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1. 发明申请

US20060257494A1 Coated tablets 有权
公开(公告)号：US20060257494A1
公开(公告)日：2006-11-16
申请号：US11492373
申请日：2006-07-24
申请人： Michael Vachon , Awadhesh Mishra , Robert Snow , Pol-Henri Guivarc'h
发明人： Michael Vachon , Awadhesh Mishra , Robert Snow , Pol-Henri Guivarc'h
IPC分类号： A61K31/192 , A61K9/14
CPC分类号： A61K9/14 , A61K9/145 , A61K9/146 , A61K9/148 , A61K9/16 , A61K9/1623 , A61K9/1629 , A61K9/167 , A61K9/1676 , A61K9/19 , A61K9/20 , A61K9/2077 , A61K9/282 , A61K9/284 , A61K9/2866 , A61K9/48 , A61K31/192 , A61K31/216 , A61K31/22 , A61K31/365 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/505 , A61K31/66 , A61K2300/00
摘要： Disclosed is a pharmaceutically acceptable oral dosage form comprising fenofibrate, phospholipid, a buffer salt, a water-soluble bulking agent selected from maltodextrin, mannitol, and combinations thereof, a cellulosic additive, beads or crystals of a pharmaceutically acceptable water-soluble excipient support material, a polyvinylpyrrolidone or crospovidone, croscarmellose sodium, granular mannitol, sodium dodecyl sulfate, silicon dioxide, and a stearate, wherein the fenofibrate is in the form of microparticles, and wherein at least a portion of the phospholipid is coated on the surfaces of the fenofibrate microparticles, the phospholipid coated microparticles are embedded in a matrix comprising the water-soluble bulking agent, phospholipid that is not coated on the microparticles, the buffer salt and the cellulosic additive, and the matrix is coated on up to 100% of the surfaces of the beads or crystals of the excipient support material.

2. 发明申请

US20060210622A1 Surface modified particulate compositions of biologically active substances 审中-公开
标题翻译：生物活性物质的表面改性颗粒组合物
公开(公告)号：US20060210622A1
公开(公告)日：2006-09-21
申请号：US11272902
申请日：2005-11-14
申请人： Gary Pace , Awadhesh Mishra , Robert Snow
发明人： Gary Pace , Awadhesh Mishra , Robert Snow
IPC分类号： A61K9/64 , A61K9/26
CPC分类号： A61K9/1075 , A61K9/145 , A61K9/4858
摘要： This invention disclosure relates to compositions for the delivery of stable surface modified sub-micron and micron sized particles of water-insoluble biologically active substances from a non-aqueous medium that self-disperses on exposure to an aqueous environment.
摘要翻译：本发明公开内容涉及用于从暴露于水性环境中自分散的非水介质中递送稳定的表面改性的亚微米和微米尺寸的水不溶性生物活性物质颗粒的组合物。

3. 发明授权

US06596097B1 Method of coating a metal substrate with a radioactive layer 有权
标题翻译：用放射性层涂覆金属基材的方法
公开(公告)号：US06596097B1
公开(公告)日：2003-07-22
申请号：US09577441
申请日：2000-05-24
申请人： Robert Snow , Gregory McIntire , Edward Bacon , Evan Gustow
发明人： Robert Snow , Gregory McIntire , Edward Bacon , Evan Gustow
IPC分类号： C23C1816
CPC分类号： A61N5/1001 , A61N2005/1019 , C23C22/68 , G21G4/06 , G21G4/08
摘要： A method for the immobilization of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidizing agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is 125I− and the binding agent comprises bromide ions.
摘要翻译：一种在金属基材表面上固定放射性阴离子的方法，所述方法包括在与所述金属的离子形成不溶性盐的放射性阴离子的溶液的存在下用氧化剂处理底物。优选地，还将存在粘合剂。优选地，金属是银，放射性阴离子是125I-，并且结合剂包括溴离子。

4. 发明授权

US06177160B1 Container containing contrast agents 失效
标题翻译：含有造影剂的容器
公开(公告)号：US06177160B1
公开(公告)日：2001-01-23
申请号：US09258397
申请日：1999-02-26
申请人： Robert Snow
发明人： Robert Snow
IPC分类号： A61B1000
CPC分类号： A61K49/223 , A61B2090/3925 , A61J1/06 , A61J1/10 , A61J1/14 , A61M5/007 , A61M2207/00 , B65D51/005 , B65D51/30 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/214
摘要： Plastics material-containing closed containers (e.g., elastomer-stoppered vials) for contrast agents and contrast agent precursors which incorporate or are adapted to incorporate a volatile substance (e.g., a gaseous halocarbon such as a perfluorocarbon), where the plastics material is pretreated by exposure to the volatile substance. Such containers may enhance the storage stability of the contrast agent or precursor content.
摘要翻译：用于造影剂和造影剂前体的含塑料材料的密封容器（例如，弹性体塞子小瓶），其包含或适于掺入挥发性物质（例如气态卤化碳，例如全氟化碳）），其中塑料材料由暴露于挥发性物质。这样的容器可以增强造影剂或前体物质的储存稳定性。

5. 发明申请

US20210299381A1 Surgical Device For Creating A Surgical Airway 有权
公开(公告)号：US20210299381A1
公开(公告)日：2021-09-30
申请号：US16833661
申请日：2020-03-29
申请人： Robert Snow
发明人： Robert Snow
IPC分类号： A61M16/04
摘要： A surgical device used for creating a surgical airway into the patient's trachea is disclosed. The device could enable a person or medical professional to make an incision through the patient tissue for creating the surgical airway in the patient's trachea. The device comprises a handle and a bolster. The handle having a longitudinal cavity at a second end for securely receiving and holding a blade. The bolster is securely and slidably positioned into a recess at the second end of the handle using a pair of latches. The bolster is configured to freely slide in and out of the handle for concealing and exposing the blade, thereby enabling a person or medical professional to make an incision proximate the patient's trachea for creating the surgical airway and allowing to simply insert a conventional tracheal tube via the incision to facilitate oxygenation and ventilation during emergency medical conditions.

6. 发明申请

US20060199991A1 Apparatus and methods for radiotherapy 审中-公开
标题翻译：放射疗法的装置和方法
公开(公告)号：US20060199991A1
公开(公告)日：2006-09-07
申请号：US11363844
申请日：2006-02-28
申请人： Dewi Lewis , Lucinda Dollimore , Nigel Powell , Gregory McIntire , Evan Gustow , Robert Snow
发明人： Dewi Lewis , Lucinda Dollimore , Nigel Powell , Gregory McIntire , Evan Gustow , Robert Snow
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1025 , G21G4/08
摘要： The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.
摘要翻译：本发明提供了一种辐射源的使用，该辐射源是低能X射线发射器，例如，主要光子的发射能量在20至100keV，优选20至40keV的范围内，半衰期为10至100天，优选为15至70天，用于治疗再狭窄。合适的放射性同位素包括钯-103，镝-159，钐-145，镉-109，镱-169，优选碘-125。还公开了高活性放射性体和包含这种放射性同位素的来源，以及制造这种来源的方法。

7. 发明申请

US20060027037A1 Transmission system gear shift selection and control 有权
标题翻译：变速系统变速选择和控制
公开(公告)号：US20060027037A1
公开(公告)日：2006-02-09
申请号：US10913901
申请日：2004-08-06
申请人： Hussein Dourra , Robert Snow
发明人： Hussein Dourra , Robert Snow
IPC分类号： F16H61/00
CPC分类号： F16H61/0213 , F16H3/66 , F16H61/686 , F16H2061/0218 , F16H2061/0444 , F16H2061/0448 , F16H2200/0047 , F16H2200/0052 , F16H2200/0056 , F16H2200/201 , F16H2302/00 , Y10T74/19251
摘要： A transmission includes an input shaft, an output shaft, a first plurality of gears, a second plurality of gears, and a series of engagement elements operable between an engaged position and a disengaged position. A controller is further provided to selectively toggle the series of engagement elements between the engaged position and the disengaged position to selectively couple one of the first plurality of gears or one of the second plurality of gears to the input shaft and the output shaft. The series of engagement elements sequentially couples the first plurality of gears to the input shaft and the output shaft during operation of the transmission and selectively couples one of the first plurality of gears or the second plurality of gears to the input shaft and the output shaft during a downshift operation of the transmission.
摘要翻译：变速器包括输入轴，输出轴，第一多个齿轮，第二多个齿轮以及可在接合位置和分离位置之间操作的一系列接合元件。还提供控制器以选择性地在所述接合位置和所述分离位置之间切换所述一系列接合元件，以选择性地将所述第一多个齿轮中的一个或所述第二多个齿轮中的一个齿轮联接到所述输入轴和所述输出轴。一系列接合元件在变速器运行期间顺序地将第一多个齿轮耦合到输入轴和输出轴，并且在第一多个齿轮或第二多个齿轮中的一个齿轮选择性地将输入轴和输出轴耦合到输入轴和输出轴变速箱的降档操作。

8. 发明授权

US06632176B2 Products and methods for brachytherapy 失效
标题翻译：近距离放射疗法的产品和方法
公开(公告)号：US06632176B2
公开(公告)日：2003-10-14
申请号：US09860011
申请日：2001-05-17
申请人： Gregory McIntire , Robert Snow , Edward Bacon , Morten Eriksen , Auden Tornes , Geraldine Cooney , Virginia Ann Gates , Joel Cornacoff , Christopher Black
发明人： Gregory McIntire , Robert Snow , Edward Bacon , Morten Eriksen , Auden Tornes , Geraldine Cooney , Virginia Ann Gates , Joel Cornacoff , Christopher Black
IPC分类号： A61B800
CPC分类号： A61N5/1027 , A61B2090/3925 , A61N2005/1024 , G21G4/08
摘要： Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.
摘要翻译：用于近距离放射治疗的放射源，优选放射性种子，其包括在密封的生物相容性容器内的放射性同位素，其中容器的表面的至少一部分被粗糙化，成形或以其它方式处理，使得其不再光滑。表面处理可以增强源的超声可见性和/或减少一旦植入患者体内的源迁移的趋势。优选的放射性同位素是钯-103和碘-125

9. 发明授权

US07572913B2 4-substituted piperidine derivatives 失效
标题翻译： 4-取代的哌啶衍生物
公开(公告)号：US07572913B2
公开(公告)日：2009-08-11
申请号：US11065696
申请日：2005-02-24
申请人： Lisa McKerracher , Eryk Thouin , William Lubell , Robert Snow , Karine Gingras
发明人： Lisa McKerracher , Eryk Thouin , William Lubell , Robert Snow , Karine Gingras
IPC分类号： C07D217/22 , C07D215/38 , A61K31/47
CPC分类号： C07D211/74 , C07D211/58 , C07D211/72 , C07D401/06 , C07D403/12
摘要： Substituted piperidine compounds represented by the structure I are provided, wherein each of R1a, R1b, R1c, R1d, R1e, R1f, R1g, R1h, R2, R2A, R3, R4, A, X, a, x and n is as defined in the specification. Substituted piperidine compounds of structure I may permeate or penetrate across a nerve cell membrane into the interior of a nerve cell, may inhibit intracellular Rho kinase enzyme found in nerve cells in mammals, and may find utility in repair of damaged nerves in the central and peripheral nervous system of such mammals. These compounds may induce the regeneration or growth of neurites in mammalian nerve cells and may thereby induce regeneration of damaged or diseased nerve tissue. These compounds also find additional utility as antagonists of the enzyme Rho kinase in treatment of disease states in which Rho kinase is implicated. Pharmaceutical compositions containing these substituted piperidine compounds may be useful to promote neurite growth and in the treatment of diseases in which Rho kinase inhibition is indicated.
摘要翻译：提供由结构I表示的取代的哌啶化合物，其中R1a，R1b，R1c，R1d，R1e，R1f，R1g，R1h，R2f，R1g，R1h，R2，R2A，R3，R4，A，X，a，x和n如在规范中。结构I的取代的哌啶化合物可渗透或穿过神经细胞膜进入神经细胞的内部，可以抑制哺乳动物神经细胞中发现的细胞内Rho激酶，并可用于修复中枢和外周的受损神经这些哺乳动物的神经系统。这些化合物可诱导哺乳动物神经细胞中神经突的再生或生长，从而诱导损伤或患病神经组织的再生。这些化合物在治疗其中涉及Rho激酶的疾病状态中也发现作为Rho激酶的拮抗剂的附加效用。含有这些取代的哌啶化合物的药物组合物可用于促进神经突生长和治疗其中指示Rho激酶抑制的疾病。

10. 发明申请

US20050272751A1 4-Substituted piperidine derivatives 失效
标题翻译： 4-取代的哌啶衍生物
公开(公告)号：US20050272751A1
公开(公告)日：2005-12-08
申请号：US11065696
申请日：2005-02-24
申请人： Lisa McKerracher , Eryk Thouin , William Lubell , Robert Snow , Karine Gingras
发明人： Lisa McKerracher , Eryk Thouin , William Lubell , Robert Snow , Karine Gingras
IPC分类号： A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/52 , A61P25/00 , A61P35/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/72 , C07D211/74 , C07D211/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D473/00 , C07D473/14 , C07D41/02 , C07D43/02
CPC分类号： C07D211/74 , C07D211/58 , C07D211/72 , C07D401/06 , C07D403/12
摘要： Substituted piperidine compounds represented by the structure I are provided, wherein each of R1a, R1b, R1c, R1d, R1e, R1f, R1g, R1h, R2, R2A, R3, R4, A, X, a, x and n is as defined in the specification. Substituted piperidine compounds of structure I may permeate or penetrate across a nerve cell membrane into the interior of a nerve cell, may inhibit intracellular Rho kinase enzyme found in nerve cells in mammals, and may find utility in repair of damaged nerves in the central and peripheral nervous system of such mammals. These compounds may induce the regeneration or growth of neurites in mammalian nerve cells and may thereby induce regeneration of damaged or diseased nerve tissue. These compounds also find additional utility as antagonists of the enzyme Rho kinase in treatment of disease states in which Rho kinase is implicated. Pharmaceutical compositions containing these substituted piperidine compounds may be useful to promote neurite growth and in the treatment of diseases in which Rho kinase inhibition is indicated.
摘要翻译：提供了由结构I表示的取代的哌啶化合物，其中R 1a，R 1b，R 1c，R 1d， R 1，R 1，R 1，R 1，R 1，R 1，R 2， R 2，R 3，R 3，R 4，A，X，a，x和n如说明书中所定义。结构I的取代的哌啶化合物可渗透或穿过神经细胞膜进入神经细胞的内部，可以抑制哺乳动物神经细胞中发现的细胞内Rho激酶，并可用于修复中枢和外周的受损神经这些哺乳动物的神经系统。这些化合物可诱导哺乳动物神经细胞中神经突的再生或生长，从而诱导受损或患病的神经组织的再生。这些化合物在治疗其中涉及Rho激酶的疾病状态中也发现作为Rho激酶的拮抗剂的附加效用。含有这些取代的哌啶化合物的药物组合物可用于促进神经突生长和治疗其中指示Rho激酶抑制的疾病。

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