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1. 发明授权

US07598290B2 Cytotoxic agents comprising new C-2 modified taxanes 失效
标题翻译：包含新的C-2修饰紫杉烷的细胞毒剂
公开(公告)号：US07598290B2
公开(公告)日：2009-10-06
申请号：US11679347
申请日：2007-02-27
申请人： Michael L. Miller , Ravi V. J. Chari , Erkan Baloglu
发明人： Michael L. Miller , Ravi V. J. Chari , Erkan Baloglu
IPC分类号： A61K31/335 , C07D305/00
CPC分类号： C07D305/14
摘要： The invention relates to taxanes and to novel cytotoxic agents comprising taxanes and their therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent.
摘要翻译：本发明涉及紫杉烷类和包含紫杉烷类的新型细胞毒性剂及其治疗用途，这是通过将紫杉烷与细胞结合剂化学连接而以目标方式将紫杉烷递送至特定细胞群的结果。

2. 发明授权

US07667054B2 Cytotoxic agents comprising new taxanes 失效
标题翻译：包含新紫杉烷的细胞毒剂
公开(公告)号：US07667054B2
公开(公告)日：2010-02-23
申请号：US11295294
申请日：2005-12-06
申请人： Michael L. Miller , Ravi V. J. Chari , Erkan Baloglu , Alain Commercon
发明人： Michael L. Miller , Ravi V. J. Chari , Erkan Baloglu , Alain Commercon
IPC分类号： C07D305/00
CPC分类号： C07D493/06
摘要： The invention relates to novel cytotoxic agents comprising taxanes and their therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent.
摘要翻译：本发明涉及包含紫杉烷的新型细胞毒性剂及其治疗用途，其通过将紫杉烷与细胞结合剂化学连接而以目标方式将紫杉烷递送至特定细胞群。

3. 发明授权

US07414073B2 Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
标题翻译：含有新型有效紫杉烷类及其治疗用途的细胞毒素
公开(公告)号：US07414073B2
公开(公告)日：2008-08-19
申请号：US10963711
申请日：2004-10-14
申请人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
发明人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
IPC分类号： A61K31/335 , A61K31/38 , C07D305/00 , C07D307/00 , C07D409/00
CPC分类号： C07D407/12 , A61K31/337 , C07D305/14 , C07D407/14 , C07D409/12 , Y02A50/423 , Y02A50/491
摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a link, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.
摘要翻译：包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒性量的一种或多种通过连接体与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂。还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

4. 发明授权

US07390898B2 Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
标题翻译：含有新型有效紫杉烷类及其治疗用途的细胞毒素
公开(公告)号：US07390898B2
公开(公告)日：2008-06-24
申请号：US10369563
申请日：2003-02-21
申请人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
发明人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
IPC分类号： C07D413/00 , C07D305/00
CPC分类号： C07D407/12 , A61K31/337 , C07D305/14 , C07D407/14 , C07D409/12 , Y02A50/423 , Y02A50/491
摘要： Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.
摘要翻译：包括在本发明范围内的有效的紫杉烷含有连接基团。还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。一种用于在所选择的细胞群体中诱导细胞死亡的治疗组合物，其包含：（A）通过连接基团与细胞粘附剂共价结合的一种或多种紫杉烷的细胞毒性量，和（B）药学上可接受的载体，稀释剂或赋形剂包括。还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

5. 发明授权

US07495114B2 Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
标题翻译：含有新型有效紫杉烷类及其治疗用途的细胞毒素
公开(公告)号：US07495114B2
公开(公告)日：2009-02-24
申请号：US10926192
申请日：2004-08-26
申请人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
发明人： Erkan Baloglu , Michael Miller , Ravi V. J. Chari
IPC分类号： C07D305/00
CPC分类号： C07D407/12 , A61K31/337 , C07D305/14 , C07D407/14 , C07D409/12 , Y02A50/423 , Y02A50/491
摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.
摘要翻译：包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒量的一种或多种通过连接基团与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂包括。还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

6. 发明授权

US08981084B2 Oxadiazole HDAC inhibitors 有权
标题翻译：恶二唑HDAC抑制剂
公开(公告)号：US08981084B2
公开(公告)日：2015-03-17
申请号：US13522070
申请日：2011-01-13
申请人： Erkan Baloglu , Shomir Ghosh , Mercedes Lobera , Darby Schmidt
发明人： Erkan Baloglu , Shomir Ghosh , Mercedes Lobera , Darby Schmidt
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08 , C07D271/06 , C07D409/12 , C07D409/14 , C07D495/04
CPC分类号： C07D487/08 , C07D271/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04
摘要： Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, Y, Q, X, B and L are as defined herein, and methods of making and using the same.
摘要翻译：公开了具有下式的化合物：其中X1，X2，X3，R1，R2，Y，Q，X，B和L如本文所定义，以及制备和使用它们的方法。

7. 发明申请

US20130059883A1 COMPOUNDS AND METHODS 有权
公开(公告)号：US20130059883A1
公开(公告)日：2013-03-07
申请号：US13522044
申请日：2011-01-13
申请人： Erkan Baloglu , Shomir Ghosh , Mercedes Lobera , Darby Schmidt
发明人： Erkan Baloglu , Shomir Ghosh , Mercedes Lobera , Darby Schmidt
IPC分类号： A61K31/4439 , A61K31/4245 , C07D413/12 , C07D417/14 , A61K31/4545 , A61K31/4725 , A61K31/454 , A61P35/00 , A61P3/10 , A61P29/00 , A61P9/00 , A61P3/04 , A61P7/02 , A61P25/08 , A61P25/24 , A61P37/02 , A61P31/12 , A61P31/10 , C07D413/14
CPC分类号： C07D413/12 , A61K31/497 , C07D271/06 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/463
摘要： Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

8. 发明申请

US20120322827A1 COMPOUNDS AND METHODS 审中-公开
标题翻译：化合物和方法
公开(公告)号：US20120322827A1
公开(公告)日：2012-12-20
申请号：US13522051
申请日：2011-01-13
申请人： Erkan Baloglu , Shomir Ghosh , Mercedes Lobera , Darby Schmidt
发明人： Erkan Baloglu , Shomir Ghosh , Mercedes Lobera , Darby Schmidt
IPC分类号： A61K31/4245 , C07D413/12 , A61K31/4196 , A61K31/422 , C07D409/12 , C07D413/14 , A61K31/454
CPC分类号： C07D413/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, n and L are as defined herein, and methods of making and using the same.
摘要翻译：公开了具有下式的化合物：其中X1，X2，X3，R1，R2，R3，R4，Y，A，n和L如本文所定义，以及制备和使用它们的方法。

9. 发明申请

US20050085513A1 Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
标题翻译：含有新型有效紫杉烷类及其治疗用途的细胞毒素
公开(公告)号：US20050085513A1
公开(公告)日：2005-04-21
申请号：US10963711
申请日：2004-10-14
申请人： Erkan Baloglu , Michael Miller , Ravi Chari
发明人： Erkan Baloglu , Michael Miller , Ravi Chari
IPC分类号： A61K31/337 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D305/14 , C07D407/12 , C07D407/14 , C07D409/12 , A61K31/4025 , A61K31/4433 , C07D45/02
CPC分类号： C07D407/12 , A61K31/337 , C07D305/14 , C07D407/14 , C07D409/12 , Y02A50/423 , Y02A50/491
摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a link, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.
摘要翻译：包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒性量的一种或多种通过连接体与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂。还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

10. 发明申请

US20140155381A1 COMPOUNDS AND METHODS 审中-公开
公开(公告)号：US20140155381A1
公开(公告)日：2014-06-05
申请号：US14235512
申请日：2012-07-27
申请人： Erkan Baloglu , Gary J. Bohnert , Shomir Ghosh , Mercedes Lobera , Darby R. Schmidt , Leonard Sung
发明人： Erkan Baloglu , Gary J. Bohnert , Shomir Ghosh , Mercedes Lobera , Darby R. Schmidt , Leonard Sung
IPC分类号： C07D413/14 , C07D407/06 , C07D407/14 , C07D413/06
CPC分类号： C07D413/14 , C07D405/06 , C07D405/14 , C07D407/06 , C07D407/14 , C07D413/06 , C07D491/048
摘要： The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

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