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1. 发明申请

WO2013027054A3 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 审中-公开
公开(公告)号：WO2013027054A3
公开(公告)日：2013-02-28
申请号：PCT/GB2012/052053
申请日：2012-08-22
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.

2. 发明申请

WO2012120297A1 DC ION GUIDE FOR ANALYTICAL FILTERING/SEPARATION 审中-公开
标题翻译：用于分析过滤/分离的直流离子指南
公开(公告)号：WO2012120297A1
公开(公告)日：2012-09-13
申请号：PCT/GB2012/050502
申请日：2012-03-07
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42
CPC分类号： G21K1/00 , H01J49/062 , H01J49/28 , H01J49/427
摘要： An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage 103 to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first (y) direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second (z) direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second (z) direction.
摘要翻译：公开了一种离子导向器，其包括多个电极。第一装置被布置并适于将RF电压103施加到至少一些电极，以在使用中形成用于在离子导向器内以第一（y）方向限制离子的伪电位阱。第二装置被布置并适于将DC电压施加到至少一些电极，以便在使用中形成用于将离子限制在离子导向器内的第二（z）方向上的DC势阱。第三装置被布置并适于使具有期望或不期望质量的充电比例的离子成为在第二（z）方向上从离子导向器选择性地喷射的质荷比。

3. 发明申请

WO2013027055A1 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 审中-公开
标题翻译：离子阱与空间扩展离子捕获区域
公开(公告)号：WO2013027055A1
公开(公告)日：2013-02-28
申请号：PCT/GB2012/052054
申请日：2012-08-22
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译：公开了将离子引导到小的喷射区域中的质量或质量比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。二次直流电势的曲线沿着第二（x）方向逐渐变化。

4. 发明申请

WO2012056239A1 ASYMMETRIC FIELD ION MOBILITY IN A LINEAR GEOMETRY ION TRAP 审中-公开
标题翻译：线性几何离子阱中的不对称场离子移动
公开(公告)号：WO2012056239A1
公开(公告)日：2012-05-03
申请号：PCT/GB2011/052085
申请日：2011-10-26
申请人： Micromass UK Limited , GREEN, Martin Raymond , GILES, Kevin , LANGRIDGE, David J.
发明人： GREEN, Martin Raymond , GILES, Kevin , LANGRIDGE, David J.
IPC分类号： G01N27/62 , H01J49/00
CPC分类号： H01J49/04 , G01N27/622 , H01J49/0031 , H01J49/36 , H01J49/422
摘要： A linear ion trap is disclosed wherein an asymmetric voltage waveform is applied to electrodes forming the ion trap which causes ions to become radially separated according to their differential ion mobility. An axial potential barrier is arranged at the exit of the ion trap such that ions having a first differential ion mobility and a first radial displacement are retained axially within the ion trap but ions having a second differential ion mobility and a second radial displacement are ejected axially from the ion trap.
摘要翻译：公开了一种线性离子阱，其中对形成离子阱的电极施加不对称电压波形，这导致离子根据其离子迁移率的差异而径向分离。轴向势垒布置在离子阱的出口处，使得具有第一差分离子迁移率和第一径向位移的离子轴向保留在离子阱内，但具有第二差分离子迁移率和第二径向位移的离子被轴向地排出离子阱。

5. 发明申请

WO2012114124A1 CURVED ION GUIDE WITH NON MASS TO CHARGE RATIO DEPENDENT CONFINEMENT 审中-公开
标题翻译：弯曲离子指南与非质量来收取比例依赖的约定
公开(公告)号：WO2012114124A1
公开(公告)日：2012-08-30
申请号：PCT/GB2012/050432
申请日：2012-02-24
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , WILDGOOSE, Jason Lee , LANGRIDGE, David J.
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , WILDGOOSE, Jason Lee , LANGRIDGE, David J.
IPC分类号： H01J49/42 , H01J49/06
CPC分类号： H01J49/063 , H01J49/065 , H01J49/26 , H01J49/42
摘要： A non-linear ion guide is disclosed comprising a plurality of electrodes (6). An ion guiding region is arranged between the electrodes (6), and the ion guiding region curves at least in a first (x) direction. A DC voltage is applied to at least some of the electrodes (6) in order to form a DC potential well which acts to confine ions within the ion guiding region in the first (x) direction.
摘要翻译：公开了一种包括多个电极（6）的非线性离子导向器。离子引导区域布置在电极（6）之间，并且离子引导区域至少在第一（x）方向上弯曲。 DC电压被施加到至少一些电极（6），以便形成用于将离子限制在第一（x）方向上的离子引导区域内的DC势阱。

6. 发明申请

WO2013005061A2 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：质谱仪中蛋白质和肽的光解离
公开(公告)号：WO2013005061A2
公开(公告)日：2013-01-10
申请号：PCT/GB2012/051610
申请日：2012-07-06
申请人： MICROMASS UK LIMITED , BROWN, Jeffery Mark , GILES, Kevin , KENNY, Daniel James , MURRAY, Paul , RICHARDSON, Keith
发明人： BROWN, Jeffery Mark , GILES, Kevin , KENNY, Daniel James , MURRAY, Paul , RICHARDSON, Keith
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
摘要翻译：公开了一种质谱法，其包括将来自激光器的第一光子引导到位于2D或线性离子引导器或离子阱内的离子。扫描第一光子的频率并检测由离子发射的第一光子和/或第二光子。然后使用飞行时间质量分析仪对离子进行质量分析。

7. 发明申请

WO2008059255A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008059255A2
公开(公告)日：2008-05-22
申请号：PCT/GB2007/004364
申请日：2007-11-15
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , GILES, Kevin , PRINGLE, Steven, Derek , WILDGOOSE, Jason, Lee
发明人： BATEMAN, Robert, Harold , GILES, Kevin , PRINGLE, Steven, Derek , WILDGOOSE, Jason, Lee
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。碰撞室（10）布置在离子门（9）的下游。离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。

8. 发明申请

WO2008007105A1 APPARATUS COMPRISING AN ION MOBILILITY SPECTROMETER 审中-公开
标题翻译：包含离子动力光谱仪的装置
公开(公告)号：WO2008007105A1
公开(公告)日：2008-01-17
申请号：PCT/GB2007/002622
申请日：2007-07-12
申请人： MICROMASS UK LIMITED , GILES, Kevin
发明人： GILES, Kevin
IPC分类号： G01N27/64
CPC分类号： H01J49/0481 , G01N27/622 , H01J49/004 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first chamber (10) and a second chamber (5). The second chamber (5) is located downstream of the first chamber 10 and an inter-chamber aperture (12) is provided between the two chambers (5,10). An ion guide (13) is located in the first chamber (10) and an ion mobility spectrometer (6) is located in the second chamber (5). Helium gas is provided to the first chamber (10). As ions are accelerated towards the ion mobility spectrometer 6 from a relatively low pressure region they pass initially into the first chamber (10). The helium gas provided in the first chamber (10) minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide (13) and are subsequently transmitted to the ion mobility spectrometer (6) located in the second chamber (5).
摘要翻译：公开了一种质谱仪，其包括第一室（10）和第二室（5）。第二室（5）位于第一室10的下游，并且在两个室（5,10）之间设置室间孔（12）。离子导向器（13）位于第一室（10）中，离子迁移谱仪（6）位于第二室（5）中。氦气被提供到第一室（10）。当离子从相对低的压力区域向离子迁移谱仪6加速时，它们首先进入第一腔室（10）。设置在第一室（10）中的氦气最小化离子碎片和离子鉴别效应，因为离子被加速到相对高的压力区域。然后离子由离子引导件（13）传输，随后被传递到位于第二室（5）中的离子迁移谱仪（6）。

9. 发明申请

WO2006030205A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2006030205A3
公开(公告)日：2006-03-23
申请号：PCT/GB2005/003543
申请日：2005-09-14
申请人： MICROMASS UK LIMITED , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek , GILES, Kevin , BATEMAN, Robert, Harold
发明人： WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek , GILES, Kevin , BATEMAN, Robert, Harold
IPC分类号： H01J49/40 , G01N27/00 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (5).

10. 发明申请

WO2013005058A1 ION GUIDE COUPLED TO MALDI ION SOURCE 审中-公开
标题翻译：离子导管与MALDI离子源相连
公开(公告)号：WO2013005058A1
公开(公告)日：2013-01-10
申请号：PCT/GB2012/051607
申请日：2012-07-06
申请人： MICROMASS UK LIMITED , WILDGOOSE, Jason Lee , PRINGLE, Steven Derek , GILES, Kevin , BROWN, Jeffery Mark , MURRAY, Paul , KENNY, Daniel James
发明人： WILDGOOSE, Jason Lee , PRINGLE, Steven Derek , GILES, Kevin , BROWN, Jeffery Mark , MURRAY, Paul , KENNY, Daniel James
IPC分类号： H01J49/06
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

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