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    • 3. 发明申请
    • INSULIN FORMULATIONS FOR RAPID UPTAKE
    • 胰岛素制剂用于快速摄取
    • US20100227795A1
    • 2010-09-09
    • US12397219
    • 2009-03-03
    • Solomon S. SteinerRoderike PohlMing LiRobert Hauser
    • Solomon S. SteinerRoderike PohlMing LiRobert Hauser
    • A61K38/28A61P3/10
    • A61K9/0019A61K38/00A61K38/28A61K47/12A61K47/183C07K14/62
    • Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection. In the preferred embodiment, the insulin is provided as a clear liquid, neutral pH, in a multi-use sterile vial. In an alternative embodiment, the insulin is provided as a powder in a sterile vial. This is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water, a zinc chelator such as EDTA and a dissolution agent such as citric acid shortly before or at the time of administration. In another embodiment, the insulin is stored as a frozen mixture, ready for use upon thawing.
    • 本文描述了具有改善的稳定性和快速起效的可注射的胰岛素制剂。 制剂可用于皮下,皮内或肌内给药。 在优选的实施方案中,通过皮下注射施用制剂。 制剂含有与螯合剂和溶解剂以及任选的其它赋形剂组合的胰岛素。 在优选的实施方案中,制剂含有人胰岛素,锌螯合剂如EDTA和溶解剂如柠檬酸或柠檬酸钠。 当通过皮下注射给药时,这些制剂被快速地吸收到血流中。 在优选的实施方案中,胰岛素以多用途无菌小瓶中的透明液体中性pH提供。 在替代实施方案中,胰岛素以无菌小瓶中的粉末形式提供。 将其与包含药学上可接受的载体如水,锌螯合剂如EDTA的稀释剂和不久之前或给药时的溶解剂如柠檬酸混合。 在另一个实施方案中,将胰岛素作为冷冻混合物储存,准备在解冻时使用。
    • 6. 发明授权
    • Active part for a surge arrester
    • 电涌放电器的主动部件
    • US07154728B2
    • 2006-12-26
    • US10776271
    • 2004-02-12
    • Walter SchmidtRobert Hauser
    • Walter SchmidtRobert Hauser
    • H02H1/00
    • H01C7/12H01T4/06
    • The active part which is provided for use in a surge arrester includes two connecting fittings, which are arranged along an axis at a distance from one another, at least one cylindrical varistor column, which is provided between the two connecting fittings, and at least one dielectric loop. This loop is supported on the two connecting fittings and thus holds the active part together, thus forming a contact force. The active part is distinguished by a small physical height and little use of materials. This is achieved in that at least one of the two connecting fittings has an electrode, which is arranged at right angles to the axis and is in the form of a plate, as well as an electrical connection, which is integrally formed on the plate. Furthermore, supporting means which are in the form of shoulders are provided for the dielectric loop, and are formed in the plate and/or are integrally formed at the edge of the plate.
    • 提供用于电涌放电器的有源部分包括两个连接配件,它们沿轴线彼此间隔一定距离设置,设置在两个连接配件之间的至少一个圆柱形压敏电阻柱和至少一个 介质回路。 这个环路支撑在两个连接配件上,从而将活动部件保持在一起,从而形成接触力。 活动部分的特点是体积小,材料使用少。 这是通过两个连接配件中的至少一个具有电极,该电极与轴线成直角并且呈板形,以及一体地形成在板上的电连接。 此外,为了电介质回路设置有肩部形式的支撑装置,并且形成在板上和/或一体地形成在板的边缘。
    • 7. 发明申请
    • Active part for a surge arrester
    • 电涌放电器的主动部件
    • US20050105238A1
    • 2005-05-19
    • US10776271
    • 2004-02-12
    • Walter SchmidtRobert Hauser
    • Walter SchmidtRobert Hauser
    • H01R25/00H01B17/42H01C7/12H01T4/06H02H1/00
    • H01C7/12H01T4/06
    • The active part which is provided for use in a surge arrester includes two connecting fittings, which are arranged along an axis at a distance from one another, at least one cylindrical varistor column, which is provided between the two connecting fittings, and at least one dielectric loop. This loop is supported on the two connecting fittings and thus holds the active part together, thus forming a contact force. The active part is distinguished by a small physical height and little use of materials. This is achieved in that at least one of the two connecting fittings has an electrode, which is arranged at right angles to the axis and is in the form of a plate, as well as an electrical connection, which is integrally formed on the plate. Furthermore, supporting means which are in the form of shoulders are provided for the dielectric loop, and are formed in the plate and/or are integrally formed at the edge of the plate.
    • 提供用于电涌放电器的有源部分包括两个连接配件,它们沿轴线彼此间隔一定距离设置,设置在两个连接配件之间的至少一个圆柱形压敏电阻柱和至少一个 介质回路。 这个环路支撑在两个连接配件上,从而将活动部件保持在一起,从而形成接触力。 活动部分的特点是体积小,材料使用少。 这是通过两个连接配件中的至少一个具有电极,该电极与轴线成直角并且呈板形,以及一体地形成在板上的电连接。 此外,为了电介质回路设置有肩部形式的支撑装置,并且形成在板上和/或一体地形成在板的边缘。