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1. 发明授权

US06593343B2 Quinoline derivatives 有权
标题翻译：喹啉衍生物
公开(公告)号：US06593343B2
公开(公告)日：2003-07-15
申请号：US10131176
申请日：2002-04-25
申请人： Anders Björk , Stig Jönsson , Tomas Fex , Gunnar Hedlund
发明人： Anders Björk , Stig Jönsson , Tomas Fex , Gunnar Hedlund
IPC分类号： A61K314704
CPC分类号： C07D215/56
摘要： Compounds of formula (I) and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.
摘要翻译：式（I）化合物及其互变异构体对于治疗患有由自身免疫和病理性炎症引起的疾病的哺乳动物是有效的。

2. 发明授权

US06605616B1 Quinoline derivatives 有权
标题翻译：喹啉衍生物
公开(公告)号：US06605616B1
公开(公告)日：2003-08-12
申请号：US09621486
申请日：2000-07-21
申请人： Anders Björk , Stig Jönsson , Tomas Fex , Gunnar Hedlund
发明人： Anders Björk , Stig Jönsson , Tomas Fex , Gunnar Hedlund
IPC分类号： A61K314704
CPC分类号： C07D215/56
摘要： The invention is related to compounds of general formula (I) wherein R is methyl, ethyl, n-propyl, iso-propyl, n-butyl or allyl; R′ is methyl, methoxy, fluoro, chloro, bromo, azido, trifluorometlhyl, or OCHxFy, wherein x=0−2, y=1−3 with the. proviso that x+y=3; R″ is hydrogen, fluoro or chloro; with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; R4 is hydrogen or pharmaceutically acceptable inorganic or organic cations; R5 is dimethylamino or nitro; R6 is hydrogen; and when R′ is azido R5 is also ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCHxFy, wherein x=0−2, y=1−3 with the proviso that x+y=3, or R5 and R6 taken together are methylenedioxy; and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of the general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation by administering of a compound having the formula (I) to said mammal.
摘要翻译：本发明涉及通式（I）的化合物，其中R是甲基，乙基，正丙基，异丙基，正丁基或烯丙基; R'是甲基，甲氧基，氟，氯，溴，叠氮基，三氟甲基或OCH x Fy，其中x = 0-2，y = 1-3。条件是x + y = 3; R“是氢，氟或氯; 条件是仅当R'为氟或氯时R“为氟或氯; R4是氢或药学上可接受的无机或有机阳离子; R5是二甲基氨基或硝基; R6是氢; 当R'为叠氮基时，R 5也是乙基，正丙基，异丙基，甲氧基，乙氧基，氯，溴，三氟甲基，OCH x Fy，其中x = 0-2，y = 1-3，条件是x + y = 3，或R5和R6一起是亚甲二氧基; 及其互变异构体。本发明还涉及含有通式（I）的化合物与药学上可接受的载体的药物组合物。还包括制备式（I）化合物的方法，以及通过向所述哺乳动物施用具有式（I）的化合物来治疗患有由自身免疫和病理性炎症引起的疾病的哺乳动物的方法。

3. 发明授权

US06395750B1 Drugs for the treatment of malignant tumors 有权
公开(公告)号：US06395750B1
公开(公告)日：2002-05-28
申请号：US09694757
申请日：2000-10-24
申请人： Gunnar Hedlund , Karl Jansson , Stig Jönsson , Anders Björk
发明人： Gunnar Hedlund , Karl Jansson , Stig Jönsson , Anders Björk
IPC分类号： A61K3147
CPC分类号： A61K31/47 , C07D215/54 , C07D215/56
摘要： The invention relates to a method for the treatment of tumors in mammals by the administration of compounds of the general formula (I) wherein A is O41 or NR42 R43 wherein R41 is hydrogen or a pharmaceutically acceptable inorganic or organic cation, or CORA wherein RA is alkyl and aryl; R42 and R43 are hydrogen, C1-C4-alkyl, cyclopropyl, cyclopentyl or cyclohexyl; or R42 is benzyl or phenethyl, optionally mono- or disubstituted by methyl, iso-propyl methoxy, fluoro, chloro, bromo, dimethylamino, trifluoromethyl or nitro and R43 is hydrogen; or R42 and R43 form a 5- or 6-membered ring; or R42 is CORB wherein RB is alkyl or aryl, —CH2N(CH3)2 or —CH2CH2COOH or CORB is a 2-acyloxymethylbenzoyl group wherein RC is methyl, ethyl, phenyl or benzyl; R42 is COORD wherein RD is C1-C4-alkyl, phenyl or benzyl; or R42 is —CH2OCO-tert.-butyl or R42 is CONRFRG wherein RF and RG are C1-C4-alkyl; or R42 is CXNHRE wherein X is O or S and RE is C1-C4-alkyl, C2-C4-alkyl functionalized with an tertiary amino group, or phenyl, optionally functionalised with a p-chloro group; or R42 is CH2NRHRI wherein RH and RI are C1-C4-alkyl and RH and RI form a morpholine ring and R43 is hydrogen, C1-C2-alkyl or cyclopropyl; R is hydrogen, C1-C4-alkyl or allyl; with the proviso that R is not hydrogen when A is OR41; R′ is hydrogen, methyl, methoxy, fluoro, chloro, bromo, cyano, nitro, azido, trifluoromethyl, or OCHxFy, wherein x=0-2, y=1-3 with the proviso that x+y=3; and that R′ is not hydrogen when R is methyl and A is OR41; R″ is hydrogen, fluoro or chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; R5 is hydrogen, C1-C3-alkyl; methoxy, ethoxy, thio-C1-C3-alkyl fluoro, chloro, bromo, trifluoromethyl, nitro, amino, dimethylamino or OCHxFy, or OCH2CHxFy wherein x=0-2, y=1-3 with the proviso that x+y=3 and that R5 is not fluoro or amino when A is OR41; and that R5 is hydrogen only when A is NR42 R43 and R′ is trifluoromethyl; R6 is hydrogen; or R5 and R6 taken together are methylenedioxy, or any tautomer, optical isomer or racemate thereof. The invention also comprises novel compounds, therapeutic compositions and processes for the preparation of the compounds of formula I.

4. 发明申请

US20120128842A1 POROUS POLYMERIC SEPARATION MATERIAL 审中-公开
标题翻译：多孔聚合物分离材料
公开(公告)号：US20120128842A1
公开(公告)日：2012-05-24
申请号：US13321279
申请日：2010-05-18
申请人： Stig Jönsson , Ecevit Yilmaz , Sanja Bevowich
发明人： Stig Jönsson , Ecevit Yilmaz , Sanja Bevowich
IPC分类号： A23L1/015 , A23K1/00 , C08J9/00 , A23L1/00
CPC分类号： C08J9/36 , A23L5/273 , A23V2002/00 , B01D15/00 , B01J20/223 , B01J20/26 , B01J20/261 , B01J20/267 , B01J20/28057 , B01J20/28059 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28083 , C08J2205/042 , C08J2325/02
摘要： The present invention relates to a mesoporous polymeric separation material comprising one or more functional groups bound to metal ions from Cu, Zn, Ag, or Pd. Methods of producing the material, as well as methods for its preparation, and use of said material in separation of pesticides from food or feed products is disclosed.
摘要翻译：本发明涉及一种介孔聚合物分离材料，其包含与Cu，Zn，Ag或Pd的金属离子结合的一个或多个官能团。公开了生产该材料的方法及其制备方法，以及所述材料用于将农药与食品或饲料产品分离的方法。

5. 发明授权

US07074831B2 Compounds, methods for their preparation and use thereof 失效
标题翻译：化合物，其制备方法和用途
公开(公告)号：US07074831B2
公开(公告)日：2006-07-11
申请号：US11050430
申请日：2005-02-04
申请人： Stig Jönsson , Gunnar Andersson , Ulf Wellmar , Ingela Fritzson
发明人： Stig Jönsson , Gunnar Andersson , Ulf Wellmar , Ingela Fritzson
IPC分类号： A61K31/192 , C07C65/105
CPC分类号： C07C233/54 , C07C233/63 , C07C233/75 , C07C235/56 , C07C275/36 , C07C323/59 , C07C323/63 , C07C2601/02 , C07D207/06 , C07D211/14 , C07D295/096 , C07D295/155
摘要： Compounds of formula (I) for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.
摘要翻译：用于临床治疗自身免疫疾病，炎性疾病，器官移植排斥和恶性肿瘤的式（I）化合物。一种药物组合物，其包含给予每日剂量为0.005mg / kg至10mg / kg体重，特别是0.025mg / kg至2mg / kg体重的式（I）化合物。

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