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1. 发明申请

US20090053180A1 Tandem cardiac pacemaker system 审中-公开
标题翻译：串联心脏起搏器系统
公开(公告)号：US20090053180A1
公开(公告)日：2009-02-26
申请号：US11490997
申请日：2006-07-21
申请人： Michael R. Rosen , Peter R. Brink , Richard B. Robinson , Ira S. Cohen , Steven Girouard , Bruce Kenknight
发明人： Michael R. Rosen , Peter R. Brink , Richard B. Robinson , Ira S. Cohen , Steven Girouard , Bruce Kenknight
IPC分类号： A61K35/12 , A61N1/362 , A61P9/00
CPC分类号： A61N1/372 , C12N5/0657 , C12N2502/1329 , C12N2502/1358 , C12N2510/00
摘要： This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.
摘要翻译：本发明提供了起搏器系统，其包括（1）电子起搏器和（2）生物起搏器，其中生物起搏器包括功能性地表达嵌合超极化激活的环核苷酸门控（HCN）离子通道的细胞，其水平有效在细胞中诱导起搏器电流。本发明还提供了相关的生物起搏器，房室桥梁，其制造方法以及治疗患有心律失常的受试者的方法。

2. 发明申请

US20080027757A1 SYSTEM AND METHOD FOR CORRELATING BIOMETRIC TRENDS WITH A RELATED TEMPORAL EVENT 有权
标题翻译：将相关时间事件与生物量趋势相关联的系统和方法
公开(公告)号：US20080027757A1
公开(公告)日：2008-01-31
申请号：US11869611
申请日：2007-10-09
申请人： Scott Mazar , Bruce Kenknight
发明人： Scott Mazar , Bruce Kenknight
IPC分类号： G06Q50/00
CPC分类号： A61B5/0002 , G06F19/00 , G06Q50/22
摘要： Systems and methods for correlating biometric trends with a related temporal event are disclosed. A preferred embodiment utilizes an implantable medical device comprising at least one sensor in electronic communication with a patient management system adapted to temporally analyze and correlate biometric data. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management system that helps better monitor, predict and manage chronic diseases.
摘要翻译：公开了将生物识别趋势与相关时间事件相关联的系统和方法。优选实施例利用可植入医疗装置，其包括至少一个传感器，该传感器与患者管理系统进行电子通信，患者管理系统适于暂时分析和关联生物特征数据。本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。

3. 发明申请

US20070135847A1 Subcutaneous defibrillation system and method using same 审中-公开
标题翻译：皮下除颤系统及其使用方法
公开(公告)号：US20070135847A1
公开(公告)日：2007-06-14
申请号：US11301241
申请日：2005-12-12
申请人： Bruce Kenknight
发明人： Bruce Kenknight
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61B5/0031 , A61B5/7203 , A61N1/05 , A61N1/0563 , A61N1/0587 , A61N1/375 , A61N1/3918
摘要： A medical system includes a housing configured for implantation within a patient's subclavicular region. Detection circuitry provided in the housing is configured to detect cardiac electrical activity. Energy delivery circuitry provided in the housing is configured to deliver therapy to treat a detected tachycardia or fibrillation episode. A lead is coupled to the housing, detection circuitry, and energy delivery circuitry. The lead is configured for subcutaneous, non-intrathoracic placement within the patient, and extends from the subclavicular region to just below the patient's ribs or the subxiphoid process. A defibrillation electrode is provided at a distal end of the lead body. A pair of sensing electrodes is provided on the lead body at locations consistent with positions V2-V5 of surface electrocardiogram electrodes.
摘要翻译：医疗系统包括被配置用于植入患者的锁骨下区域内的壳体。设置在外壳中的检测电路被配置为检测心脏电活动。设置在壳体中的能量输送电路被配置为递送治疗以治疗所检测到的心动过速或纤维性颤动发作。引线耦合到外壳，检测电路和能量输送电路。导线被配置为在患者体内皮下，非胸腔内放置，并且从锁骨下区域延伸到恰好在患者肋骨下方或亚剑下进程。除颤电极设置在引线体的远端。一对感测电极设置在引线体上与表面心电图电极的位置V 2 -V 5一致的位置处。

4. 发明申请

US20060293604A1 Evaluating a patient condition using autonomic balance information in implatable cardiac devices 有权
标题翻译：使用植入式心脏装置中的自主平衡信息评估患者状况
公开(公告)号：US20060293604A1
公开(公告)日：2006-12-28
申请号：US11168614
申请日：2005-06-28
申请人： Gerrard Carlson , Bruce Kenknight , Qingsheng Zhu
发明人： Gerrard Carlson , Bruce Kenknight , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0205 , A61B5/4809 , A61B5/4812 , A61M16/024 , A61M2230/04 , A61M2230/10 , A61M2230/63 , A61M2230/65 , A61N1/3622 , A61N1/365
摘要： Systems and methods for evaluating a patient condition using autonomic balance information involve providing an implantable cardiac device that acquires a cardiac waveform from a patient. One or more characteristics associated with autonomic balance of the patient are detected and used to evaluate a patient condition, such as sleep onset, sleep stage, cardiac vulnerability over a predetermined duration, and sleep disordered breathing. Patient activity levels may be sensed and used to evaluate the patient's condition, such as for determining a level of systemic stress. Characteristics associated with the autonomic balance include calculating an LF/HF ratio waveform and/or determining one or more morphological features of the LF/HF ratio waveform. Coordination with a patient-external device may facilitate transmission of information about one or more of the cardiac waveform, the one or more characteristics associated with the autonomic balance, and a marked cardiac waveform.
摘要翻译：使用自主平衡信息评估患者状况的系统和方法涉及提供从患者获取心脏波形的可植入心脏装置。检测与患者的自主平衡相关联的一个或多个特征，并用于评估患者状况，例如睡眠发作，睡眠阶段，预定持续时间内的心脏易感性和睡眠呼吸障碍。可以感测患者活动水平并用于评估患者的状况，例如用于确定全身应激水平。与自主平衡相关的特征包括计算LF / HF比率波形和/或确定LF / HF比波形的一个或多个形态特征。与患者外部设备的协调可以促进关于心脏波形中的一个或多个的信息的传输，与自主平衡相关联的一个或多个特征以及标记的心脏波形。

5. 发明申请

US20050042589A1 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US20050042589A1
公开(公告)日：2005-02-24
申请号：US10642998
申请日：2003-08-18
申请人： John Hatlestad , Quan Ni , Jeffrey Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce Kenknight , Douglas Daum , Kent Lee
发明人： John Hatlestad , Quan Ni , Jeffrey Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce Kenknight , Douglas Daum , Kent Lee
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/11 , A61N1/362 , G09B23/28
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an imlantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。睡眠质量可以使用收集的数据由不可变的或患者外部的睡眠质量处理器进行评估。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

6. 发明申请

US20050119707A1 Subcutaneous cardiac rhythm management 失效
标题翻译：皮下心律管理
公开(公告)号：US20050119707A1
公开(公告)日：2005-06-02
申请号：US11026707
申请日：2004-12-30
申请人： Robert Hauser , Roger Dahl , Bruce Kenknight
发明人： Robert Hauser , Roger Dahl , Bruce Kenknight
IPC分类号： A61N1/05 , A61N1/368 , A61N1/375 , A61N1/362
CPC分类号： A61N1/056 , A61N1/05 , A61N1/368 , A61N1/375 , A61N1/3756
摘要： An implantable system includes a housing configured for subcutaneous, non-intrathoracic placement in a patient, and a plurality of electrodes coupled to the housing, each of the plurality of electrodes configured for subcutaneous, non-intrathoracic placement in the patient. Detection circuitry is provided in the housing and coupled to the plurality of electrodes. The detection circuitry is configured to detect cardiac activity necessitating a cardiac stimulation therapy. Energy delivery circuitry is provided in the housing and coupled to the plurality of electrodes. The energy delivery circuitry is configured to deliver the cardiac stimulation therapy.
摘要翻译：可植入系统包括：构造成用于皮下，非胸腔内放置在患者体内的壳体，以及耦合到所述壳体的多个电极，所述多个电极中的每一个被配置用于在患者体内皮下，非胸腔内放置。检测电路设置在壳体中并耦合到多个电极。检测电路被配置为检测需要心脏刺激治疗的心脏活动。能量输送电路设置在壳体中并且耦合到多个电极。能量递送电路被配置为递送心脏刺激疗法。

7. 发明申请

US20050065815A1 Information management system and method for an implantable medical device 审中-公开
标题翻译：可植入医疗器械的信息管理系统和方法
公开(公告)号：US20050065815A1
公开(公告)日：2005-03-24
申请号：US10665792
申请日：2003-09-19
申请人： Scott Mazar , Bruce Kenknight
发明人： Scott Mazar , Bruce Kenknight
IPC分类号： A61B5/117 , G06F17/60 , A61B5/00
CPC分类号： G06F19/3418 , A61B5/117 , G06Q50/22 , G16H10/60
摘要： Systems and methods for an information management system for an implantable medical device are disclosed. A preferred embodiment uses an implantable medical device that is automatically recognized by a publicly accessible information access portal. Some embodiments of a system disclosed herein also can be configured as a component of an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.
摘要翻译：公开了用于可植入医疗装置的信息管理系统的系统和方法。优选实施例使用由可公开访问的信息访问门户自动识别的可植入医疗设备。本文公开的系统的一些实施例还可以被配置为高级患者管理系统的组件，其有助于更好地监测，预测和管理慢性疾病。

8. 发明申请

US20050043652A1 Sleep state classification 有权
标题翻译：睡眠状态分类
公开(公告)号：US20050043652A1
公开(公告)日：2005-02-24
申请号：US10643006
申请日：2003-08-18
申请人： Eric Lovett , Robert Sweeney , Bruce Kenknight
发明人： Eric Lovett , Robert Sweeney , Bruce Kenknight
IPC分类号： A61B5/00 , A61B5/04 , A61B5/113 , A61N1/362 , A61B5/11
CPC分类号： A61B5/1116 , A61B5/00 , A61B5/0031 , A61B5/04 , A61B5/0476 , A61B5/0496 , A61B5/1135 , A61B5/4809 , A61B5/4812 , A61B5/686 , A61B5/7264 , A61B5/7267 , A61B2560/0468 , A61N1/362
摘要： Systems and methods for sleep state classification involve detecting conditions related to sleep, including at least one condition associated with rapid eye movement (REM) sleep. Additionally, a condition modulated by the sleep-wake status of the patient may be detected. A medical system that is partially or fully implantable incorporates sensors and circuitry for detecting and processing the sleep-related signals. A sleep state processor classifies the patient's sleep state based on the sleep-related signals. Sleep state classification may be used in connection with the delivery of sleep state appropriate therapy, diagnostic testing, or patient monitoring.
摘要翻译：用于睡眠状态分类的系统和方法涉及检测与睡眠相关的病症，包括与快速眼动（REM）睡眠相关的至少一种病症。此外，可以检测由患者的睡眠 - 唤醒状态调制的状况。部分或完全可植入的医疗系统包括用于检测和处理睡眠相关信号的传感器和电路。睡眠状态处理器根据睡眠相关信号对患者的睡眠状态进行分类。睡眠状态分类可用于与睡眠状态适当的治疗，诊断测试或患者监测的传递有关。

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