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1. 发明授权

US5892060A Method for the preparation of (+)-calanolide a and analogues thereof 失效
标题翻译：制备（+） - 蒎烯内酯a及其类似物的方法
公开(公告)号：US5892060A
公开(公告)日：1999-04-06
申请号：US609537
申请日：1996-03-01
申请人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychak , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
发明人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychak , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
IPC分类号： A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , C07D407/14
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
摘要翻译：提供了从色烯4制备（+） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。根据所公开的方法，将色烯4中间体与乙醛进行氯代钛介导的醛醇缩合反应以选择性地产生（+/-） - 8a。（+） - 8a的（+/-） - 8a的分离和酶介导的分辨率。（+） - 8a在中性Mitsunobu条件下循环，然后以高产率和对映异构体纯度，（+） - 7产生（+） - 卡立拉内酯A的Luche还原。已经扩展了本发明的方法，以产生强效的抗病毒性甘露糖苷A类似物。

2. 发明授权

US5981770A Method for the preparation of (+)-calanolide A and analogues thereof 失效
标题翻译：制备（+） - 蒎烯内酯A及其类似物的方法
公开(公告)号：US5981770A
公开(公告)日：1999-11-09
申请号：US924840
申请日：1997-09-05
申请人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
发明人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
IPC分类号： A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , C07D493/00
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
摘要翻译：提供了从色烯4制备（+） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。根据所公开的方法，将色烯4中间体与乙醛进行氯代钛介导的醛醇缩合反应以选择性地产生（+/-） - 8a。（+） - 8a的（+/-） - 8a的分离和酶介导的分辨率。（+） - 8a在中性Mitsunobu条件下循环，然后以高产率和对映异构体纯度，（+） - 7产生（+） - 卡立拉内酯A的Luche还原。已经扩展了本发明的方法，以产生强效的抗病毒性甘露糖苷A类似物。

3. 发明授权

US5872264A (+)-calanolide A and analogues thereof 失效
标题翻译：（+） - 蒎烯内酯A及其类似物
公开(公告)号：US5872264A
公开(公告)日：1999-02-16
申请号：US924803
申请日：1997-09-05
申请人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
发明人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
IPC分类号： A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , C07D493/22
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (.+-.)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
摘要翻译：提供了从色烯4制备（+） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。根据所公开的方法，将色烯4中间体与乙醛进行氯代钛介导的醛醇缩合反应以选择性地产生（+/-） - 8a。（+） - 8a的（+/-） - 8a的分离和酶介导的分辨率。在中性Mitsunobu条件下环化（+） - 8a，然后以高产率和对映体纯度，（+/-） - 7产生（+） - 卡立拉内酯A的Luche还原。已经扩展了本发明的方法，以产生强效的抗病毒性甘露糖苷A类似物。

4. 发明授权

US5977385A Method for the preparation of (+)-calanolide A and analogues thereof 失效
公开(公告)号：US5977385A
公开(公告)日：1999-11-02
申请号：US115984
申请日：1998-07-15
申请人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
发明人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Shuyuan Liao , Aye Mar , Lin Lin , Vilayphone Vilaychack , Darko Brankovic , Sergey Dzekhster , Jinjun Liu
IPC分类号： A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , C07D493/00
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

5. 发明授权

US5859050A Method for the preparation of (+)-calanolide A and analogues thereof 失效
公开(公告)号：US5859050A
公开(公告)日：1999-01-12
申请号：US926307
申请日：1997-09-05
申请人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Lin Lin
发明人： Michael T. Flavin , Ze-Qi Xu , Albert Khilevich , David Zembower , John D. Rizzo , Lin Lin
IPC分类号： A61K45/06 , C07D311/16 , C07D493/04 , C07D493/14 , A61K31/35
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

6. 发明授权

US5869324A Method for the preparation of (.+-.)-calanolide A and intermediates thereof 失效
标题翻译：（+/-） - 丙内酰脲A及其中间体的制备方法
公开(公告)号：US5869324A
公开(公告)日：1999-02-09
申请号：US933619
申请日：1997-09-08
申请人： Michael T. Flavin , Ze-Qi Xu , John D. Rizzo , Alla Kucherenko , Albert Khilevich , Abram Kivovich Sheinkman , Vilayphone Vilaychack , Lin Lin , Wei Chen , William A. Boulanger
发明人： Michael T. Flavin , Ze-Qi Xu , John D. Rizzo , Alla Kucherenko , Albert Khilevich , Abram Kivovich Sheinkman , Vilayphone Vilaychack , Lin Lin , Wei Chen , William A. Boulanger
IPC分类号： C07D311/58 , A61K31/365 , A61K45/06 , A61P31/12 , A61P37/04 , C07D311/16 , C07D493/04 , C07D493/14 , C12P41/00
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing viral infections using (.+-.)-calanolide A or (-)-calanolide A is provided.
摘要翻译：提供了从色烯4制备（+/-） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。还提供了制备（+/-） - 丙内酰脲A及其衍生物的有用中间体。根据所公开的方法，在酸催化剂的存在下，将色烯4中间体与乙醛二乙基缩醛或对甲醛反应，或者在酸性条件或中性Mitsunobu条件下，包括醛醇与乙醛反应和醛化反应的两步反应，产生苯并二氢吡喃酮7.在三氯化铈的存在下，用硼氢化钠还原色酮7.产生（+/-） - 甘露糖苷A。一种通过手性拆分（+/-） - 卡立拉内酯A至其光学活性形式的方法还公开了HPLC系统或通过酶酰化和水解。最后，提供了一种使用（+/-） - 蒎烯内酰胺A或（ - ） - cal醇酯A治疗或预防病毒感染的方法。

7. 发明授权

US6043271A Method for the preparation of (.+-.)-calanolide A and intermediates thereof 失效
标题翻译：（+/-） - 丙内酰脲A及其中间体的制备方法
公开(公告)号：US6043271A
公开(公告)日：2000-03-28
申请号：US510213
申请日：1995-08-02
申请人： Michael T. Flavin , Ze-Qi Xu , John D. Rizzo , Alla Kucherenko , Albert Khilevich , Abram Kivovich Sheinkman , Vilayphone Vilaychack , Lin Lin , Wei Chen , William A. Boulanger
发明人： Michael T. Flavin , Ze-Qi Xu , John D. Rizzo , Alla Kucherenko , Albert Khilevich , Abram Kivovich Sheinkman , Vilayphone Vilaychack , Lin Lin , Wei Chen , William A. Boulanger
IPC分类号： C07D311/58 , A61K31/365 , A61K45/06 , A61P31/12 , A61P37/04 , C07D311/16 , C07D493/04 , C07D493/14 , A61K31/35 , C07D407/00
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing a viral infections using (.+-.)-calanolide or (-)-calanolide is provided.
摘要翻译：提供了从色烯4制备（+/-） - 丙内酰脲A，1，一种有效的HIV逆转录酶抑制剂的方法。还提供了制备（+/-） - 丙内酰脲A及其衍生物的有用中间体。根据所公开的方法，在酸催化剂的存在下，将色烯4中间体与乙醛二乙基缩醛或对甲醛反应，或者在酸性条件或中性Mitsunobu条件下，包括醛醇与乙醛反应和醛化反应的两步反应，产生苯并二氢吡喃酮7.在三氯化铈的存在下，用硼氢化钠还原色酮7.产生（+/-） - 甘露糖苷A。一种通过手性拆分（+/-） - 卡立拉内酯A至其光学活性形式的方法还公开了HPLC系统或通过酶酰化和水解。最后，提供了使用（+/-） - 蒎烯内酯或（ - ） - 蒎烯内酯治疗或预防病毒感染的方法。

8. 发明授权

US5874591A Method for the preparation of (.+-.)-calanolide A and intermediates thereof 失效
公开(公告)号：US5874591A
公开(公告)日：1999-02-23
申请号：US925707
申请日：1997-09-09
申请人： Michael T. Flavin , Ze-Qi Xu , Vilayphone Vilaychack , Lin Lin
发明人： Michael T. Flavin , Ze-Qi Xu , Vilayphone Vilaychack , Lin Lin
IPC分类号： C07D311/58 , A61K31/365 , A61K45/06 , A61P31/12 , A61P37/04 , C07D311/16 , C07D493/04 , C07D493/14 , C07D493/00
CPC分类号： C07D493/04 , A61K45/06 , C07D311/16 , C07D493/14
摘要： A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing viral infections using (.+-.)-calanolide A or (-)-calanolide A is provided.

9. 发明授权

US08909718B2 Methods and systems for incorporating a third user into an instant message session 有权
标题翻译：将第三用户并入即时消息会话的方法和系统
公开(公告)号：US08909718B2
公开(公告)日：2014-12-09
申请号：US13172098
申请日：2011-06-29
申请人： Lin Lin , Ping Lin
发明人： Lin Lin , Ping Lin
IPC分类号： G06F15/16 , H04L12/64
CPC分类号： H04L12/6418
摘要： A method and apparatus for incorporating a third user into an instant message (IM) session. In one embodiment, an IM server receives a first IM from a first user directed toward a second user. The IM server makes a determination that the second user is not available to respond to the first IM. In response to the determination, the IM server identifies a third user to whom the first IM is to be forwarded, and automatically forwards the first IM to the third user. In another embodiment, the IM server receives a transfer request from the second user to transfer the IM session from the second user to the third user. The IM server automatically determines a subset portion of a plurality of IMs communicated between the first user and the second user, and provides the transfer request and the subset portion to the third user.
摘要翻译：一种用于将第三用户并入即时消息（IM）会话的方法和装置。在一个实施例中，IM服务器从第一用户接收指向第二用户的第一IM。 IM服务器确定第二用户无法响应第一个IM。响应于该确定，IM服务器识别要向其转发第一IM的第三用户，并自动将第一IM转发给第三用户。在另一个实施例中，IM服务器从第二用户接收传送请求，以将IM会话从第二用户传送到第三用户。 IM服务器自动确定在第一用户和第二用户之间传送的多个IM的子集部分，并且向第三用户提供传送请求和子集部分。

10. 发明授权

US08558822B2 Liquid crystal display 有权
标题翻译：液晶显示器
公开(公告)号：US08558822B2
公开(公告)日：2013-10-15
申请号：US12717413
申请日：2010-03-04
申请人： Lin Lin , Wen-Hung Wang , Shyh-Jeng Chen
发明人： Lin Lin , Wen-Hung Wang , Shyh-Jeng Chen
IPC分类号： G06F3/038
CPC分类号： G09G3/3655 , G02F1/136204 , G09G2300/0426 , G09G2330/04 , H01L23/60 , H01L27/0251 , H01L2924/0002 , H01L2924/00
摘要： A liquid crystal display includes an array substrate, a color filter substrate facing the array substrate, and a liquid crystal layer provided between the array substrate and the color filter substrate. The array substrate includes a driving device, at least one conductive wiring, and a transient voltage suppressor. The driving device includes a driver. The driver has at least one common voltage terminal. The conductive wiring has a connection point and is coupled to the common voltage terminal of the driver. The transient voltage suppressor is coupled to a ground terminal and the connection point, and the connection point is near the common voltage terminal.
摘要翻译：液晶显示器包括阵列基板，面向阵列基板的滤色器基板和设置在阵列基板和滤色器基板之间的液晶层。阵列基板包括驱动装置，至少一个导电布线和瞬态电压抑制器。驱动装置包括驱动器。驱动器至少有一个公共电压端子。导电布线具有连接点并耦合到驱动器的公共电压端子。瞬态电压抑制器耦合到接地端子和连接点，连接点靠近公共电压端子。

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