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1. 发明授权

US07647112B2 System and method for selectively stimulating different body parts 有权
标题翻译：选择性刺激不同身体部位的系统和方法
公开(公告)号：US07647112B2
公开(公告)日：2010-01-12
申请号：US11344285
申请日：2006-01-31
申请人： Michael R. Tracey , Anthony DiUbaldi , Douglas B. Johns
发明人： Michael R. Tracey , Anthony DiUbaldi , Douglas B. Johns
IPC分类号： A61N1/36
CPC分类号： A61N1/36017 , A61N1/0492 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/36014 , A61N1/36021
摘要： Devices and methods are provided for electrically stimulating a predetermined body part of a mammal. The method includes placing at least one electrode in proximity to the mammal's skin, injecting an electrically conductive gel into the body of the mammal so as to form a conductive gel pathway extending at least partially along a distance between the at least one electrode and the predetermined body part, and stimulating the predetermined body part by applying an electrical signal via the electrode that travels, at least in part, through the conductive gel pathway.
摘要翻译：提供了用于电刺激哺乳动物的预定身体部位的装置和方法。该方法包括将至少一个电极放置在哺乳动物的皮肤附近，将导电凝胶注射到哺乳动物的体内，以便形成至少部分地沿着至少一个电极与预定的电极之间的距离延伸的导电凝胶通路并通过经由至少部分地穿过导电凝胶路径行进的电极施加电信号来刺激预定的身体部位。

2. 发明申请

US20090157149A1 DERMATOME STIMULATION DEVICES AND METHODS 有权
标题翻译： DERMATOME刺激装置和方法
公开(公告)号：US20090157149A1
公开(公告)日：2009-06-18
申请号：US11957240
申请日：2007-12-14
申请人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
发明人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
IPC分类号： A61N1/04
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0492 , A61N1/36007 , A61N1/36014 , A61N1/36017 , A61N1/36171
摘要： A nerve stimulation device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating nerves within a dermatome, a second waveform generator adapted to generate a first carrier waveform having a second frequency capable of passing through tissue of a mammal, and a third waveform generator adapted to generate a second carrier waveform having a third frequency different than the second frequency and being capable of passing through the tissue of the mammal. The device includes a modulator electrically coupled to the first, second and third waveform generators and adapted to modulate the first waveform, the first carrier waveform, and the second carrier waveform to generate a modulated signal package capable of stimulating the nerves at different depths within the dermatome. The device also has an electrode electrically coupled to the modulator for applying the modulated waveform to the dermatomic region.
摘要翻译：神经刺激装置包括：第一波形发生器，其适于产生具有能够刺激皮肤内的神经的第一频率的第一波形;适于产生具有能够穿过哺乳动物组织的第二频率的第一载波波形的第二波形发生器以及适于生成具有与第二频率不同的第三频率并且能够通过哺乳动物的组织的第二载波波形的第三波形发生器。该装置包括电耦合到第一，第二和第三波形发生器并且适于调制第一波形，第一载波波形和第二载波波形的调制器，以产生调制信号包，该调制信号包能够在不同深度内刺激神经皮肤病该装置还具有电耦合到调制器的电极，用于将调制波形施加到皮肤原始区域。

3. 发明授权

US08352026B2 Implantable pulse generators and methods for selective nerve stimulation 有权
标题翻译：植入脉冲发生器和选择性神经刺激的方法
公开(公告)号：US08352026B2
公开(公告)日：2013-01-08
申请号：US11866588
申请日：2007-10-03
申请人： Anthony DiUbaldi
发明人： Anthony DiUbaldi
IPC分类号： A61N1/00
CPC分类号： A61N1/0514 , A61N1/36007 , A61N1/36017 , A61N1/36071 , A61N1/36171 , A61N1/36196
摘要： An Implantable Pulse Generator (IPG) includes a surgically implantable housing, a battery, a first waveform generator, a second waveform generator, a modulator, and electrodes. The IPG produces a pulse envelope, a carrier waveform, and a modulated waveform. The pulse envelope is a low frequency waveform with specific pulse width, amplitude and shape to selectively stimulate a target nerve or body part. The carrier waveform is a high frequency waveform with properties such as amplitude, frequency and the like chosen so as to overcome tissue impedance and the stimulation threshold of the target nerve. The modulated waveform is the waveform obtained by modulating the carrier waveform by the pulse envelope.
摘要翻译：可植入脉冲发生器（IPG）包括手术可植入的壳体，电池，第一波形发生器，第二波形发生器，调制器和电极。 IPG产生脉冲包络，载波波形和调制波形。脉冲包络是具有特定脉冲宽度，幅度和形状的低频波形，以选择性地刺激目标神经或身体部位。载波波形是选择幅度，频率等特性的高频波形，以克服组织阻抗和目标神经的刺激阈值。调制波形是通过脉冲包络调制载波波形而获得的波形。

4. 发明授权

US08170683B2 Dermatome stimulation devices and methods 有权
标题翻译：皮肤刺激装置和方法
公开(公告)号：US08170683B2
公开(公告)日：2012-05-01
申请号：US11957240
申请日：2007-12-14
申请人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
发明人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
IPC分类号： A61N1/00
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0492 , A61N1/36007 , A61N1/36014 , A61N1/36017 , A61N1/36171
摘要： A nerve stimulation device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating nerves within a dermatome, a second waveform generator adapted to generate a first carrier waveform having a second frequency capable of passing through tissue of a mammal, and a third waveform generator adapted to generate a second carrier waveform having a third frequency different than the second frequency and being capable of passing through the tissue of the mammal. The device includes a modulator electrically coupled to the first, second and third waveform generators and adapted to modulate the first waveform, the first carrier waveform, and the second carrier waveform to generate a modulated signal package capable of stimulating the nerves at different depths within the dermatome. The device also has an electrode electrically coupled to the modulator for applying the modulated waveform to the dermatomic region.
摘要翻译：神经刺激装置包括：第一波形发生器，其适于产生具有能够刺激皮肤内的神经的第一频率的第一波形;适于生成具有能够穿过哺乳动物的组织的第二频率的第一载波波形的第二波形发生器以及适于生成具有与第二频率不同的第三频率并且能够通过哺乳动物的组织的第二载波波形的第三波形发生器。该装置包括电耦合到第一，第二和第三波形发生器并且适于调制第一波形，第一载波波形和第二载波波形的调制器，以产生调制信号包，该调制信号包能够在不同深度内刺激神经皮肤病该装置还具有电耦合到调制器的电极，用于将调制波形施加到皮肤原始区域。

5. 发明申请

US20110264163A1 System and Method for Nerve Stimulation 有权
标题翻译：神经刺激的系统和方法
公开(公告)号：US20110264163A1
公开(公告)日：2011-10-27
申请号：US13094644
申请日：2011-04-26
申请人： Michael R. Tracey , Anthony DiUbaldi
发明人： Michael R. Tracey , Anthony DiUbaldi
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/20 , A61B5/202 , A61B5/205 , A61B5/6874 , A61B2562/028 , A61N1/0492 , A61N1/0514 , A61N1/0521 , A61N1/36017 , A61N1/36021 , G06F19/00
摘要： A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.
摘要翻译：一种用于刺激神经的系统和方法，其中所述系统包括适于产生具有能够刺激哺乳动物的预定神经的频率的第一波形的第一波形发生器，适于生成具有频率能力的载波波形的第二波形发生器通过哺乳动物的组织的调制装置，电耦合到第一和第二波形发生器并适于调制第一和载波波形以产生调制波形的调制装置，以及电耦合到调制装置并基本上邻近皮肤定位的电极并且适于将调制波形应用于其。

6. 发明申请

US20070185541A1 Conductive mesh for neurostimulation 有权
标题翻译：用于神经刺激的导电网
公开(公告)号：US20070185541A1
公开(公告)日：2007-08-09
申请号：US11497861
申请日：2006-08-02
申请人： Anthony DiUbaldi , Michael Tracey
发明人： Anthony DiUbaldi , Michael Tracey
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61F2/0045 , A61N1/0512 , A61N1/0514 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： A medial treatment device for treating at least first and second medical conditions is provided, as well as a method for using the same. The medical treatment device includes a stimulation device for treating the first medical condition with electrical stimulation, and an implantable mesh adapted for implantation within the patient to treat the second medical condition. The implantable mesh has a plurality of incorporated electrically conductive elements adapted to conduct electrical stimulation from the stimulation device to a position closer to a predetermined body part the stimulation of which at least partially treats the first medical condition.
摘要翻译：提供了用于至少治疗第一和第二医疗条件的内侧治疗装置，以及使用该内侧治疗装置的方法。医疗处理装置包括用于通过电刺激来治疗第一医疗状况的刺激装置，以及适于植入患者体内以治疗第二医疗状况的可植入网。可植入网具有多个结合的导电元件，其适于将电刺激从刺激装置传导到更靠近其刺激至少部分地治疗第一医疗状况的预定身体部位的位置。

7. 发明授权

US09044606B2 Methods and devices for activating brown adipose tissue using electrical energy 有权
标题翻译：使用电能激活棕色脂肪组织的方法和装置
公开(公告)号：US09044606B2
公开(公告)日：2015-06-02
申请号：US12980659
申请日：2010-12-29
申请人： Jason L. Harris , Nicholas Stylopoulos , Lee M. Kaplan , Tamara C. Baynham , Jeyakumar Subbaroyan , James W. Voegele , Taylor Aronhalt , Anthony Diubaldi , David N. Plescia , Mark S. Ortiz , Theodore L. Stephens
发明人： Jason L. Harris , Nicholas Stylopoulos , Lee M. Kaplan , Tamara C. Baynham , Jeyakumar Subbaroyan , James W. Voegele , Taylor Aronhalt , Anthony Diubaldi , David N. Plescia , Mark S. Ortiz , Theodore L. Stephens
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/0456 , A61N1/0492 , A61N1/0504 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/3606 , A61N1/36153 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/36192 , A61N1/36196 , A61N1/3787
摘要： Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.
摘要翻译：提供了用于激活棕色脂肪组织（BAT）的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热量产生，其随着时间的推移可导致体重减轻。在一个实施方案中，提供了通过电刺激直接激活BAT和/或电刺激棕色脂肪细胞的神经来激活BAT的医疗装置，从而增加BAT中的产热并通过能量消耗引起体重减轻。

8. 发明授权

US08588930B2 Piezoelectric stimulation device 有权
标题翻译：压电刺激装置
公开(公告)号：US08588930B2
公开(公告)日：2013-11-19
申请号：US12661949
申请日：2010-03-26
申请人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
发明人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译：一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。表面电极经常地施加所生成的电波形信号。可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。电波形信号可以是高频连续波形或高频突发分组。

9. 发明授权

US08165695B2 System and method for selectively stimulating different body parts 有权
标题翻译：选择性刺激不同身体部位的系统和方法
公开(公告)号：US08165695B2
公开(公告)日：2012-04-24
申请号：US11343627
申请日：2006-01-31
申请人： Anthony DiUbaldi , Michael R. Tracey
发明人： Anthony DiUbaldi , Michael R. Tracey
IPC分类号： A61N1/00
CPC分类号： A61N1/0492 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/36014 , A61N1/36017 , A61N1/36021
摘要： A device and method is provided for transdermally stimulating selected body parts of a mammal. The device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating a first predetermined body part, a second waveform generator adapted to generate a carrier waveform having a second frequency capable of passing through tissue of the mammal, and a third waveform generator adapted to generate a third waveform having a third frequency different from and out of phase with that of the first waveform, and capable of stimulating a second predetermined body part. The device further includes a modulation device electrically coupled to the first, second and third waveform generators and adapted to modulate the carrier, first, and third waveforms to create a modulated signal package, and a first electrode electrically coupled to the modulation device and positioned substantially adjacent to the skin of the mammal, and adapted to apply the modulated signal package thereto.
摘要翻译：提供了用于经皮刺激哺乳动物的选定身体部位的装置和方法。该装置包括适于产生具有能够刺激第一预定身体部位的第一频率的第一波形的第一波形发生器，适于产生能够通过哺乳动物组织的第二频率的载波波形的第二波形发生器，以及第三波形发生器，其适于产生具有与所述第一波形的第三频率不同且与所述第一波形不相位的第三频率的第三波形，并且能够刺激第二预定体部。该装置还包括电耦合到第一，第二和第三波形发生器并且适于调制载波，第一和第三波形以产生调制信号封装的调制装置，以及电耦合到调制装置并基本上位于与哺乳动物的皮肤相邻，并且适于将调制信号包施加到其上。

10. 发明授权

US08128576B2 System and method for urodynamic evaluation utilizing micro electro-mechanical system technology 有权
标题翻译：使用微机电系统技术进行尿动力学评估的系统和方法
公开(公告)号：US08128576B2
公开(公告)日：2012-03-06
申请号：US11635403
申请日：2006-12-07
申请人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
发明人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
IPC分类号： A61B5/00 , A61B1/307
CPC分类号： A61B5/14507 , A61B5/0031 , A61B5/205 , A61B5/208 , A61B5/6874 , A61B2562/028
摘要： An implantable urodynamic system includes an implantable first device deployable in a patient's bladder, an implantable second device deployable in a patient's vaginal canal, and a data acquisition and analysis module or processing unit external to the body of the patient. The first device includes a magnet and an inductive coil, and the second device includes a magnet, an inductive coil and a battery. When deployed in the patient's body, attraction between the magnets maintains the two devices in close proximity to one another to effect an inductive coupling between the coils so that the first device may be powered by the battery of the second device. The urodynamic system is intended to facilitate measurement, collection, and wireless transmission of real-time, or near real-time, data (bladder pressure, abdominal pressure, and temperature) from an ambulatory patient. This data is of value in diagnosing a number of abnormal bladder conditions, such as infection, overactive bladder, bladder spasms, and the like.
摘要翻译：可植入尿动力系统包括可部署在患者膀胱中的可植入第一装置，可植入患者阴道内的可植入第二装置，以及在患者身体外部的数据采集和分析模块或处理单元。第一装置包括磁体和感应线圈，并且第二装置包括磁体，感应线圈和电池。当部署在患者体内时，磁体之间的吸引力将两个装置彼此紧密地保持在彼此附近以实现线圈之间的感应耦合，使得第一装置可以由第二装置的电池供电。尿动力系统旨在便于来自流动患者的实时或近实时数据（膀胱压力，腹压和温度）的测量，收集和无线传输。该数据在诊断膀胱膀胱状况异常，例如感染，膀胱过度活动症，膀胱痉挛等中是有价值的。

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