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1. 发明授权

US06596758B1 Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process 有权
标题翻译：苯并吡喃和苯并恶庚英酮，包含它们的药物组合物和制备方法
公开(公告)号：US06596758B1
公开(公告)日：2003-07-22
申请号：US09869518
申请日：2001-06-29
申请人： Michel Brunet , Jean-Jaques Zeiller , Jean-Jaques Berthelon , Francis Contard , Guy Augert , Daniel Guerrier
发明人： Michel Brunet , Jean-Jaques Zeiller , Jean-Jaques Berthelon , Francis Contard , Guy Augert , Daniel Guerrier
IPC分类号： A61K31382
CPC分类号： C07D313/08 , C07D311/58 , C07D337/08
摘要： The present invention relates to benzopyrans and benzoxepines of formula (I), wherein X, A, R1, R2 and (R)p have the meanings as given in claim 1, which can be used in the treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds.
摘要翻译：本发明涉及式（I）的苯并吡喃和苯并氧杂环庚烯，其中X，A，R 1，R 2和（R）p具有权利要求1中给出的含义，其可用于治疗血脂异常，动脉粥样硬化和糖尿病，包含它们的药物组合物和允许制备这些化合物的方法。

2. 发明授权

US06509362B2 N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them 失效
公开(公告)号：US06509362B2
公开(公告)日：2003-01-21
申请号：US09985002
申请日：2001-11-01
申请人： Diedier Festal , Jean Yves Nioche , Guy Augert , Jacques Deserprit
发明人： Diedier Festal , Jean Yves Nioche , Guy Augert , Jacques Deserprit
IPC分类号： A61K3144
CPC分类号： C07D213/75 , C07C57/50 , C07D311/58 , C07D335/06 , C07D405/12 , C07D409/12
摘要： The present invention relates to the compounds of formula (I) in which X, R1, R2 and R3 are as defined in claim 1. These compounds are cholesteryl acyl transferase (ACAT) inhibitors.

3. 发明授权

US06339097B1 N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them 失效
标题翻译： N-苯基酰胺和N-吡啶酰胺衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06339097B1
公开(公告)日：2002-01-15
申请号：US09581991
申请日：2000-06-21
申请人： Diedier Festal , Jean Yves Nioche , Guy Augert , Jacques Deserprit
发明人： Diedier Festal , Jean Yves Nioche , Guy Augert , Jacques Deserprit
IPC分类号： A61K314433
CPC分类号： C07D213/75 , C07C57/50 , C07D311/58 , C07D335/06 , C07D405/12 , C07D409/12
摘要： The present invention relates to the compounds of formula (I) in which X, R1, R2 and R3 are as defined in claim 1. These compounds are cholesteryl acyl transferase (ACAT) inhibitors.
摘要翻译：本发明涉及式（I）化合物，其中X，R 1，R 2和R 3如权利要求1所定义。这些化合物是胆固醇酰基转移酶（ACAT）抑制剂。

4. 发明申请

US20070105115A1 Promoter of the human fatp5 gene and uses 审中-公开
标题翻译：人类fatp5基因的启动子和用途
公开(公告)号：US20070105115A1
公开(公告)日：2007-05-10
申请号：US10569795
申请日：2004-08-04
申请人： Geneviève Martin , Guy Augert , Maryam Asfari , Herve Dupont , Daniel Ruggiero , Philippe Durbin
发明人： Geneviève Martin , Guy Augert , Maryam Asfari , Herve Dupont , Daniel Ruggiero , Philippe Durbin
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N1/21 , C07K14/47
CPC分类号： C07K14/705
摘要： The invention relates to an isolated human nucleic acid, characterized in that it corresponds to the promoter of the human FATP5 protein, and to an isolated human nucleic acid coding for a protein, particularly for the human FATP5 protein, placed under the dependence of said promoter. The invention further relates to a vector comprising said nucleic acid, or to a host cell into which said nucleic acid or said vector has been introduced. Finally, the invention relates to the use of said nucleic acid, said vector or said host cell in a method of identifying a product capable of modulating the expression of a nucieotide sequence placed under the dependence of said promoter of the human FATP5 protein, and to said method of identification. The invention finally relates to the product capable of modulating the expression of a nucleotide sequence placed under the dependence of said promoter of the human FATP5 protein, and to the use of said product in the preparation of a drug for preventing and/or treating diabetes or for inducing the β oxidation of fatty acids in the liver.
摘要翻译：本发明涉及一种分离的人核酸，其特征在于它对应于人FATP5蛋白的启动子，以及编码一种分离的人核酸，其编码一种蛋白，特别是对于人FATP5蛋白，其置于所述启动子。本发明进一步涉及包含所述核酸的载体，或涉及引入了所述核酸或载体的宿主细胞。最后，本发明涉及所述核酸，所述载体或所述宿主细胞在鉴定能够调节在人FATP5蛋白的所述启动子的依赖下置换的核苷酸序列的表达的产物的方法中的用途，以及所述识别方法。本发明最终涉及能够调节在人FATP5蛋白的所述启动子的依赖下置换的核苷酸序列的表达的产物，以及所述产物在制备用于预防和/或治疗糖尿病的药物中的用途用于诱导肝脏中脂肪酸的β氧化。

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