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1. 发明授权

US06382921B1 Low reynolds number, low drag, high lift airfoil 失效
标题翻译：低雷诺数，低阻力，高升力翼型
公开(公告)号：US06382921B1
公开(公告)日：2002-05-07
申请号：US09772367
申请日：2001-01-30
申请人： Michael S. Selig , William Holmes , Frank Stauder
发明人： Michael S. Selig , William Holmes , Frank Stauder
IPC分类号： F04D2938
CPC分类号： F04D29/384 , Y10S416/02 , Y10S416/05
摘要： Airfoils 10 having high lift to drag characteristics at low Reynolds number are disclosed. The airfoils including a leading edge 12, a trailing edge 14 spaced from the leading edge, an upper surface 16 extending from the leading edge to the trailing edge, and a lower surface 18 extending from the leading edge to the trailing edge. An airfoil designed for a tip region of a blade has a thickness in a range of 3% to 13%, a Reynolds number in a range from 120,000 to 400,000, and a maximum lift coefficient in a range from 1.0 to 1.2. An airfoil designed for a midspan region of a blade has a thickness in a range of 3% to 13%, a Reynolds number in a range from 90,000 to 200,000, and a maximum lift coefficient in a range from 1.4 to 1.6. An airfoil designed for a root region of a blade has a thickness in a range of 5% to 15%, a Reynolds number in a range from 60,000 to 120,000, and a maximum lift coefficient in a range from 1.8 to 2.0.
摘要翻译：公开了具有在低雷诺数下具有高提升力的特征的翼型件10。翼片包括前缘12，与前缘间隔开的后缘14，从前缘延伸到后缘的上表面16以及从前缘延伸到后缘的下表面18。设计用于叶片尖端区域的翼型件的厚度在3％至13％的范围内，雷诺数在12万至400,000的范围内，最大升力系数在1.0至1.2的范围内。设计用于叶片中跨区域的翼型件的厚度在3％至13％的范围内，雷诺数在90,000至200,000的范围内，最大升力系数在1.4至1.6的范围内。设计用于叶片根部区域的翼型件的厚度为5％至15％的范围，雷诺数在60,000至120,000范围内，最大升力系数在1.8至2.0的范围内。

2. 发明授权

US06471472B1 Turbomachine shroud fibrous tip seal 失效
标题翻译：涡轮机罩纤维尖端密封
公开(公告)号：US06471472B1
公开(公告)日：2002-10-29
申请号：US09645773
申请日：2000-08-25
申请人： Frank Stauder , Ian Lockley , Sylvain Nadeau , William Holmes , Alexander Graham Hunt
发明人： Frank Stauder , Ian Lockley , Sylvain Nadeau , William Holmes , Alexander Graham Hunt
IPC分类号： F04D2908
CPC分类号： F04D29/164 , F01D11/00 , F04D29/326 , F05D2240/56
摘要： A turbomachine for moving air comprising includes a shroud disposed about a longitudinal axis and a rotor assembly mounted for rotation about the longitudinal axis. The rotor assembly has a plurality of blades and tips of the blades are coupled to an annular band. The annular band is disposed with respect to the shroud so as to define a gap extending continuously between an outer surface of the annular band and an inner surface of the shroud. A seal structure extends from the inner surface of the shroud and into the gap. The seal structure has a density sufficient to reduce swirl in recirculating airflow and to minimize air leakage across the gap.
摘要翻译：用于移动空气的涡轮机包括围绕纵向轴线设置的护罩和安装成围绕纵向轴线旋转的转子组件。转子组件具有多个叶片，并且叶片的尖端联接到环形带。环形带相对于护罩布置，以便限定在环形带的外表面和护罩的内表面之间连续延伸的间隙。密封结构从护罩的内表面延伸到间隙中。密封结构具有足够的密度，以减少再循环气流中的漩涡并且最小化穿过间隙的空气泄漏。

3. 发明申请

US20130149284A1 METHODS OF PRODUCING HUMAN RPE CELLS AND PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS 审中-公开
标题翻译：生产人RPE细胞的方法和人类RPE细胞的药物制备
公开(公告)号：US20130149284A1
公开(公告)日：2013-06-13
申请号：US13510426
申请日：2010-11-17
申请人： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
发明人： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
IPC分类号： A61K35/12
CPC分类号： A61K35/12 , C12N5/0621 , C12N2506/02
摘要： The present invention provides improved methods for producing retinal pigmented epithelial (RPE) cells from human embryonic stem cells, human induced pluripotent stem (iPS), human adult stem cells, human hematopoietic stem cells, human fetal stem cells, human mesenchymal stem cells, human postpartum stem cells, human multipotent stem cells, or human embryonic germ cells. The RPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The RPE cells described herein are useful for treating retinal degenerative conditions including retinal detachment and macular degeneration.
摘要翻译：本发明提供了用于从人胚胎干细胞，人诱导多能干（iPS），人成体干细胞，人造血干细胞，人胎儿干细胞，人间充质干细胞，人类的人类胚胎干细胞中产生视网膜色素上皮（RPE）细胞的改进方法产后干细胞，人多能干细胞或人胚胎生殖细胞。衍生自胚胎干细胞的RPE细胞与成体和胎儿衍生的RPE细胞分子不同，并且也不同于胚胎干细胞。本文所述的RPE细胞可用于治疗视网膜退行性疾病，包括视网膜脱离和黄斑变性。

4. 发明申请

US20050006855A1 Restraining gasket for mechanical joints of pipes 有权
标题翻译：管道机械接头的限位垫片
公开(公告)号：US20050006855A1
公开(公告)日：2005-01-13
申请号：US10841197
申请日：2004-05-07
申请人： William Holmes , Daniel Copeland
发明人： William Holmes , Daniel Copeland
IPC分类号： F16L19/025 , F16L19/028 , F16L19/075 , F16L21/03 , F16L17/00
CPC分类号： F16L21/08 , F16L21/04
摘要： A gasket for connecting two lengths of pipe in a standard mechanical joint is disclosed, which gasket maximizes of both restrained push-on joints as well as mechanical joints, as are known commonly in the art. The invention has application to long-run pipe lengths as well as appurtenances, including fittings and connections. The gasket contains locking members that act to retrain separation the instance of any force tending to separate the connected pipe lengths.
摘要翻译：公开了一种用于在标准机械接头中连接两段管道的垫圈，该垫圈使得约束的推压接头以及机械接头最大化，如本领域中通常所公知的。本发明适用于长管道长度以及附件，包括配件和连接件。垫圈包含锁定构件，其用于将分离连接的管道长度的任何力的实例重新分离。

5. 发明申请

US20190000246A1 Display Stand 审中-公开
公开(公告)号：US20190000246A1
公开(公告)日：2019-01-03
申请号：US15878964
申请日：2018-01-24
申请人： William Holmes , Lisa Holmes
发明人： William Holmes , Lisa Holmes
IPC分类号： A47G1/14 , F16B2/12 , F16B2/00
摘要： A display stand for securement of a photograph to a surface. The display stand is provided having a base with a bottom surface with an adhesive thereon. The display stand includes a screw that selectively moves a middle panel along a rail from a clamped to an unclamped position. A gripping surface is provided on the middle panel and a front surface.

6. 发明授权

US07142944B2 Apparatus for securing drawer contents 有权
标题翻译：用于固定抽屉内容物的装置
公开(公告)号：US07142944B2
公开(公告)日：2006-11-28
申请号：US10936332
申请日：2004-09-08
申请人： William Holmes , Kent V. Savage , Charles A. Tyack
发明人： William Holmes , Kent V. Savage , Charles A. Tyack
IPC分类号： G06F17/00
CPC分类号： G07F17/0092 , A47B88/00 , A47B88/90 , B25H3/028 , E05B47/0002 , E05B47/0004 , E05B47/026 , E05B65/0003 , E05B65/46 , G07F5/26 , G07F11/62 , G07G1/0027
摘要： A cabinet suitable for use in storing items. The cabinet includes a drawer having a base. A plurality of cassettes are arranged within the drawer. Each cassette is individually movable in a direction that is substantially perpendicular to the base. A plurality of locking mechanisms cooperate to inhibit movement of each of the plurality of cassettes. A controller is operable to actuate one or more locking mechanisms to release one of the plurality of cassettes for movement.
摘要翻译：适用于存放物品的柜子。机柜包括一个带有底座的抽屉。多个盒被布置在抽屉内。每个盒可以在基本上垂直于底座的方向上单独移动。多个锁定机构协作以抑制多个盒中的每一个的移动。控制器可操作以致动一个或多个锁定机构以释放多个盒中的一个用于移动。

7. 发明申请

US20050149077A1 Devices and methods for performing a vascular anastomosis 审中-公开
标题翻译：用于进行血管吻合的装置和方法
公开(公告)号：US20050149077A1
公开(公告)日：2005-07-07
申请号：US11059169
申请日：2005-02-16
申请人： Hanson Gifford , Lee Bolduc , Jeffrey Stein , Paul DiCesare , Peter Costa , William Holmes
发明人： Hanson Gifford , Lee Bolduc , Jeffrey Stein , Paul DiCesare , Peter Costa , William Holmes
IPC分类号： A61B17/00 , A61B17/064 , A61B17/11 , A61B17/115 , A61B17/12 , A61F2/00 , A61B17/08
CPC分类号： A61B17/12109 , A61B17/064 , A61B17/0643 , A61B17/11 , A61B17/115 , A61B17/12036 , A61B17/12045 , A61B17/12136 , A61B2017/00243 , A61B2017/0641 , A61B2017/1135 , A61B2017/12127 , A61F2002/30092 , A61F2210/0014
摘要： A system for performing an end-to-side vascular anastomosis including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis
摘要翻译：一种用于执行端对侧血管吻合的系统，包括吻合装置，应用仪器和用于进行血管吻合的方法。该系统适用于在冠状动脉旁路手术中进行血管移植物和升主动脉之间的吻合，特别是在进入CABG手术中。本发明的第一方面包括血管吻合缝。第一构造具有两部分：锚定构件，与目标血管壁形成附件和联接构件，与旁路移植血管形成附件。通过将连接构件插入到锚定构件中来完成吻合。第二种结构将锚定构件和联接构件的功能结合成一体式吻合钉。本发明的第二方面包括一种吻合装置，其具有内部凸缘，移植物容器在其上延伸，外部凸缘接触靶容器的外表面。由内外法兰施加的定制的压缩量夹住目标血管壁，并在移植血管和靶血管之间产生防漏密封。本发明的第三方面具有凸缘，移植管通过使移植物容器穿过凸缘而附接到该凸缘上，以及多个钉状构件，其将该移植物容器的凸缘和脱出端附接到靶血管形成吻合

8. 发明授权

US06508624B2 Turbomachine with double-faced rotor-shroud seal structure 有权
标题翻译：涡轮机具有双面转子 - 护罩密封结构
公开(公告)号：US06508624B2
公开(公告)日：2003-01-21
申请号：US09865983
申请日：2001-05-02
申请人： Sylvain Nadeau , William Holmes
发明人： Sylvain Nadeau , William Holmes
IPC分类号： F01D1108
CPC分类号： F16J15/3288 , F01D5/225 , F01D11/08 , F04D29/164 , F04D29/326 , F05D2240/56
摘要： A turbomachine for moving air includes a shroud 12 disposed about an axis A. The shroud 12 has a pair of opposing faces 14 and 16 defining a gap 18 therebetween. The opposing faces are disposed generally transversely with respect to the axis. A rotor assembly 13 is mounted for rotation about the axis. The rotor assembly has a plurality of blades 22 with tips of the blades being coupled to an annular band 30. At least a portion 32 of the annular band is disposed in the gap 18. Seal structure 36 extends from each opposing face of the shroud and into the gap to reduce swirl and minimize air leakage across the gap.
摘要翻译：用于移动空气的涡轮机包括围绕轴线A设置的护罩12.护罩12具有在其间限定间隙18的一对相对面14和16。相对的面相对于轴线大致横向设置。转子组件13安装成围绕轴线旋转。转子组件具有多个叶片22，叶片的尖端联接到环形带30.环形带的至少一部分32设置在间隙18中。密封结构36从护罩的每个相对面延伸，并且进入间隙以减少涡流，并最大限度地减少跨越间隙的空气泄漏。

9. 发明申请

US20120219507A1 METHOD OF DETERMINING METABOLIC FUNCTION 有权
标题翻译：确定代谢功能的方法
公开(公告)号：US20120219507A1
公开(公告)日：2012-08-30
申请号：US13394212
申请日：2010-09-03
申请人： Celestine Santosh , William Holmes , Rosario Lopez
发明人： Celestine Santosh , William Holmes , Rosario Lopez
IPC分类号： A61K49/06 , A61B5/055
CPC分类号： G01R33/483 , A61B5/055 , A61B5/4076 , A61B5/4088 , A61B5/4094 , A61B5/415 , A61B5/418 , G01N24/08 , G01N24/088 , G01R33/4828 , G01R33/5601 , G01R33/5607 , G01R33/5617 , G01R33/56341 , G01R33/56366
摘要： The present invention provides a novel lactate difference imaging (LDI) technique, allowing assessment of the metabolic responses of tissue over a period of time. This approach utilises lactate change over a time period as an indicator of viable tissue, and offers benefits in the management and treatment of the effects of many common diseases, in particular stroke.
摘要翻译：本发明提供了一种新的乳酸盐差异成像（LDI）技术，允许评估一段时间内组织的代谢反应。这种方法利用一段时间内的乳酸盐变化作为活组织的指标，并且在治疗和治疗许多常见疾病，特别是中风的效果方面提供益处。

10. 发明申请

US20110274662A1 Methods of Producing RPE Cells and Compositions of RPE Cells 审中-公开
标题翻译： RPE细胞的产生方法及RPE细胞的组成
公开(公告)号：US20110274662A1
公开(公告)日：2011-11-10
申请号：US12682712
申请日：2008-10-10
申请人： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
发明人： Christopher Malcuit , Linda Lemieux , William Holmes , Pedro Huertas , Lucy Vilner
IPC分类号： A61K35/12 , C12N5/071 , A61P27/02 , C12Q1/02
摘要： The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.
摘要翻译：本发明提供了用于从人胚胎干细胞或其他人多能干细胞产生RPE细胞的改进方法。本发明还涉及源自人胚胎干细胞或其他人多能或多能干细胞的人视网膜色素上皮细胞。衍生自胚胎干细胞的hRPE细胞与成体和胎儿衍生的RPE细胞分子不同，并且也不同于胚胎干细胞。本文所述的hRPE细胞可用于治疗视网膜退行性疾病。

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