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1. 发明申请

US20110250206A1 MARKERS FOR DETERMINATION OF PATIENT RESPONSIVENESS 审中-公开
公开(公告)号：US20110250206A1
公开(公告)日：2011-10-13
申请号：US13026181
申请日：2011-02-11
申请人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi , Tito A. Serafini
发明人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi , Tito A. Serafini
IPC分类号： A61K39/395 , A61P3/10 , A61P11/06 , G06F19/00 , A61P1/16 , A61P25/16 , A61P9/10 , A61P3/04 , A61P29/00 , A61P11/00
CPC分类号： A61K31/225 , A61K31/18 , G01N33/6863 , G01N33/6896 , G01N2333/54 , G01N2800/285 , Y02A90/26
摘要： Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.

2. 发明申请

US20110243893A1 MARKERS FOR DETERMINATION OF PATIENT RESPONSIVENESS 有权
标题翻译：用于确定患者反应的标记
公开(公告)号：US20110243893A1
公开(公告)日：2011-10-06
申请号：US13026173
申请日：2011-02-11
申请人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi
发明人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi
IPC分类号： A61K38/21 , A61K38/02 , A61K31/225 , A61K39/395 , A61P29/00 , A61P25/00 , G06F19/00
CPC分类号： A61K31/225 , A61K31/18 , G01N33/6863 , G01N33/6896 , G01N2333/54 , G01N2800/285 , Y02A90/26
摘要： Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.
摘要翻译：提供组合物和方法用于炎性疾病的预后分类，例如炎症性脱髓鞘疾病，患者进入亚型，哪些亚型对患者的治疗需求和对感兴趣的治疗的反应有信息。细胞因子的模式提供了一种能够识别可能受益于治疗干预的患者的特征模式，并且将具有高反应概率的治疗反应能力高的患者区分开来。因此，这种签名模式的评估允许改进护理方法。在本发明的一个实施方案中，自身免疫性疾病是多发性硬化症或神经性脊髓炎。

3. 发明授权

US08828668B2 Markers for determination of patient responsiveness 有权
标题翻译：确定患者反应性的标记
公开(公告)号：US08828668B2
公开(公告)日：2014-09-09
申请号：US13026173
申请日：2011-02-11
申请人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi
发明人： Robert C. Axtell , Lawrence Steinman , May H. Han , Brigit A. de Jong , Chander Raman , Michael Walker , Jing Shi
IPC分类号： G01N33/53 , A61K39/395 , A61K38/00
CPC分类号： A61K31/225 , A61K31/18 , G01N33/6863 , G01N33/6896 , G01N2333/54 , G01N2800/285 , Y02A90/26
摘要： Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.
摘要翻译：提供组合物和方法用于炎性疾病的预后分类，例如炎症性脱髓鞘疾病，患者进入亚型，哪些亚型对患者的治疗需求和对感兴趣的治疗的反应有信息。细胞因子的模式提供了一种能够识别可能受益于治疗干预的患者的特征模式，并且将具有高反应概率的那些对治疗具有高反应能力的患者区分开来。因此，这种签名模式的评估允许改进护理方法。在本发明的一个实施方案中，自身免疫性疾病是多发性硬化症或神经性脊髓炎。

4. 发明申请

US20130046015A1 Therapeutic Inhibition of Granulocyte Function in Demyelinating Disease 审中-公开
标题翻译：脱髓鞘性粒细胞功能的治疗抑制作用
公开(公告)号：US20130046015A1
公开(公告)日：2013-02-21
申请号：US13577579
申请日：2011-02-11
申请人： Robert C. Axtell , Lawrence Steinman
发明人： Robert C. Axtell , Lawrence Steinman
IPC分类号： A61K31/225 , A61P25/00 , A61P29/00
CPC分类号： A61K31/225 , A61K31/18 , G01N33/6863 , G01N33/6896 , G01N2333/54 , G01N2800/285 , Y02A90/26
摘要： Compositions and methods are provided for the treatment of IL-17-type inflammatory demyelinating diseases with inhibitors of granulocyte function, e.g. elastase inhibitors. Diseases of interest include multiple sclerosis, neuromyelitis optica, animal models of such diseases, etc. In some embodiments pharmaceutical formulations comprising an elastase inhibitor in an effective dose for treatment of IL-17-type inflammatory demyelinating disease and a pharmaceutically acceptable excipient are provided. Patients may be classified into subtypes prior to treatment, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest.
摘要翻译：提供组合物和方法用于治疗IL-17型炎性脱髓鞘疾病与粒细胞功能抑制剂，例如，弹性蛋白酶抑制剂。感兴趣的疾病包括多发性硬化症，视神经脊髓炎，这种疾病的动物模型等。在一些实施方案中，提供了包含用于治疗IL-17型炎性脱髓鞘疾病的有效剂量的弹性蛋白酶抑制剂和药学上可接受的赋形剂的药物制剂。患者可以在治疗之前分为亚型，哪些亚型对患者的治疗需求和对感兴趣的治疗的反应性是有益的。

5. 发明授权

US06246125B1 Portable wind and hydro electric generating system 失效
标题翻译：便携式风力发电和水力发电系统
公开(公告)号：US06246125B1
公开(公告)日：2001-06-12
申请号：US09625369
申请日：2000-07-25
申请人： Robert C. Axtell
发明人： Robert C. Axtell
IPC分类号： F03D102
CPC分类号： F03D3/002 , F03B17/063 , F03D9/11 , F03D9/25 , F03D13/20 , F05B2220/706 , F05B2240/2212 , F05B2240/9151 , Y02E10/28 , Y02E10/38 , Y02E10/728 , Y02E10/74
摘要： A portable generating system for converting either water or wind energy into electricity comprises a paddle wheel assembly having a housing and a plurality of impellers rotatably mounted therein. The housing defines inlet and outlet openings for receiving a fluid stream, whether water or air, therebetween so as to rotate the impellers. The impellers are axially connected to a generator for producing electricity upon impeller rotation as the fluid stream flows between the housing openings. The generator may be mounted within the paddle wheel housing adjacent the impellers or at a distance therefrom and coupled thereto with a shaft. A plurality of mounting brackets are fixedly attached to the outer surface of the housing. The generating system further includes a plurality of height-adjustable support legs that may be coupled to the mounting brackets so that the paddle wheel housing may be positioned at a predetermined height above a support surface. The support surface may be a dry ground area such that electricity is generated as a result of an air stream or may be a body of water such that electricity is generated as a result of a water stream. The system may easily be assembled and disassembled and moved between desired locations.
摘要翻译：一种用于将水或风能转换为电力的便携式发电系统包括具有壳体和可旋转地安装在其中的多个叶轮的叶轮组件。壳体限定用于接收流体流（不论是水或空气）之间的入口和出口开口，以便使叶轮旋转。当流体流在壳体开口之间时，叶轮轴向连接到发电机，用于在叶轮旋转时产生电力。发电机可以安装在桨叶轮壳体内，与叶轮相邻或距离其一定距离，并与轴连接。多个安装支架固定地附接到壳体的外表面。发电系统还包括可连接到安装支架的多个高度可调的支撑腿，使得叶轮壳体可以定位在支撑表面上方的预定高度处。支撑表面可以是干燥的地面区域，使得由于空气流而产生电力，或者可以是水体，使得由于水流而产生电力。该系统可以容易地组装和拆卸并在所需位置之间移动。

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