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1. 发明申请

US20090179171A1 CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES 有权
标题翻译：材料和多孔磁性颗粒的控制
公开(公告)号：US20090179171A1
公开(公告)日：2009-07-16
申请号：US12300369
申请日：2007-05-16
申请人： Michael J. Sailor , Ji-Ho Park , Austin M. Derfus , Ester Segal , Kenneth S. Vecchio , Sangeeta N. Bhatia
发明人： Michael J. Sailor , Ji-Ho Park , Austin M. Derfus , Ester Segal , Kenneth S. Vecchio , Sangeeta N. Bhatia
IPC分类号： H01F1/00 , H05B6/02
CPC分类号： H05B6/02 , B82Y25/00 , H01F1/0063 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/32
摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are associated with a material. Application of a DC magnetic field allows them to be moved with their associated material, and application of an AC RF electromagnetic field allows them to be heated with their associated material. The material can be associated with the particles by being contained in the pores of the particles, or in other cases the particles can adhere to the associated material, which can be an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.
摘要翻译：本发明使用外部施加的电磁刺激来控制和加热与颗粒相关联的多孔磁性颗粒和材料。颗粒含有磁性材料，例如超顺磁性氧化铁，并与材料相关联。 DC磁场的应用允许它们与其相关材料一起移动，并且AC RF电磁场的应用允许它们与其相关材料一起被加热。该材料可以通过包含在颗粒的孔中与颗粒相关联，或者在其它情况下，颗粒可以附着到可以是水性液滴的相关材料上。本发明还提供一种多层多孔磁性颗粒。颗粒包括具有尺寸以接受磁性纳米颗粒的孔的主体层。磁性纳米颗粒注入到主体层的孔内编码层包括限定光谱代码的孔。编码层中的孔的大小被确定为基本排除磁性纳米颗粒。编码层也可以是多层，表现出例如复谱谱。

2. 发明授权

US08377147B2 Control of materials and porous magnetic particles 有权
标题翻译：材料和多孔磁性颗粒的控制
公开(公告)号：US08377147B2
公开(公告)日：2013-02-19
申请号：US12300369
申请日：2007-05-16
申请人： Michael J. Sailor , Ji-Ho Park , Austin Derfus , Ester Segal , Kenneth S. Vecchio , Sangeeta N. Bhatia
发明人： Michael J. Sailor , Ji-Ho Park , Austin Derfus , Ester Segal , Kenneth S. Vecchio , Sangeeta N. Bhatia
IPC分类号： B32B15/00 , B44C1/22
CPC分类号： H05B6/02 , B82Y25/00 , H01F1/0063 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/32
摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are infused with a material. Application of a DC magnetic field allows them to be moved with their infused material, and application of an AC RF electromagnetic field allows them to be heated with their infused material. The material can be infused into pores of the particles and the particles can also adhere to an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer. An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.
摘要翻译：本发明使用外部施加的电磁刺激来控制和加热与颗粒相关联的多孔磁性颗粒和材料。颗粒包含磁性材料，例如超顺磁性氧化铁，并且注入材料。直流磁场的应用使得它们可以通过其输入的材料移动，并且使用AC RF电磁场允许它们与其输入的材料一起被加热。该材料可以注入到颗粒的孔中，并且颗粒也可以粘附到水滴上。本发明还提供一种多层多孔磁性颗粒。颗粒包括具有尺寸以接受磁性纳米颗粒的孔的主体层。磁性纳米颗粒注入主体层的孔内。编码层包括限定光谱代码的孔。编码层中的孔的大小被确定为基本排除磁性纳米颗粒。编码层也可以是多层，表现出例如复谱谱。

3. 发明申请

US20100254914A1 NANOWORMS FOR IN VIVO TUMOR TARGETING 审中-公开
标题翻译：用于血液肿瘤指南的纳米血管
公开(公告)号：US20100254914A1
公开(公告)日：2010-10-07
申请号：US12712552
申请日：2010-02-25
申请人： Ji-Ho Park , Lianglin Zhang , Austin M. Derfus , Michael J. Sailor , Geoffrey A. Von Maltzahn , Todd Harris , Sangeeta N. Bhatia , Dmitri Simberg
发明人： Ji-Ho Park , Lianglin Zhang , Austin M. Derfus , Michael J. Sailor , Geoffrey A. Von Maltzahn , Todd Harris , Sangeeta N. Bhatia , Dmitri Simberg
IPC分类号： A61K9/14 , B32B5/16 , A61B5/055 , A61K38/04 , A61K9/127 , A61K31/704 , A61P35/00 , C01G49/02 , C12Q1/02
CPC分类号： A61K9/5115 , A61K9/5123 , A61K31/704 , B82Y30/00 , C01G49/08 , C01P2004/04 , C01P2004/32 , C01P2004/45 , C01P2004/64 , C01P2006/42 , G01N33/5434 , Y10T428/2991
摘要： The disclosure provides elongated nanostructures useful for biological imaging and measurement. More particularly the disclosure provides nanoworms having an increased bioavailability compared to nanospheres.
摘要翻译：本公开提供可用于生物成像和测量的细长纳米结构。更具体地，本公开提供了与纳米球相比具有增加的生物利用度的纳米虫。

4. 发明申请

US20120059240A1 METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于治疗和诊断应用的细胞杂交纳米颗粒的制备方法及其组合物
公开(公告)号：US20120059240A1
公开(公告)日：2012-03-08
申请号：US13219906
申请日：2011-08-29
申请人： Michael J. Sailor , Sangeeta N. Bhatia , Ji-Ho Park , Geoffrey A. Von Maltzahn
发明人： Michael J. Sailor , Sangeeta N. Bhatia , Ji-Ho Park , Geoffrey A. Von Maltzahn
IPC分类号： A61B5/055 , A61K31/704 , A61K49/00 , A61K49/18 , A61P35/00 , G01N33/566 , C12Q1/68 , A61N2/10 , A61K9/14 , C12Q1/02 , B82Y5/00 , B82Y40/00 , B82Y25/00
CPC分类号： A61K9/1271 , A61K49/0002 , A61K49/0019 , A61K49/0067 , A61K49/0082 , A61K49/1806 , A61K49/1839 , A61K49/1887
摘要： The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG)-phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR-fluorescent and MR imaging of diseased tissue in vitro and in vivo.
摘要翻译：本公开提供了在单一聚乙二醇（PEG） - 磷脂胶束内含有MN，QD和抗癌药物多柔比星（DOX）的长循环，胶束混合纳米粒子（MHN），并提供同时靶向药物的第一个实例递送和双模NIR荧光和MR成像的病变组织体外和体内。

5. 发明授权

US07312046B2 Method of screening compounds using a nanoporous silicon support containing macrowells for cells 失效
标题翻译：使用包含用于细胞的孔眼的纳米多孔硅载体筛选化合物的方法
公开(公告)号：US07312046B2
公开(公告)日：2007-12-25
申请号：US10787015
申请日：2004-02-25
申请人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
发明人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
IPC分类号： C12Q1/02 , C12Q1/18 , C12Q1/20 , C12N1/00 , C12N5/00 , C12M1/00 , C12M3/00
CPC分类号： G01N33/5014 , C12M25/14 , C12M29/10 , G01N33/5008 , G01N33/502 , G01N33/5067 , G01N33/5088 , G01N33/552 , G01N2500/20
摘要： A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by means such as perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that promotes cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The supports are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.
摘要翻译：提供包含多个大孔的纳米多孔硅载体用作生物反应器，用于维持分化状态的培养中的细胞。每个细胞或一组细胞在单独的大孔中生长，并通过诸如用流体灌注纳米多孔硅载体的方式提供营养。大孔可以在0.2和200微米之间，并且涂覆有促进细胞粘附的物质。含有细胞的载体可用于测试化合物的生物活性，代谢，毒性，致突变性，致癌性或表征新颖或未知的化合物。载体足够坚固，可将其组装成较大的反应器以模拟器官功能或用于生产生物分子。

6. 发明授权

US06734000B2 Nanoporous silicon support containing macropores for use as a bioreactor 失效
标题翻译：含有大孔的纳米多孔硅载体用作生物反应器
公开(公告)号：US06734000B2
公开(公告)日：2004-05-11
申请号：US09981691
申请日：2001-10-12
申请人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
发明人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
IPC分类号： C12M1114
CPC分类号： G01N33/5014 , C12M25/14 , C12M29/10 , G01N33/5008 , G01N33/502 , G01N33/5067 , G01N33/5088 , G01N33/552 , G01N2500/20
摘要： A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients such as by perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that provides cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The support is sufficiently robust that it may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.
摘要翻译：提供包含多个大孔的纳米多孔硅载体用作生物反应器，用于维持分化状态的培养中的细胞。每个细胞或一组细胞在单个大孔中生长并且提供营养物质，例如通过用流体灌注纳米多孔硅载体。大孔可以在0.2至200微米之间，并且涂覆有提供细胞粘附的物质。含有细胞的载体可用于测试化合物的生物活性，代谢，毒性，致突变性，致癌性或表征新颖或未知的化合物。支架足够坚固，可将其装配到较大的反应器中以模拟器官功能或用于生产生物分子。

7. 发明申请

US20110300222A1 LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：发光多孔硅纳米粒子，其制造方法和使用方法
公开(公告)号：US20110300222A1
公开(公告)日：2011-12-08
申请号：US13202271
申请日：2010-02-20
申请人： Michael J. Sailor , Luo Gu , Ji-Ho Park
发明人： Michael J. Sailor , Luo Gu , Ji-Ho Park
IPC分类号： A61K9/16 , C12Q1/02 , C01B33/12 , B32B5/16 , A61K9/00 , A61K47/00 , B82Y40/00 , B82Y5/00
CPC分类号： C09K11/59 , A61K49/0017 , A61K49/0067 , A61K49/0093 , C09K11/02 , C09K11/025 , Y10T428/2982
摘要： The disclosure relates to imaging agents and drug delivery systems.
摘要翻译：本公开涉及成像剂和药物递送系统。

8. 发明授权

US09007593B2 Temperature response sensing and classification of analytes with porous optical films 有权
标题翻译：多孔光学薄膜的分析物的温度响应感测和分类
公开(公告)号：US09007593B2
公开(公告)日：2015-04-14
申请号：US13811147
申请日：2011-07-19
申请人： Michael J. Sailor , Brian H King , Sadafumi Noda
发明人： Michael J. Sailor , Brian H King , Sadafumi Noda
IPC分类号： G01N21/00 , G01N21/25 , G01N21/17
CPC分类号： G01N21/25 , G01N21/171 , Y10T436/153333
摘要： Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The porous optical film is heated and its optical response is monitored during heating. An optical response observed via heating can determine the identity and/or quantity of the analyte. In preferred embodiments, optical response during a thermal pulse is compared to a database of sensor responses that are characteristic of various analytes. Preferred methods are conducted a relatively low temperatures, for example below about 200° C. In preferred methods, a heating and cooling cycle produces a hysteresis curve in the optical response that is indicative of analytes. In preferred embodiments, a thermal reset pulse resets the porous optical film for later use and also provides an optical response that can be used for sensing.
摘要翻译：本发明的方法和系统可以确定蒸汽中分析物的身份和数量。在优选的方法中，多孔光学膜暴露于含有分析物的蒸汽。加热多孔光学膜并在加热期间监测其光学响应。通过加热观察到的光学响应可以确定分析物的身份和/或数量。在优选实施例中，将热脉冲期间的光学响应与各种分析物的特征的传感器响应的数据库进行比较。优选的方法进行相对较低的温度，例如低于约200℃。在优选的方法中，加热和冷却循环在指示分析物的光学响应中产生滞后曲线。在优选实施例中，热复位脉冲复位多孔光学膜用于稍后使用，并且还提供可用于感测的光学响应。

9. 发明授权

US08206780B2 Polymer composite photonic particles 有权
标题翻译：聚合物复合光子粒子
公开(公告)号：US08206780B2
公开(公告)日：2012-06-26
申请号：US11791933
申请日：2005-12-14
申请人： Yang Yang Li , Vijay S. Kollengode , Michael J. Sailor , Shawn O. Meade
发明人： Yang Yang Li , Vijay S. Kollengode , Michael J. Sailor , Shawn O. Meade
IPC分类号： B01J13/02 , B05B5/00 , A61K9/50 , A61K9/16
CPC分类号： B01J2/22 , Y10S977/70 , Y10S977/895 , Y10T428/2982
摘要： A method for forming photonic particles, where the method includes the steps of preparing a porous photonic material layer, patterning a soluble polymer on the porous photonic material layer, leaving dividing portions of the material layer untreated, infusing the polymer into the material layer, and removing the dividing portions of the material to obtain the photonic particles.
摘要翻译：一种形成光子粒子的方法，其中该方法包括制备多孔光子材料层的步骤，在多孔光子材料层上构图可溶性聚合物，使材料层的分割部分未经处理，将聚合物注入材料层，以及去除材料的分割部分以获得光子粒子。

10. 发明申请

US20080204752A1 SYSTEM AND METHOD FOR REMOTE, FREE-SPACE OPTICAL DETECTION OF POTENTIAL THREAT AGENT 有权
标题翻译：用于遥感，自由空间光学检测潜在威胁剂的系统和方法
公开(公告)号：US20080204752A1
公开(公告)日：2008-08-28
申请号：US11680309
申请日：2007-02-28
申请人： Jason R. Dorvee , Jamie R. Link , Michael J. Sailor , Harold E. Hager , William D. Sherman
发明人： Jason R. Dorvee , Jamie R. Link , Michael J. Sailor , Harold E. Hager , William D. Sherman
IPC分类号： G01J3/46
CPC分类号： G01N21/39 , G01N21/783 , G01N2015/0088 , G01N2021/1793 , G01N2021/7773 , G01N2021/7796 , G01N2201/0214 , G01N2201/06113
摘要： A system and method for free space, optical remote sensing of a potential threat agent using spectrally responsive sensor material. In one example the sensor material is formed by particles, which in one particular form are porous photonic crystals. The particles are dispersed into an area being monitored for the presence of the potential threat agent. A pair of lasers is used to generate optical light beams that are directed at the sensor particles after the particles have been dispersed. The light reflected by the sensor particles is then analyzed. The presence of the potential threat agent causes a shift in the spectral peak of light reflected from the sensor particles that can be sensed using photo detectors and a processing subsystem. The system can be tuned to remotely detect for specific chemical, biological or environmental agents that may be present within a given area.
摘要翻译：使用光谱响应传感器材料的自由空间，潜在威胁剂的光学遥感的系统和方法。在一个示例中，传感器材料由颗粒形成，其在一种特定形式中是多孔光子晶体。颗粒被分散到正在监测的潜在威胁剂的存在的区域中。使用一对激光器在颗粒分散之后产生指向传感器颗粒的光束。然后分析由传感器颗粒反射的光。潜在威胁剂的存在导致从可以使用光电检测器和处理子系统感测的传感器颗粒反射的光的光谱峰值的偏移。该系统可以被调整以远程检测可能存在于给定区域内的特定化学，生物或环境因素。

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