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1. 发明授权

US07329777B2 Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis 失效
标题翻译：治疗心力衰竭，血栓栓塞性疾病和肺纤维化的方法
公开(公告)号：US07329777B2
公开(公告)日：2008-02-12
申请号：US11209517
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： C07C229/00
CPC分类号： C07C229/38 , C07C2601/14
摘要： This invention relates to methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.
摘要翻译：本发明涉及治疗心力衰竭，血栓栓塞障碍和肺纤维化的方法，包括施用有效量的式（I）化合物，其中若干变量如说明书和权利要求中所定义。

2. 发明申请

US20060111444A1 Novel halogen-substituted aminodicarboxylic acid derivatives 失效
标题翻译：新型卤素取代的氨基二羧酸衍生物
公开(公告)号：US20060111444A1
公开(公告)日：2006-05-25
申请号：US11210131
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译：本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义在说明书和权利要求中。

3. 发明申请

US20050288366A1 Novel aminodicarboxylic acid derivatives 失效
标题翻译：新型氨基二羧酸衍生物
公开(公告)号：US20050288366A1
公开(公告)日：2005-12-29
申请号：US11209517
申请日：2005-08-22
申请人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Harter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61P1/16 , A61K31/195 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/08 , A61P15/10 , A61P15/12 , A61P25/04 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P29/02 , A61P43/00 , C07B61/00 , C07C227/02 , C07C229/38 , C07C253/30 , C07C255/54 , A61K31/277
CPC分类号： C07C229/38 , C07C2601/14
摘要： This invention relates to methods for treating cardiovascular disorder selected from heart failure, thromboembolic disorders, venous diseases, and fibrotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.
摘要翻译：本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括给予有效量的式（I）化合物，其中几个变量为在说明书和权利要求中限定。

4. 发明授权

US07705043B2 Substituted aminodicarboxylic acid derivatives having pharmaceutical properties 失效
标题翻译：具有药物性质的取代的氨基二羧酸衍生物
公开(公告)号：US07705043B2
公开(公告)日：2010-04-27
申请号：US11581261
申请日：2006-10-10
申请人： Cristina Alonso-Alija , Michael Harter , Michael Hahn , Josef Pernerstorfer , Stefan Weigand , Johannes-Peter Stasch , Frank Wunder
发明人： Cristina Alonso-Alija , Michael Harter , Michael Hahn , Josef Pernerstorfer , Stefan Weigand , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/34 , C07D333/02
CPC分类号： C07C229/38 , C07C2602/10 , C07D213/65 , C07D333/20
摘要： The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions containing them, and methods of using them are claimed.
摘要翻译：本发明涉及式（I）化合物及其盐和立体异构体，其中变量如说明书和权利要求中所定义，用于制备用于治疗心血管和其他疾病的药物。要求保护这些化合物，制备方法，含有它们的组合物和使用它们的方法。

5. 发明申请

US20070179139A1 Substituted aminodicarboxylic acid derivatives having pharmaceutical properties 失效
标题翻译：具有药物性质的取代的氨基二羧酸衍生物
公开(公告)号：US20070179139A1
公开(公告)日：2007-08-02
申请号：US11581261
申请日：2006-10-10
申请人： Cristina Alonso-Alija , Michael Harter , Michael Hahn , Josef Pernerstorfer , Stefan Weigand , Johannes-Peter Stasch , Frank Wunder
发明人： Cristina Alonso-Alija , Michael Harter , Michael Hahn , Josef Pernerstorfer , Stefan Weigand , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/496 , A61K31/495 , A61K31/445 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07C229/38 , C07C2602/10 , C07D213/65 , C07D333/20
摘要： The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions containing them, and methods of using them are claimed.
摘要翻译：本发明涉及式（I）化合物及其盐和立体异构体，其中变量如说明书和权利要求中所定义，用于制备用于治疗心血管和其他疾病的药物。要求保护这些化合物，制备方法，含有它们的组合物和使用它们的方法。

6. 发明申请

US20060154912A1 Isophtalic acid derivatives 失效
标题翻译：异代酸衍生物
公开(公告)号：US20060154912A1
公开(公告)日：2006-07-13
申请号：US10537623
申请日：2003-11-28
申请人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： A61K31/455 , A61K31/397 , A61K31/195 , A61K31/445
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译：本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。

7. 发明申请

US20080176898A1 Phenyl Acetamides 审中-公开
标题翻译：苯乙酰胺
公开(公告)号：US20080176898A1
公开(公告)日：2008-07-24
申请号：US11587318
申请日：2005-04-14
申请人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
发明人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
IPC分类号： A61K31/445 , C07D211/06 , A61K31/195 , A61P9/00 , C07C229/06
CPC分类号： C07D211/62 , C07C235/34 , C07C235/36 , C07D205/04 , C07D207/08 , C07D211/60
摘要： The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.
摘要翻译：本发明涉及苯乙酰胺，其制备方法及其用于制备用于治疗和/或预防人和动物尤其是心血管疾病疾病的药物。

8. 发明申请

US20070287698A1 Tetrahydrobenzo(D)Azepin-2-One Derivatives and the Use Thereof for Treating Cardiovascular Diseases 失效
标题翻译：四氢苯并（D）Azepin-2-One衍生物及其用途治疗心血管疾病
公开(公告)号：US20070287698A1
公开(公告)日：2007-12-13
申请号：US10588862
申请日：2005-02-01
申请人： Nils Griebenow , Timo Flessner , Michael Harter , Martin Raabe , Anja Buchmuller , Hilmar Bischoff , Peter Ellinghaus , Peter Kolkhof
发明人： Nils Griebenow , Timo Flessner , Michael Harter , Martin Raabe , Anja Buchmuller , Hilmar Bischoff , Peter Ellinghaus , Peter Kolkhof
IPC分类号： A61K31/55 , A61P9/00 , C07D223/16
CPC分类号： C07D223/16 , C07D401/06
摘要： The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
摘要翻译：本申请涉及新的四氢苯并[d]吖庚因-2-酮衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和缺血性疾病。

9. 发明申请

US20110067970A1 FLUID FRICTION CLUTCH 有权
标题翻译：流体摩擦离合器
公开(公告)号：US20110067970A1
公开(公告)日：2011-03-24
申请号：US12566363
申请日：2009-09-24
申请人： Michael Harter , David McDermott
发明人： Michael Harter , David McDermott
IPC分类号： F16D31/06
CPC分类号： F16D35/024
摘要： A fluid friction clutch includes a drivable housing having a working chamber and a reservoir, at least one opening between the reservoir and the working chamber configured to provide fluid communication between the reservoir and the working chamber, a driven disk supported for rotation in the working chamber, and a rotor mounted in the reservoir and rotatably coupled to the driven disk for rotation about an axis of rotation, the rotor having a plurality of arms, separated by a plurality of gaps, projecting away from its axis of rotation.
摘要翻译：流体摩擦离合器包括具有工作室和储存器的可驱动壳体，所述储存器和所述工作室之间的至少一个开口被构造成在所述储存器和所述工作室之间提供流体连通;被驱动盘，所述从动盘被支撑以在所述工作室中旋转以及转子，其安装在所述储存器中并且可旋转地联接到所述从动盘以围绕旋转轴线旋转，所述转子具有多个臂，所述多个臂由多个间隙分开，远离其旋转轴线突出。

10. 发明申请

US20050159431A1 Substituted alkyl uracils and thereof 审中-公开
标题翻译：取代的烷基尿嘧啶及其
公开(公告)号：US20050159431A1
公开(公告)日：2005-07-21
申请号：US10501033
申请日：2003-01-03
申请人： Barbara Albrecht , Michael Gerisch , Michael Harter , Thomas Krahn , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Barbara Albrecht , Michael Gerisch , Michael Harter , Thomas Krahn , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： A61P9/10 , C07D239/96 , C07D401/06 , C07D403/06 , C07D409/12 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/519 , A61K31/517 , C07D491/02 , C07D498/02
CPC分类号： C07D401/06 , C07D239/96 , C07D403/06 , C07D409/12 , C07D491/04 , C07D495/04
摘要： The invention relates to novel compounds of formula (I), to a method for the production thereof, and to their use as medicament active ingredients for the prophylaxis and/or treatment of diseases.
摘要翻译：本发明涉及式（I）的新型化合物，其制备方法及其作为预防和/或治疗疾病的药物活性成分的用途。

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