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1. 发明申请

US20070156012A1 Stress urinary incontinence implant and device for deploying same 有权
标题翻译：压力性尿失禁植入物及其部署装置
公开(公告)号：US20070156012A1
公开(公告)日：2007-07-05
申请号：US11321659
申请日：2005-12-29
申请人： Michael R. Tracey , Steve Bell , Bryan Knodel
发明人： Michael R. Tracey , Steve Bell , Bryan Knodel
IPC分类号： A61F2/02
CPC分类号： A61F2/0045 , A61B17/0625 , A61B2017/00805 , A61F2/0036
摘要： A suburethral implant for treating stress urinary incontinence (SUI) includes an elongated plate-like member which is slightly curved in transverse cross-section, and a pair of spaced apart arms having hooked ends or barbs which extend from the plate-like member. A device for deploying the suburethral implant for treating SUI includes a vaginal probe for insertion in the vaginal canal of a patient, and a urethra locator probe for the simultaneous insertion in the urethra of a patient. The urethra probe is spaced apart from and overlies the vaginal probe. The vaginal probe includes a wall in which is formed an exit port. A suburethral implant introducer assembly is extendable and retractable through the exit port on the vaginal probe. The introducer assembly has a distal end on which is removably mounted a suburethral implant. The introducer assembly is extendable through the exit port to pierce the vaginal canal wall of the patient in order to position the suburethral implant in proximity to the patient's urethra. The hooked ends or barbs on the arms of the suburethral implant engage the tissue surrounding the patient's urethra and are affixed thereto during deployment of the implant. The introducer assembly is then retracted into the vaginal probe, whereby the implant is released from the introducer assembly and remains affixed to tissue in proximity to the patient's urethra.
摘要翻译：用于治疗压力性尿失禁的尿道植入物（SUI）包括在横截面上略微弯曲的细长板状构件，以及一对间隔开的臂，其具有从板状构件延伸的钩端或倒钩。用于部署用于治疗SUI的尿道植入物的装置包括用于插入患者阴道内的阴道探针和用于同时插入患者尿道的尿道定位器探针。尿道探针与阴道探针间隔开并覆盖阴道探针。阴道探针包括形成有出口的壁。尿道植入物导引器组件可以通过阴道探针上的出口延伸和缩回。导引器组件具有远端，其上可移除地安装有尿道植入物。导引器组件可通过出口延伸以刺穿患者的阴道管壁，以将尿道植入物定位在患者的尿道附近。尿道植入物的手臂上的钩状端或倒钩与患者尿道周围的组织接合，并在植入物展开过程中固定在其上。导引器组件然后缩回到阴道探针中，由此植入物从导引器组件释放并且保持附着于患者尿道附近的组织。

2. 发明授权

US07942806B2 Stress urinary incontinence implant and device for deploying same 有权
标题翻译：压力性尿失禁植入物及其部署装置
公开(公告)号：US07942806B2
公开(公告)日：2011-05-17
申请号：US11321659
申请日：2005-12-29
申请人： Michael R. Tracey , Steve Bell , Bryan Knodel
发明人： Michael R. Tracey , Steve Bell , Bryan Knodel
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61B17/0625 , A61B2017/00805 , A61F2/0036
摘要： A suburethral implant for treating stress urinary incontinence (SUI) includes an elongated plate-like member which is slightly curved in transverse cross-section, and a pair of spaced apart arms having hooked ends or barbs which extend from the plate-like member. A device for deploying the suburethral implant for treating SUI includes a vaginal probe for insertion in the vaginal canal of a patient, and a urethra locator probe for the simultaneous insertion in the urethra of a patient. The urethra probe is spaced apart from and overlies the vaginal probe. The vaginal probe includes a wall in which is formed an exit port. A suburethral implant introducer assembly is extendable and retractable through the exit port on the vaginal probe. The introducer assembly has a distal end on which is removably mounted a suburethral implant. The introducer assembly is extendable through the exit port to pierce the vaginal canal wall of the patient in order to position the suburethral implant in proximity to the patient's urethra. The hooked ends or barbs on the arms of the suburethral implant engage the tissue surrounding the patient's urethra and are affixed thereto during deployment of the implant. The introducer assembly is then retracted into the vaginal probe, whereby the implant is released from the introducer assembly and remains affixed to tissue in proximity to the patient's urethra.
摘要翻译：用于治疗压力性尿失禁的尿道植入物（SUI）包括在横截面上略微弯曲的细长板状构件，以及一对间隔开的臂，其具有从板状构件延伸的钩端或倒钩。用于部署用于治疗SUI的尿道植入物的装置包括用于插入患者阴道内的阴道探针和用于同时插入患者尿道的尿道定位器探针。尿道探针与阴道探针间隔开并覆盖阴道探针。阴道探针包括形成有出口的壁。尿道植入物导引器组件可以通过阴道探针上的出口延伸和缩回。导引器组件具有远端，其上可移除地安装有尿道植入物。导引器组件可通过出口延伸以刺穿患者的阴道管壁，以将尿道植入物定位在患者的尿道附近。尿道植入物的手臂上的钩状端或倒钩与患者尿道周围的组织接合，并在植入物展开过程中固定在其上。导引器组件然后缩回到阴道探针中，由此植入物从导引器组件释放并且保持附着于患者尿道附近的组织。

3. 发明授权

US07979137B2 System and method for nerve stimulation 有权
标题翻译：神经刺激的系统和方法
公开(公告)号：US07979137B2
公开(公告)日：2011-07-12
申请号：US11146522
申请日：2005-06-07
申请人： Michael R. Tracey , Anthony DiUbaldi
发明人： Michael R. Tracey , Anthony DiUbaldi
IPC分类号： A61N1/40
CPC分类号： A61N1/36007 , A61B5/20 , A61B5/202 , A61B5/205 , A61B5/6874 , A61B2562/028 , A61N1/0492 , A61N1/0514 , A61N1/0521 , A61N1/36017 , A61N1/36021 , G06F19/00
摘要： A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.
摘要翻译：一种用于刺激神经的系统和方法，其中所述系统包括适于产生具有能够刺激哺乳动物的预定神经的频率的第一波形的第一波形发生器，适于生成具有频率能力的载波波形的第二波形发生器通过哺乳动物的组织的调制装置，电耦合到第一和第二波形发生器并适于调制第一和载波波形以产生调制波形的调制装置，以及电耦合到调制装置并基本上邻近皮肤定位的电极并且适于将调制波形应用于该哺乳动物。

4. 发明申请

US20100249677A1 Piezoelectric stimulation device 有权
标题翻译：压电刺激装置
公开(公告)号：US20100249677A1
公开(公告)日：2010-09-30
申请号：US12661949
申请日：2010-03-26
申请人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
发明人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
IPC分类号： A61H1/00
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译：一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。表面电极经常地施加所生成的电波形信号。可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。电波形信号可以是高频连续波形或高频突发分组。

5. 发明授权

US07252631B2 System and method for assessing detrusor instability 有权
标题翻译：用于评估逼尿肌不稳定的系统和方法
公开(公告)号：US07252631B2
公开(公告)日：2007-08-07
申请号：US10674452
申请日：2003-09-30
申请人： Michael R. Tracey
发明人： Michael R. Tracey
IPC分类号： A61F2/00 , A61B5/00
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A method is provided for diagnosing detrusor instability. The method includes using an insert member having a channel therethrough positioned distal of the urethral sphincter, creating a substantially fluid tight seal to substantially block fluid flow into or out of the urethral canal other than through the channel, infusing fluid from a fluid source through the channel in the insert member and into the urethral canal at a location distal of the urethral sphincter, and measuring a pressure within the urethral canal at a location distal of the urethral sphincter as the fluid is being infused therein. The infusing step further involves infusing fluid until the urethral sphincter opens, and thereafter until at least one detrusor contraction occurs.
摘要翻译：提供了一种用于诊断逼尿肌不稳定性的方法。该方法包括使用具有穿过其定位在尿道括约肌远端的通道的插入构件，产生基本上流体密封的密封，以基本阻止流体流入或流出尿道，而不是通过通道，将来自流体源的流体通过通道在尿道括约肌远端的位置处进入尿道管，并且当尿液括约肌中注入流体时，在尿道括约肌远端位置测量尿道内的压力。输注步骤还包括输注流体直到尿道括约肌打开，此后直到发生至少一次逼尿肌收缩。

6. 发明授权

US09139542B2 Crystalline form of a substituted thiazolylacetic acid triethylamine salt 有权
标题翻译：取代噻唑乙酸三乙胺盐的结晶形式
公开(公告)号：US09139542B2
公开(公告)日：2015-09-22
申请号：US14198975
申请日：2014-03-06
申请人： Weijiang Zhang , Michael R. Tracey , Junning Lee
发明人： Weijiang Zhang , Michael R. Tracey , Junning Lee
IPC分类号： C07D277/40 , C07D277/593
CPC分类号： C07D277/40 , C07D277/593
摘要： The invention relates to a crystalline form of a triethylamine salt of (2Z)-2-(2 -amino-5-chlorothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetic acid. The invention also relates to processes and intermediates for preparing the crystalline form. The crystalline form is useful as an intermediate for preparing cross-linked glycopeptide-cephalosporin antibiotics.
摘要翻译：本发明涉及（2Z）-2-（2-氨基-5-氯噻唑-4-基）-2-（3-N-叔丁氧基羰基氨基丙氧基亚氨基）乙酸的三乙胺盐的结晶形式。本发明还涉及制备结晶形式的方法和中间体。结晶形式可用作制备交联糖肽 - 头孢菌素抗生素的中间体。

7. 发明授权

US07647112B2 System and method for selectively stimulating different body parts 有权
标题翻译：选择性刺激不同身体部位的系统和方法
公开(公告)号：US07647112B2
公开(公告)日：2010-01-12
申请号：US11344285
申请日：2006-01-31
申请人： Michael R. Tracey , Anthony DiUbaldi , Douglas B. Johns
发明人： Michael R. Tracey , Anthony DiUbaldi , Douglas B. Johns
IPC分类号： A61N1/36
CPC分类号： A61N1/36017 , A61N1/0492 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/36014 , A61N1/36021
摘要： Devices and methods are provided for electrically stimulating a predetermined body part of a mammal. The method includes placing at least one electrode in proximity to the mammal's skin, injecting an electrically conductive gel into the body of the mammal so as to form a conductive gel pathway extending at least partially along a distance between the at least one electrode and the predetermined body part, and stimulating the predetermined body part by applying an electrical signal via the electrode that travels, at least in part, through the conductive gel pathway.
摘要翻译：提供了用于电刺激哺乳动物的预定身体部位的装置和方法。该方法包括将至少一个电极放置在哺乳动物的皮肤附近，将导电凝胶注射到哺乳动物的体内，以便形成至少部分地沿着至少一个电极与预定的电极之间的距离延伸的导电凝胶通路并通过经由至少部分地穿过导电凝胶路径行进的电极施加电信号来刺激预定的身体部位。

8. 发明授权

US07056288B2 System and method for assessing urinary function 有权
公开(公告)号：US07056288B2
公开(公告)日：2006-06-06
申请号：US10183075
申请日：2002-06-27
申请人： Michael R. Tracey , Frederick T. Karl
发明人： Michael R. Tracey , Frederick T. Karl
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A vaginal speculum assembly is provided including an upper arm and a lower arm movably coupled to one another by a coupling member positioned at a posterior end. Each of the upper and lower arms are dimensioned for at least partial insertion into a patient's vagina, and when so inserted, are dimensioned to exert pressure on at least upper and lower portions of an inner surface of the patient's vaginal wall. The coupling member permits movement of the upper and lower arms relative to one another to adjust their positioning relative to the vaginal wall. The assembly further includes a locking device coupled to at least one of the upper and lower arms which, when activated, substantially prevents movement of the upper and lower arms relative to one another. A connector member extends outwardly from a posterior end of the upper arm. The connector member is configured to engage a predetermined portion of an insert device assembly including an insert member to be inserted into the patient's urethral canal, to thereby maintain the insert device assembly in position relative to the vaginal speculum assembly.

9. 发明授权

US07052452B2 System and method for assessing urinary function 有权
公开(公告)号：US07052452B2
公开(公告)日：2006-05-30
申请号：US10183790
申请日：2002-06-27
申请人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
发明人： Ulf Ulmsten , Michael R. Tracey , Martin Nohilly
IPC分类号： A61F2/00 , A61M29/00
CPC分类号： A61B1/32 , A61B5/202 , A61B5/204 , A61B5/205 , A61B5/208 , A61B5/7435 , A61B2560/0443 , A61M2025/0002
摘要： A medical system is provided for assessing urinary function. The system includes a control device and at least one test module capable of being removably coupled to the control device such that, when coupled, the system is capable of performing a test to assess urinary function. The control device may include a processor and memory having stored therein a plurality of software subroutine, at least one of which directs a test to assess urinary function. The test module may include a module identification device, and the control device selects the software subroutine based upon information obtained from the module identification device. The test module may further include a tubing assembly forming a first fluid conduit between a first fluid inlet and a first fluid outlet and an insert member dimensioned for at least partial insertion into a patient's urinary tract and coupled to the first fluid outlet so that fluid infused through the first fluid conduit flows through the insert member.

10. 发明授权

US08751003B2 Conductive mesh for neurostimulation 有权
标题翻译：用于神经刺激的导电网
公开(公告)号：US08751003B2
公开(公告)日：2014-06-10
申请号：US11497861
申请日：2006-08-02
申请人： Anthony DiUbaldi , Michael R. Tracey
发明人： Anthony DiUbaldi , Michael R. Tracey
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61F2/0045 , A61N1/0512 , A61N1/0514 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： A medial treatment device for treating at least first and second medical conditions is provided, as well as a method for using the same. The medical treatment device includes a stimulation device for treating the first medical condition with electrical stimulation, and an implantable mesh adapted for implantation within the patient to treat the second medical condition. The implantable mesh has a plurality of incorporated electrically conductive elements adapted to conduct electrical stimulation from the stimulation device to a position closer to a predetermined body part the stimulation of which at least partially treats the first medical condition.
摘要翻译：提供了用于至少治疗第一和第二医疗条件的内侧治疗装置，以及使用该内侧治疗装置的方法。医疗处理装置包括用于通过电刺激来治疗第一医疗状况的刺激装置，以及适于植入患者体内以治疗第二医疗状况的可植入网。可植入网具有多个结合的导电元件，其适于将电刺激从刺激装置传导到更靠近其刺激至少部分地治疗第一医疗状况的预定身体部位的位置。

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