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1. 发明授权

US07700653B2 Halogen-substituted aminodicarboxylic acid derivatives 失效
标题翻译：卤素取代的氨基二羧酸衍生物
公开(公告)号：US07700653B2
公开(公告)日：2010-04-20
申请号：US11210131
申请日：2005-08-22
申请人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译：本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义在说明书和权利要求中。

2. 发明授权

US07067694B2 Halogen-substituted amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases 失效
标题翻译：卤素取代的氨基二羧酸衍生物作为治疗心血管疾病的药物
公开(公告)号：US07067694B2
公开(公告)日：2006-06-27
申请号：US10469180
申请日：2002-02-18
申请人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： C07C63/00
CPC分类号： C07C229/38 , A61K31/197
摘要： Compounds of the general formula (I) wherein R1 represents halogen, R2 and R3 represent H or halogen, and R4 represents C3-8-cycloalkyl or optionally substituted phenyl, pharamceutical compositions containing such materials, and methods of using such materials in the treatment of various diseases are disclosed and claimed.
摘要翻译：其中R 1表示卤素，R 2和R 3的通式（I）的化合物表示H或卤素，R“ 4表示C 3-8 - 环烷基或任选取代的苯基，含有这些材料的pharamceutical组合物，以及使用这些材料用于治疗各种疾病的方法。

3. 发明授权

US09018258B2 Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof 有权
标题翻译：取代的1-苄基环烷基羧酸及其用途
公开(公告)号：US09018258B2
公开(公告)日：2015-04-28
申请号：US13312320
申请日：2011-12-06
申请人： Thomas Lampe , Michael G. Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andŕeas Knorr , Peter Kolkhof , Elisabeth Woltering
发明人： Thomas Lampe , Michael G. Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andŕeas Knorr , Peter Kolkhof , Elisabeth Woltering
IPC分类号： A61K31/196 , C07C233/55 , C07C231/02 , C07C233/24
CPC分类号： C07C231/02 , A61K31/196 , C07C233/24 , C07C233/55
摘要： The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译：本申请涉及新的取代的1-苄基环烷基羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

4. 发明授权

US07619077B2 Nucleic acids encoding a galacturonosyl tranferase enzyme (GALAT1) from arabidopsis 有权
标题翻译：编码来自拟南芥的半乳糖醛酸转移酶（GALAT1）的核酸
公开(公告)号：US07619077B2
公开(公告)日：2009-11-17
申请号：US10544180
申请日：2004-02-05
申请人： Debra Mohnen , Jason Dwight Sterling , Ron Lou Doong , Venkata Siva Kumar Kolli , Michael G. Hahn
发明人： Debra Mohnen , Jason Dwight Sterling , Ron Lou Doong , Venkata Siva Kumar Kolli , Michael G. Hahn
IPC分类号： C07H21/04 , C12N15/82 , A01H5/00
CPC分类号： C12N9/1051 , C12N15/8245
摘要： The invention provides an isolated nucleic acid molecule encoding the polypeptide GALAT1 having galacturonosyltransferase (GalAT) activity. The Arabidopsis GALAT1 sequence disclosed represents the first pectin biosynthetic glycosyltransferase gene isolated from plants. The invention further provides 14 GALAT and 10 GALAT-like gene superfamily members. The identification of the GALAT gene superfamily offers new opportunities to modulate pectin synthesis in vivo and in vitro by modulating the GALAT gene, for example, transgenic plants that produce modified pectins can be generated by altering the GALAT gene. Since modified pectins are predicted to affect plant growth, development, and plant defense responses, the transgenic plants are expected to have improved agricultural value. The modified pectins isolated from such transgenic plants are useful as gelling and stabilizing agents in the food, neutraceutical, and pharmaceutical industries. The expressed proteins, and variants thereof, of the GALAT superfamily are useful to produce in vitro modified pectins of commercial value.
摘要翻译：本发明提供了编码具有半乳糖醛酸转移酶（GalAT）活性的多肽GALAT1的分离的核酸分子。所公开的拟南芥GALAT1序列代表从植物分离的第一个果胶生物合成糖基转移酶基因。本发明还提供14个GALAT和10个GALAT样基因超家族成员。 GALAT基因超家族的鉴定提供了通过调节GALAT基因在体内和体外调节果胶合成的新机会，例如，可以通过改变GALAT基因产生产生修饰的果胶的转基因植物。由于修饰的果胶预测会影响植物生长发育和植物防御反应，因此转基因植物预计将具有改善的农业价值。从这些转基因植物分离的修饰的果胶可用作食品，药物和制药工业中的胶凝和稳定剂。 GALAT超家族的表达蛋白及其变异体可用于产生具有商业价值的体外修饰果胶。

5. 发明授权

US5170073A Ultra-low noise port output driver circuit 失效
标题翻译：超低噪声端口输出驱动电路
公开(公告)号：US5170073A
公开(公告)日：1992-12-08
申请号：US782395
申请日：1991-10-24
申请人： Michael G. Hahn , Joseph H. Salmon , Robert E. Larsen
发明人： Michael G. Hahn , Joseph H. Salmon , Robert E. Larsen
IPC分类号： H03K17/16
CPC分类号： H03K17/164
摘要： A circuit for providing digital output signals carrying large amounts of currents without generating large transients including apparatus for providing a first current path for providing current at a first rate and a first polarity, apparatus for providing a second current path for providing current at the first rate and the first polarity after a first delay, and apparatus for providing a third current path for providing current of the first polarity at a rate greater than the first rate and sufficient for a load connected thereto after a second delay equal to the first delay whereby the current available at the load has built to a level sufficient to sustain the load prior to the provision of the third current.
摘要翻译：一种用于提供承载大量电流的数字输出信号而不产生大的瞬变的电路，包括用于提供用于以第一速率和第一极性提供电流的第一电流路径的装置，用于提供用于以第一速率提供电流的第二电流路径的装置以及第一延迟后的第一极性的装置，以及用于提供第三电流路径的装置，用于以比第一速率大的速率提供第一极性的电流，并且在等于第一延迟的第二延迟之后足以连接到其上的负载在负载下可用的电流已建立到足以在提供第三电流之前维持负载的电平。

6. 发明授权

US5216289A Asynchronous reset scheme for ultra-low noise port tri-state output driver circuit 失效
标题翻译：超低噪声端口三态输出驱动电路的异步复位方案
公开(公告)号：US5216289A
公开(公告)日：1993-06-01
申请号：US782680
申请日：1991-10-24
申请人： Michael G. Hahn , Joseph H. Salmon , Jeffery D. Wilson
发明人： Michael G. Hahn , Joseph H. Salmon , Jeffery D. Wilson
IPC分类号： H03K17/16
CPC分类号： H03K17/164
摘要： A circuit for providing digital output signals carrying large amounts of currents without generating large transients at an output terminal connected to a load comprising apparatus for providing gradually increasing amounts of current of a first polarity to the output terminal, apparatus for providing gradually increasing amounts of current of a second polarity to the output terminal, apparatus for utilizing the apparatus for providing gradually increasing amounts of current of a first polarity to the output terminal to place the output terminal at a voltage level required for input signals, apparatus for providing a high impedance path to hold the output terminal at the voltage level required for input signals, and apparatus for disabling the apparatus for providing gradually increasing amounts of current of a first polarity and the apparatus for providing gradually increasing amounts of current of a second polarity to the output terminal.
摘要翻译：一种电路，用于提供承载大量电流的数字输出信号，而不在连接到负载的输出端产生大的瞬变，所述负载包括用于向输出端提供逐渐增加的第一极性的电流的装置，用于逐渐增加电流量的装置对输出端子具有第二极性的装置，用于利用该装置向输出端子逐渐增加第一极性电流的装置，以将输出端子置于输入信号所需的电压电平的装置，用于提供高阻抗路径的装置将输出端子保持在输入信号所需的电压电平，以及用于禁止提供第一极性逐渐增加的电流的装置的装置和用于向输出端子逐渐增加第二极性电流的装置。

7. 发明授权

US5701447A Method and apparatus for eliminating latch propagation delays in an alignment unit for use in a fractional bus architecture 失效
$Method and apparatus for eliminating latch propagation delays in an alignment unit for use in a fractional bus architecture$
标题翻译：用于消除用于分数总线架构的对准单元中的锁存器传播延迟的方法和装置
公开(公告)号：US5701447A
公开(公告)日：1997-12-23
申请号：US508831
申请日：1995-07-28
申请人： Michael G. Hahn
发明人： Michael G. Hahn
IPC分类号： G06F1/12 , G06F13/40
CPC分类号： G06F1/12 , G06F13/405
摘要： An alignment unit is provided for aligning signals transmitted between a core clock domain and a bus clock domain. The alignment unit includes at least one alignment latch connected along each signal path between the core and bus clock domains. For critical path signal lines, the alignment unit also includes a latch bypass to allow critical signals to bypass the latch in circumstances when the core and bus clock signals are already aligned. The bypass mechanism includes a multiplexer which transmits the critical path signal through a tristate buffer if the clock signals are aligned or through a latch and a tristate buffer if the clock signals are unaligned. By bypassing the latch when the signals are aligned, latch propagation delays are avoided. Method and apparatus embodiments are disclosed.
摘要翻译：提供对准单元以对准在核心时钟域和总线时钟域之间传输的信号。对准单元包括沿着核心和总线时钟域之间的每个信号路径连接的至少一个对准锁存器。对于关键路径信号线，对准单元还包括锁存旁路，以在核心和总线时钟信号已经对准的情况下允许关键信号绕过锁存器。旁路机构包括多路复用器，如果时钟信号被对准，则通过三态缓冲器传送关键路径信号，或者如果时钟信号未对齐，则通过锁存器和三态缓冲器传送关键路径信号。当信号对齐时，通过旁路锁存器，避免了锁存器传播延迟。公开了方法和设备实施例。

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