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1. 发明申请

WO2013005058A1 ION GUIDE COUPLED TO MALDI ION SOURCE 审中-公开
标题翻译：离子导管与MALDI离子源相连
公开(公告)号：WO2013005058A1
公开(公告)日：2013-01-10
申请号：PCT/GB2012/051607
申请日：2012-07-06
申请人： MICROMASS UK LIMITED , WILDGOOSE, Jason Lee , PRINGLE, Steven Derek , GILES, Kevin , BROWN, Jeffery Mark , MURRAY, Paul , KENNY, Daniel James
发明人： WILDGOOSE, Jason Lee , PRINGLE, Steven Derek , GILES, Kevin , BROWN, Jeffery Mark , MURRAY, Paul , KENNY, Daniel James
IPC分类号： H01J49/06
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

2. 发明申请

WO2009087402A2 LINEAR ION TRAP 审中-公开
标题翻译：线性离子阱
公开(公告)号：WO2009087402A2
公开(公告)日：2009-07-16
申请号：PCT/GB2009/000071
申请日：2009-01-12
申请人： MICROMASS UK LIMITED , GREEN, Martin, Raymond , KENNY, Daniel, James , LANGRIDGE, David , WILDGOOSE, Jason, Lee
发明人： GREEN, Martin, Raymond , KENNY, Daniel, James , LANGRIDGE, David , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/4285
摘要： A linear ion trap (6,7,8) is disclosed comprising a central quadrupole rod set (6) and a post-filter quadrupole rod set (8). A 180° phase difference is maintained between axially adjacent rod electrodes of the central quadrupole rod set (6) and the post-filter quadrupole (8) so that an axial pseudo-potential barrier is created between the central quadrupole rod set (6) and the post-filter quadrupole (8). A supplementary AC voltage is applied to the rods of the central quadrupole (6) in order to radially excite ions which are desired to be ejected from the ion trap. The ions are ejected from the ion trap (6,7,8) non-adiabatically in an axial direction.
摘要翻译：公开了一种线性离子阱（6,7,8），其包括中心四极杆组（6）和后过滤四极杆组（8）。在中心四极杆组（6）和后过滤器四极（8）的轴向相邻杆电极之间保持180°相位差，使得在中心四极杆组（6）和后滤器四极杆（8）。补充的交流电压施加到中心四极杆（6）的杆上，以便径向地激发希望从离子阱排出的离子。离子从离子阱（6,7,8）沿轴向非绝热地排出。

3. 发明申请

WO2008071993A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008071993A3
公开(公告)日：2009-04-02
申请号：PCT/GB2007004820
申请日：2007-12-14
申请人： MICROMASS LTD , KENNY DANIEL JAMES , WILDGOOSE JASON LEE , GREEN MARTIN
发明人： KENNY DANIEL JAMES , WILDGOOSE JASON LEE , GREEN MARTIN
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap (7) or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode (2) which forms part of the Time of Flight mass analyser. Ions in the pulse or packet of ions which is released become temporally dispersed and the orthogonal acceleration electrode (2) is energised multiple times prior the release of a subsequent pulse or packet of ions.
摘要翻译：公开了一种质谱仪，其包括正交加速时间飞行质量分析器。从离子阱（7）或替代地从布置在作为飞行时间质量分析器的一部分的正交加速电极（2）的上游的行波离子导向器释放脉冲或包离子。释放的脉冲或离子束中的离子变得暂时分散，并且在随后的脉冲或包离子的释放之前，正交加速电极（2）被多次通电。

4. 发明申请

WO2008047101A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2008047101A3
公开(公告)日：2008-04-24
申请号：PCT/GB2007/003937
申请日：2007-10-16
申请人： MICROMASS UK LIMITED , KENNY, Daniel, James , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek
发明人： KENNY, Daniel, James , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek
IPC分类号： H01J49/42
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.

5. 发明申请

WO2007125354A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007125354A2
公开(公告)日：2007-11-08
申请号：PCT/GB2007001589
申请日：2007-04-30
申请人： MICROMASS LTD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , KENNY DANIEL JAMES
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , KENNY DANIEL JAMES
CPC分类号： H01J49/4235 , H01J49/065
摘要： An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.
摘要翻译：公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。在离子导向器或质量分析器（2）的出口处产生伪势垒。伪势垒的幅度或深度与离子的质荷比成反比。一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，使得离子以其质荷比相反的顺序从离子导向器或质量分析器（2）发射。

6. 发明申请

WO2013005060A3 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：质谱仪中蛋白质和肽的光解离
公开(公告)号：WO2013005060A3
公开(公告)日：2013-07-04
申请号：PCT/GB2012051609
申请日：2012-07-06
申请人： MICROMASS LTD , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH , GILES KEVIN , BROWN JEFFERY MARK
发明人： KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH , GILES KEVIN , BROWN JEFFERY MARK
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
摘要翻译：公开了质谱法，包括自动重复执行多个操作循环，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将所述第一离子暴露于第一光离解装置以形成多个第二离子并对所述第二离子进行质量分析; 和（iii）将第一离子暴露于第一光离解装置以形成多个第二离子，将第二离子碎裂以形成多个第三离子并且质量分析第三离子。

7. 发明申请

WO2013027055A1 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 审中-公开
标题翻译：离子阱与空间扩展离子捕获区域
公开(公告)号：WO2013027055A1
公开(公告)日：2013-02-28
申请号：PCT/GB2012/052054
申请日：2012-08-22
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译：公开了将离子引导到小的喷射区域中的质量或质量比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。二次直流电势的曲线沿着第二（x）方向逐渐变化。

8. 发明申请

WO2013027054A2 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 审中-公开
标题翻译：离子阱与空间扩展的离子俘获区域
公开(公告)号：WO2013027054A2
公开(公告)日：2013-02-28
申请号：PCT/GB2012052053
申请日：2012-08-22
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.
摘要翻译：公开的具有增加的电荷存储容量的质量或质荷比选择离子阱。 RF电压用于在离子阱内的第一（y）方向上限制离子。直流电压和/或RF电压用于在离子阱内的第二（x）方向上限制离子。二次直流势阱用于在离子阱内的第三（z）方向上限制离子。离子在第三（z）方向上被激发，并且导致质量或质荷比选择性地在第三（z）方向上喷射。

9. 发明申请

WO2012164309A2 APERTURE GAS FLOW RESTRICTION 审中-公开
标题翻译：气体流量限制
公开(公告)号：WO2012164309A2
公开(公告)日：2012-12-06
申请号：PCT/GB2012/051254
申请日：2012-06-01
申请人： MICROMASS UK LIMITED , KENNY, Daniel James
发明人： KENNY, Daniel James
IPC分类号： H01J49/06
CPC分类号： H01J49/0495 , H01J49/0418 , H01J49/062 , H01J49/067 , H01J49/24
摘要： A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture (5a). The effective area of the opening (5a) between the two vacuum chambers may be varied by rotating a disk (7) having an aperture (7) a in front of the differential pumping aperture (5a) so as to vary the gas flow rate through the opening (5a) and between the two chambers.
摘要翻译：公开了一种质谱仪，其包括保持在不同压力下的两个真空室。两个真空室通过差动泵浦孔（5a）相互连接。两个真空室之间的开口（5a）的有效面积可以通过在差动泵送孔（5a）的前面旋转具有孔（7）a的盘（7）来改变气体流速通过开口（5a）和两个室之间。

10. 发明申请

WO2010084307A1 MASS SPECTROMETER ARRANGED TO PERFORM MS/MS/MS 审中-公开
标题翻译：质谱仪安装MS / MS / MS
公开(公告)号：WO2010084307A1
公开(公告)日：2010-07-29
申请号：PCT/GB2010/000079
申请日：2010-01-20
申请人： MICROMASS UK LIMITED , KENNY, Daniel, James
发明人： KENNY, Daniel, James
IPC分类号： H01J49/00
CPC分类号： H01J49/0045 , H01J49/0031 , H01J49/06 , H01J49/10
摘要： A mass spectrometer is disclosed comprising an ion trap (14) and a fragmentation device (15). Ions are fragmented in the ion trap (14) to form first generation fragment ions. The ion trap (14) has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device (15) which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device (15) and may optionally be stored in an ion accumulation region (18) prior to being passed to a mass analyser (16) for subsequent mass analysis.
摘要翻译：公开了一种质谱仪，其包括离子阱（14）和碎裂装置（15）。离子阱（14）中的离子被分散以形成第一代碎片离子。离子阱（14）具有相对高的质量截止。然后将第一代碎片离子转移到碎片装置（15），碎裂装置被布置成具有基本上较低的低质量截止值。第一代碎片离子在碎裂装置（15）内碎裂，并且可以任选地在被传递到质量分析器（16）之前存储在离子累积区域（18）中以用于随后的质量分析。

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