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1. 发明授权

US08128576B2 System and method for urodynamic evaluation utilizing micro electro-mechanical system technology 有权
标题翻译：使用微机电系统技术进行尿动力学评估的系统和方法
公开(公告)号：US08128576B2
公开(公告)日：2012-03-06
申请号：US11635403
申请日：2006-12-07
申请人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
发明人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
IPC分类号： A61B5/00 , A61B1/307
CPC分类号： A61B5/14507 , A61B5/0031 , A61B5/205 , A61B5/208 , A61B5/6874 , A61B2562/028
摘要： An implantable urodynamic system includes an implantable first device deployable in a patient's bladder, an implantable second device deployable in a patient's vaginal canal, and a data acquisition and analysis module or processing unit external to the body of the patient. The first device includes a magnet and an inductive coil, and the second device includes a magnet, an inductive coil and a battery. When deployed in the patient's body, attraction between the magnets maintains the two devices in close proximity to one another to effect an inductive coupling between the coils so that the first device may be powered by the battery of the second device. The urodynamic system is intended to facilitate measurement, collection, and wireless transmission of real-time, or near real-time, data (bladder pressure, abdominal pressure, and temperature) from an ambulatory patient. This data is of value in diagnosing a number of abnormal bladder conditions, such as infection, overactive bladder, bladder spasms, and the like.
摘要翻译：可植入尿动力系统包括可部署在患者膀胱中的可植入第一装置，可植入患者阴道内的可植入第二装置，以及在患者身体外部的数据采集和分析模块或处理单元。第一装置包括磁体和感应线圈，并且第二装置包括磁体，感应线圈和电池。当部署在患者体内时，磁体之间的吸引力将两个装置彼此紧密地保持在彼此附近以实现线圈之间的感应耦合，使得第一装置可以由第二装置的电池供电。尿动力系统旨在便于来自流动患者的实时或近实时数据（膀胱压力，腹压和温度）的测量，收集和无线传输。该数据在诊断膀胱膀胱状况异常，例如感染，膀胱过度活动症，膀胱痉挛等中是有价值的。

2. 发明申请

US20080139875A1 System and method for urodynamic evaluation utilizing micro electro-mechanical system technology 有权
标题翻译：使用微机电系统技术进行尿动力学评估的系统和方法
公开(公告)号：US20080139875A1
公开(公告)日：2008-06-12
申请号：US11635403
申请日：2006-12-07
申请人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
发明人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
IPC分类号： A61B5/00
CPC分类号： A61B5/14507 , A61B5/0031 , A61B5/205 , A61B5/208 , A61B5/6874 , A61B2562/028
摘要： An implantable urodynamic system includes an implantable first device deployable in a patient's bladder, an implantable second device deployable in a patient's vaginal canal, and a data acquisition and analysis module or processing unit external to the body of the patient. The first device includes a magnet and an inductive coil, and the second device includes a magnet, an inductive coil and a battery. When deployed in the patient's body, attraction between the magnets maintains the two devices in close proximity to one another to effect an inductive coupling between the coils so that the first device may be powered by the battery of the second device. The urodynamic system is intended to facilitate measurement, collection, and wireless transmission of real-time, or near real-time, data (bladder pressure, abdominal pressure, and temperature) from an ambulatory patient. This data is of value in diagnosing a number of abnormal bladder conditions, such as infection, overactive bladder, bladder spasms, and the like.
摘要翻译：可植入尿动力系统包括可部署在患者膀胱中的可植入第一装置，可植入患者阴道内的可植入第二装置，以及在患者身体外部的数据采集和分析模块或处理单元。第一装置包括磁体和感应线圈，并且第二装置包括磁体，感应线圈和电池。当部署在患者体内时，磁体之间的吸引力将两个装置彼此紧密地保持在彼此附近以实现线圈之间的感应耦合，使得第一装置可以由第二装置的电池供电。尿动力系统旨在便于来自流动患者的实时或近实时数据（膀胱压力，腹压和温度）的测量，收集和无线传输。该数据在诊断膀胱膀胱状况异常，例如感染，膀胱过度活动症，膀胱痉挛等中是有价值的。

3. 发明授权

US08588930B2 Piezoelectric stimulation device 有权
标题翻译：压电刺激装置
公开(公告)号：US08588930B2
公开(公告)日：2013-11-19
申请号：US12661949
申请日：2010-03-26
申请人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
发明人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译：一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。表面电极经常地施加所生成的电波形信号。可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。电波形信号可以是高频连续波形或高频突发分组。

4. 发明申请

US20100249677A1 Piezoelectric stimulation device 有权
标题翻译：压电刺激装置
公开(公告)号：US20100249677A1
公开(公告)日：2010-09-30
申请号：US12661949
申请日：2010-03-26
申请人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
发明人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
IPC分类号： A61H1/00
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译：一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。表面电极经常地施加所生成的电波形信号。可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。电波形信号可以是高频连续波形或高频突发分组。

5. 发明授权

US09402999B2 Transdermal medical patch 有权
标题翻译：透皮贴片
公开(公告)号：US09402999B2
公开(公告)日：2016-08-02
申请号：US13464634
申请日：2012-05-04
申请人： Stephen Wahlgren , Martin J. Nohilly , Anthony R. DiUbaldi , Rex O. Bare , Bradley Sargent , Michael W. Ammerman , Jeffrey C. Smith , Kathryn M. Kukulka
发明人： Stephen Wahlgren , Martin J. Nohilly , Anthony R. DiUbaldi , Rex O. Bare , Bradley Sargent , Michael W. Ammerman , Jeffrey C. Smith , Kathryn M. Kukulka
IPC分类号： A61N1/04 , A61N1/30 , A61N1/36
CPC分类号： A61N1/303 , A61N1/0428 , A61N1/0456 , A61N1/0492 , A61N1/36014
摘要： A medical patch having a multi-piece bottom liner including a central liner sequentially removable independently of two outer perimeter liners. The multi-piece liner covering two adhesives of different peel force. Removal of the central liner exposes a first temporary/repositionable adhesive. Once properly positioned, the outer perimeter liners are removed to expose a second stronger adhesive. A foam cushioning layer is disposed beneath and extends beyond a footprint of every printed circuit board to prevent skin irritation. The medical patch may be designed specifically for stimulation of the sacral (S3 foramen) spinal nerve without the use of a separate mechanical placement tool or assistance by another.
摘要翻译：一种具有多片底部衬垫的医疗贴片，其包括独立于两个外周边衬垫顺序地移除的中心衬垫。多片衬里覆盖两种不同剥离力的粘合剂。去除中心衬垫露出第一个临时/可重新定位的粘合剂。一旦正确定位，移除外周衬里以露出第二较强的粘合剂。泡沫缓冲层设置在每个印刷电路板的下方并延伸超过每个印刷电路板的印迹，以防止皮肤刺激。医疗补片可以专门设计用于刺激骶骨（S3孔）脊神经，而不使用单独的机械放置工具或由另一机械辅助。

6. 发明申请

US20130296996A1 Transdermal Medical Patch 有权
标题翻译：透皮医疗贴片
公开(公告)号：US20130296996A1
公开(公告)日：2013-11-07
申请号：US13464634
申请日：2012-05-04
申请人： Stephen Wahlgren , Martin J. Nohilly , Anthony R. DiUbaldi , Rex O. Bare , Bradley Sargent , Michael W. Ammerman , Jeffrey C. Smith , Kathryn M. Kukulka
发明人： Stephen Wahlgren , Martin J. Nohilly , Anthony R. DiUbaldi , Rex O. Bare , Bradley Sargent , Michael W. Ammerman , Jeffrey C. Smith , Kathryn M. Kukulka
IPC分类号： A61N1/04
CPC分类号： A61N1/303 , A61N1/0428 , A61N1/0456 , A61N1/0492 , A61N1/36014
摘要： A medical patch having a multi-piece bottom liner including a central liner sequentially removable independently of two outer perimeter liners. The multi-piece liner covering two adhesives of different peel force. Removal of the central liner exposes a first temporary/repositionable adhesive. Once properly positioned, the outer perimeter liners are removed to expose a second stronger adhesive. A foam cushioning layer is disposed beneath and extends beyond a footprint of every printed circuit board to prevent skin irritation. The medical patch may be designed specifically for stimulation of the sacral (S3 foramen) spinal nerve without the use of a separate mechanical placement tool or assistance by another.
摘要翻译：一种具有多片底部衬垫的医疗贴片，其包括独立于两个外周边衬垫顺序地移除的中心衬垫。多片衬里覆盖两种不同剥离力的粘合剂。去除中心衬垫露出第一个临时/可重新定位的粘合剂。一旦正确定位，移除外周衬里以露出第二较强的粘合剂。泡沫缓冲层设置在每个印刷电路板的下方并延伸超过每个印刷电路板的印迹，以防止皮肤刺激。医疗补片可以专门设计用于刺激骶骨（S3孔）脊神经，而不使用单独的机械放置工具或由另一机械辅助。

7. 发明授权

US08897885B2 Optimizing the stimulus current in a surface based stimulation device 有权
标题翻译：优化基于表面的刺激装置中的刺激电流
公开(公告)号：US08897885B2
公开(公告)日：2014-11-25
申请号：US12317193
申请日：2008-12-19
申请人： Anthony DiUbaldi , Stephen Wahlgren
发明人： Anthony DiUbaldi , Stephen Wahlgren
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/36014
摘要： A method and associated stimulation device for ensuring firing of an action potential in an intended physiological target activated by a stimulus pulse generated by an electrode of a non-invasive surface based stimulation device irrespective of skin-to-electrode impedance by: (i) increasing internal impedance of the stimulation device so as to widen a Chronaxie time period thereby ensuring firing of the action potential of the intended physiological target irrespective of the skin-to-electrode impedance; and/or (ii) generating a stimulation waveform that optimizes a non-zero average current (e.g., non-zero slope of the envelope of the stimulation waveform) during preferably substantially the entire current decay of the stimulus pulse.
摘要翻译：一种方法和相关联的刺激装置，用于确保由无创表面刺激装置的电极产生的刺激脉冲激活的预期生理目标中的动作电位的点火，而不管皮肤对电极的阻抗如何：（i）增加刺激装置的内部阻抗，以便扩大Chronaxie时间段，从而确保预期生理目标的动作电位的发射，而不管皮肤对电极的阻抗如何; 和/或（ii）在刺激脉冲的优选基本上整个电流衰减期间产生优化非零平均电流（例如，刺激波形的包络的非零斜率）的刺激波形。

8. 发明申请

US20100161001A1 Optimizing the stimulus current in a surface based stimulation device 有权
标题翻译：优化基于表面的刺激装置中的刺激电流
公开(公告)号：US20100161001A1
公开(公告)日：2010-06-24
申请号：US12317193
申请日：2008-12-19
申请人： Anthony DiUbaldi , Stephen Wahlgren
发明人： Anthony DiUbaldi , Stephen Wahlgren
IPC分类号： A61N1/08
CPC分类号： A61N1/36014
摘要： A method and associated stimulation device for ensuring firing of an action potential in an intended physiological target activated by a stimulus pulse generated by an electrode of a non-invasive surface based stimulation device irrespective of skin-to-electrode impedance by: (i) increasing internal impedance of the stimulation device so as to widen a Chronaxie time period thereby ensuring firing of the action potential of the intended physiological target irrespective of the skin-to-electrode impedance; and/or (ii) generating a stimulation waveform that optimizes a non-zero average current (e.g., non-zero slope of the envelope of the stimulation waveform) during preferably substantially the entire current decay of the stimulus pulse.
摘要翻译：一种方法和相关联的刺激装置，用于确保由无创表面刺激装置的电极产生的刺激脉冲激活的预期生理目标中的动作电位的点火，而不管皮肤对电极的阻抗如何：（i）增加刺激装置的内部阻抗，以便扩大Chronaxie时间段，从而确保预期生理目标的动作电位的发射，而不管皮肤对电极的阻抗如何; 和/或（ii）在刺激脉冲的优选基本上整个电流衰减期间产生优化非零平均电流（例如，刺激波形的包络的非零斜率）的刺激波形。

9. 发明申请

US20080147146A1 Electrode patch and method for neurostimulation 有权
标题翻译：电极贴片和神经刺激方法
公开(公告)号：US20080147146A1
公开(公告)日：2008-06-19
申请号：US11641617
申请日：2006-12-19
申请人： Stephen Wahlgren , Anthony DiUbaldi , John Young , Michael Freeman
发明人： Stephen Wahlgren , Anthony DiUbaldi , John Young , Michael Freeman
IPC分类号： A61N1/04
CPC分类号： A61N1/0456 , A61B5/04001 , A61B5/6833 , A61B2562/046 , A61N1/0476 , A61N1/0492 , A61N1/36014
摘要： A system for stimulating a nerve or nerves in a patient includes an electrode patch having an array of equally spaced concentric electrodes each having a central cathode and a concentrically surrounding anode. The electrode array patch is used to determine the location of the nerve or nerves to be stimulated by electrical pulses. Once the location of the nerve is determined, a concentric electrode patch having a central cathode and a concentrically surrounding anode is positioned at the optimal location on the patient's skin to effect neurostimulation. The concentric electrode patch may be removably affixed to the patient's skin by adhesive or magnets.
摘要翻译：用于刺激患者中的神经或神经的系统包括具有等间隔的同心电极阵列的电极贴片，每个均具有中心阴极和同心环绕的阳极。电极阵列贴片用于确定由电脉冲刺激的神经或神经的位置。一旦确定了神经的位置，具有中心阴极和同心环绕的阳极的同心电极贴片就位于病人皮肤上的最佳位置上，以进行神经刺激。同心电极贴片可以通过粘合剂或磁体可移除地固定到患者的皮肤上。

10. 发明授权

US08175718B2 Electrode patch and method for neurostimulation 有权
标题翻译：电极贴片和神经刺激方法
公开(公告)号：US08175718B2
公开(公告)日：2012-05-08
申请号：US11641617
申请日：2006-12-19
申请人： Stephen Wahlgren , Anthony DiUbaldi , John Young , Michael Freeman
发明人： Stephen Wahlgren , Anthony DiUbaldi , John Young , Michael Freeman
IPC分类号： A61N1/04
CPC分类号： A61N1/0456 , A61B5/04001 , A61B5/6833 , A61B2562/046 , A61N1/0476 , A61N1/0492 , A61N1/36014
摘要： A system for stimulating a nerve or nerves in a patient includes an electrode patch having an array of equally spaced concentric electrodes each having a central cathode and a concentrically surrounding anode. The electrode array patch is used to determine the location of the nerve or nerves to be stimulated by electrical pulses. Once the location of the nerve is determined, a concentric electrode patch having a central cathode and a concentrically surrounding anode is positioned at the optimal location on the patient's skin to effect neurostimulation. The concentric electrode patch may be removably affixed to the patient's skin by adhesive or magnets.
摘要翻译：用于刺激患者中的神经或神经的系统包括具有等间隔的同心电极阵列的电极贴片，每个均具有中心阴极和同心环绕的阳极。电极阵列贴片用于确定由电脉冲刺激的神经或神经的位置。一旦确定了神经的位置，具有中心阴极和同心环绕的阳极的同心电极贴片就位于病人皮肤上的最佳位置上，以进行神经刺激。同心电极贴片可以通过粘合剂或磁体可移除地固定到患者的皮肤上。

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