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1. 发明申请

US20080004327A1 FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE 有权
标题翻译： D-氨基酸氧化酶的荧光取代抑制剂
公开(公告)号：US20080004327A1
公开(公告)日：2008-01-03
申请号：US11772798
申请日：2007-07-02
申请人： Michele Heffernan , Robert Foglesong , Seth Hopkins , Mustapha Soukri , Steven Jones , Kerry Spear , Mark Varney
发明人： Michele Heffernan , Robert Foglesong , Seth Hopkins , Mustapha Soukri , Steven Jones , Kerry Spear , Mark Varney
IPC分类号： A61K31/407 , C07D491/02
CPC分类号： C07D495/04 , C07D491/04
摘要： This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O−X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.
摘要翻译：本发明提供了D-氨基酸氧化酶酶的新型抑制剂以及包含本发明化合物的药物组合物。本发明还提供了治疗和预防神经系统疾病如神经精神和神经退行性疾病以及疼痛，共济失调和惊厥的方法。本发明的化合物具有以下一般结构：其中A是NH或S.Q是选自CR 1和N的成员.X和Y是独立地选自O，S，CR < > 2，N和NH。 R 1，R 2和R 4都是独立地选自H和F的成员，条件是选自R 1，R 2， R 1，R 2，R 4和R 4是F.R 6是选自O - >其中X + +为正离子，其为选自无机正离子和有机正离子的成员。

2. 发明申请

US20080058395A1 Fused heterocyclic inhibitors of D-amino acid oxidase 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂
公开(公告)号：US20080058395A1
公开(公告)日：2008-03-06
申请号：US11825093
申请日：2007-07-02
申请人： Michele Heffernan , James Dorsey , Qun Fang , Robert Foglesong , Seth Hopkins , Michael Jones , Steven Jones , Cyprian Ogbu , Joe Perales , Mustapha Soukri , Kerry Spear , Mark Varney
发明人： Michele Heffernan , James Dorsey , Qun Fang , Robert Foglesong , Seth Hopkins , Michael Jones , Steven Jones , Cyprian Ogbu , Joe Perales , Mustapha Soukri , Kerry Spear , Mark Varney
IPC分类号： A61K31/40 , A61K31/415 , A61K31/425 , A61K31/48 , A61P43/00 , C07D231/02 , C07D303/02 , C07D487/02 , C07D513/00
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.
摘要翻译：本发明提供了D-氨基酸氧化酶酶的新型抑制剂以及包含本发明化合物的药物组合物。还提供了治疗和预防神经系统疾病如神经精神和神经退行性疾病以及疼痛，共济失调和惊厥的方法。本发明的化合物具有以下通式结构：其中Q是选自O，S，CR 1和N中的一个，X和Y是独立地选自CR 2，，O，S，N和NR 3。

3. 发明申请

US20050143434A1 Benzo[d]isoxazol-3-ol DAAO inhibitors 有权
标题翻译：苯并[d]异恶唑-3-醇DAAO抑制剂
公开(公告)号：US20050143434A1
公开(公告)日：2005-06-30
申请号：US11024151
申请日：2004-12-28
申请人： Q. Fang , Seth Hopkins , Steven Jones
发明人： Q. Fang , Seth Hopkins , Steven Jones
IPC分类号： A61K31/42 , C07D261/20
CPC分类号： C07D261/20
摘要： Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutic amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein Z1 is N or CR3; Z2 is N or CR4; Z3is O or S; A is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc or a mixture thereof; R1, R2, R3 and R4 are independently selected from hydrogen, alkyl, hydroxy alkoxy, aryl, acyl, halo, cyano, haloalkyl, NHCOOR5 and SO2NH2; R5 is aryl, arylalkyl, heteroaryl or heteroarylalkyl; at least one of R1, R2, R3 and R4 is other than hydrogen; and at least one of Z1 and Z2 is other than N.
摘要翻译：提高D-丝氨酸浓度和降低D-丝氨酸氧化毒性浓度的方法，用于增强学习，记忆和/或认知，或用于治疗精神分裂症，阿尔茨海默病，共济失调或神经性疼痛，或防止神经功能丧失的方法神经变性疾病的特征包括向需要治疗的受试者施用治疗量的式I化合物或其药学上可接受的盐或溶剂合物：其中Z 1是N或CR 3 ; Z 2是N或CR 4; Z 3是O或S; A是氢，烷基或M + M是铝，钙，锂，镁，钾，钠，锌或它们的混合物; R 1，R 2，R 3和R 4独立地选自氢，烷基，羟基烷氧基，芳基，酰基，卤素，氰基，卤代烷基，NHCOOR 5和SO 2 NH 2。 R 5是芳基，芳基烷基，杂芳基或杂芳基烷基; R 1，R 2，R 3和R 4中的至少一个不是氢; 并且Z 1和Z 2中的至少一个不是N。

4. 发明申请

US20050143443A1 Pyrrole and pyrazole DAAO inhibitors 有权
标题翻译：吡咯和吡唑DAAO抑制剂
公开(公告)号：US20050143443A1
公开(公告)日：2005-06-30
申请号：US11023924
申请日：2004-12-28
申请人： Q. Fang , Seth Hopkins , Steven Jones
发明人： Q. Fang , Seth Hopkins , Steven Jones
IPC分类号： A61K31/401 , A61K31/405 , A61K31/415 , A61K31/416 , C07D207/34 , C07D209/42 , C07D209/44 , C07D231/14 , C07D231/16 , C07D231/54 , C07D231/56 , C07D491/04
CPC分类号： C07D231/56 , C07D207/34 , C07D209/42 , C07D209/44 , C07D231/14 , C07D231/16 , C07D231/54 , C07D491/04
摘要： Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein R1 and R2 are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl, and XYR5; or R1 and R2, taken together, form a 5, 6, 7 or 8-membered substituted or unsubstituted carbocyclic or heterocyclic group; X and Y are independently selected from O, S, NH, and (CR6R7)n; R3 is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc ion or a mixture thereof; Z is N or CR4; R4 is from selected from hydrogen, halo, nitro, alkyl, alkylaryl, and XYR5; R5 is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl; R6 and R7 are independently selected from hydrogen and alkyl; n is an integer from 1 to 6; at least one of R1, R2 and R4 is other than hydrogen; and at least one of X and Y is (CR6R7)n. D-serine or cycloserine may be coadministered along with the compound of formula I.
摘要翻译：提高D-丝氨酸浓度，降低D-丝氨酸氧化毒性浓度的方法，用于增强学习，记忆和/或认知，或用于治疗精神分裂症，阿尔茨海默病，共济失调或神经性疼痛，或防止神经功能特征丧失的神经变性疾病涉及向需要治疗的受试者施用治疗有效量的式I化合物或其药学上可接受的盐或溶剂合物：其中R 1和R 2， SUP>独立地选自氢，卤素，硝基，烷基，酰基，烷基芳基和XYR 5。或R 1和R 2一起形成5,6或7元或8元的取代或未取代的碳环或杂环基; X和Y独立地选自O，S，NH和（CR 6）R 7）。 R 3是氢，烷基或M + H; M是铝，钙，锂，镁，钾，钠，锌离子或它们的混合物; Z是N或CR 4; R 4选自氢，卤素，硝基，烷基，烷基芳基和XYR 5; R 5选自芳基，取代的芳基，杂芳基和取代的杂芳基; R 6和R 7独立地选自氢和烷基; n是1至6的整数; R 1，R 2和R 4中的至少一个不是氢; 并且X和Y中的至少一个是（CR 6）R 7）。 D-丝氨酸或环丝氨酸可以与式I化合物共同给药。

5. 发明申请

US20070258999A1 Sars Virus Nucleotide and Amino Acid Sequences and Uses Thereof 有权
标题翻译： Sars病毒核苷酸和氨基酸序列及其用途
公开(公告)号：US20070258999A1
公开(公告)日：2007-11-08
申请号：US10555073
申请日：2004-04-28
申请人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
发明人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
IPC分类号： A61K39/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N1/21 , C12N15/00 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译：本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列相关疾病。

6. 发明授权

US07897744B2 SARS virus nucleotide and amino acid sequences and uses thereof 有权
标题翻译： SARS病毒核苷酸和氨基酸序列及其用途
公开(公告)号：US07897744B2
公开(公告)日：2011-03-01
申请号：US10555073
申请日：2004-04-28
申请人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Conrad Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
发明人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Conrad Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
IPC分类号： C12N15/50 , C12N7/00
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译：本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列相关疾病。

7. 发明授权

US09041119B2 Forming CMOS with close proximity stressors 有权
标题翻译：形成具有接近应力的CMOS
公开(公告)号：US09041119B2
公开(公告)日：2015-05-26
申请号：US13465159
申请日：2012-05-07
申请人： Desmond J. Donegan, Jr. , Abhishek Dube , Steven Jones , Jophy S. Koshy , Viorel Ontalus
发明人： Desmond J. Donegan, Jr. , Abhishek Dube , Steven Jones , Jophy S. Koshy , Viorel Ontalus
IPC分类号： H01L29/02 , H01L29/78 , H01L29/66
CPC分类号： H01L29/7848 , H01L21/823807 , H01L21/823814 , H01L29/66628 , H01L29/66636
摘要： A method of forming transistors with close proximity stressors to channel regions of the transistors is provided. The method includes forming a first transistor, in a first region of a substrate, having a gate stack on top of the first region of the substrate and a set of spacers adjacent to sidewalls of the gate stack, the first region including a source and drain region of the first transistor; forming a second transistor, in a second region of the substrate, having a gate stack on top of the second region of the substrate and a set of spacers adjacent to sidewalls of the gate stack, the second region including a source and drain region of the second transistor; covering the first transistor with a photo-resist mask without covering the second transistor; creating recesses in the source and drain regions of the second transistor; and forming stressors in the recesses.
摘要翻译：提供了一种形成具有接近应力的晶体管到晶体管的沟道区域的方法。该方法包括在衬底的第一区域中形成第一晶体管，在衬底的第一区域的顶部上具有栅极叠层，以及邻近栅堆叠的侧壁的一组间隔物，第一区域包括源极和漏极第一晶体管的区域; 在所述衬底的第二区域中形成第二晶体管，在所述衬底的所述第二区域的顶部上具有栅极叠层，以及邻近所述栅极叠层的侧壁的一组间隔区，所述第二区域包括所述栅极叠层的源极和漏极区域第二晶体管; 用光致抗蚀剂掩模覆盖第一晶体管而不覆盖第二晶体管; 在所述第二晶体管的源极和漏极区域中产生凹陷; 并在凹槽中形成应力源。

8. 发明授权

US07648827B2 Use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferative diseases 失效
标题翻译：使用影响细胞周期控制或细胞周期进程的真核基因来诊断和治疗增殖性疾病
公开(公告)号：US07648827B2
公开(公告)日：2010-01-19
申请号：US10572289
申请日：2004-09-15
申请人： Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
发明人： Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
IPC分类号： G01N33/574
CPC分类号： C12N15/113 , A61K38/17 , A61K39/00 , A61K48/00 , C07K14/43545 , C07K14/43581 , C07K14/4738 , C12Q1/6886 , C12Q2600/136 , G01N33/574 , G01N33/6893 , G01N2500/00
摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
摘要翻译：本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间细胞周期进程中的重要功能作用，可通过RNA介导的干扰（RNAi）鉴定和鉴定和分离功能所述基因的直向同源物包括其所有生物功能衍生物。本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

9. 发明申请

US20080280150A1 Iridescent Magnetic Effect Pigments 有权
标题翻译：彩色磁效应颜料
公开(公告)号：US20080280150A1
公开(公告)日：2008-11-13
申请号：US11548361
申请日：2006-10-11
申请人： Steven Jones
发明人： Steven Jones
IPC分类号： B32B15/04 , B05D1/36
CPC分类号： C09C1/0015 , C01G49/0018 , C01P2002/72 , C01P2004/20 , C01P2006/42 , C01P2006/60 , C09C1/0021 , C09C2200/1004 , C09C2200/102 , C09C2200/1087 , C09C2200/407 , C09C2200/408 , C09C2220/103 , Y10S428/90 , Y10T428/2911 , Y10T428/2991 , Y10T428/2993
摘要： Iridescent magnetic pigments are produced by depositing a ferrite layer and a second metal oxide layer in succession on a substrate. The substrate may be platy and is coated with the ferrite, which is then coated with the second metal oxide layer to provide interference color effect. At least one of the layers is magnetic. The magnetic pigment may be used in coatings such as paints.
摘要翻译：彩色磁性颜料通过在衬底上相继沉积铁素体层和第二金属氧化物层来制备。衬底可以是板状的并且被铁氧体涂覆，然后用第二金属氧化物层涂覆以提供干涉色彩效果。至少一层是磁性的。磁性颜料可用于涂料如油漆。

10. 发明申请

US20070154277A1 Blind rivet, removal system and related method 审中-公开
标题翻译：盲铆钉，拆卸系统及相关方法
公开(公告)号：US20070154277A1
公开(公告)日：2007-07-05
申请号：US11444274
申请日：2006-05-31
申请人： Daniel Smith , Steven Jones , David Evans
发明人： Daniel Smith , Steven Jones , David Evans
IPC分类号： F16B13/06
CPC分类号： F16B19/1054 , B21J15/50
摘要： The present invention relates to a blind rivet and blind rivet removal system and related method. Once set the blind rivet is not normally removed. However, increasingly removal is required due to the need to recycle automobiles. In order to remove blind rivets it has been necessary to remove the rivet flange by a variety of methods. Generally these methods were ineffective due to the resistance afforded by the mandrel and the risk of damage to the application or workpiece. Removing this unwanted swarf and debris often proved difficult. The invention provides a rivet with a stepped flange and a rivet removal tool with clips adapted to fit between the flange and surface of a workpiece so that upon relative displacement of the clips a rivet is extracted in a substantially axial direction as a single item. The invention also includes a tool and related method of blind rivet removal.
摘要翻译：本发明涉及一种盲铆钉和盲铆钉去除系统及其相关方法。一旦设置，盲铆钉通常不会被去除。然而，由于需要回收汽车，需要越来越多的清除。为了去除盲铆钉，必须通过各种方法去除铆钉法兰。通常这些方法由于心轴提供的阻力以及损坏应用或工件的风险而无效。去除这种不需要的切屑和碎屑通常被证明是困难的。本发明提供了一种具有阶梯式凸缘的铆钉和具有适于装配在工件的凸缘和表面之间的夹子的铆钉移除工具，使得当夹具的相对移位时，将铆钉作为单个项目沿基本轴向方向抽出。本发明还包括一种盲铆钉去除工具和相关方法。

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