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1. 发明授权

US07816103B2 Protein and process for preparing the same 失效
标题翻译：蛋白质及其制备方法
公开(公告)号：US07816103B2
公开(公告)日：2010-10-19
申请号：US11833653
申请日：2007-08-03
申请人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
发明人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
IPC分类号： C12P21/02 , C12N1/21 , C12N15/70 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , Y10S514/801
摘要： A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.
摘要翻译：衍生自人MP52的序列表的SEQ ID No.1中具有氨基酸序列的蛋白质及其二聚体蛋白质。上述同型二聚体蛋白可以通过在N末端构建含有序列表SEQ ID No.1的DNA编码氨基酸序列的质粒与甲硫氨酸，将质粒导入大肠杆菌进行转化，溶解包合物通过培养转化体获得的物质，从溶解的溶液中纯化单体蛋白质，将单体蛋白质重折叠成二聚体蛋白质并进行纯化。上述同型二聚体蛋白质可用作治疗软骨和骨疾病的药物组合物。

2. 发明申请

US20090003742A1 Grease Composition For Hub Unit Bearing, And Hub Unit Bearing For Vehicle 审中-公开
标题翻译：轮毂单元轴承和轮毂单元轴承的润滑脂组成
公开(公告)号：US20090003742A1
公开(公告)日：2009-01-01
申请号：US11814624
申请日：2006-01-24
申请人： Shinya Nakatani , Jun Kuraishi , Tomoaki Matsumoto , Minoru Namiki , Ryo Aida , Toshiaki Endo
发明人： Shinya Nakatani , Jun Kuraishi , Tomoaki Matsumoto , Minoru Namiki , Ryo Aida , Toshiaki Endo
IPC分类号： F16C31/04 , C10M169/04
CPC分类号： F16C33/6607 , B60B27/0005 , B60B27/0094 , C10M169/00 , C10M169/04 , C10M169/06 , C10M2203/1006 , C10M2205/0285 , C10M2207/06 , C10M2207/126 , C10M2207/127 , C10M2207/1276 , C10M2207/1285 , C10M2207/289 , C10M2215/02 , C10M2215/04 , C10M2215/042 , C10M2215/064 , C10M2215/1026 , C10M2215/223 , C10M2219/044 , C10M2219/068 , C10N2210/01 , C10N2210/02 , C10N2210/05 , C10N2230/12 , C10N2230/26 , C10N2240/02 , C10N2250/10 , F16C19/06 , F16C19/185 , F16C19/186 , F16C33/6633 , F16C2326/02
摘要： An object of the invention is to provide a grease composition capable of keeping a good lubrication condition for a long period of time even when water has mixed therein, thereby inhibiting white structure flaking and corrosion. Another object is to provide a vehicular hub unit bearing which hardly suffers from white structure flaking and corrosion even when used in an environment where water may penetrate into it and which therefore has a long life.The invention provides a rolling bearing with, sealed up therein, a grease composition containing a waterproof film-forming additive added thereto; a grease composition for hub unit bearings, containing a base oil that comprises at least one of mineral oil and synthetic oil as the main ingredient thereof, and a thickener and a flaking inhibitor; and a vehicular hub unit bearing with the grease composition sealed up therein.
摘要翻译：本发明的目的是提供即使在其中混合水的情况下也能长时间保持良好润滑状态的润滑脂组合物，从而抑制白色结构剥落和腐蚀。另一个目的是提供一种即使在水可能渗入其中并且因此具有长寿命的环境中使用时也几乎不遭受白色结构剥落和腐蚀的车辆毂单元轴承。本发明提供一种滚动轴承，其中密封有一种润滑脂组合物，其中含有添加了防水成膜助剂; 一种用于轮毂单元轴承的润滑脂组合物，含有包含矿物油和合成油中的至少一种作为其主要成分的基础油，以及增稠剂和防剥落剂; 以及在其中密封有润滑脂组合物的车辆毂单元。

3. 发明申请

US20090325864A1 NOVEL PROTEIN AND PROCESS FOR PREPARING THE SAME 失效
标题翻译：新蛋白及其制备方法
公开(公告)号：US20090325864A1
公开(公告)日：2009-12-31
申请号：US11833653
申请日：2007-08-03
申请人： Fusao MAKISHIMA , Hiroyuki TAKAMATSU , Hideo MIKI , Shinji KAWAI , Michio KIMURA , Tomoaki MATSUMOTO , Mieko KATSUURA , Koichi ENOMOTO , Yusuke SATOH
发明人： Fusao MAKISHIMA , Hiroyuki TAKAMATSU , Hideo MIKI , Shinji KAWAI , Michio KIMURA , Tomoaki MATSUMOTO , Mieko KATSUURA , Koichi ENOMOTO , Yusuke SATOH
IPC分类号： A61K38/18 , C07K14/51 , C12P21/02 , C07H21/04
CPC分类号： C07K14/51 , A61K38/00 , Y10S514/801
摘要： A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same.The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.
摘要翻译：衍生自人MP52的序列表的SEQ ID No.1中具有氨基酸序列的蛋白质及其二聚体蛋白质。上述同型二聚体蛋白可以通过在N末端构建含有序列表SEQ ID No.1的DNA编码氨基酸序列的质粒与甲硫氨酸，将质粒导入大肠杆菌进行转化，溶解包合物通过培养转化体获得的物质，从溶解的溶液中纯化单体蛋白质，将单体蛋白质重折叠成二聚体蛋白质并进行纯化。上述同型二聚体蛋白质可用作治疗软骨和骨疾病的药物组合物。

4. 发明授权

US07235527B2 Protein and process for producing the same 失效
标题翻译：蛋白质及其生产方法
公开(公告)号：US07235527B2
公开(公告)日：2007-06-26
申请号：US08945459
申请日：1996-04-19
申请人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
发明人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
IPC分类号： A61K38/18 , A61K38/39 , A61K9/14 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , Y10S514/801
摘要： A protein consisting of the amino acid sequence in SEQ ID No: 1 derived from human MP52 and a homodimer protein thereof useful for treating cartilage and/or bone diseases and a process for its preparation.
摘要翻译：由源自人MP52的SEQ ID No：1的氨基酸序列和用于治疗软骨和/或骨疾病的同二聚体蛋白质组成的蛋白质及其制备方法。

5. 发明授权

US4531893A Variable output vane pump 失效
标题翻译：可变输出叶片泵
公开(公告)号：US4531893A
公开(公告)日：1985-07-30
申请号：US532834
申请日：1983-09-16
申请人： Tomio Okoh , Tomoaki Matsumoto , Noboru Hirokawa
发明人： Tomio Okoh , Tomoaki Matsumoto , Noboru Hirokawa
IPC分类号： F04C14/22 , F04C2/344 , F04C15/00 , F04B49/00
CPC分类号： F04C14/226 , F04C15/0034 , F04C2/3442
摘要： A variable output vane pump for use with an automotive automatic transmission. At least one pressure chamber is formed between the circular bore of a housing and the outer circumference of a ring by means of at least one seal pin which is fitted in the axial groove formed in the ring circumference and which is opened in the housing bore. The ring is urged by the action of a spring, which is fitted in the housing, in a direction opposite to the pressure to be built up by the pressure chamber. An elastic member is fitted in the bottom of the axial groove to urge the seal pin both toward the housing bore and at the same time toward one of the side walls of the axial groove. The urging direction of the elastic member and a tangential line, on which the seal pin is tangential to the housing bore, are angularly positioned at an acute angle with respect to each other.
摘要翻译：一种用于汽车自动变速器的可变输出叶片泵。通过至少一个密封销在壳体的圆形孔和环的外周之间形成至少一个压力室，所述至少一个密封销装配在形成在环形圆周中并在壳体孔中敞开的轴向槽中。通过弹簧的作用，环被推压，该弹簧以与由压力室构建的压力相反的方向装配在壳体中。弹性构件装配在轴向凹槽的底部中，以将密封销朝向壳体孔推动，并且同时朝向轴向凹槽的侧壁中的一个侧壁。弹性构件的推动方向和密封销与壳体孔相切的切线相对于彼此成角度地定位成锐角。

6. 发明申请

US20140205226A1 ROLLING DEVICE 审中-公开
标题翻译：滚动装置
公开(公告)号：US20140205226A1
公开(公告)日：2014-07-24
申请号：US14234707
申请日：2012-06-26
申请人： Kentaro Sonoda , Atsushi Yokouchi , Tomoaki Matsumoto , Kazunori Nakagawa
发明人： Kentaro Sonoda , Atsushi Yokouchi , Tomoaki Matsumoto , Kazunori Nakagawa
IPC分类号： F16C33/66
CPC分类号： F16C33/6688 , C10M171/00 , C10M2201/041 , C10M2201/062 , C10M2201/103 , C10M2201/105 , C10M2207/0206 , C10M2207/022 , C10M2207/04 , C10M2207/0406 , C10M2207/0413 , C10M2207/1285 , C10M2207/2835 , C10M2207/289 , C10M2209/103 , C10M2209/104 , C10M2215/026 , C10M2215/04 , C10M2215/08 , C10M2215/0813 , C10M2215/1026 , C10M2223/04 , C10M2223/049 , C10M2223/06 , C10N2210/01 , C10N2220/033 , C10N2220/082 , C10N2230/02 , C10N2230/06 , C10N2230/68 , C10N2240/02 , C10N2240/08 , C10N2250/10 , F16C19/06 , F16C33/6633 , C10M2209/108
摘要： The rolling device of the present invention is a rolling device that is equipped with an inner ring, an outer ring, and a plurality of rolling elements disposed between the inner ring and the outer ring so as to freely roll, and that is packed with a lubricant composition containing a gelling agent in which a difference between a worked consistency and an unworked consistency is 40-130, and this rolling device has low-torque characteristics, is excellent in terms of recovery property and heat resistance, is free from lubricant leakage, and has a long life.
摘要翻译：本发明的滚动装置是一种滚动装置，其具有设置在内圈和外圈之间的内圈，外圈和多个滚动元件，以便自由地滚动，并且被包装有含有胶合剂的润滑剂组合物，其中加工一致性和未加工稠度之间的差异为40-130，该滚动装置具有低扭矩特性，在回复性能和耐热性方面优异，没有润滑剂泄漏，并且寿命长。

7. 发明申请

US20080219610A1 Waterproof Grease Composition and Wheel-Supporting Roller Bearing 审中-公开
标题翻译：防水润滑脂组合物和车轮支承滚子轴承
公开(公告)号：US20080219610A1
公开(公告)日：2008-09-11
申请号：US11665533
申请日：2005-10-18
申请人： Shinya Nakatani , Jun Kuraishi , Tomoaki Matsumoto
发明人： Shinya Nakatani , Jun Kuraishi , Tomoaki Matsumoto
IPC分类号： F16C19/24 , C10M101/00
CPC分类号： C10M169/06 , B60B27/00 , B60B27/0005 , B60B27/0094 , C10M115/08 , C10M125/02 , C10M129/28 , C10M147/00 , C10M155/02 , C10M159/06 , C10M171/02 , C10M2201/041 , C10M2203/1006 , C10M2205/0285 , C10M2207/12 , C10M2207/126 , C10M2207/289 , C10M2209/104 , C10M2209/108 , C10M2211/00 , C10M2211/06 , C10M2213/00 , C10M2213/043 , C10M2213/06 , C10M2215/02 , C10M2215/1026 , C10M2215/223 , C10M2217/0456 , C10M2219/04 , C10M2219/044 , C10M2229/02 , C10M2229/025 , C10M2229/041 , C10N2210/01 , C10N2210/02 , C10N2220/022 , C10N2230/26 , C10N2240/02 , C10N2250/10 , F16C33/6633 , F16C2326/02
摘要： The waterproof grease composition of the present application comprises a base oil that comprises at least one of mineral oil and synthetic oil and having a kinematic viscosity of from 10 to 400 mm2/sec at 40° C., a thickener, and a waterproofness-imparting agent selected from surfactant, metal soap, fluorine-containing water repellent, silicone-type water repellent, pH-controlling agent, wax, polymer and graphite. Accordingly, it may prevent peeling such as white structure peeling even when water is mixed therein.The wheel-supporting roller bearing of the invention comprises an inner member having a raceway surface in the outer peripheral surface thereof, an outer member having, in the inner peripheral surface thereof, a raceway surface that faces the raceway surface of the inner member and disposed outside the inner member, and plural rolling elements rollably disposed between the two raceway surfaces, and which contains the above waterproof grease composition sealed therein; and this has excellent waterproofness.
摘要翻译：本申请的防水润滑脂组合物包括基础油，其在40℃下包含矿物油和合成油中的至少一种，运动粘度为10〜400mm 2 / sec，增稠剂和选自表面活性剂，金属皂，含氟防水剂，硅氧烷型防水剂，pH调节剂，蜡，聚合物和石墨的防水性赋予剂。因此，即使在水混合的情况下也可以防止白色结构剥离等剥离。本发明的车轮支承滚子轴承包括在其外周面上具有滚道面的内部构件，在其内周面中具有面向内部构件的轨道面的轨道面的外部构件，在内部构件外部，以及滚动地设置在两个滚道表面之间的多个滚动元件，并且其中包含密封在其中的上述防水润滑脂组合物; 这具有优异的防水性。

8. 发明授权

US07268114B2 Protein and process for preparing the same 失效
标题翻译：蛋白质及其制备方法
公开(公告)号：US07268114B2
公开(公告)日：2007-09-11
申请号：US10365231
申请日：2003-02-12
申请人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
发明人： Fusao Makishima , Hiroyuki Takamatsu , Hideo Miki , Shinji Kawai , Michio Kimura , Tomoaki Matsumoto , Mieko Katsuura , Koichi Enomoto , Yusuke Satoh
IPC分类号： A61K38/18 , C07K14/51 , C12N15/12 , C12N1/21 , C12P21/02 , A61F2/30 , A61F2/28
CPC分类号： C07K14/51 , A61K38/00 , Y10S514/801
摘要： A protein having amino acid sequence in SEQ ID NO: 1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID NO: 1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid into E. coli for transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.
摘要翻译：衍生自人MP52的序列表的SEQ ID NO：1中具有氨基酸序列的蛋白质及其二聚体蛋白质。可以通过在N末端构建含有序列表的SEQ ID NO：1的DNA编码氨基酸序列的质粒与甲硫氨酸在N末端引入，将质粒导入大肠杆菌进行转化，从而增溶包涵体通过培养转化体获得，从溶解的溶液中纯化单体蛋白质，将单体蛋白重折叠成二聚体蛋白质并进行纯化。上述同型二聚体蛋白质可用作治疗软骨和骨疾病的药物组合物。

9. 发明授权

US5908828A Synthetic peptide derivatives and the salts thereof 失效
标题翻译：合成肽衍生物及其盐
公开(公告)号：US5908828A
公开(公告)日：1999-06-01
申请号：US497599
申请日：1995-06-30
申请人： Takashi Kurita , Tomoaki Matsumoto , Reiko Kikuno , Yoko Otawara-Hamamoto , Gerhard Breipohl
发明人： Takashi Kurita , Tomoaki Matsumoto , Reiko Kikuno , Yoko Otawara-Hamamoto , Gerhard Breipohl
IPC分类号： A61K38/00 , C07K14/51 , A61K38/16 , C07K14/00
CPC分类号： C07K14/51 , A61K38/00
摘要： The present invention provides synthetic peptide derivatives represented by the formulaP.sup.1 -R.sup.1 -P.sup.2wherein P.sup.1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P.sup.2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R.sup.1 denotes a linker with a property that does not interfere with the activity of the each peptide P.sup.1 and P.sup.2 to bind N-terminal end of the peptides P.sup.1 and P.sup.2.The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.
摘要翻译：本发明提供由式P1-R1-P2表示的合成肽衍生物，其中P1是具有序列表SEQ ID NO：1中的氨基酸序列的肽或其类似物; P2是具有序列表的SEQ ID NO：2中的氨基酸序列的肽或其类似物; R1表示具有不影响各肽P1和P2与肽P1和P2的N末端结合的活性的性质的连接体。本发明还提供了用于治疗骨相关疾病的药物组合物，其包含所述肽衍生物或其治疗上可接受的盐和药学上可接受的载体。本发明还提供了治疗哺乳动物中骨相关疾病的方法，其包括向其施用有效量的所述肽衍生物或其可治疗可接受的盐。

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