专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07312046B2 Method of screening compounds using a nanoporous silicon support containing macrowells for cells 失效
标题翻译：使用包含用于细胞的孔眼的纳米多孔硅载体筛选化合物的方法
公开(公告)号：US07312046B2
公开(公告)日：2007-12-25
申请号：US10787015
申请日：2004-02-25
申请人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
发明人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
IPC分类号： C12Q1/02 , C12Q1/18 , C12Q1/20 , C12N1/00 , C12N5/00 , C12M1/00 , C12M3/00
CPC分类号： G01N33/5014 , C12M25/14 , C12M29/10 , G01N33/5008 , G01N33/502 , G01N33/5067 , G01N33/5088 , G01N33/552 , G01N2500/20
摘要： A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by means such as perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that promotes cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The supports are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.
摘要翻译：提供包含多个大孔的纳米多孔硅载体用作生物反应器，用于维持分化状态的培养中的细胞。每个细胞或一组细胞在单独的大孔中生长，并通过诸如用流体灌注纳米多孔硅载体的方式提供营养。大孔可以在0.2和200微米之间，并且涂覆有促进细胞粘附的物质。含有细胞的载体可用于测试化合物的生物活性，代谢，毒性，致突变性，致癌性或表征新颖或未知的化合物。载体足够坚固，可将其组装成较大的反应器以模拟器官功能或用于生产生物分子。

2. 发明授权

US06734000B2 Nanoporous silicon support containing macropores for use as a bioreactor 失效
标题翻译：含有大孔的纳米多孔硅载体用作生物反应器
公开(公告)号：US06734000B2
公开(公告)日：2004-05-11
申请号：US09981691
申请日：2001-10-12
申请人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
发明人： Vicki I. Chin , Sangeeta N. Bhatia , Michael J. Sailor , Boyce E. Collins
IPC分类号： C12M1114
CPC分类号： G01N33/5014 , C12M25/14 , C12M29/10 , G01N33/5008 , G01N33/502 , G01N33/5067 , G01N33/5088 , G01N33/552 , G01N2500/20
摘要： A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients such as by perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that provides cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The support is sufficiently robust that it may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.
摘要翻译：提供包含多个大孔的纳米多孔硅载体用作生物反应器，用于维持分化状态的培养中的细胞。每个细胞或一组细胞在单个大孔中生长并且提供营养物质，例如通过用流体灌注纳米多孔硅载体。大孔可以在0.2至200微米之间，并且涂覆有提供细胞粘附的物质。含有细胞的载体可用于测试化合物的生物活性，代谢，毒性，致突变性，致癌性或表征新颖或未知的化合物。支架足够坚固，可将其装配到较大的反应器中以模拟器官功能或用于生产生物分子。

3. 发明授权

US08852447B2 Porous nanostructures and methods involving the same 有权
标题翻译：多孔纳米结构及其相关方法
公开(公告)号：US08852447B2
公开(公告)日：2014-10-07
申请号：US13590825
申请日：2012-08-21
申请人： Michael J. Sailor , Gaurav Abbi , Boyce E. Collins , Keiki-Pua S. Dancil
发明人： Michael J. Sailor , Gaurav Abbi , Boyce E. Collins , Keiki-Pua S. Dancil
IPC分类号： B44C1/22 , G01N33/552 , C25F3/14 , G01N33/543 , A61K9/00 , G01N21/77
CPC分类号： A61K47/02 , A61K9/0097 , A61K31/436 , A61K31/573 , C25F3/14 , G01N33/5438 , G01N33/552 , G01N2021/7773 , G01N2021/7776
摘要： A method for simultaneously detecting and separating a target analyte such as a protein or other macromolecule that includes providing a porous silicon matrix on the silicon substrate, exposing the porous silicon matrix to an environment suspect of containing the target analyte, observing optical reflectivity of the porous silicon matrix; and correlating the changes in the silicon substrate to the target analyte.
摘要翻译：一种用于同时检测和分离诸如蛋白质或其它高分子的目标分析物的方法，其包括在硅衬底上提供多孔硅基质，将多孔硅基质暴露于怀疑含有目标分析物的环境，观察多孔硅的光学反射率硅基体; 并将硅衬底中的变化与目标分析物相关联。

4. 发明授权

US08274643B2 Porous nanostructures and methods involving the same 有权
标题翻译：多孔纳米结构及其相关方法
公开(公告)号：US08274643B2
公开(公告)日：2012-09-25
申请号：US10546522
申请日：2004-03-05
申请人： Michael J. Sailor , Gaurav Abbi , Boyce E. Collins , Keiki-Pua S. Dancil
发明人： Michael J. Sailor , Gaurav Abbi , Boyce E. Collins , Keiki-Pua S. Dancil
IPC分类号： G01N1/00
CPC分类号： A61K47/02 , A61K9/0097 , A61K31/436 , A61K31/573 , C25F3/14 , G01N33/5438 , G01N33/552 , G01N2021/7773 , G01N2021/7776
摘要： A method for simultaneously detecting and separating a target analyte such as a protein or other macromolecule that includes providing a porous silicon matrix on the silicon substrate, exposing the porous silicon matrix to an environment suspect of containing the target analyte, observing optical reflectivity of the porous silicon matrix; and correlating the changes in the silicon substrate to the target analyte.
摘要翻译：一种用于同时检测和分离诸如蛋白质或其它高分子的目标分析物的方法，其包括在硅衬底上提供多孔硅基质，将多孔硅基质暴露于怀疑含有目标分析物的环境，观察多孔硅的光学反射率硅基体; 并将硅衬底中的变化与目标分析物相关联。

5. 发明授权

US07814652B2 Method of making through-hole vias in a substrate 有权
标题翻译：在基板上制作通孔的方法
公开(公告)号：US07814652B2
公开(公告)日：2010-10-19
申请号：US12180169
申请日：2008-07-25
申请人： Colby Bellew , Boyce E. Collins , Kelvin Liu
发明人： Colby Bellew , Boyce E. Collins , Kelvin Liu
IPC分类号： H01R43/00
CPC分类号： G01N29/223 , B06B1/0292 , G01N29/02 , G01N29/022 , G01N29/222 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0423 , G01N2291/0427 , G01N2291/106 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49169 , Y10T29/53052
摘要： A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias. The signals are then processed through an amplifier and a digital signal processor using a modified periodogram.
摘要翻译：公开了一种用于诸如微结构谐振传感器的传感器的传感器组件。所公开的组件通过提供热不敏感的环境和用于信号行进到处理部件的短路径来提供传感器的改进的性能。此外，组件为传感器和壳体模块提供模块化结构，从而以更低的成本实现更换传感器。该组件包括传感器模块，该传感器模块包括形成在一个表面上形成有空腔的导电基底上的传感器。衬底具有从腔体延伸到衬底的第二表面的导电通孔。壳体组件容纳传感器并且包括优选由陶瓷制成的刚性壳体。诸如放大器的电子部件安装在刚性壳体上。电子部件基本上在基板的第二表面上电接合通孔。电子部件通过通孔从传感器接收信号。然后通过放大器和使用改进的周期图的数字信号处理器处理信号。

6. 发明申请

US20090074951A1 SUBSTRATES HAVING THROUGH-HOLE VIAS AND METHOD OF MAKING SAME 有权
标题翻译：具有贯通孔VIAS的基板及其制造方法
公开(公告)号：US20090074951A1
公开(公告)日：2009-03-19
申请号：US12180169
申请日：2008-07-25
申请人： Colby Bellew , Boyce E. Collins , Kelvin Liu
发明人： Colby Bellew , Boyce E. Collins , Kelvin Liu
IPC分类号： B05D5/12
CPC分类号： G01N29/223 , B06B1/0292 , G01N29/02 , G01N29/022 , G01N29/222 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0423 , G01N2291/0427 , G01N2291/106 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49169 , Y10T29/53052
摘要： A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias. The signals are then processed through an amplifier and a digital signal processor using a modified periodogram.
摘要翻译：公开了一种用于诸如微结构谐振传感器的传感器的传感器组件。所公开的组件通过提供热不敏感的环境和用于信号行进到处理部件的短路径来提供传感器的改进的性能。此外，组件为传感器和壳体模块提供模块化结构，从而以更低的成本实现更换传感器。该组件包括传感器模块，该传感器模块包括形成在一个表面上形成有空腔的导电基底上的传感器。衬底具有从腔体延伸到衬底的第二表面的导电通孔。壳体组件容纳传感器并且包括优选由陶瓷制成的刚性壳体。诸如放大器的电子部件安装在刚性壳体上。电子部件基本上在基板的第二表面上电接合通孔。电子部件通过通孔从传感器接收信号。然后通过放大器和使用改进的周期图的数字信号处理器处理信号。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式