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1. 发明申请

US20130011147A1 DEGRADATION LEVEL ESTIMATING DEVICE AND IMAGE FORMING APPARATUS 审中-公开
标题翻译：降级水平估算装置和图像形成装置
公开(公告)号：US20130011147A1
公开(公告)日：2013-01-10
申请号：US13466461
申请日：2012-05-08
申请人： Michio KIMURA , Takaaki IKEGAMI , Tomoharu ASANO
发明人： Michio KIMURA , Takaaki IKEGAMI , Tomoharu ASANO
IPC分类号： G03G15/00
CPC分类号： G03G15/553 , G03G15/5037
摘要： A degradation level estimating device for estimating degradation level of a photoreceptor of an image forming apparatus performing at least a charging process, an optical image writing process, a developing process, and a transferring process in which a toner image on the photoreceptor is transferred onto a receiver while applying a charge to the photoreceptor. The degradation level estimating device includes a charge dependence detector to detect charge quantity dependence of a charge property of the photoreceptor in the charging process on the quantity of the charge applied to the photoreceptor in the last transferring process by subjecting the photoreceptor to the processes plural times without performing the optical image writing process, followed by the charging process, while changing the quantity of the charge and measuring the charge property of the photoreceptor. The degradation level estimating device estimates the degradation level of the photoreceptor based on the charge quantity dependence.
摘要翻译：一种用于估计至少进行充电过程，光学图像写入处理，显影处理和转印过程的图像形成装置的感光体的劣化水平的劣化水平估计装置，其中将感光体上的调色剂图像转印到接收器，同时向感光体施加电荷。劣化度估计装置包括：电荷依赖检测器，用于检测充电过程中感光体的电荷特性对最后转印过程中对感光体施加的电荷的量的依赖性，通过使感光体进行多次而不进行光学图像写入处理，随后进行充电处理，同时改变电荷量并测量感光体的电荷特性。劣化水平估计装置基于电荷量依赖性估计感光体的劣化水平。

2. 发明申请

US20090259489A1 INTEGRATED DATABASE SYSTEM OF GENOME INFORMATION AND CLINICAL INFORMATION AND A METHOD FOR CREATING DATABASE INCLUDED THEREIN 审中-公开
标题翻译：基因信息和临床信息的综合数据库系统及其创建数据库的方法
公开(公告)号：US20090259489A1
公开(公告)日：2009-10-15
申请号：US12208381
申请日：2008-09-11
申请人： Michio KIMURA , Terutaka Furuta , Takeshi Numano
发明人： Michio KIMURA , Terutaka Furuta , Takeshi Numano
IPC分类号： G06Q50/00 , G06F17/30
CPC分类号： G06F19/324 , G06Q50/22 , G06Q50/24 , G16B50/00
摘要： There is provided an integrated database system that incorporates genome information into a clinical information database contrary to conventional databases, while complying with guidelines preventing identification of a provider of the genome information, thereby enabling an easy search for a correlation between the genome information and clinical information and the like. The integrated database system includes an information database including a data storage unit for storing clinical information of a plurality of patients and genome information of at least a part of the plurality of patients. In the data storage unit, the clinical information does not include personal information that identifies the individual patients, and the genome information and the clinical information of the same patient are stored in association with each other by link information that does not identify the individual patients.
摘要翻译：提供了一种综合数据库系统，其将基因组信息并入临床信息数据库中，与常规数据库相反，同时遵守防止基因组信息提供者识别的准则，从而能够轻松搜索基因组信息与临床信息之间的相关性等等。综合数据库系统包括信息数据库，其包括用于存储多个患者的临床信息的数据存储单元和多个患者的至少一部分的基因组信息。在数据存储单元中，临床信息不包括识别个体患者的个人信息，并且通过不识别个体患者的链接信息彼此关联地存储同一患者的基因组信息和临床信息。

3. 发明申请

US20080318856A1 MONOMER PROTEIN WITH BONE MORPHOGENETIC ACTIVITY AND MEDICINAL AGENT CONTAINING THE SAME FOR PREVENTING AND TREATING DISEASES OF CARTILAGE AND BONE 失效
标题翻译：具有骨形态活性的单体蛋白质和含有其的药物代谢物，用于预防和治疗骨髓和骨骼的疾病
公开(公告)号：US20080318856A1
公开(公告)日：2008-12-25
申请号：US11758878
申请日：2007-06-06
申请人： Shinji KAWAI , Michio KIMURA , Yoshifumi MURAKI , Mieko KATSUURA
发明人： Shinji KAWAI , Michio KIMURA , Yoshifumi MURAKI , Mieko KATSUURA
IPC分类号： A61K38/16 , A61P19/08
CPC分类号： C07K14/51 , A61K38/00
摘要： This invention provides for a protein of the TGF-β superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
摘要翻译：本发明提供了TGF-β超家族的蛋白质，其中参与同型二聚体正常形成的半胱氨酸改变为另一种氨基酸。这些突变蛋白，作为单体，显示比野生型蛋白二聚体更高的骨形态发生活性。还提供了通过在包括大肠杆菌的各种宿主系统中的质粒驱动表达来产生和分离这些单体的方法。此外，本发明公开了含有纯化单体的药剂在预防和治疗疾病和影响骨和/或软骨的问题中的用途。

4. 发明申请

US20100065315A1 RESIN COMPOSITION, INSULATING SHEET WITH BASE, PREPREG, MULTILAYER PRINTED WIRING BOARD AND SEMICONDUCTOR DEVICE 有权
标题翻译：树脂组合物，绝缘基片，PREPREG，多层印刷线路板和半导体器件绝缘片
公开(公告)号：US20100065315A1
公开(公告)日：2010-03-18
申请号：US12443822
申请日：2007-10-02
申请人： Michio KIMURA
发明人： Michio KIMURA
IPC分类号： H05K1/00 , B32B27/38 , C08K3/36 , C08L101/10 , C08G67/00
CPC分类号： H05K3/4626 , B32B5/022 , B32B5/024 , B32B15/08 , B32B15/14 , B32B15/20 , B32B27/16 , B32B27/18 , B32B27/20 , B32B27/26 , B32B27/28 , B32B27/38 , B32B2260/021 , B32B2260/046 , B32B2262/02 , B32B2262/0261 , B32B2262/0269 , B32B2262/0276 , B32B2262/0284 , B32B2262/10 , B32B2262/101 , B32B2264/102 , B32B2307/206 , B32B2307/306 , B32B2307/3065 , B32B2307/308 , B32B2307/50 , B32B2307/538 , B32B2307/72 , B32B2307/7265 , B32B2457/00 , B32B2457/08 , C08K5/5425 , C08K5/548 , C08L63/00 , H05K3/389 , H05K2201/0209 , Y10T428/24917 , Y10T428/24994 , Y10T428/249994 , Y10T428/252 , Y10T428/254 , Y10T428/287 , Y10T428/31511 , Y10T428/31663
摘要： The present invention provides a resin composition which can produce a multilayer printed wiring board not causing peeling and crack in a thermal shock test such as a cooling/heating cycle, and having high heat resistance and low-thermal expansion characteristics, when the resin composition is used for an insulating layer of the multilayer printed wiring board; and also an insulating sheet provided on a base, a prepreg, a multilayer printed wiring board and a semiconductor device using thereof. The resin composition is used for forming an insulating layer of the multilayer printed wiring board, wherein a surface roughness parameter Rvk value of the insulating layer is from 0.1 μm to 0.8 μm, measured after the insulating layer being formed with the resin composition, and subject to roughening treatment.
摘要翻译：本发明提供一种树脂组合物，其可以在树脂组合物为热塑性树脂组合物为热塑性树脂组合物时，能够制造在冷热循环等热冲击试验中不产生剥离和裂纹的多层印刷布线板，并且具有高耐热性和低热膨胀特性用于多层印刷线路板的绝缘层; 以及设置在基底上的绝缘片，预浸料，多层印刷线路板和使用其的半导体器件。树脂组合物用于形成多层印刷线路板的绝缘层，其中绝缘层的表面粗糙度参数Rvk值为0.1μm至0.8μm，在用树脂组合物形成绝缘层之后测量，并且对象进行粗糙处理。

5. 发明申请

US20090325864A1 NOVEL PROTEIN AND PROCESS FOR PREPARING THE SAME 失效
标题翻译：新蛋白及其制备方法
公开(公告)号：US20090325864A1
公开(公告)日：2009-12-31
申请号：US11833653
申请日：2007-08-03
申请人： Fusao MAKISHIMA , Hiroyuki TAKAMATSU , Hideo MIKI , Shinji KAWAI , Michio KIMURA , Tomoaki MATSUMOTO , Mieko KATSUURA , Koichi ENOMOTO , Yusuke SATOH
发明人： Fusao MAKISHIMA , Hiroyuki TAKAMATSU , Hideo MIKI , Shinji KAWAI , Michio KIMURA , Tomoaki MATSUMOTO , Mieko KATSUURA , Koichi ENOMOTO , Yusuke SATOH
IPC分类号： A61K38/18 , C07K14/51 , C12P21/02 , C07H21/04
CPC分类号： C07K14/51 , A61K38/00 , Y10S514/801
摘要： A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same.The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.
摘要翻译：衍生自人MP52的序列表的SEQ ID No.1中具有氨基酸序列的蛋白质及其二聚体蛋白质。上述同型二聚体蛋白可以通过在N末端构建含有序列表SEQ ID No.1的DNA编码氨基酸序列的质粒与甲硫氨酸，将质粒导入大肠杆菌进行转化，溶解包合物通过培养转化体获得的物质，从溶解的溶液中纯化单体蛋白质，将单体蛋白质重折叠成二聚体蛋白质并进行纯化。上述同型二聚体蛋白质可用作治疗软骨和骨疾病的药物组合物。

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