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1. 发明授权

US06498850B1 Multichannel echo canceller with a compander 失效
标题翻译：多通道回波消除器与压缩扩展器
公开(公告)号：US06498850B1
公开(公告)日：2002-12-24
申请号：US09282212
申请日：1999-03-31
申请人： Michael Walker , Hans Jürgen Matt , Armin Mann , Fritz Weinschenk , Holger Söhnle
发明人： Michael Walker , Hans Jürgen Matt , Armin Mann , Fritz Weinschenk , Holger Söhnle
IPC分类号： H04M908
CPC分类号： H04B3/23
摘要： A compander circuit (20) for echo cancellation in telecommunications apparatus with an estimator module (21) for estimating an echo coupling and a delay of a line echo and a characteristic module (23) with an associated multiplier (24) for controlling the short-time output level of zout(k) as a function of the short-time input level of zin(k) is characterized in that at all inputs and outputs of the compander circuit (20), a plurality of N communications channels are applied and outputted, respectively, at an N-fold clock rate as compared with a single communications channel; that all memory units in the compander circuit (20) are designed as multiplexer-buffer-demultiplexer (MBD) units (30); and that a modulo-N counter (26) is provided which controls all MBD units (30) so that in each of the MBD units (30), always the same memory cell (351, 352, 35N) assigned to a particular communications channel is addressed.
摘要翻译：一种用于在具有估计模块（21）的电信设备中用于回波消除的压缩扩展电路（20），用于估计回波耦合和线路回波延迟以及具有相关联的乘法器（24）的特征模块（23）作为zin（k）的短时输入电平的函数的zout（k）的时间输出电平的特征在于，在压缩扩展电路（20）的所有输入和输出处，施加并输出多个N个通信信道，与单个通信信道相比分别为N倍时钟速率; 所述压缩扩展电路（20）中的所有存储器单元被设计为多路复用器 - 缓冲器解多路复用器（MBD）单元（30）; 并且提供了模N计数器（26），其控制所有MBD单元（30），使得在每个MBD单元（30）中，总是相同的存储器单元（351,352,35N）分配给特定通信信道被解决。

2. 发明授权

US06493448B1 Process for echo suppression with adaptive fir filters 失效
标题翻译：具有自适应冷杉滤波器的回波抑制过程
公开(公告)号：US06493448B1
公开(公告)日：2002-12-10
申请号：US09231794
申请日：1999-01-15
申请人： Armin Mann , Hans Jürgen Matt , Michael Walker
发明人： Armin Mann , Hans Jürgen Matt , Michael Walker
IPC分类号： H04M908
CPC分类号： H04B3/23
摘要： A process for suppressing total echoes comprising a plurality of partial echoes in telecommunications (TK) equipment such as terminals, transmission systems, or switching equipment by means of adaptive FIR (=Finite Impulse Response) filters that simulate the total echo and subtract it from the echo-affected useful signal transmitted to the respective TK equipment, whereby n partial FIR filters are provided, which respectively simulate a partial echo, is characterized in that m parallel, mutually independent TK channels are provided with an echo suppression function and that for this purpose a variable sub-quantity of the partial FIR filters is assigned to a TK channel to be operated, respectively, as required depending on the number of partial echoes and the size of the occurring delay times between signal and echo. This permits effective echo suppression without significant memory space and computational effort even for a large number of m parallel, mutually independent TK channels, such as must be processed in switching equipment or gateways.
摘要翻译：一种用于通过自适应FIR（=有限脉冲响应）滤波器抑制电信（TK）设备中诸如终端，传输系统或交换设备的多个部分回波的总回波的过程，该自适应FIR（=有限脉冲响应）滤波器模拟总回波并将其从回波影响的有用信号被发送到相应的TK设备，由此提供分别模拟部分回波的n个部分FIR滤波器，其特征在于m个并行的，相互独立的TK信道被提供回波抑制功能，为此目的根据需要，根据部分回波的数量和信号和回波之间出现的延迟时间的大小，分配将部分FIR滤波器的可变子量分配给要被操作的TK信道。这允许有效的回波抑制，即使对于大量的并行，相互独立的TK信道也不会有显着的存储空间和计算量，例如必须在交换设备或网关中处理。

3. 发明授权

US06483915B1 Equipment and processes for echo suppression with adaptive fir filters 失效
标题翻译：用自适应冷杉滤波器进行回波抑制的设备和过程
公开(公告)号：US06483915B1
公开(公告)日：2002-11-19
申请号：US09231793
申请日：1999-01-15
申请人： Armin Mann , Hans Jürgen Matt , Michael Walker
发明人： Armin Mann , Hans Jürgen Matt , Michael Walker
IPC分类号： H04M908
CPC分类号： H04B3/23
摘要： An equipment (1) for the suppression of whole echoes composed of several partial echoes in telecommunications (TC) equipment, such as end devices, transmission systems or exchange equipment, with the help of adaptive FIR (=Finite Impulse Response) filters, which reproduce the whole echo and extract it from the echo-laden useful signal and which has been transferred to the respective TC equipment, in which the homogeneous FIR filters or partial filters (10), each of which are able to reproduce a whole echo or partial echo, are implemented on a single ASIC (=Application Specific Integrated Circuit) (9) for the m parallel and independent TC channels n to be served; and in which the whole echoes or partial echoes to be reproduced can be calculated in real time in the ASIC (9) and in which a digital signal processor (4) is designed to control the ASIC (9) and set the filter settings, especially after the coefficient required to reproduce the echo is calculated on the ASIC (9). This calculation is carried out in the digital signal processor (4). This makes it possible to effectively suppress echoes in a large number of m parallel and independent TC channels, as they must be processed in exchanges and network hybrids, without requiring a large amount of memory space and computational effort.
摘要翻译：在自适应FIR（=有限脉冲响应）滤波器的帮助下，用于抑制电信（TC）设备中的几个部分回波（例如终端设备，传输系统或交换设备）的整个回波的设备（1）整个回波并将其从有回波的有用信号中提取出来，并将其传送到相应的TC设备，其中均匀的FIR滤波器或部分滤波器（10）能够再现整个回波或部分回波在单个ASIC（=专用集成电路）（9）上实现，用于要并行和独立的TC信道n被服务; 并且其中可以在ASIC（9）中实时地计算整个回波或部分回波以被再现，并且其中数字信号处理器（4）被设计为控制ASIC（9）并设置滤波器设置，特别是在ASIC（9）上计算再现回波所需的系数之后。该计算在数字信号处理器（4）中进行。这使得可以有效地抑制大量m个并行和独立的TC信道中的回波，因为它们必须在交换和网络混合中被处理，而不需要大量的存储空间和计算量。

4. 发明授权

US06320918B1 Procedure for reducing interference in the transmission of an electrical communication signal 失效
标题翻译：降低电通信信号传输干扰的步骤
公开(公告)号：US06320918B1
公开(公告)日：2001-11-20
申请号：US09133830
申请日：1998-08-13
申请人： Michael Walker , Hans Jürgen Matt , Michael Trompf
发明人： Michael Walker , Hans Jürgen Matt , Michael Trompf
IPC分类号： H03D104
CPC分类号： G10L21/0208 , H04L25/03019
摘要： Through crosstalk on lines, interference from current transmission lines or line echoes, the useable signal is superimposed by different interference signals. The task is to find a procedure for reducing interference which, compared to the current state of the art, can be achieved with a smaller amount of computing input and is suited to both the reduction of quasi steady-state and non-steady interference. In this, the interference of a received signal is classified with regards to characteristics in the time range as a click, crackle, rumble or noise interference signal. The time range in which the interference occurs is marked. Depending on the interference type, interference blanking and/or an interpolation of the useable signal and/or a subtraction of the interference signal from the useable signal and/or a regeneration of the useable signal is carried out.
摘要翻译：通过线路上的串扰，来自当前传输线路或线路回波的干扰，可用信号由不同的干扰信号叠加。任务是找到一种减少干扰的过程，与目前的现有技术相比，可以用更少量的计算输入来实现干扰，并且适用于准稳态和非稳态干扰的降低。在此，接收信号的干扰在时间范围内被分类为点击，裂纹，隆隆声或噪声干扰信号。发生干扰的时间范围被标记。根据干扰类型，执行干扰消隐和/或可用信号的内插和/或可用信号的干扰信号的减法和/或可用信号的再生。

5. 发明授权

US06999920B1 Exponential echo and noise reduction in silence intervals 有权
标题翻译：沉默间隔的指数回波和降噪
公开(公告)号：US06999920B1
公开(公告)日：2006-02-14
申请号：US09716272
申请日：2000-11-21
申请人： Hans-Jürgen Matt , Michael Walker , Michael Maurer
发明人： Hans-Jürgen Matt , Michael Walker , Michael Maurer
IPC分类号： G10L11/06
CPC分类号： G10L21/0208 , G10L2021/02082 , G10L2021/02168
摘要： Method for the reduction of echo and/or noise signals in TK systems for the transmission of useful acoustic signals, in which, when a silence interval is present, the distorted useful signal is modified by a time-dependent control signal ao(t) or by a control signal ao(k) cycled in the rhythm of a scan rate fT=1/T. The control signal ao(k) is varied in such manner that, during the presence of speech signals in the useful signals, the amplitude of the control signal ao(k) is set to a predetermined constant value co and, when a silence interval begins, the amplitude of the control signal ao(k) is reduced continuously from one sample value to the next in accordance with the recurrence formula ao(k+1)=ao(k).β with β
摘要翻译：用于减少用于传输有用声信号的TK系统中的回波和/或噪声信号的方法，其中当存在静默间隔时，失真的有用信号由时间相关的控制信号修改（t）或通过以扫描速率f T T = 1 / T的节奏循环的控制信号a <0>（k）。控制信号a k（k）以这样的方式变化，使得在有用信号中的语音信号存在期间，控制信号的幅度α（k ）被设置为预定的常数值c 0，并且当静默间隔开始时，控制信号a 0（k）的振幅从一个采样值连续地减小根据递增公式α（k + 1）=β（β）β，其中β<1。在静默间隔结束之后，再次将（k）设置为等于（c）。

6. 发明申请

US20140064435A1 NUCLEAR FUEL ASSEMBLY FOR BOILING WATER REACTOR COMPRISING A FUEL CHANNEL SPACER 审中-公开
标题翻译：用于燃料通道间隙的锅炉水反应堆核燃料组件
公开(公告)号：US20140064435A1
公开(公告)日：2014-03-06
申请号：US13822508
申请日：2012-05-18
申请人： Dirk Blavius , Erhard Friedrich , Bernd Block , Viktor Ruder , Corey Long , Michael Walker
发明人： Dirk Blavius , Erhard Friedrich , Bernd Block , Viktor Ruder , Corey Long , Michael Walker
IPC分类号： G21C3/356
CPC分类号： G21C3/3566 , G21C3/332 , G21C3/34 , Y02E30/40
摘要： A nuclear fuel assembly for boiling water reactor is provided. The nuclear fuel assembly includes a base, a head, a bundle of fuel rods extending longitudinally between the base and the head, a tubular fuel channel encasing the bundle of fuel rods, and at least one fuel channel spacer for transversely spacing the fuel assembly from an adjacent element. The or each fuel channel spacer includes a support having at least one plate and at least one corresponding leaf spring supported by the corresponding plate, the or each plate being fixed to a corresponding sidewall of the fuel channel.
摘要翻译：提供了一种用于沸水反应堆的核燃料组件。核燃料组件包括基座，头部，在基部和头部之间纵向延伸的一组燃料棒，包围燃料棒束的管状燃料通道，以及用于将燃料组件横向间隔开的至少一个燃料通道间隔件相邻元素。该或每个燃料通道间隔件包括具有至少一个板的支撑件和由对应的板支撑的至少一个对应的板簧，该板或每个板固定到燃料通道的相应侧壁。

7. 发明授权

US08273544B2 Methods for diagnosis, prognosis and methods of treatment 有权
公开(公告)号：US08273544B2
公开(公告)日：2012-09-25
申请号：US13083156
申请日：2011-04-08
申请人： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
发明人： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC分类号： G01N33/53 , G01N33/567 , G01N33/00
CPC分类号： G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

8. 发明申请

US20110269154A1 Methods for Diagnosis, Prognosis and Methods of Treatment 有权
标题翻译：诊断方法，预后及治疗方法
公开(公告)号：US20110269154A1
公开(公告)日：2011-11-03
申请号：US13083156
申请日：2011-04-08
申请人： Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
发明人： Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC分类号： G01N33/567 , G01N33/574
CPC分类号： G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要翻译：本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。此外，这种方法允许细胞活动或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。

9. 外观设计

USD647985S1 Golf club head 有权
公开(公告)号：USD647985S1
公开(公告)日：2011-11-01
申请号：US29380776
申请日：2010-12-10
申请人： Zac Atwell , Robert Nunez , Chris Piniarski , Brian Bazzel , Sean Toulon , Bret H. Wahl , Allan Capili Saliba , Marni D. Ines , Michael Walker
设计人： Zac Atwell , Robert Nunez , Chris Piniarski , Brian Bazzel , Sean Toulon , Bret H. Wahl , Allan Capili Saliba , Marni D. Ines , Michael Walker

10. 发明申请

US20110250206A1 MARKERS FOR DETERMINATION OF PATIENT RESPONSIVENESS 审中-公开
公开(公告)号：US20110250206A1
公开(公告)日：2011-10-13
申请号：US13026181
申请日：2011-02-11
申请人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi , Tito A. Serafini
发明人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi , Tito A. Serafini
IPC分类号： A61K39/395 , A61P3/10 , A61P11/06 , G06F19/00 , A61P1/16 , A61P25/16 , A61P9/10 , A61P3/04 , A61P29/00 , A61P11/00
CPC分类号： A61K31/225 , A61K31/18 , G01N33/6863 , G01N33/6896 , G01N2333/54 , G01N2800/285 , Y02A90/26
摘要： Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.

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