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1. 发明申请

US20060063714A1 Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides 审中-公开
标题翻译：液体，水性，因子VII多肽的药物组合物
公开(公告)号：US20060063714A1
公开(公告)日：2006-03-23
申请号：US11229427
申请日：2005-09-15
申请人： Michael Jensen , Birthe Hansen , Troels Kornfelt , Kirsten Jakobsen , Janus Krarup , Egon Persson , Anders Petersen , Andrew Bowler
发明人： Michael Jensen , Birthe Hansen , Troels Kornfelt , Kirsten Jakobsen , Janus Krarup , Egon Persson , Anders Petersen , Andrew Bowler
IPC分类号： A61K38/36
CPC分类号： A61K38/4846 , A61K9/0019 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/186
摘要： The invention relates to a liquid, aqueous pharmaceutical composition comprising a Factor VII polypeptide (e.g. human Factor VIIa) and a buffering agent; wherein the molar ratio of non-complexed calcium ions (Ca2+) to the Factor VII polypeptide is lower than 0.5. The composition may further comprise a stabilizing agent (e.g. copper or magnesium ions, benzamidine, or guanidine), a non-ionic surfactant, a tonicity modifying agent, an antioxidant and a preservative. The composition is useful for treating a Factor VII-responsive syndrome, such as bleeding disorders, including those caused by clotting Factor deficiencies (e.g. haemophilia A, haemophilia B, coagulation Factor XI deficiency, coagulation Factor VII deficiency); by thrombocytopenia or von Willebrand's disease, or by clotting Factor inhibitors, and intra cerebral haemorrhage, or excessive bleeding from any cause. The preparations may also be administered to patients in association with surgery or other trauma or to patients receiving anticoagulant therapy.
摘要翻译：本发明涉及包含因子VII多肽（例如人因子VIIa）和缓冲剂的液体含水药物组合物; 其中非络合钙离子（Ca 2+ 2 +）与因子VII多肽的摩尔比低于0.5。组合物还可以包含稳定剂（例如铜或镁离子，苯甲脒或胍），非离子表面活性剂，张力调节剂，抗氧化剂和防腐剂。该组合物可用于治疗因子VII反应性综合征，例如出血性疾病，包括由凝血因子缺乏引起的出血性疾病（例如血友病A，血友病B，凝血因子XI缺乏症，凝血因子VII缺乏症）。血小板减少症或维勒布兰氏病，或凝血因子抑制剂，脑内出血或任何原因引起的过度出血。制剂也可以与外科手术或其他创伤相关的患者或接受抗凝治疗的患者给予。

2. 发明申请

US20060205648A1 Liquid, aqueous pharmaceutical compositions of factor VII polypeptides 失效
标题翻译：液体，因子VII多肽的水性药物组合物
公开(公告)号：US20060205648A1
公开(公告)日：2006-09-14
申请号：US11353335
申请日：2006-02-14
申请人： Michael Jensen , Anders Petersen , Andrew Bowler
发明人： Michael Jensen , Anders Petersen , Andrew Bowler
IPC分类号： A61K38/36 , A61K31/17
CPC分类号： A61K38/4846 , A61K9/0019 , A61K31/17 , A61K38/36 , A61K47/02 , A61K47/16 , A61K47/183 , A61K47/42
摘要： The present invention is directed to liquid, aqueous pharmaceutical compositions stabilised against chemical and/or physical degradation containing Factor VII polypeptides, and methods for preparing and using such compositions, as well as vials containing such compositions, and the use of such compositions in the treatment of a Factor VII-responsive syndrome. The main embodiment is represented by a liquid, aqueous pharmaceutical composition comprising at least 0.01 mg/mL of a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 4.0 to about 9.0; and at least one stabilising agent (iii) comprising a —C(═N-Z1-R1)—NH-Z2-R2 motif, e.g. benzamidine compounds and guanidine compounds such as arginine.
摘要翻译：本发明涉及针对含有因子VII多肽的化学和/或物理降解稳定的液体水性药物组合物，以及用于制备和使用这些组合物的方法以及含有该组合物的小瓶，以及这些组合物在治疗中的用途的因子VII反应综合征。主要实施方案由包含至少0.01mg / mL的因子VII多肽（i）的液体含水药物组合物表示; 适于将pH保持在约4.0至约9.0范围内的缓冲剂（ii）; 和至少一种稳定剂（ⅲ），其包含-C（-NZ 1）1 -OR 1 -NH-Z 2 - SUP> 2 图案，例如苄脒化合物和胍化合物如精氨酸。

3. 发明申请

US20080093692A1 Audio Processing Device with Encapsulated Electronic Component 审中-公开
标题翻译：具有封装电子元件的音频处理装置
公开(公告)号：US20080093692A1
公开(公告)日：2008-04-24
申请号：US11661935
申请日：2005-09-05
申请人： Frank Rasmussen , Jorgen Skindhoj , Anders Petersen
发明人： Frank Rasmussen , Jorgen Skindhoj , Anders Petersen
IPC分类号： H01L29/84 , H01L21/56
CPC分类号： H05K3/4694 , H01L23/315 , H01L2223/6677 , H01L2224/16225 , H01L2224/48227 , H01L2224/97 , H01L2924/00011 , H01L2924/00014 , H01L2924/1433 , H01L2924/15192 , H01L2924/19041 , H01L2924/3025 , H05K1/16 , H05K1/186 , H05K3/284 , H05K3/4644 , H01L2224/0401 , H01L2224/85 , H01L2224/81
摘要： The invention regards an audio processing device with at least one encapsulated electronic component mounted and electrically connected to electric leads in a mounting substrate. Further electric components are mounted for connection with the encapsulated electronic component through the substrate and the encapsulation material is moulded onto the substrate. According to the invention at least one metal layer is deposited on a surface part of the encapsulation material. The invention further regards a method for producing an amplifier for an audio device whereby at least one encapsulated electronic component is mounted on, and electrically connected to a PCB and where the encapsulation material is provided to protect the electronic component wherein further a metal layer is generated at least on a surface area of the encapsulation material.
摘要翻译：本发明涉及一种具有至少一个封装的电子部件的音频处理装置，其在安装基板中安装并电连接到电引线。另外的电气部件被安装用于通过衬底与封装的电子部件连接，并且封装材料被模制到衬底上。根据本发明，至少一个金属层沉积在封装材料的表面部分上。本发明还涉及一种用于制造用于音频装置的放大器的方法，其中至少一个封装的电子部件安装在PCB上并电连接到PCB，并且其中提供封装材料以保护电子部件，其中还产生金属层至少在封装材料的表面积上。

4. 发明申请

US20070144946A1 Apparatus for use to check potatoes or similar items 有权
标题翻译：用于检查土豆或类似物品的装置
公开(公告)号：US20070144946A1
公开(公告)日：2007-06-28
申请号：US10584701
申请日：2004-12-22
申请人： Gunnar Petersen , Anders Petersen
发明人： Gunnar Petersen , Anders Petersen
IPC分类号： B07C5/00
CPC分类号： B07C5/3422 , Y10S209/914
摘要： An apparatus for use to check potatoes or similar items comprises a feeding device (2) for advancing the potatoes in a plurality of rows, a conveying device (13) adapted to receive the rows of potatoes from the feeding device (2) and advancing them while maintaining the row structure, a camera (42) with associated image processing means for recording and evaluating each individual potato on the conveying device (13), and a sorting device (31) controlled by the image processing means, said sorting device being adapted to sort the potatoes. The conveying device (13) comprises a plurality of substantially horizontal rollers (14, 15), the axes of rotation of said rollers extending parallel to the advance direction (12) of the potatoes. The rollers (14, 15) are rotatably mounted in a support frame (25, 26) and connected with a first driving device (29) for rotating them, said rollers each independently being additionally displaceable in parallel forwards and backwards in a substantially straight line extending in a vertical plane, said plane comprising the axis of rotation of each roller, and inclining somewhat upwards, seen in the advance direction. Finally, the rollers (14, 15) are connected with a second driving device (27) adapted to confer a reciprocating oscillating movement to each roller along said line.
摘要翻译：用于检查马铃薯或类似物品的装置包括用于使马铃薯以多行推进的进料装置（2），适于从进料装置（2）接收马铃薯排并将其推进的输送装置（13）同时保持行结构，具有用于记录和评估输送装置（13）上的每个单独马铃薯的相关图像处理装置的相机（42）以及由图像处理装置控制的分类装置（31），所述分类装置适于对土豆进行分类。输送装置（13）包括多个基本上水平的辊子（14,15），所述辊子的旋转轴线平行于马铃薯的前进方向（12）延伸。辊子（14,15）可旋转地安装在支撑框架（25,26）中并与第一驱动装置（29）连接，用于旋转它们，所述辊子各自独立地在基本上直线上向前和向后平行地平行移动在垂直平面上延伸，所述平面包括每个辊子的旋转轴线，并且在前进方向上看起来稍微向上倾斜。最后，辊子（14,15）与第二驱动装置（27）连接，第二驱动装置（27）适于沿着所述线路向每个辊子赋予往复摆动运动。

5. 发明申请

US20060069013A1 Pharmaceutical preparations comprising acid-stabilised insulin 审中-公开
标题翻译：包含酸稳定胰岛素的药物制剂
公开(公告)号：US20060069013A1
公开(公告)日：2006-03-30
申请号：US11227760
申请日：2005-09-12
申请人： Soren Ostergaard , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
发明人： Soren Ostergaard , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
IPC分类号： A61K38/28 , A61K31/555
CPC分类号： A61K38/28 , A61K9/0019 , A61K31/41 , A61K31/555
摘要： Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.
摘要翻译：公开了能够延长胰岛素制剂作用的R状态胰岛素六聚体的HisB10 Zn 2+ 2 +位点的新配体。

6. 发明申请

US20050215054A1 Feed-through process and amplifier with feed-through 审中-公开
标题翻译：直通过程和放大器与馈通
公开(公告)号：US20050215054A1
公开(公告)日：2005-09-29
申请号：US10516886
申请日：2003-05-22
申请人： Frank Rasmussen , Jorgen Skindhoj , Anders Petersen
发明人： Frank Rasmussen , Jorgen Skindhoj , Anders Petersen
IPC分类号： H01L21/306 , H01L21/768 , H01L21/308 , H01L29/40
CPC分类号： H01L21/30608 , H01L21/76898
摘要： The invention concerns a process for generating a feed-through in a semiconductor wafer, which has electric circuitry embedded in a front surface whereby the hole for the feed-through is generated by the combined use of a front side protection layer and a wet KOH etch process etching the hole from the back side of the wafer, where a photomasking process is subsequently used do define the via followed by deposition of the via material.
摘要翻译：本发明涉及一种用于在半导体晶片中产生馈通的方法，该半导体晶片具有嵌入在前表面中的电路，由此通过组合使用前侧保护层和湿KOH蚀刻来产生馈通孔从晶片的背面对孔进行蚀刻，随后使用光掩模工艺来确定通孔，然后沉积通孔材料。

7. 发明授权

US07607544B2 Apparatus for use to check potatoes or similar items 有权
标题翻译：用于检查土豆或类似物品的装置
公开(公告)号：US07607544B2
公开(公告)日：2009-10-27
申请号：US10584701
申请日：2004-12-22
申请人： Gunnar Petersen , Anders Petersen
发明人： Gunnar Petersen , Anders Petersen
IPC分类号： B07C5/00 , B07C5/02 , B07C5/36
CPC分类号： B07C5/3422 , Y10S209/914
摘要： Apparatus for use to check potatoes or similar items, the apparatus including a feeding device for advancing the potatoes in a plurality of rows, a conveying device adapted to receive the rows of potatoes from the feeding device and advancing them while maintaining the row structure, at least one camera with associated image processor for recording and evaluating each individual potato on the conveying device and a sorting device controlled by the image processor, the sorting device being adapted to sort the potatoes. The conveying device includes a plurality of substantially horizontal rollers, the axes of rotation of the rollers extending parallel to the advance direction of the potatoes, the rollers being rotatably mounted in a support frame and connected with a first driving device for rotating the rollers. The rollers are each independently additionally displaceable in parallel forwards and backwards in a substantially straight line.
摘要翻译：用于检查马铃薯或类似物品的装置，该装置包括用于使马铃薯多行进给的进给装置，适于从进给装置接收马铃薯排并在保持行结构的同时推进马铃薯的输送装置，具有相关图像处理器的至少一个相机，用于记录和评估所述输送装置上的每个单独的马铃薯以及由所述图像处理器控制的分类装置，所述分选装置适于对所述马铃薯进行分类。输送装置包括多个基本上水平的辊子，辊子的转动轴线平行于马铃薯的前进方向延伸，辊子可旋转地安装在支撑框架中，并与用于转动辊子的第一驱动装置连接。辊子各自独立地在基本上直线上前后平行地平行移位。

8. 发明申请

US20060258561A1 Novel NPH insulin preparations 审中-公开
标题翻译：新型NPH胰岛素制剂
公开(公告)号：US20060258561A1
公开(公告)日：2006-11-16
申请号：US11226870
申请日：2005-09-09
申请人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
发明人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
IPC分类号： A61K38/28 , A61K31/522 , A61K31/513 , A61K31/426 , A61K31/4196 , A61K31/4184 , A61K31/4166 , A61K33/32
CPC分类号： A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/426 , A61K31/513 , A61K31/522 , A61K33/30 , A61K38/28 , A61K45/06
摘要： This invention relates to NPH-insulin (crystalline preparations) that are prepared in the presence of certain high-affinity ligands for the HisB10 Zn2+-sites of the R-state insulin hexamer. Preparation of NPH-insulin in the presence of high-affinity ligand results in crystalline NPH-insulin suspensions that are absorbed more slowly from subcutis than regular NPH-insulin. Hence the resulting action profile is longer and the spike is less pronounced than observed with regular NPH-insulin
摘要翻译：本发明涉及在R状态胰岛素六聚体的HisB10 Zn 2+ 2+的某些高亲和力配体存在下制备的NPH-胰岛素（结晶制剂）。在高亲和力配体的存在下制备NPH-胰岛素导致结晶NPH-胰岛素悬浮液比皮下组织比常规NPH-胰岛素更慢吸收。因此，所得到的作用谱更长，并且峰值不如用常规NPH-胰岛素观察到的

9. 发明申请

US20050123157A1 Method for producing a hearing aid 有权
标题翻译：助听器的制造方法
公开(公告)号：US20050123157A1
公开(公告)日：2005-06-09
申请号：US10497855
申请日：2002-12-02
申请人： Lasse Kragelund , Jorgen Skindhoj , Anders Petersen
发明人： Lasse Kragelund , Jorgen Skindhoj , Anders Petersen
IPC分类号： H04R25/00
CPC分类号： H04R25/604 , B29C45/14639 , B29C45/14836 , B29C2045/14844 , H04R25/405 , H04R25/602
摘要： The invention concerns a hearing aid, which has a casing accommodating one or more sound to electric signal converting transducers (11,12) and a signal path from the transducer (11,12) to a receiver which provides a sound signal at the ear of the user. The signal processing is provided in the signal path to ensure a signal amplification/attenuation according to the needs of the user. A battery (6) is accommodated in the casing and a battery lid is arranged with a first side (1) facing the surrounding and a second side (2) facing the interior of the casing whereby the battery lid is operable for replacement of the battery. According to the invention the battery lid has means (3) for receiving at least one sound to electric signal converting transducer (11,12) and a sound transmission path is provided between the first side (1) of the battery lid and the at least one transducer (11,12).
摘要翻译：本发明涉及助听器，该助听器具有容纳一个或多个声音对电信号转换换能器（11,12）的壳体和从换能器（11,12）到接收器的信号路径，该接收器在耳朵的耳朵处提供声音信号用户。在信号路径中提供信号处理，以确保根据用户需要的信号放大/衰减。电池（6）容纳在壳体中，并且电池盖布置有面向周围的第一侧面（1）和面向壳体内部的第二侧面（2），由此电池盖可操作以更换电池。根据本发明，电池盖具有用于接收至少一个声音到电信号转换换能器（11,12）的装置（3），并且在电池盖的第一侧（1）和至少一个换能器（11,12）。

10. 发明申请

US20050065066A1 Stabilised insulin compositions 审中-公开
标题翻译：稳定的胰岛素组合物
公开(公告)号：US20050065066A1
公开(公告)日：2005-03-24
申请号：US10825995
申请日：2004-04-16
申请人： Niels Kaarsholm , Peter Madsen , Morten Schlein , Helle Olsen , Svend Havelund , Dorte Steensgaard , Svend Ludvigsen , Palle Jakobsen , Anders Petersen , Gerd Schluckebier
发明人： Niels Kaarsholm , Peter Madsen , Morten Schlein , Helle Olsen , Svend Havelund , Dorte Steensgaard , Svend Ludvigsen , Palle Jakobsen , Anders Petersen , Gerd Schluckebier
IPC分类号： A61K31/416 , A61K31/4192 , A61K38/00 , A61K38/28 , C07D249/06 , C07D249/18 , C07D277/34 , C07D403/04 , C07D413/12 , C07D417/12 , C07K14/62
CPC分类号： C07D403/04 , A61K31/416 , A61K31/4192 , A61K38/28 , C07D249/06 , C07D249/18 , C07D277/34 , C07D413/12 , C07D417/12 , C07K14/62 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The resulting preparations have improved physical and chemical stability.
摘要翻译：本发明提供包含胰岛素和R状态胰岛素六聚体的His Zn 2+位点的新配体的药物组合物。所得制剂具有改善的物理和化学稳定性。

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