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1. 发明授权

US06174323B1 Method and assembly for lung volume reduction 失效
标题翻译：肺体积减少的方法和装配
公开(公告)号：US06174323B1
公开(公告)日：2001-01-16
申请号：US09092727
申请日：1998-06-05
申请人： Michael J. Biggs , Bryan Loomas , James M. Davenport
发明人： Michael J. Biggs , Bryan Loomas , James M. Davenport
IPC分类号： A61B1704
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/064 , A61B17/0644 , A61B17/12022 , A61B17/12104 , A61B17/12172 , A61B2017/00349 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0451 , A61B2017/0496 , A61B2017/1205
摘要： A method and assembly for reducing the volume of a lung. A plurality of anchors are anchored at different positions in the lung. A cord is attached to each of the anchors. The anchors are drawn towards one another via the cords to cause the lung to collapse, thus compressing the tissue in the lung and establishing a reduction in lung volume.
摘要翻译：用于减少肺体积的方法和装置。多个锚定在肺中的不同位置。一根绳索连接到每个锚。锚通过绳索相互牵引以引起肺塌陷，从而压缩肺中的组织并建立肺容积的减少。

2. 发明授权

US07175644B2 Devices and methods for maintaining collateral channels in tissue 失效
标题翻译：用于维持组织中的旁路通道的装置和方法
公开(公告)号：US07175644B2
公开(公告)日：2007-02-13
申请号：US09947144
申请日：2001-09-04
申请人： Joel D. Cooper , James M. Davenport , Bryan Loomas , Don Tanaka , Gary Kaplan
发明人： Joel D. Cooper , James M. Davenport , Bryan Loomas , Don Tanaka , Gary Kaplan
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61F2/90 , A61B5/489 , A61B8/06 , A61B8/12 , A61B8/445 , A61B17/064 , A61B17/11 , A61B17/320068 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B90/36 , A61B2017/00106 , A61B2017/00252 , A61B2017/00575 , A61B2017/00809 , A61B2017/22067 , A61B2018/00214 , A61B2018/00541 , A61B2018/00601 , A61B2018/00738 , A61B2018/00982 , A61B2018/1417 , A61B2018/1425 , A61B2018/1472 , A61B2090/395 , A61B2218/002 , A61F2/07 , A61F2/2412 , A61F2/91 , A61F2/92 , A61F2002/043 , A61F2002/061 , A61F2002/072 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2230/005 , A61F2230/0058 , A61F2230/0067 , A61F2230/0076 , A61F2230/0078
摘要： The devices and methods of placement of such devices disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices produce and maintain collateral openings or channels through the airway wall so that oxygen depleted/carbon dioxide rich air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. The medical kits disclosed herein are also directed to produce and maintain collateral openings through airway walls.
摘要翻译：本文公开的这种装置的放置装置和方法旨在改变肺内的气流以改善例如具有慢性阻塞性肺疾病的个体的呼气循环。更具体地说，这些装置通过气道壁产生和保持侧支开口或通道，使得贫氧/富含二氧化碳的空气能够直接从肺组织中流出，以促进氧气最终进入血液和/或减压超膨胀肺。本文公开的医疗用具还涉及通过气道壁产生和维持侧支开口。

3. 发明授权

US06692494B1 Methods and devices for creating collateral channels in the lungs 有权
标题翻译：在肺部产生旁路通道的方法和装置
公开(公告)号：US06692494B1
公开(公告)日：2004-02-17
申请号：US09633651
申请日：2000-08-07
申请人： Joel D. Cooper , Bryan Loomas , Don Tanaka , Michael D. Laufer , David Thompson , James M. Davenport , Gary Kaplan , Dave Haugaard , Glendon E. French
发明人： Joel D. Cooper , Bryan Loomas , Don Tanaka , Michael D. Laufer , David Thompson , James M. Davenport , Gary Kaplan , Dave Haugaard , Glendon E. French
IPC分类号： A61B1818
CPC分类号： A61B17/064 , A61B5/489 , A61B8/06 , A61B8/12 , A61B8/445 , A61B17/0644 , A61B17/08 , A61B17/11 , A61B17/22 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B90/36 , A61B2017/00106 , A61B2017/00252 , A61B2017/00575 , A61B2017/00809 , A61B2017/1135 , A61B2017/1139 , A61B2017/22067 , A61B2017/22077 , A61B2017/3425 , A61B2017/3484 , A61B2018/00005 , A61B2018/00029 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00541 , A61B2018/1425 , A61B2018/1437 , A61B2018/1475 , A61B2018/1497 , A61B2090/08021 , A61B2090/3782 , A61B2090/395 , A61F2/02 , A61F2/07 , A61F2/20 , A61F2/2412 , A61F2/2418 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/92 , A61F2002/043 , A61F2002/8483 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0058 , A61F2230/0076 , A61F2230/0078 , A61F2230/0091 , A61N2007/0078
摘要： The devices and methods disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices and methods produce and to maintain collateral openings or channels through the airway wall so that expired air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. The devices and methods also disclose locating and selecting a site for creation of a collateral opening.
摘要翻译：本文公开的装置和方法旨在改变肺内的气流以改善例如具有慢性阻塞性肺疾病的个体的呼气循环。更具体地说，这些装置和方法产生和保持通过气道壁的侧支开口或通道，使得呼出的空气能够直接从肺组织中流出，以促进氧气最终进入血液和/或解压缩超氧化物充气的肺。设备和方法还公开了定位和选择用于创建抵押开放的站点。

4. 发明授权

US06599311B1 Method and assembly for lung volume reduction 有权
标题翻译：肺体积减少的方法和装配
公开(公告)号：US06599311B1
公开(公告)日：2003-07-29
申请号：US09576786
申请日：2000-05-23
申请人： Michael Biggs , Bryan Loomas , Steven Masterson , Keith M. Burger , Dave Haugaard , James M. Davenport , John Arthur Ross
发明人： Michael Biggs , Bryan Loomas , Steven Masterson , Keith M. Burger , Dave Haugaard , James M. Davenport , John Arthur Ross
IPC分类号： A61B1704
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/064 , A61B17/0644 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B2017/00349 , A61B2017/00809 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0451 , A61B2017/0496 , A61B2017/1205
摘要： Methods and assemblies for reducing the volume of a lung. A plurality of anchors are anchored at different positions in the lung. A cord is attached to each of the anchors. The anchors are drawn towards one another via the cords to cause the lung to collapse, thus compressing the tissue in the lung and establishing a reduction in lung volume.
摘要翻译：用于减少肺体积的方法和装置。多个锚定在肺中的不同位置。一根绳索连接到每个锚。锚通过绳索相互牵引以引起肺塌陷，从而压缩肺中的组织并建立肺容积的减少。

5. 发明授权

US08985116B2 Layered nasal devices 有权
标题翻译：分层鼻装置
公开(公告)号：US08985116B2
公开(公告)日：2015-03-24
申请号：US11759916
申请日：2007-06-07
申请人： Rajiv Doshi , Bryan Loomas , Ryan Kendall Pierce , Arthur Ferdinand , Arthur G. Sandoval , Jeffrey W. Servaites , Matthew Durack , Daniel Francis Kennedy
发明人： Rajiv Doshi , Bryan Loomas , Ryan Kendall Pierce , Arthur Ferdinand , Arthur G. Sandoval , Jeffrey W. Servaites , Matthew Durack , Daniel Francis Kennedy
IPC分类号： A61M11/00 , A61M16/06 , A62B23/06 , A61M16/08 , A61M16/20 , A61M16/10 , A61F5/08 , A61M15/08 , A61F5/56
CPC分类号： A62B23/06 , A61F5/08 , A61F5/56 , A61M15/08 , A61M15/085 , A61M16/0616 , A61M16/0688 , A61M16/0866 , A61M16/106 , A61M16/208
摘要： Described herein are nasal devices. In particular, layered nasal respiratory devices are described. Layered nasal device may include a layered airflow resistor that is configured to resist airflow in a first direction more than airflow in a second direction and that includes a flap valve adjacent to a flap valve limiting layer and an adhesive holdfast layer that is configured to secure the layered airflow resistor in communication with the subject's nasal cavity. Methods of using and methods of assembling layered nasal device are also described.
摘要翻译：这里描述的是鼻装置。特别地，描述了分层的鼻呼吸装置。层状鼻装置可以包括分层气流阻力器，其被配置成抵抗第一方向上的气流，而不是沿着第二方向的气流，并且包括与瓣阀限制层相邻的瓣阀和被配置成固定分层气流电阻器与受试者的鼻腔连通。还描述了使用方法和组装分层鼻装置的方法。

6. 发明授权

US08944071B2 Method for treating an asthma attack 有权
标题翻译：治疗哮喘发作的方法
公开(公告)号：US08944071B2
公开(公告)日：2015-02-03
申请号：US13590129
申请日：2012-08-20
申请人： Bryan Loomas , Michael D. Laufer , David P. Thompson
发明人： Bryan Loomas , Michael D. Laufer , David P. Thompson
IPC分类号： A61B19/00 , A61F7/12 , A61B18/18 , A61M29/00 , A61B18/08 , A61B18/02 , A61B18/14 , A61M29/02 , A61N1/40 , A61N5/00 , A61N1/06 , A61B18/00 , A61M25/00 , A61B17/00
CPC分类号： A61B18/02 , A61B18/04 , A61B18/08 , A61B18/1492 , A61B18/18 , A61B2017/003 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00434 , A61B2018/00541 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/0212 , A61B2090/3614 , A61F7/123 , A61F2007/0018 , A61F2007/0059 , A61F2007/126 , A61M25/0043 , A61M29/00 , A61M29/02 , A61M2025/0096 , A61M2210/1039 , A61N1/06 , A61N1/403 , A61N5/00
摘要： Methods of increasing gas exchange performed by the lung by damaging lung cells, damaging tissue, causing trauma, and/or destroying airway smooth muscle tone with an apparatus inserted into an airway of the lung are disclosed. The damaging of lung cells, damaging tissue, causing trauma, and/or destroying smooth muscle tone with the apparatus may be accomplished via any one of or combinations of the following: heating the airway; cooling the airway; delivering a liquid to the airway; delivering a gas to the airway; puncturing the airway; tearing the airway; cutting the airway; applying ultrasound to the airway; and applying ionizing radiation to the airway.
摘要翻译：公开了通过用插入肺内气道的装置来增加由肺损伤肺细胞，损伤组织，引起创伤和/或破坏气道平滑肌张力的气体交换的方法。可以通过以下任何一种或组合来实现肺细胞损伤，损伤组织，引起创伤和/或破坏平滑肌张力：加热气道; 冷气道向气道输送液体; 向气道输送气体; 刺穿气道; 撕裂气道; 切断气道; 将超声波应用于气道; 并向气道施加电离辐射。

7. 发明授权

US08020700B2 Packaging and dispensing nasal devices 有权
标题翻译：包装和分配鼻装置
公开(公告)号：US08020700B2
公开(公告)日：2011-09-20
申请号：US12329271
申请日：2008-12-05
申请人： Rajiv Doshi , Bryan Loomas , Enrique F. Mendez , Arthur G. Sandoval , Jeffrey W. Servaites , Matthew Durack
发明人： Rajiv Doshi , Bryan Loomas , Enrique F. Mendez , Arthur G. Sandoval , Jeffrey W. Servaites , Matthew Durack
IPC分类号： B65D83/10 , A61M15/08
CPC分类号： B26D3/10 , B26D3/08 , B26F1/02 , B26F1/3846
摘要： Described herein are packaging systems for nasal devices, and methods of packaging and/or dispensing nasal devices. A packaging system may include one or a plurality of nasal devices removably secured to a support backing, and a dispenser. In some variations an applicator may also be included. Methods of using and methods of assembling packaging systems and dispensers are also described.
摘要翻译：这里描述了用于鼻装置的包装系统，以及包装和/或分配鼻装置的方法。包装系统可以包括可拆卸地固定到支撑背衬的一个或多个鼻部装置和分配器。在一些变型中，还可以包括施用器。还描述了使用方法和组装包装系统和分配器的方法。

8. 发明申请

US20100204689A1 METHOD FOR TREATING AN ASTHMA ATTACK 有权
标题翻译：治疗哮喘病的方法
公开(公告)号：US20100204689A1
公开(公告)日：2010-08-12
申请号：US12765704
申请日：2010-04-22
申请人： Christopher J. Danek , Bryan Loomas , Thomas Keast , Michael D. Laufer
发明人： Christopher J. Danek , Bryan Loomas , Thomas Keast , Michael D. Laufer
IPC分类号： A61B17/00 , A61B18/04
CPC分类号： A61N5/00 , A61B18/08 , A61B18/1492 , A61B18/18 , A61B2017/003 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00541 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2090/3614 , A61M25/0043 , A61M29/02 , A61M2025/0096 , A61M2210/1039 , A61N1/06 , A61N1/403
摘要： A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.
摘要翻译：在可逆性慢性阻塞性肺疾病如哮喘发作的急性发作期间治疗肺的方法。该方法包括将能量传递到气道的气道壁，使得气道的直径增加。在哮喘发作之前，期间或之后，能量可能转移到气道壁。能量可以以足以临时或永久地增加气道直径的量来转移。该方法可以在气道打开，关闭或部分关闭时进行。

9. 发明授权

US07422584B2 Extrapleural airway device and method 有权
标题翻译：胸外气道装置及方法
公开(公告)号：US07422584B2
公开(公告)日：2008-09-09
申请号：US10615491
申请日：2003-07-07
申请人： Bryan Loomas , Gary Kaplan
发明人： Bryan Loomas , Gary Kaplan
IPC分类号： A61B18/18
CPC分类号： A61F2/04 , A61F2002/046
摘要： This is directed to improving the gaseous exchange in a lung of an individual and particularly, this is directed to improving the gaseous exchange in individuals having chronic obstructive pulmonary disease. It generally includes fluidly connecting the lung to an extrapleural airway such as the trachea. In one variation, a conduit is deployed to place the lung and the trachea in fluid communication which allows trapped oxygen-reduced air to pass directly out of the lung and into the trachea. Removing nonfunctional air from the lung tends to improve the gaseous exchange of oxygen into the blood and decompress hyper-inflated lungs. Sealant and biocompatible adhesives may be provided on the exterior of the conduit to prevent side flow, leaks and to otherwise prevent air from entering spaces not intended to receive air such as the pleura space.
摘要翻译：这旨在改善个体肺中的气体交换，特别是涉及改善具有慢性阻塞性肺疾病的个体中的气体交换。它通常包括将肺流体连接到胸膜前气道如气管。在一个变型中，部署导管以将肺和气管置于流体连通中，其允许被捕获的减氧空气直接通过肺部并进入气管。从肺部去除非功能性空气有助于改善氧气进入血液的气体交换并减压超膨胀的肺。可以在导管的外部设置密封剂和生物相容性粘合剂，以防止侧流，泄漏并防止空气进入不想接收诸如胸膜空间的空气的空间。

10. 发明申请

US20080041373A1 Nasal devices 有权
标题翻译：鼻装置
公开(公告)号：US20080041373A1
公开(公告)日：2008-02-21
申请号：US11811339
申请日：2007-06-07
申请人： Rajiv Doshi , Bryan Loomas , Ryan Pierce , Elliot Sather , Arthur Sandoval , Jeffrey Servaites , Sandrine Lebas , Matthew Durack
发明人： Rajiv Doshi , Bryan Loomas , Ryan Pierce , Elliot Sather , Arthur Sandoval , Jeffrey Servaites , Sandrine Lebas , Matthew Durack
IPC分类号： A61M15/08
CPC分类号： A62B23/06 , A61F5/08 , A61F5/56 , A61M15/08 , A61M15/085 , A61M16/0616 , A61M16/0688 , A61M16/0866 , A61M16/106 , A61M16/208
摘要： Described herein are adhesive nasal devices. In particular, the adhesive nasal respiratory devices described herein are configured to be worn in communication with a subject's nasal cavity and may include a rim body having a passageway therethrough, an airflow resistor in communication with the passageway of the rim body, and a flexible, adhesive holdfast layer extending outward from the periphery of the rim body. The rim body region may be formed from multiple parts (e.g., a first and a second rim body region), and the airflow resistor may be secured between the parts forming the rim body. Methods of manufacturing and assembling these adhesive nasal devices are also described.
摘要翻译：这里描述的是粘性鼻装置。特别地，本文所述的粘合性鼻呼吸器具被配置为与被检者的鼻腔连通，并且可以包括具有通过其的通道的边缘体，与边缘体的通道连通的气流电阻器，粘合保持层从边缘体的周边向外延伸。轮辋体区域可以由多个部分（例如，第一和第二边缘体区域）形成，并且气流阻力器可以固定在形成轮辋主体的部件之间。还描述了制造和组装这些粘合剂鼻装置的方法。

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