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1. 发明申请

US20060258942A1 Spectroscopic analysis apparatus and method with excitation system and focus monitoring system 失效
标题翻译：光谱分析装置及方法与激励系统和焦点监测系统
公开(公告)号：US20060258942A1
公开(公告)日：2006-11-16
申请号：US10547971
申请日：2004-03-01
申请人： Michael Van Beek , Peter Greve
发明人： Michael Van Beek , Peter Greve
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0068 , G01J3/44 , G01N21/65 , G02B21/241
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analyzing an object, such as blood of a patient, and a corresponding analysis method. To aim the confocal detection volume inside a blood vessel orthogonal polarized spectral imaging (OPSI) is used to locate blood capillaries in the skin. An imaging system (img) with slightly shifted imaging planes (i1, i2) for OPS imaging of blood vessels is proposed to provide auto-focusing. The confocal Raman detection plane (dp) is located in between these two imaging planes (i1, i2). Based on measured amount of defocus for the imaging planes (i1, i2), the focusing of the imaging system (img), the excitation system (exs) for exciting the target region and the detection system (dsy) are adjusted such that the difference of the amount of defocus equals a predetermined amount so that the confocal detection plane (dp) is located inside the blood vessel (V). Thus, continuous auto-focusing with high accuracy can be achieved. The invention relates also to an optical tracking system for continuously tracking a point of a moving object (obj).
摘要翻译：本发明涉及用于分析患者血液等物体的分析装置，特别是光谱分析装置以及相应的分析方法。为了瞄准血管内的共焦检测体积，使用正交偏振光谱成像（OPSI）来定位皮肤中的毛细血管。提出了一种具有稍微偏移的成像平面（i 1，i 2）用于血管的OPS成像的成像系统（img），以提供自动聚焦。共焦拉曼检测平面（dp）位于这两个成像平面（i 1，i 2）之间。基于测量的成像平面（i 1，i 2）的散焦量，调整成像系统（img）的聚焦，用于激发目标区域的激发系统（exs）和检测系统（dsy），使得散焦量的差别等于预定量，使得共焦检测平面（dp）位于血管（V）内。因此，可以实现高精度的连续自动聚焦。本发明还涉及用于连续跟踪移动物体（obj）的点的光学跟踪系统。

2. 发明申请

US20070293766A1 Transmission Based Imaging for Spectroscopic Analysis 审中-公开
标题翻译：基于透射的光谱分析成像
公开(公告)号：US20070293766A1
公开(公告)日：2007-12-20
申请号：US11574163
申请日：2005-08-24
申请人： Bernardus Bakker , Gerald Lucassen , Michael Van Beek , Marjolein Van Der Voort , Robert Hendriks , Frank Schuurmans
发明人： Bernardus Bakker , Gerald Lucassen , Michael Van Beek , Marjolein Van Der Voort , Robert Hendriks , Frank Schuurmans
IPC分类号： G01J3/28
CPC分类号： A61B5/489 , A61B5/0059 , A61B2562/0238 , G01J3/36 , G01J3/42 , G01N21/31 , G01N21/35 , G01N21/59
摘要： The present invention provides a spectroscopic system and a transmission based imaging system for a spectroscopic system as well as a probe head for a transmission based imaging system for a spectroscopic system and a corresponding transmission based imaging method. The spectroscopic system is preferably applicable to in vivo noninvasive blood analysis. Transmission based imaging makes use of a transmitted portion of an imaging or monitoring beam that has been transmitted through biological tissue. By means of transmission based imaging, a contrast decreasing impact of scattered radiation can be effectively reduced. Additionally, by arranging the imaging light source opposite to an objective lens of the spectroscopic system, unintended propagation of spectroscopic excitation radiation into free space can be effectively prevented.
摘要翻译：本发明提供了一种用于分光系统的光谱系统和基于透射的成像系统以及用于分光系统的基于透射的成像系统和相应的基于透射的成像方法的探针头。光谱系统优选适用于体内非侵入性血液分析。基于传输的成像利用已经通过生物组织传输的成像或监视光束的透射部分。通过基于传输的成像，可以有效降低散射辐射的对比度减小的影响。此外，通过将成像光源与分光系统的物镜相对设置，可以有效地防止光谱激发辐射的非预期传播进入自由空间。

3. 发明申请

US20070010727A1 Catheter head 失效
标题翻译：导管头
公开(公告)号：US20070010727A1
公开(公告)日：2007-01-11
申请号：US10554352
申请日：2004-04-23
申请人： Michael Van Beek , Coen Theodorus Hubertus Liedenbaum , Wouter Rensen
发明人： Michael Van Beek , Coen Theodorus Hubertus Liedenbaum , Wouter Rensen
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1459 , A61B6/481 , A61B6/504 , A61B2562/0238
摘要： The present invention relates to a catheter head comprising: means (104, 108; 306, 304; 320, 322; 326; 338) for directing of radiation to a blood detection volume (220, 310), means (104, 108; 306, 304; 320; 322; 326; 332, 334, 330; 338) for receiving of return radiation from the blood detection volume, means (104; 306; 330) for transmitting of the return radiation to means (122) for analysis of the return radiation for determination of at least one property of the blood.
摘要翻译：本发明涉及一种导管头，其包括：用于将辐射引导到血液检测体积（220,310）的装置（104,108; 306,304; 320,322; 326; 338），装置（104,108; 306 用于从所述血液检测体积接收返回辐射的装置，用于将所述返回辐射传送到装置（122）的装置（104; 306; 330）用于分析用于确定血液的至少一种性质的返回辐射。

4. 发明申请

US20060215132A1 Lithographic apparatus and device manufacturing method 失效
标题翻译：平版印刷设备和器件制造方法
公开(公告)号：US20060215132A1
公开(公告)日：2006-09-28
申请号：US11373503
申请日：2006-03-13
申请人： Mark Kroon , Michael Van Beek , Peter Dirksen , Ralph Kurt , Cassandra Owen
发明人： Mark Kroon , Michael Van Beek , Peter Dirksen , Ralph Kurt , Cassandra Owen
IPC分类号： G03B27/52
CPC分类号： G03F7/70983 , G03F7/70808 , G03F7/70916 , G03F7/70933
摘要： A lithographic apparatus includes a radiation system that provides a beam of radiation, and a support structure that supports a patterning structure. The patterning structure is configured to pattern the beam of radiation according to a desired pattern. The apparatus also includes a substrate support that supports a substrate, and a projection system that projects the patterned beam onto a target portion of the substrate. The projection system includes an optical element that has a beam exit area through each of which the patterned beam passes. The apparatus further includes a fluid cleaning system that cleans a fluid to be introduced into a region in between the optical element and the substrate. The fluid cleaning system includes a fluid inlet, a fluid outlet, and a cleaning zone disposed between the inlet and outlet. The cleaning zone includes a nucleated surface provided with a plurality of nucleation sites.
摘要翻译：光刻设备包括提供辐射束的辐射系统和支撑图案化结构的支撑结构。图形结构被配置为根据期望的图案对辐射束进行图案化。该装置还包括支撑基板的基板支撑件和将图案化的光束投影到基板的目标部分上的投影系统。投影系统包括光学元件，该光学元件具有通过图案化光束通过的每一个的光束出射区域。该装置还包括清洁被引入到光学元件和基板之间的区域中的流体的流体清洁系统。流体清洁系统包括流体入口，流体出口和布置在入口和出口之间的清洁区域。清洁区包括具有多个成核位点的成核表面。

5. 发明申请

US20060176463A1 Lithographic apparatus, device manufacturing method, and device manufactured thereby 失效
标题翻译：平版印刷设备，器件制造方法和由此制造的器件
公开(公告)号：US20060176463A1
公开(公告)日：2006-08-10
申请号：US11345316
申请日：2006-02-02
申请人： Mark Kroon , Michael Van Beek , Peter Dirksen , Ralph Kurt , Cassandra Owen
发明人： Mark Kroon , Michael Van Beek , Peter Dirksen , Ralph Kurt , Cassandra Owen
IPC分类号： G03B27/72
CPC分类号： G03F7/70983 , G03F7/70808 , G03F7/70916 , G03F7/70933
摘要： A lithographic apparatus is disclosed. The apparatus includes a radiation system that provides a beam of radiation, and a support structure that supports a patterning structure. The patterning structure is configured to pattern the beam of radiation according to a desired pattern. The apparatus also includes a substrate support that supports a substrate, and a projection system that projects the patterned beam onto a target portion of the substrate. The projection system includes an optical element that has a beam entry area and an optical element that has a beam exit area through each of which the patterned beam passes. The apparatus further includes a nucleated surface that is associated with the projection system on which a plurality of nucleation sites are provided. The surface is disposed away from at least one of the beam entry area and the beam exit area.
摘要翻译：公开了一种光刻设备。该装置包括提供辐射束的辐射系统和支撑图形结构的支撑结构。图形结构被配置为根据期望的图案对辐射束进行图案化。该装置还包括支撑基板的基板支撑件和将图案化的光束投影到基板的目标部分上的投影系统。投影系统包括具有光束入射区域的光学元件和具有通过图案化光束通过的每一个的光束出射区域的光学元件。该装置还包括与投影系统相关联的成核表面，其上设置有多个成核位置。表面远离光束入射区域和光束出射区域中的至少一个设置。

6. 发明申请

US20070291251A1 Optical Analysis System With Background Signal Compensation 审中-公开
标题翻译：具有背景信号补偿的光学分析系统
公开(公告)号：US20070291251A1
公开(公告)日：2007-12-20
申请号：US11574181
申请日：2005-08-24
申请人： Wouter Rensen , Bernardus Leonardus Bakker , Michael Van Beek
发明人： Wouter Rensen , Bernardus Leonardus Bakker , Michael Van Beek
IPC分类号： G01N33/48 , G01N21/00 , G06F19/00
CPC分类号： G01J3/30 , G01J3/02 , G01J3/0229 , G01J3/32 , G01J3/44
摘要： The invention provides an optical analysis system for efficient compensation of spectroscopic broadband back-ground, such as spectroscopic fluorescence background or background signals that are due to the dark current of a detector. The optical analysis system effectively provides multivariate optical analysis of a spectroscopic signal. It provides wavelength selective detection of various spectral components that are indicative of a superposition of spectroscopic peaks or bands and their broadband background. Additionally, the optical analysis system is adapted to acquire spectral components that predominantly correspond to the broadband background of the spectroscopic peaks or bands. Wavelength selective selection of various spectral components is performed on the basis of reconfigurable multivariate optical elements or on the basis of a position displacement of a spatial optical transmission mask.
摘要翻译：本发明提供了一种用于有效补偿光谱宽带背景的光学分析系统，例如由于检测器的暗电流引起的分光荧光背景或背景信号。光学分析系统有效地提供了光谱信号的多变量光学分析。它提供各种光谱分量的波长选择性检测，这些光谱分量指示光谱峰或带的叠加及其宽带背景。此外，光学分析系统适于获取主要对应于光谱峰或带的宽带背景的光谱分量。基于可重构多变量光学元件或者基于空间光学透射掩模的位置位移来执行各种光谱分量的波长选择性选择。

7. 发明申请

US20070252978A1 Method and Apparatus for Optical Spectroscopy 审中-公开
标题翻译：光谱学方法与装置
公开(公告)号：US20070252978A1
公开(公告)日：2007-11-01
申请号：US10596501
申请日：2004-12-13
申请人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
发明人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01N21/65 , G01J3/44 , G01J2003/4424
摘要： The present invention provides for a method of optical spectroscopy, in particular Raman spectroscopy for performing invasive or non-invasive blood analysis. The fluorescence component of return radiation which is received from a detection volume is eliminated which is enabled by the usage of a pulsed excitation light source. The pulse length is substantially shorter than the fluorescence life time Hence, the elimination of the fluorescence composent can be performed by time gating or by other electronics or optical means.
摘要翻译：本发明提供一种用于进行侵入性或非侵入性血液分析的光谱学方法，特别是拉曼光谱法。消除了从检测体积接收的返回辐射的荧光分量，其通过使用脉冲激发光源来实现。脉冲长度明显短于荧光寿命。因此，荧光成分的消除可以通过时间选通或其他电子学或光学方法进行。

8. 发明申请

US20070177240A1 Optical analysis system using multivariate optical elements 失效
标题翻译：光学分析系统采用多元光学元件
公开(公告)号：US20070177240A1
公开(公告)日：2007-08-02
申请号：US10596564
申请日：2004-12-16
申请人： Michael Van Beek , Frank Schuurmans , Levinus Bakker
发明人： Michael Van Beek , Frank Schuurmans , Levinus Bakker
IPC分类号： G02B26/08
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , G01J3/36 , G01N21/65 , G01N33/49
摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.
摘要翻译：本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。光信号优选分为对应于加权函数的正和负光谱带的两部分。分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。光信号的分离和加权由两个多元光学元件实现。

9. 发明申请

US20070070328A1 Method of determining a property of a fluid and spectroscopic system 失效
标题翻译：确定流体和光谱系统性质的方法
公开(公告)号：US20070070328A1
公开(公告)日：2007-03-29
申请号：US10595358
申请日：2004-10-15
申请人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
发明人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
IPC分类号： G01N33/48 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/489
摘要： The present invention enables to determine the property of a fluid, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by means of an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective to the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.
摘要翻译：本发明能够确定流体的性质，例如用于体内血液分析的目的。首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。优选地，光学检测步骤是成像步骤。接下来，将目标转移到目标的焦点。在该位置，进行光学分光步骤。这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

10. 发明申请

US20080002199A1 Aberration Correction for Spectroscopic Analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US20080002199A1
公开(公告)日：2008-01-03
申请号：US11570133
申请日：2005-06-13
申请人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
发明人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
IPC分类号： G01J3/30 , G06F19/00
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).
摘要翻译：本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

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