215/56
摘要： The invention relates to a method for the treatment of tumors in mammals by the administration of compounds of the general formula (I) wherein A is O41 or NR42 R43 wherein R41 is hydrogen or a pharmaceutically acceptable inorganic or organic cation, or CORA wherein RA is alkyl and aryl; R42 and R43 are hydrogen, C1-C4-alkyl, cyclopropyl, cyclopentyl or cyclohexyl; or R42 is benzyl or phenethyl, optionally mono- or disubstituted by methyl, iso-propyl methoxy, fluoro, chloro, bromo, dimethylamino, trifluoromethyl or nitro and R43 is hydrogen; or R42 and R43 form a 5- or 6-membered ring; or R42 is CORB wherein RB is alkyl or aryl, —CH2N(CH3)2 or —CH2CH2COOH or CORB is a 2-acyloxymethylbenzoyl group wherein RC is methyl, ethyl, phenyl or benzyl; R42 is COORD wherein RD is C1-C4-alkyl, phenyl or benzyl; or R42 is —CH2OCO-tert.-butyl or R42 is CONRFRG wherein RF and RG are C1-C4-alkyl; or R42 is CXNHRE wherein X is O or S and RE is C1-C4-alkyl, C2-C4-alkyl functionalized with an tertiary amino group, or phenyl, optionally functionalised with a p-chloro group; or R42 is CH2NRHRI wherein RH and RI are C1-C4-alkyl and RH and RI form a morpholine ring and R43 is hydrogen, C1-C2-alkyl or cyclopropyl; R is hydrogen, C1-C4-alkyl or allyl; with the proviso that R is not hydrogen when A is OR41; R′ is hydrogen, methyl, methoxy, fluoro, chloro, bromo, cyano, nitro, azido, trifluoromethyl, or OCHxFy, wherein x=0-2, y=1-3 with the proviso that x+y=3; and that R′ is not hydrogen when R is methyl and A is OR41; R″ is hydrogen, fluoro or chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; R5 is hydrogen, C1-C3-alkyl; methoxy, ethoxy, thio-C1-C3-alkyl fluoro, chloro, bromo, trifluoromethyl, nitro, amino, dimethylamino or OCHxFy, or OCH2CHxFy wherein x=0-2, y=1-3 with the proviso that x+y=3 and that R5 is not fluoro or amino when A is OR41; and that R5 is hydrogen only when A is NR42 R43 and R′ is trifluoromethyl; R6 is hydrogen; or R5 and R6 taken together are methylenedioxy, or any tautomer, optical isomer or racemate thereof. The invention also comprises novel compounds, therapeutic compositions and processes for the preparation of the compounds of formula I.

5. 发明授权

US4748362A D. C. motor with multi-tooth poles 失效
标题翻译： D.多马杆电机
公开(公告)号：US4748362A
公开(公告)日：1988-05-31
申请号：US884584
申请日：1986-07-11
申请人： Gunnar Hedlund
发明人： Gunnar Hedlund
IPC分类号： H02K29/00 , H02K20060101 , H02K1/06 , H02K19/06 , H02K19/10 , H02K23/42 , H02K29/06 , H02K1/14 , H02K17/12
CPC分类号： H02K1/246 , H02K19/06 , H02K19/103 , H02K29/06
摘要： A variable reluctance motor fed by D.C. pulses is controlled by a rotation sensor. The motor has at least two phases. The stator is designed as a continuous magnetic circuit with two stator poles per phase. The stator poles for the different phases are arranged in sequence along the periphery of the rotor so that each pole adjoins poles pertaining to another phase, and such that diametrically opposed poles pertain to the same phase, each stator pole having at least two teeth per stator pole. The rotor is provided with teeth that cooperate with the stator teeth. The spaces between adjacent stator poles are shorter than the spaces between the teeth of any one stator pole.
摘要翻译：由D.C.脉冲馈送的可变磁阻电动机由旋转传感器控制。电机至少有两相。定子被设计为每相具有两个定子极点的连续磁路。用于不同相的定子极沿着转子的周边依次布置，使得每个极与相邻的相邻极相邻，并且使直径相对的极与相同的相位相关，每个定子极每个定子具有至少两个齿极。转子设有与定子齿配合的齿。相邻定子极之间的空间比任何一个定子极的齿之间的空间短。

6. 发明授权

US07540277B2 Fuel system for a vibratory rammer 有权
标题翻译：用于振动夯的燃油系统
公开(公告)号：US07540277B2
公开(公告)日：2009-06-02
申请号：US11700030
申请日：2007-01-31
申请人： Gunnar Hedlund
发明人： Gunnar Hedlund
IPC分类号： F02M33/00 , F02M37/00 , F02M5/00
CPC分类号： F02M37/007 , F02B63/02 , F02M17/04 , F02M37/20
摘要： A fuel system (1) for a vibratory rammer (2) includes a tank arrangement (3), a diaphragm carburetor (4), a fuel line arrangement (5) and a venting line arrangement (6) for complementary venting of air from the fuel system (1) to the atmosphere. The fuel system (1) also includes a venting valve (7) which is open and closeable to the atmosphere. The tank arrangement (3) includes a primary fuel tank (8) and a secondary fuel tank (11).
摘要翻译：用于振动夯锤（2）的燃料系统（1）包括油箱装置（3），隔膜化油器（4），燃料管线装置（5）和排气管路装置（6），用于将空气燃油系统（1）到大气。燃料系统（1）还包括可与大气敞开和关闭的通气阀（7）。油箱装置（3）包括主燃料箱（8）和辅助燃料箱（11）。

7. 发明申请

US20070193566A1 Fuel system for a vibratory rammer 有权
标题翻译：用于振动夯的燃油系统
公开(公告)号：US20070193566A1
公开(公告)日：2007-08-23
申请号：US11700030
申请日：2007-01-31
申请人： Gunnar Hedlund
发明人： Gunnar Hedlund
IPC分类号： F02B13/00 , F02N17/00
CPC分类号： F02M37/007 , F02B63/02 , F02M17/04 , F02M37/20
摘要： A fuel system (1) for a vibratory rammer (2) includes a tank arrangement (3), a diaphragm carburetor (4), a fuel line arrangement (5) and a venting line arrangement (6) for complementary venting of air from the fuel system (1) to the atmosphere. The fuel system (1) also includes a venting valve (7) which is open and closeable to the atmosphere. The tank arrangement (3) includes a primary fuel tank (8) and a secondary fuel tank (11).
摘要翻译：用于振动夯锤（2）的燃料系统（1）包括油箱装置（3），隔膜化油器（4），燃料管线装置（5）和排气管路装置（6），用于将空气燃油系统（1）到大气。燃料系统（1）还包括可与大气敞开和关闭的通气阀（7）。油箱装置（3）包括主燃料箱（8）和辅助燃料箱（11）。

8. 发明授权

US06593343B2 Quinoline derivatives 有权
标题翻译：喹啉衍生物
公开(公告)号：US06593343B2
公开(公告)日：2003-07-15
申请号：US10131176
申请日：2002-04-25
申请人： Anders Björk , Stig Jönsson , Tomas Fex , Gunnar Hedlund
发明人： Anders Björk , Stig Jönsson , Tomas Fex , Gunnar Hedlund
IPC分类号： A61K314704
CPC分类号： C07D215/56
摘要： Compounds of formula (I) and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.
摘要翻译：式（I）化合物及其互变异构体对于治疗患有由自身免疫和病理性炎症引起的疾病的哺乳动物是有效的。

9. 发明授权

US5043643A Energizing system for a variable reluctance motor 失效
标题翻译：用于可变磁阻电机的励磁系统
公开(公告)号：US5043643A
公开(公告)日：1991-08-27
申请号：US198816
申请日：1988-05-26
申请人： Gunnar Hedlund , Henrik Lundberg
发明人： Gunnar Hedlund , Henrik Lundberg
IPC分类号： H02P6/08 , H02P6/18 , H02P25/08
CPC分类号： H02P6/18 , H02P25/089
摘要： Drive system for a variable reluctance motor having a pulsated drive. The motor has a stator provided with one or more windings for one or more phases, and a rotor which, upon rotation, co-acts with the magnetic circuit in each stator phase and produces in the magnetic circuit for each stator winding a permeance which changes with changes in the rotor angle. A sensing and control circuit (1-10) senses the inductance in the phase winding (L1, L2, L3) in each phase, at least during a part of a rotor revolution. Upon the indication of a pre-determined inductance L.sub.k, the circuit permits the rotational position of the rotor at which the determined inductance L.sub.k was indicated to constitute a starting point for determining a rotational position .theta..sub.OFF) for changing the energized state of the phase winding.

10. 发明申请

US20060057111A1 Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent 有权
标题翻译：用超抗原与另一种抗癌剂联合治疗过度增殖性疾病
公开(公告)号：US20060057111A1
公开(公告)日：2006-03-16
申请号：US11202507
申请日：2005-08-12
申请人： Gunnar Hedlund , Goran Forsberg , Marie Wallen-ohman
发明人： Gunnar Hedlund , Goran Forsberg , Marie Wallen-ohman
IPC分类号： A61K38/16 , A61K31/7072
CPC分类号： A61K39/00 , A61K31/7072 , A61K33/24 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K45/06 , A61K47/6811 , A61K47/6851 , C07K14/31 , C07K2319/30 , C07K2319/33 , A61K2300/00
摘要： The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.
摘要翻译：本发明涉及通过施用肿瘤靶向的超抗原和化学治疗剂来治疗受到例如癌症的过度增殖性疾病影响的哺乳动物的方法，由此施用肿瘤靶向的超抗原和化学治疗剂降低抗体应答并增强T细胞反应。将超抗原，野生型或修饰的融合到寻靶部位，例如抗体或抗体活性片段。超抗原和化学治疗剂的组合给药在治疗的动物中提供增强的治疗效果。

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