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1. 发明申请

US20080194608A1 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof 审中-公开
标题翻译： 6-苯基己-5-烯酸衍生物，其制备方法，包含它们的药物组合物及其治疗用途
公开(公告)号：US20080194608A1
公开(公告)日：2008-08-14
申请号：US11813927
申请日：2005-12-22
申请人： Michel Brunet , Herve Dumas , Catherine Vidal , Nathalie Adje , Benoit Van Hille , Francis Contard
发明人： Michel Brunet , Herve Dumas , Catherine Vidal , Nathalie Adje , Benoit Van Hille , Francis Contard
IPC分类号： A61K31/44 , C07C69/00 , A61K31/216 , C07C59/00 , A61K31/19 , C07D263/02 , A61P9/10 , A61P3/10 , A61K31/421 , C07D333/50 , A61K31/381 , C07D213/02
CPC分类号： C07D333/28 , C07C59/68 , C07C59/90 , C07D213/30 , C07D263/32 , C07D333/56
摘要： Compounds of the formula (I): in which R1, R2, R3, R′3 and R4 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, the pharmaceutical compositions comprising them, and the processes for the preparation of these compounds.
摘要翻译：式（I）化合物：其中R 1，R 2，R 3，R 3，和R 4如在描述中所定义，其用于治疗血脂异常，动脉粥样硬化和糖尿病的用途，包含它们的药物组合物以及这些化合物的制备方法。

2. 发明授权

US6012615A Precompression pump formed within the pusher element 失效
标题翻译：在推动元件内形成预压泵
公开(公告)号：US6012615A
公开(公告)日：2000-01-11
申请号：US91900
申请日：1998-08-17
申请人： Michel Brunet , Olivier de Pous
发明人： Michel Brunet , Olivier de Pous
IPC分类号： B05B11/00
CPC分类号： B05B11/3007 , B05B11/3004 , B05B11/304 , B05B11/3074
摘要： Precompression pump intended to dispense selectively a product contained in a container, said pump comprising a pump chamber (3) having an inlet valve (4), a piston (1) sliding in a first cylinder (2), a differential piston (5) forming an outlet valve of said pump chamber (3) and sliding in a second cylinder (11) between a closing position and an opening position of the pump chamber (3), said pump comprising also a pusher (6) provided with a dispensing orifice (7), said pusher element (6) being movable between a rest position and a pump actuation position, the pump being characterized in that said first and second cylinders (2 and 11) are directly formed by first and second respective internal walls of said pusher (6), the latter delimiting partially said pump chamber (3), the pump being also characterized in that it comprises only one spring (15) bearing on one side on a portion of the pusher (6) and on the other side on a portion of the differential piston (5), said spring (15) acting on the one hand as a return spring for the pusher (6) towards its rest position and on the other hand as a precompression spring for the differential piston (5).
摘要翻译： PCT No.PCT / FR96 / 01895 Sec。 371日期1998年8月17日第 102（e）日期1998年8月17日PCT 1996年11月29日PCT公布。公开号WO97 / 23304 PCT 日期1997年7月3日预压泵旨在选择性地分配容纳在容器中的产品，所述泵包括具有入口阀（4）的泵室（3），在第一气缸（2）中滑动的活塞（1）形成所述泵室（3）的出口阀并在第二气缸（11）中在泵室（3）的关闭位置和打开位置之间滑动的差动活塞（5），所述泵还包括推动器（6）设置有分配孔口（7），所述推动器元件（6）可在静止位置和泵致动位置之间移动，所述泵的特征在于，所述第一和第二气缸（2和11）直接由第一和第二气缸所述推动器（6）的相应的内壁，其中部分地限定所述泵室（3），所述泵的特征还在于其仅包括一个在所述推动器（6）的一部分上的一侧上支承的弹簧（15），并且在另一侧在差动活塞（5）的一部分上弹簧（15）一方面作为推动器（6）朝向其静止位置的复位弹簧，另一方面作为用于差速活塞（5）的预压缩弹簧。

3. 发明授权

US5261574A Closable and flow rate adjusting pushbutton for a hand-held fluid spray or dispenser device 失效
标题翻译：用于手持式流体喷雾或分配器装置的可闭合和流量调节按钮
公开(公告)号：US5261574A
公开(公告)日：1993-11-16
申请号：US834398
申请日：1992-02-12
申请人： Claude Jouillat , Michel Brunet
发明人： Claude Jouillat , Michel Brunet
IPC分类号： B05B1/30 , B65D83/44
CPC分类号： B05B1/3006
摘要： A pushbutton for actuating a device for dispensing or spraying a fluid substance includes a hollow body 1 having an outlet end 2 in which an outlet orifice 3 is formed, the outlet end including an inside surface 2a which is not perpendicular to the axis 1a of the body. An adjustment member 10 is rotatably received in the body of the pushbutton, and includes a shutter 19 provided with a front surface 19a that is complementary in shape to the inside surface of the outlet end. The shutter is urged towards the outlet end by a resilient tongue 18. The rotation of the adjustment member and shutter varies the outlet flow rate from the pushbutton.
摘要翻译：用于致动用于分配或喷射流体物质的装置的按钮包括具有出口端2的中空本体1，其中形成有出口孔3，该出口端包括内表面2a，内表面2a不垂直于身体。调节构件10被可旋转地容纳在按钮的主体中，并且包括一个活门19，活门19具有形状与出口端的内表面互补的前表面19a。快门通过弹性舌片18朝向出口端被推动。调节构件和快门的旋转使得按钮的出口流量变化。

4. 发明授权

US4413755A Metered aerosol valve for use in inverted position 失效
标题翻译：计量式气溶胶阀用于倒置位置
公开(公告)号：US4413755A
公开(公告)日：1983-11-08
申请号：US363748
申请日：1982-03-30
申请人： Michel Brunet
发明人： Michel Brunet
IPC分类号： B65D83/14 , B65D83/00
CPC分类号： B65D83/54
摘要： Part (14) of stem (4) which extends through opening (31) of lower basket (12) is provided with ribs (17) for having an easier passage of material, either during initial filling or during normal use. The lower part of valve body (1) is provided with openings (19), the number of which is different from the number of ribs (17).
摘要翻译：杆（4）的延伸穿过下篮（12）的开口（31）的部分（14）设置有用于在初始填充期间或在正常使用期间更容易通过材料的肋（17）。阀体（1）的下部设有开口（19），其数量与肋（17）的数量不同。

5. 发明申请

US20080139599A1 Phenylbenzoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof 有权
标题翻译：苯基苯甲酸衍生物，其制备方法，包含它们的药物组合物及其治疗用途
公开(公告)号：US20080139599A1
公开(公告)日：2008-06-12
申请号：US11813926
申请日：2005-12-22
申请人： Michel Brunet , Nathalie Adje , Valerie Guyard-Dangremont , Francis Contard
发明人： Michel Brunet , Nathalie Adje , Valerie Guyard-Dangremont , Francis Contard
IPC分类号： A61K31/192 , C07C63/33 , C07D263/34 , C07D213/28 , C07D261/06 , C07D307/68 , C07D277/22 , C07D249/04 , C07D271/06 , A61K31/435 , A61P3/10 , A61P9/10 , A61K31/4245 , A61K31/4192 , A61K31/421 , A61K31/42 , A61K31/426 , A61K31/425 , A61K31/40
CPC分类号： C07D207/32 , C07C65/40 , C07D213/30 , C07D249/04 , C07D249/06 , C07D261/08 , C07D263/32 , C07D271/06 , C07D307/38 , C07D413/04 , C07D417/04
摘要： Compounds of the formula (1) in which R1, R2,X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
摘要翻译：其中R 1，R 2，X，Y和Z的式（1）化合物如说明书中所定义，这些化合物的制备方法，其用于治疗血脂异常，动脉粥样硬化和糖尿病的用途，以及包含它们的药物组合物。

6. 发明申请

US20060052447A1 Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositios comprising them and processes for the preparation of them 失效
标题翻译：新型取代的芳基己二烯酸及其酯可用于
公开(公告)号：US20060052447A1
公开(公告)日：2006-03-09
申请号：US10530022
申请日：2003-08-11
申请人： Michel Brunet , Jean-Jacques Zeiller , Gerard Ferrand , Yves Bonhomme
发明人： Michel Brunet , Jean-Jacques Zeiller , Gerard Ferrand , Yves Bonhomme
IPC分类号： C07C69/76 , A61K31/235 , A61K31/192
CPC分类号： C07C69/738 , C07C67/343
摘要： The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.
摘要翻译：本发明涉及式I化合物：

7. 发明授权

US6155496A Two-phase spray device for a fluid or pasty material 失效
标题翻译：用于流体或糊状材料的两相喷雾装置
公开(公告)号：US6155496A
公开(公告)日：2000-12-05
申请号：US180036
申请日：1999-03-11
申请人： Michel Brunet , Olivier de Pous
发明人： Michel Brunet , Olivier de Pous
IPC分类号： B65D83/14 , B05B11/00 , B67D5/52 , B05B9/043
CPC分类号： B05B11/3087
摘要： A device mountable on a material container for dispensing fluid or pasty material therefrom is disclosed. The device comprises a first pump (10) for selectively dispensing the material from the container through an outlet (31), said first pump being mountable on the container by means of an attachment member (11), and a manual actuation member (30) movable between an inoperative position and an actuated position. The device further comprises a second pump (20) for dispensing compressed air at the same time as the material is dispensed. The second pump comprises two elements (21, 22), i.e. a plunger (21) and a pump cylinder (22) slidably housing the plunger (21), and is designed to feed a flow of compressed air to the outlet (31) in order to spray the material. One of said two elements (21, 22) of said second pump (20) is secured to said attachment member (11) of the first pump (10), whereas the other of said two elements (21, 22) is secured to the actuation member (30).
摘要翻译： PCT No.PCT / FR97 / 00808 Sec。 371 1999年3月11日 102（e）1999年3月11日PCT PCT 1997年5月6日PCT公布。公开号WO97 / 41965 PCT 日期1997年11月13日公开了一种可安装在用于从其分配流体或糊状材料的材料容器上的装置。该装置包括用于通过出口（31）选择性地分配来自容器的材料的第一泵（10），所述第一泵借助于附接构件（11）安装在容器上，以及手动致动构件（30）可在非操作位置和致动位置之间移动。该装置还包括用于在分配材料的同时分配压缩空气的第二泵（20）。第二泵包括两个元件（21,22），即柱塞（21）和可滑动地容纳柱塞（21）的泵缸（22），并被设计成将压缩空气流供给到出口（31）命令喷涂材料。所述第二泵（20）的所述两个元件（21,22）中的一个固定到所述第一泵（10）的所述附接构件（11），而所述两个元件（21,22）中的另一个固定到致动构件（30）。

8. 发明授权

US4989763A Pushbutton for a spray device arranged to mix a predetermined quantity of a secondary substance in the emission of a main sustance 失效
标题翻译：用于喷射装置的按钮，其布置成在主维持物的发射中混合预定量的第二物质
公开(公告)号：US4989763A
公开(公告)日：1991-02-05
申请号：US301790
申请日：1989-01-26
申请人： Michel Brunet
发明人： Michel Brunet
IPC分类号： B05B9/04 , B05B11/00 , B65D83/14 , B65D83/16
CPC分类号： B65D83/685 , B65D83/20
摘要： A pushbutton for use with a spray device for mixing a primary substance with a predetermined quantity of a secondary substance stored in such a manner as to be sheltered from the air. The pushbutton is constituted by a first piece (2) which is moveable relative to a second piece (1) containing the emission channel (11) of the pushbutton. The first piece (2) includes containers (22) advantageously disposed like rounds in the cylinder of a revolver. Each container (22) contains the desired quantity of the secondary substance and is hermetically closed by a membrane (23). When the user actuates the pushbutton, a suitable resilient piece (3) and suitable connection pieces (15, 25) ensure that the user automatically displaces the first piece (2) in such a manner that the membrane (23) of one of the containers (22) is pierced and the corresponding dose of secondary substance is delivered into the emission channel (11) so as to be sprayed out together with the main substance.
摘要翻译：一种与喷雾装置一起使用的按钮，用于将初级物质与预定量的次要物质混合，以便从空气中避开。按钮由相对于包含按钮的发射通道（11）的第二件（1）可移动的第一件（2）构成。第一件（2）包括有利地设置在左轮手枪的气缸中的圆形的容器（22）。每个容器（22）包含所需量的第二物质，并被膜（23）气密地封闭。当用户致动按钮时，合适的弹性件（3）和适当的连接件（15,25）确保使用者以这样一种方式自动地移动第一件（2），使得容器之一的膜（23）（22）被刺穿，并将相应剂量的次级物质输送到排放通道（11）中，以便与主要物质一起被喷出。

9. 发明授权

US07863328B2 Phenylbenzoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic uses thereof 有权
标题翻译：苯基苯甲酸衍生物，其制备方法，包含它们的药物组合物及其治疗用途
公开(公告)号：US07863328B2
公开(公告)日：2011-01-04
申请号：US11813926
申请日：2005-12-22
申请人： Michel Brunet , Nathalie Adje , Valérie Guyard-Dangremont , Francis Contard
发明人： Michel Brunet , Nathalie Adje , Valérie Guyard-Dangremont , Francis Contard
IPC分类号： A61K31/015 , A61K31/16 , A61K31/19 , A61K31/216 , C07C69/003 , C07C63/06 , C07C237/30
CPC分类号： C07D207/32 , C07C65/40 , C07D213/30 , C07D249/04 , C07D249/06 , C07D261/08 , C07D263/32 , C07D271/06 , C07D307/38 , C07D413/04 , C07D417/04
摘要： Compounds of the formula (1) in which R1, R2, X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
摘要翻译：其中R1，R2，X，Y和Z如说明书中所定义的式（1）化合物，这些化合物的制备方法，其用于治疗血脂异常，动脉粥样硬化和糖尿病的用途，以及药物包含它们的组合物。

10. 发明授权

US07323458B1 Dihydrobenzodiazepins and their use for treating dyslipidemia 失效
标题翻译：二氢苯并二氮杂类及其用于治疗血脂异常的用途
公开(公告)号：US07323458B1
公开(公告)日：2008-01-29
申请号：US10019683
申请日：2000-07-04
申请人： Jean-Jacques Berthelon , Daniel Guerrier , Michel Brunet , Jean-Jacques Zeiller , Francis Contard , Fréderic Ausseil
发明人： Jean-Jacques Berthelon , Daniel Guerrier , Michel Brunet , Jean-Jacques Zeiller , Francis Contard , Fréderic Ausseil
IPC分类号： A61P7/00 , A61K31/55 , C07D243/04
CPC分类号： C07D401/12 , C07D243/04 , C07D405/12 , C07D413/12 , C07D487/04 , C07D513/04 , C07D513/14
摘要： The invention concerns a benzodiazepin derivative of formula (I) and their use for treating dyslipidemia, atherosclerosis, diabetes and its complications.
摘要翻译：本发明涉及式（I）的苯并二氮杂衍生物及其用于治疗血脂异常，动脉粥样硬化，糖尿病及其并发症的用途。

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